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P50626 (P19_TBSVB) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene names
ORF Names:ORF4
OrganismTomato bushy stunt virus (strain BS-3) (TBSV)
Taxonomic identifier12146 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCapsicum annuum (Bell pepper) [TaxID: 4072]
Malus [TaxID: 3749]
Pyrus (pears) [TaxID: 3766]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Tolmiea menziesii [TaxID: 29777]
Tulipa [TaxID: 13305]

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the tombusvirus protein p19 family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
Gene Ontology (GO)
   Cellular_componentvirion

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172RNA silencing suppressor p19
PRO_0000222880

Sequences

Sequence LengthMass (Da)Tools
P50626 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 445AF16F16498841

FASTA17219,451
        10         20         30         40         50         60 
MERAIQGNDA REQAYGERWN GGSGSSTSPF KLPDESPSWT EWRLHNDETI SNQDNPLGFK 

        70         80         90        100        110        120 
ESWGFGKVVF KRYLRYERTE TSLHRVLGSW TGDSVNYAAS RFLGFDQIGC TYSIRFRGVS 

       130        140        150        160        170 
VTISGGSRTL QHLSEMAIRS KQELLQLTPV EVESDVSRGC PEGIETFKEE SE 

« Hide

References

[1]"Different tomato bushy stunt virus strains cause disease outbreaks on solanaceous crops in Spain."
Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E., Garcia-Arenal F.
Phytopathology 86:535-542(1996) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z68895 Genomic RNA. Translation: CAA93124.1.
Z68900 Genomic RNA. Translation: CAA93134.1.
Z68902 Genomic RNA. Translation: CAA93138.1.

3D structure databases

ProteinModelPortalP50626.
SMRP50626. Positions 9-152.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004905. Tombusvirus_p19.
[Graphical view]
PfamPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF103145. SSF103145. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP19_TBSVB
AccessionPrimary (citable) accession number: P50626
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families