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Protein

Translocator protein

Gene

Tspo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060).By similarity5 Publications

GO - Molecular functioni

  • androgen binding Source: MGI
  • benzodiazepine receptor activity Source: MGI
  • ion channel binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-196108 Pregnenolone biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name:
PBR
Gene namesi
Name:Tspo
Synonyms:Bzrp, Mbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88222 Tspo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5Mitochondrial intermembrane1 Publication5
Transmembranei6 – 26Helical; Name=1Add BLAST21
Topological domaini27 – 46Cytoplasmic1 PublicationAdd BLAST20
Transmembranei47 – 67Helical; Name=2Add BLAST21
Topological domaini68 – 79Mitochondrial intermembrane1 PublicationAdd BLAST12
Transmembranei80 – 100Helical; Name=3Add BLAST21
Topological domaini101 – 105Cytoplasmic1 Publication5
Transmembranei106 – 126Helical; Name=4Add BLAST21
Topological domaini127 – 134Mitochondrial intermembrane1 Publication8
Transmembranei135 – 155Helical; Name=5Add BLAST21
Topological domaini156 – 169Cytoplasmic1 PublicationAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No obvious phenotype. Mice are viable and fertile and present only very minor changes in gonadal and adrenal steroid hormone production. testis-specific gene disruption (PubMed:24174323) does not affect testosterone production, gametogenesis and male fertility.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi147A → T: No effect. 1 Publication1
Mutagenesisi153Y → S: Abolishes cholesterol transport. 1 Publication1
Mutagenesisi156R → L: Abolishes cholesterol transport. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909981 – 169Translocator proteinAdd BLAST169

Proteomic databases

PaxDbiP50637
PeptideAtlasiP50637
PRIDEiP50637
TopDownProteomicsiQ541E3

PTM databases

iPTMnetiP50637
PhosphoSitePlusiP50637

Expressioni

Tissue specificityi

Detected in liver (at protein level). Ubiquitous.2 Publications

Inductioni

By dimethyl sulfoxide and diazepam.1 Publication

Gene expression databases

BgeeiENSMUSG00000041736
CleanExiMM_TSPO
ExpressionAtlasiP50637 baseline and differential
GenevisibleiP50637 MM

Interactioni

Subunit structurei

Interacts with TSPOAP1. Interacts with MOST-1. May interact with STAR.By similarity

GO - Molecular functioni

  • ion channel binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi198410, 2 interactors
STRINGi10090.ENSMUSP00000037039

Chemistry databases

BindingDBiP50637

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Helixi6 – 36Combined sources31
Helixi46 – 49Combined sources4
Helixi52 – 71Combined sources20
Beta strandi72 – 75Combined sources4
Helixi76 – 93Combined sources18
Helixi96 – 98Combined sources3
Turni99 – 103Combined sources5
Helixi105 – 108Combined sources4
Helixi109 – 125Combined sources17
Turni126 – 129Combined sources4
Helixi131 – 137Combined sources7
Helixi138 – 140Combined sources3
Helixi141 – 158Combined sources18
Helixi164 – 166Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MGYNMR-A1-167[»]
2N02NMR-A1-169[»]
ProteinModelPortaliP50637
SMRiP50637
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3797 Eukaryota
COG3476 LUCA
GeneTreeiENSGT00390000012980
HOGENOMiHOG000224659
HOVERGENiHBG001296
InParanoidiP50637
KOiK05770
OMAiWYASLQK
OrthoDBiEOG091G0W79
PhylomeDBiP50637
TreeFamiTF342852

Family and domain databases

CDDicd15904 TSPO_MBR, 1 hit
Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR030164 TSPO
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR
PANTHERiPTHR10057 PTHR10057, 1 hit
PTHR10057:SF5 PTHR10057:SF5, 1 hit
PfamiView protein in Pfam
PF03073 TspO_MBR, 1 hit
PIRSFiPIRSF005859 PBR, 1 hit

Sequencei

Sequence statusi: Complete.

P50637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESWVPAVG LTLVPSLGGF MGAYFVRGEG LRWYASLQKP SWHPPRWTLA
60 70 80 90 100
PIWGTLYSAM GYGSYIVWKE LGGFTEDAMV PLGLYTGQLA LNWAWPPIFF
110 120 130 140 150
GARQMGWALA DLLLVSGVAT ATTLAWHRVS PPAARLLYPY LAWLAFATVL
160
NYYVWRDNSG RRGGSRLPE
Length:169
Mass (Da):18,841
Last modified:October 1, 1996 - v1
Checksum:i2EF93420C3842A85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36S → G in AAH02055 (PubMed:15489334).Curated1
Sequence conflicti54G → A in BAA04749 (PubMed:8125973).Curated1
Sequence conflicti168P → A in BAA04749 (PubMed:8125973).Curated1
Sequence conflicti168P → A in AAH02055 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17306 mRNA Translation: AAA20127.1
D21207 mRNA Translation: BAA04749.1
AY079441 Genomic DNA Translation: AAL87529.1
AY079442 Genomic DNA Translation: AAL87530.1
AK149743 mRNA Translation: BAE29056.1
AK150516 mRNA Translation: BAE29628.1
AK151421 mRNA Translation: BAE30386.1
AK151569 mRNA Translation: BAE30511.1
AK151824 mRNA Translation: BAE30721.1
AK152082 mRNA Translation: BAE30932.1
AK152827 mRNA Translation: BAE31528.1
AK153159 mRNA Translation: BAE31769.1
AK153273 mRNA Translation: BAE31860.1
AK156489 mRNA Translation: BAE33730.1
AK165450 mRNA Translation: BAE38192.1
AK165822 mRNA Translation: BAE38396.1
AK166125 mRNA Translation: BAE38585.1
AK172384 mRNA Translation: BAE42976.1
CH466550 Genomic DNA Translation: EDL04468.1
BC002055 mRNA Translation: AAH02055.1
U12419 Genomic DNA Translation: AAA83253.1
CCDSiCCDS27705.1
PIRiA53405
I57953
RefSeqiNP_033905.3, NM_009775.4
UniGeneiMm.1508

Genome annotation databases

EnsembliENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736
GeneIDi12257
KEGGimmu:12257
UCSCiuc007xbg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTSPO_MOUSE
AccessioniPrimary (citable) accession number: P50637
Secondary accession number(s): Q541E3
, Q62118, Q6LCZ0, Q99M32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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