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P50649 (RIR2_PLAFG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small subunit

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene names
Name:RNR2
OrganismPlasmodium falciparum (isolate FCR-3 / Gambia)
Taxonomic identifier5838 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Ribonucleoside-diphosphate reductase small subunit
PRO_0000190458

Sites

Active site1081 By similarity
Metal binding701Iron 1 By similarity
Metal binding1011Iron 1 By similarity
Metal binding1011Iron 2 By similarity
Metal binding1041Iron 1 By similarity
Metal binding1631Iron 2 By similarity
Metal binding1971Iron 2 By similarity
Metal binding2001Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50649 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 73AD1257E294A013

FASTA32237,372
        10         20         30         40         50         60 
MRRILNKESD RFTLYPILYP DVFPFYKKAE ACFWTAEEID YSSDLKDFEK LNENEKHFIK 

        70         80         90        100        110        120 
HVLAFFAASD GIVLENLAVS FLREVQITEA KKFYSFQIAV ENIHSETYSL LIDNYIKDEK 

       130        140        150        160        170        180 
ERLNLFHAIE NIPAVKNKAL WAAKWINDTN SFAERIVANA CVEGILFSGS FCAIFWFKKQ 

       190        200        210        220        230        240 
NKLHGLTFSN ELISRDEGLH TDFNCLIYSL LDNKLPEQMV QNIVKEAGGV EVEKSFICES 

       250        260        270        280        290        300 
LPCDLIGMNS RLMSQYIEFV ADRLLECLGC SKIFHSKNPF NWMDLISLQG KTNFFEKRVA 

       310        320 
DYQKSGVMAQ RKDHVFCLNT EF 

« Hide

References

[1]"Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy."
Rubin H., Salem J.S., Li L.S., Yang F.D., Mama S., Wang Z.M., Fisher A., Hamann C.S., Cooperman B.S.
Proc. Natl. Acad. Sci. U.S.A. 90:9280-9284(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22058 Genomic DNA. Translation: AAA29754.1.

3D structure databases

ProteinModelPortalP50649.
SMRP50649. Positions 3-285.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_PLAFG
AccessionPrimary (citable) accession number: P50649
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways