Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P50644 (RIR2_EHV4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
OrganismEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifier10333 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Ribonucleoside-diphosphate reductase small chain
PRO_0000190509

Sites

Active site1141 By similarity
Metal binding771Iron 1 By similarity
Metal binding1071Iron 1 By similarity
Metal binding1071Iron 2 By similarity
Metal binding1101Iron 1 By similarity
Metal binding1701Iron 2 By similarity
Metal binding2041Iron 2 By similarity
Metal binding2071Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50644 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7AF3511937730202

FASTA32036,172
        10         20         30         40         50         60 
MALENSKKTD FADELLINAY FYTPECPDIE HLRLLSVANR WLDTDLPISD DLKDVAKLAP 

        70         80         90        100        110        120 
AEREFYRFLF AFLSAADDLV NLNLGDLSAL FTQKDILHYY IEQESIEVTH SRVYSAIQLM 

       130        140        150        160        170        180 
LFGNDATARA RYVASVVKDV AIDLKVSWLQ AKVRECKSVA EKYILMILIE GVFFASSFAS 

       190        200        210        220        230        240 
IAYLRTHNLF VVTCQSNDLI SRDEAIHTNA SCCIYNNYLG GFEKPAPTRI YALFSEAVNI 

       250        260        270        280        290        300 
ECEFLLSHAP KSSHLLDIEA IICYVRYSAD RLLGEIGLSP LFNAPKPPPS FPLAFMTVEK 

       310        320 
HTNFFERRST AYSGTLINDL 

« Hide

References

[1]"Sequences of the ribonucleotide reductase-encoding genes of equine herpesvirus 4."
Riggio M.P., Onions D.E.
Gene 143:217-222(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1942.
[2]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75354 Genomic DNA. Translation: CAA53101.1.

3D structure databases

ProteinModelPortalP50644.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP50644. 2 interactions.
MINTMINT-6732622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_EHV4
AccessionPrimary (citable) accession number: P50644
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways