P50646RIR1_BHV1CRibonucleoside-diphosphate reductase large subunitR11.17.4.1Ribonucleotide reductase large subunitRIR1UL39Bovine herpesvirus 1.1 (strain Cooper)BoHV-1Infectious bovine rhinotracheitis virusVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesOrthoherpesviridaeAlphaherpesvirinaeVaricellovirusVaricellovirus bovinealpha1Bos taurusBovineSequence analysis of the UL39, UL38, and UL37 homologues of bovine herpesvirus 1 and expression studies of UL40 and UL39, the subunits of ribonucleotide reductase.NUCLEOTIDE SEQUENCE [GENOMIC DNA]Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1.NUCLEOTIDE SEQUENCE [GENOMIC DNA]Tinkering with a viral ribonucleotide reductase.REVIEWRibonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphateHeterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.Belongs to the ribonucleoside diphosphate reductase large chain family.ATP-bindingDisulfide bondDNA replicationEarly proteinNucleotide-bindingOxidoreductaseViral latencyViral reactivation from latencysubstratesubstratesubstratesubstratesubstrateMASDAFMQTACPADAAEQLEAEHAEWAQLGCGAVPPPPAAASRPSRAAVAAYVGEVVDRMRAQSRADERVYVKCGQLVHLRVRARSVPLDDWLTSAELALVSEVAEPVRANRAFVEVSLRYFELTEYATLRALGLQSALKYEEMYLAKLEGGAIESMGQFFVRIAATAATWTMREPAFGRALVGEGATWCAVFNAYLTALYRQLVVPATPIMLFAGRARGSLASCYLLNPQVSSSTEAVEAITTEVARILLNRGGIGISFQSFDRAVSRDCKRGIMGALKLLDSMAMAINSDSERPTGICVYLEPWHCDVRAVLNMRGLLARDESTRCDNLFSCLWVPDLLFDRYLAHLEGREGVVWTLFDDRASHLSRLHGPAFTAEYERLEREGLGVETVPVQDLAFLIVRSIVMTGSPFVMFKDACNRHYHMDTAGDALTGSNLCTEIVQRASPDAHGVCNLASVNLPRCVREGEGGALAFDFAALSTAAATAAIFVNAMMLGGQYPTEKAARGVARHRSLGIGFQGLHTLLLELGMDMLSPAARRLNVEIAERLLLAVMATSATLCEYGCAPFEDFARSKFARGLMPFDGYEGVVLSLPRAWARLREKVARHGLYNAQFVALMPTVSSSQVTEGSEGFSPVFTNMFSKVTMSGELLRPNLPLMRALRKHFTREASRLGAVRALDREQWSVAAALGDLAPGHPLAKFKTAFEYDQERLIDLCADRAPFVDQSQSMSLFVTEPMDGKVPASQIMNLLVYAYKKGLKTGLYYCKIRKATNNGVFTGGDLVCSGCHL
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