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Protein

Ribonucleoside-diphosphate reductase small subunit

Gene

RIR2

Organism
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77Iron 1UniRule annotation1
Metal bindingi107Iron 1UniRule annotation1
Metal bindingi107Iron 2UniRule annotation1
Metal bindingi110Iron 1UniRule annotation1
Active sitei114UniRule annotation1
Metal bindingi170Iron 2UniRule annotation1
Metal bindingi204Iron 2UniRule annotation1
Metal bindingi207Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication, Viral latency, Viral reactivation from latency
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small subunitUniRule annotation (EC:1.17.4.1UniRule annotation)
Alternative name(s):
Ribonucleotide reductase small subunitUniRule annotation
Gene namesi
Name:RIR2UniRule annotation
OrganismiEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifieri10333 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

Subcellular locationi

  • Host membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001905091 – 320Ribonucleoside-diphosphate reductase small subunitAdd BLAST320

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.UniRule annotation

Protein-protein interaction databases

IntActiP50644, 2 interactors
MINTiP50644

Structurei

3D structure databases

ProteinModelPortaliP50644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
HAMAPiMF_04028 HSV_RIR2, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR034715 HSV_RIR2
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

P50644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALENSKKTD FADELLINAY FYTPECPDIE HLRLLSVANR WLDTDLPISD
60 70 80 90 100
DLKDVAKLAP AEREFYRFLF AFLSAADDLV NLNLGDLSAL FTQKDILHYY
110 120 130 140 150
IEQESIEVTH SRVYSAIQLM LFGNDATARA RYVASVVKDV AIDLKVSWLQ
160 170 180 190 200
AKVRECKSVA EKYILMILIE GVFFASSFAS IAYLRTHNLF VVTCQSNDLI
210 220 230 240 250
SRDEAIHTNA SCCIYNNYLG GFEKPAPTRI YALFSEAVNI ECEFLLSHAP
260 270 280 290 300
KSSHLLDIEA IICYVRYSAD RLLGEIGLSP LFNAPKPPPS FPLAFMTVEK
310 320
HTNFFERRST AYSGTLINDL
Length:320
Mass (Da):36,172
Last modified:October 1, 1996 - v1
Checksum:i7AF3511937730202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75354 Genomic DNA Translation: CAA53101.1

Similar proteinsi

Entry informationi

Entry nameiRIR2_EHV4
AccessioniPrimary (citable) accession number: P50644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health