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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Tomato bushy stunt virus (strain BS-3) (TBSV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiTomato bushy stunt virus (strain BS-3) (TBSV)
Taxonomic identifieri12146 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228801 – 172RNA silencing suppressor p19Add BLAST172

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP50626.
SMRiP50626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

Gene3Di2.60.40.1810. 1 hit.
InterProiView protein in InterPro
IPR004905. Tombusvirus_p19.
IPR036131. VP19_sf.
PfamiView protein in Pfam
PF03220. Tombus_P19. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005743. Tombus_P19. 1 hit.
SUPFAMiSSF103145. SSF103145. 1 hit.

Sequencei

Sequence statusi: Complete.

P50626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAIQGNDA REQAYGERWN GGSGSSTSPF KLPDESPSWT EWRLHNDETI
60 70 80 90 100
SNQDNPLGFK ESWGFGKVVF KRYLRYERTE TSLHRVLGSW TGDSVNYAAS
110 120 130 140 150
RFLGFDQIGC TYSIRFRGVS VTISGGSRTL QHLSEMAIRS KQELLQLTPV
160 170
EVESDVSRGC PEGIETFKEE SE
Length:172
Mass (Da):19,451
Last modified:October 1, 1996 - v1
Checksum:i445AF16F16498841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68895 Genomic RNA. Translation: CAA93124.1.
Z68900 Genomic RNA. Translation: CAA93134.1.
Z68902 Genomic RNA. Translation: CAA93138.1.

Similar proteinsi

Entry informationi

Entry nameiP19_TBSVB
AccessioniPrimary (citable) accession number: P50626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program