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P50645 (RIR2_SUHVK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:RR2
Synonyms:UL40
OrganismSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Taxonomic identifier33703 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Ribonucleoside-diphosphate reductase small chain
PRO_0000190511

Sites

Active site971 By similarity
Metal binding601Iron 1 By similarity
Metal binding901Iron 1 By similarity
Metal binding901Iron 2 By similarity
Metal binding931Iron 1 By similarity
Metal binding1531Iron 2 By similarity
Metal binding1871Iron 2 By similarity
Metal binding1901Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50645 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 560F19FDE6C7A9C3

FASTA30334,375
        10         20         30         40         50         60 
MEYFYTSQCP DMDHLRSLSV ANRWLETDLP LGDDAKDVAA LSEPELEFYR FLFAFLSAAD 

        70         80         90        100        110        120 
DLVNVNLGSL SELFTQKDIL HYYIEQECIE VVHSRVYSAI QLMLFRGDAA ARERYVRAAL 

       130        140        150        160        170        180 
RDEAIRRKVE WLDSRVAECA SVAEKYLLMI LIEGIFFASS FASISYLRTH NLFVVTCQSN 

       190        200        210        220        230        240 
DFISRDEAIH TSASCCIYNN YLGDAPRPDE ARIHQLFAEA VEIECEFLRA RAPRDSLLLD 

       250        260        270        280        290        300 
LPAIISYVRY SADRLLQAIG ASPLFGAPAP AADFPMALMV AEKHTNFFER RSTNYTGTVV 


NDL 

« Hide

References

[1]"Large and small subunits of the Aujeszky's disease virus ribonucleotide reductase: nucleotide sequence and putative structure."
Kaliman A., Boldogkoi Z., Fodor I.
Biochim. Biophys. Acta 1219:151-156(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X72087 Genomic DNA. Translation: CAA50977.1.
X80797 Genomic DNA. Translation: CAA56776.1.
PIRS47526.
RefSeqYP_068343.1. NC_006151.1.

3D structure databases

ProteinModelPortalP50645.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2952536.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_SUHVK
AccessionPrimary (citable) accession number: P50645
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways