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P50637 (TSPO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name=PBR
Gene names
Name:Tspo
Synonyms:Bzrp, Mbr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme By similarity. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells By similarity.

Subunit structure

Interacts with BZRAP1 By similarity. Interacts with MOST-1 By similarity. May interact with STAR By similarity.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein.

Induction

By dimethyl sulfoxide and diazepam. Ref.2

Sequence similarities

Belongs to the TspO/BZRP family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

behavioral response to pain

Inferred from electronic annotation. Source: Ensembl

cellular hypotonic response

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to zinc ion

Inferred from electronic annotation. Source: Ensembl

chloride transport

Inferred from electronic annotation. Source: Ensembl

contact inhibition

Inferred from electronic annotation. Source: Ensembl

glial cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of glial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system axon regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of glial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitochondrial depolarization

Inferred from electronic annotation. Source: Ensembl

positive regulation of necrotic cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of steroid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to manganese ion

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to testosterone

Inferred from electronic annotation. Source: Ensembl

response to vitamin B1

Inferred from electronic annotation. Source: Ensembl

steroid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial outer membrane

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI

   Molecular_functionandrogen binding

Inferred from electronic annotation. Source: Ensembl

benzodiazepine receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Translocator protein
PRO_0000190998

Regions

Transmembrane6 – 2621Helical; Name=1; Potential
Transmembrane47 – 6721Helical; Name=2; Potential
Transmembrane80 – 10021Helical; Name=3; Potential
Transmembrane106 – 12621Helical; Name=4; Potential
Transmembrane135 – 15521Helical; Name=5; Potential

Experimental info

Sequence conflict541G → A in BAA04749. Ref.2
Sequence conflict1681P → A in BAA04749. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50637 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2EF93420C3842A85

FASTA16918,841
        10         20         30         40         50         60 
MPESWVPAVG LTLVPSLGGF MGAYFVRGEG LRWYASLQKP SWHPPRWTLA PIWGTLYSAM 

        70         80         90        100        110        120 
GYGSYIVWKE LGGFTEDAMV PLGLYTGQLA LNWAWPPIFF GARQMGWALA DLLLVSGVAT 

       130        140        150        160 
ATTLAWHRVS PPAARLLYPY LAWLAFATVL NYYVWRDNSG RRGGSRLPE 

« Hide

References

[1]"In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells."
Garnier M., Dimchev A.B., Boujrad N., Price J.M., Musto N.A., Papadopoulos V.
Mol. Pharmacol. 45:201-211(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis."
Taketani S., Kohno H., Okuda M., Furukawa T., Tokunaga R.
J. Biol. Chem. 269:7527-7531(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: BALB/c.
Tissue: Erythroleukemia.
[3]"Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes."
Yakovlev A.G., Ruffo M., Jurka J., Krueger K.E.
Gene 155:201-205(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L17306 mRNA. Translation: AAA20127.1.
D21207 mRNA. Translation: BAA04749.1.
U12419 Genomic DNA. Translation: AAA83253.1.
PIRA53405.
I57953.
RefSeqNP_033905.3. NM_009775.4.
UniGeneMm.1508.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP50637.
ChEMBLCHEMBL2149.

Proteomic databases

PaxDbP50637.
PRIDEP50637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736.
GeneID12257.
KEGGmmu:12257.
UCSCuc007xbg.2. mouse.

Organism-specific databases

CTD706.
MGIMGI:88222. Tspo.

Phylogenomic databases

eggNOGCOG3476.
HOGENOMHOG000224659.
HOVERGENHBG001296.
InParanoidP50637.
KOK05770.
OMAATTLNYC.
OrthoDBEOG7V7687.
PhylomeDBP50637.
TreeFamTF342852.

Gene expression databases

ArrayExpressP50637.
BgeeP50637.
CleanExMM_TSPO.
GenevestigatorP50637.

Family and domain databases

InterProIPR004307. TspO_MBR.
[Graphical view]
PANTHERPTHR10057. PTHR10057. 1 hit.
PfamPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFPIRSF005859. PBR. 1 hit.
ProtoNetSearch...

Other

NextBio280682.
PROP50637.
SOURCESearch...

Entry information

Entry nameTSPO_MOUSE
AccessionPrimary (citable) accession number: P50637
Secondary accession number(s): Q62118, Q6LCZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot