P50641 (RRL_HHV7J) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase large subunit-like protein U28

Gene names

Name:

U28

Organism

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) [Complete proteome]

Taxonomic identifier

57278 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Does not have ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase large chain family.
Caution	Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity. Its enzyme activity is therefore uncertain.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ribonucleoside-diphosphate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 806	806	Ribonucleoside-diphosphate reductase large subunit-like protein U28		PRO_0000187239

Sequences

	Sequence		Length	Mass (Da)
	P50641 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4BA516084FCCDCC0	FASTA	806	93,070
	10 20 30 40 50 60 MDPNNKVSIN KNMGLLRKCL CHDEYNKKRF CYSRFHHKTL LYKQLYEISK ILRRLNSGLD 70 80 90 100 110 120 MWCLRDAIIS ALGAMHDAPH VDRLLGQFYL KTNSASEFDS ISLILESENI LQKELIEFVR 130 140 150 160 170 180 DSKVELEKIL QAAIHVWRAK FSPGVLAASR FLDEISNSFN GIEENIPTIF LRISVTLASQ 190 200 210 220 230 240 IKKIEYLQKS FVSHKCPLVE EILILLYKRV CMLPFPCMSN LGLVSEKKSV FDTVFHNVSN 250 260 270 280 290 300 FSLEDFLDIN SGFFLPAMLN GSYVSVNLTR YHYEAESLME LLLSQLQIVE KDTNKTTGLT 310 320 330 340 350 360 IYLEIWHLSL LMWLDFCEIL PTTVQVKFCL ILPEIFMERL KTENSYWSVF HKALAINLGL 370 380 390 400 410 420 YDESDFTSKY LECERTAEHA RIKTETLLDN ICRCLRRGQM GFIFRKNIHK YSMLPQIASY 430 440 450 460 470 480 CLGNSMDVIP FEYGLNTAFR IALNLSYFVE NVSEEQKSHT NIDMFHYRDK IFNLKKMRKT 490 500 510 520 530 540 VTELVLIGNA VIDYALENRD FLMDGIVNAR SLAICVTGLH SALMSMNLPF NSQLGCQLYR 550 560 570 580 590 600 IVCENIYYSS VRTSMNCCKK GAEPCSFFQR SKYAQGILHC DLYDNVEYTL PNVLWTNLRS 610 620 630 640 650 660 DIKKYGLRNL TFVSGSAMSK EFDLLNCSQS FCPIEGNKIL KRSSIKVLHP NPVFHSDLSV 670 680 690 700 710 720 YSTELQTLYI PVYNGLFLNR FKNHLEYLSS VNYDVSKVNK NLFSEEEMQE MTIFLNAFDY 730 740 750 760 770 780 SVNEMLNMYV GALPFTDHGQ ANVFFINKTE NMRDILVCLY QNGFKTGIYQ AVYKNQKCDG 790 800 VNPSKKFDLL SGFSDGVVMS TMHVFQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Determination and analysis of the complete nucleotide sequence of human herpesvirus." Nicholas J. J. Virol. 70:5975-5989(1996) [PubMed: 8709220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The U28 ORF of human herpesvirus-7 does not encode a functional ribonucleotide reductase R1 subunit." Sun Y., Conner J. J. Gen. Virol. 80:2713-2718(1999) [PubMed: 10573165] [Abstract] Cited for: LACK OF RIBONUCLEOTIDE REDUCTASE ACTIVITY.
[3]	"Tinkering with a viral ribonucleotide reductase." Lembo D., Brune W. Trends Biochem. Sci. 34:25-32(2009) [PubMed: 18990579] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43400 Genomic DNA. Translation: AAC54690.1.
PIR	T41930.
RefSeq	YP_073768.1. NC_001716.2.
3D structure databases
ProteinModelPortal	P50641.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3289486.
Phylogenomic databases
ProtClustDB	CLSP2510057.
Family and domain databases
InterPro	IPR000788. Ribncl_red_lg_C. [Graphical view]
Pfam	PF02867. Ribonuc_red_lgC. 1 hit. [Graphical view]
PRINTS	PR01183. RIBORDTASEM1.
PROSITE	PS00089. RIBORED_LARGE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RRL_HHV7J

Accession

Primary (citable) accession number: P50641

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 27, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program