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P50644

- RIR2_EHV4

UniProt

P50644 - RIR2_EHV4

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene
N/A
Organism
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Iron 1 By similarity
Metal bindingi107 – 1071Iron 1 By similarity
Metal bindingi107 – 1071Iron 2 By similarity
Metal bindingi110 – 1101Iron 1 By similarity
Active sitei114 – 1141 By similarity
Metal bindingi170 – 1701Iron 2 By similarity
Metal bindingi204 – 2041Iron 2 By similarity
Metal bindingi207 – 2071Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
OrganismiEquine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)
Taxonomic identifieri10333 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Ribonucleoside-diphosphate reductase small chainPRO_0000190509Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Protein-protein interaction databases

IntActiP50644. 2 interactions.
MINTiMINT-6732622.

Structurei

3D structure databases

ProteinModelPortaliP50644.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50644-1 [UniParc]FASTAAdd to Basket

« Hide

MALENSKKTD FADELLINAY FYTPECPDIE HLRLLSVANR WLDTDLPISD    50
DLKDVAKLAP AEREFYRFLF AFLSAADDLV NLNLGDLSAL FTQKDILHYY 100
IEQESIEVTH SRVYSAIQLM LFGNDATARA RYVASVVKDV AIDLKVSWLQ 150
AKVRECKSVA EKYILMILIE GVFFASSFAS IAYLRTHNLF VVTCQSNDLI 200
SRDEAIHTNA SCCIYNNYLG GFEKPAPTRI YALFSEAVNI ECEFLLSHAP 250
KSSHLLDIEA IICYVRYSAD RLLGEIGLSP LFNAPKPPPS FPLAFMTVEK 300
HTNFFERRST AYSGTLINDL 320
Length:320
Mass (Da):36,172
Last modified:October 1, 1996 - v1
Checksum:i7AF3511937730202
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75354 Genomic DNA. Translation: CAA53101.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75354 Genomic DNA. Translation: CAA53101.1 .

3D structure databases

ProteinModelPortali P50644.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50644. 2 interactions.
MINTi MINT-6732622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of the ribonucleotide reductase-encoding genes of equine herpesvirus 4."
    Riggio M.P., Onions D.E.
    Gene 143:217-222(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1942.
  2. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR2_EHV4
AccessioniPrimary (citable) accession number: P50644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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