ID   P19_TBSVT               Reviewed;         172 AA.
AC   P50628;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=RNA silencing suppressor p19;
DE   AltName: Full=19 kDa symptom severity modulator;
GN   ORFNames=ORF4;
OS   Tomato bushy stunt virus (strain type) (TBSV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC   Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus;
OC   Tombusvirus lycopersici.
OX   NCBI_TaxID=70159;
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH   NCBI_TaxID=3749; Malus.
OH   NCBI_TaxID=3766; Pyrus (pears).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4111; Solanum melongena (Eggplant) (Aubergine).
OH   NCBI_TaxID=29777; Tolmiea menziesii.
OH   NCBI_TaxID=13305; Tulipa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   AGRICOLA=IND20581771;
RA   Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E.,
RA   Garcia-Arenal F.;
RT   "Different tomato bushy stunt virus strains cause disease outbreaks on
RT   solanaceous crops in Spain.";
RL   Phytopathology 86:535-542(1996).
CC   -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC       silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC       select siRNAs based on the length of the duplex region of the RNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC       {ECO:0000305}.
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DR   EMBL; Z68899; CAA93132.1; -; Genomic_RNA.
DR   SMR; P50628; -.
DR   GO; GO:0044423; C:virion component; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.180; RNA silencing suppressor P19; 1.
DR   InterPro; IPR004905; Tombusvirus_p19.
DR   InterPro; IPR036131; VP19_sf.
DR   Pfam; PF03220; Tombus_P19; 1.
DR   SUPFAM; SSF103145; Tombusvirus P19 core protein, VP19; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   RNA-binding; Suppressor of RNA silencing; Viral immunoevasion.
FT   CHAIN           1..172
FT                   /note="RNA silencing suppressor p19"
FT                   /id="PRO_0000222884"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19421 MW;  E51E7FB9BA7FAA29 CRC64;
     MERAIQGNDA REQANSERWD GGSGSSTSPF QLPDESPSWT EWRLHNDETN SNQDNPLGFK
     ESWGFGKVVF KRYLRYERTE TSLHRVLGSW TGDSVNYAAS RFFGVNQIGC TYSIRFRGVS
     VTISGGSRTL QHLCEMAIRS KQELLQLTPV EVESNVSRGC PEGVETFEEE SE
//