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Reviewed, UniProtKB/Swiss-Prot P50646 (RIR1_BHV1C)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ribonucleoside-diphosphate reductase large subunit
    EC=1.17.4.1
Alternative name(s):
    Ribonucleotide reductase large subunit
Gene names
Name: UL39
OrganismBovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifier10323 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length787 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family.

Ontologies

Keywords
   Biological processDNA replication
   LigandATP-binding
Nucleotide-binding
   Molecular functionOxidoreductase
   Technical termAllosteric enzyme
Gene Ontology (GO)
   Biological processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentribonucleoside-diphosphate reductase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside-diphosphate reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 787787Ribonucleoside-diphosphate reductase large subunit
PRO_0000187240

Sites

Active site2251Hydrogen atom transfer By similarity
Active site4361Proton acceptor By similarity
Active site4381Proton acceptor By similarity
Active site4401Proton acceptor By similarity
Active site4531Hydrogen atom transfer By similarity
Active site7621Electron transfer By similarity
Active site7631Electron transfer By similarity
Site7821Interacts with thioredoxin/glutaredoxin By similarity
Site7851Interacts with thioredoxin/glutaredoxin By similarity

Sequences

Sequence LengthMass (Da)Tools
P50646-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8DB0F6327862333E

FASTA78786,010
        10         20         30         40         50         60 
MASDAFMQTA CPADAAEQLE AEHAEWAQLG CGAVPPPPAA ASRPSRAAVA AYVGEVVDRM 

        70         80         90        100        110        120 
RAQSRADERV YVKCGQLVHL RVRARSVPLD DWLTSAELAL VSEVAEPVRA NRAFVEVSLR 

       130        140        150        160        170        180 
YFELTEYATL RALGLQSALK YEEMYLAKLE GGAIESMGQF FVRIAATAAT WTMREPAFGR 

       190        200        210        220        230        240 
ALVGEGATWC AVFNAYLTAL YRQLVVPATP IMLFAGRARG SLASCYLLNP QVSSSTEAVE 

       250        260        270        280        290        300 
AITTEVARIL LNRGGIGISF QSFDRAVSRD CKRGIMGALK LLDSMAMAIN SDSERPTGIC 

       310        320        330        340        350        360 
VYLEPWHCDV RAVLNMRGLL ARDESTRCDN LFSCLWVPDL LFDRYLAHLE GREGVVWTLF 

       370        380        390        400        410        420 
DDRASHLSRL HGPAFTAEYE RLEREGLGVE TVPVQDLAFL IVRSIVMTGS PFVMFKDACN 

       430        440        450        460        470        480 
RHYHMDTAGD ALTGSNLCTE IVQRASPDAH GVCNLASVNL PRCVREGEGG ALAFDFAALS 

       490        500        510        520        530        540 
TAAATAAIFV NAMMLGGQYP TEKAARGVAR HRSLGIGFQG LHTLLLELGM DMLSPAARRL 

       550        560        570        580        590        600 
NVEIAERLLL AVMATSATLC EYGCAPFEDF ARSKFARGLM PFDGYEGVVL SLPRAWARLR 

       610        620        630        640        650        660 
EKVARHGLYN AQFVALMPTV SSSQVTEGSE GFSPVFTNMF SKVTMSGELL RPNLPLMRAL 

       670        680        690        700        710        720 
RKHFTREASR LGAVRALDRE QWSVAAALGD LAPGHPLAKF KTAFEYDQER LIDLCADRAP 

       730        740        750        760        770        780 
FVDQSQSMSL FVTEPMDGKV PASQIMNLLV YAYKKGLKTG LYYCKIRKAT NNGVFTGGDL 


VCSGCHL 

« Hide

References

[1]"Sequence analysis of the UL39, UL38, and UL37 homologues of bovine herpesvirus 1 and expression studies of UL40 and UL39, the subunits of ribonucleotide reductase."
Simard C., Langlois I., Styger D., Vogt B., Vlcek C., Chalifour A., Trudel M., Schwyzer M.
Virology 212:734-740(1995) [PubMed: 7571445] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Gene contents in a 31-kb segment at the left genome end of bovine herpesvirus-1."
Schwyzer M., Styger D., Vogt B., Lowery D.E., Simard C., Laboissiere S., Misra V., Vlcek C., Paces V.
Vet. Microbiol. 53:67-77(1996) [PubMed: 9010999] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

Z54206 Genomic DNA. Translation: CAA90929.1.
Z49078 Genomic DNA. Translation: CAA88900.1.
AJ004801 Genomic DNA. Translation: CAA06094.1.
RefSeqNP_045319.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1487390.

Family and domain databases

InterProIPR013346. NrdE_NrdA.
IPR013509. Ribncl_Rdtase_lsu_N.
IPR000788. Ribncl_red_lg_C.
[Graphical view]
PANTHERPTHR11573. Ribncl_red_lg_C. 1 hit.
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
PROSITEPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR1_BHV1C
AccessionPrimary (citable) accession number: P50646
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents