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Protein

Protein Tob1

Gene

TOB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).3 Publications

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ProtInc
  • SMAD binding Source: Ensembl
  • transcription corepressor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLinkiP50616
SIGNORiP50616

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob1
Alternative name(s):
Transducer of erbB-2 1
Gene namesi
Name:TOB1
Synonyms:TOB, TROB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141232.4
HGNCiHGNC:11979 TOB1
MIMi605523 gene
neXtProtiNX_P50616

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45Y → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi55F → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi65D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi93W → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi95D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1

Organism-specific databases

DisGeNETi10140
OpenTargetsiENSG00000141232
PharmGKBiPA36663

Polymorphism and mutation databases

BioMutaiTOB1
DMDMi1729989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438121 – 345Protein Tob1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated on Ser and Thr residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50616
PaxDbiP50616
PeptideAtlasiP50616
PRIDEiP50616

PTM databases

iPTMnetiP50616
PhosphoSitePlusiP50616

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000141232
CleanExiHS_TOB1
GenevisibleiP50616 HS

Organism-specific databases

HPAiHPA047839

Interactioni

Subunit structurei

Interacts with ERBB2 (PubMed:8632892). Interacts with CNOT7 (PubMed:19276069, PubMed:21336257, PubMed:23236473). Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay (PubMed:21336257). Interacts with CNOT8 (PubMed:23236473). Interacts with CPEB4 (PubMed:21336257).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ProtInc
  • SMAD binding Source: Ensembl

Protein-protein interaction databases

BioGridi115443, 38 interactors
IntActiP50616, 30 interactors
MINTiP50616
STRINGi9606.ENSP00000268957

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Turni14 – 19Combined sources6
Helixi22 – 40Combined sources19
Turni49 – 52Combined sources4
Helixi53 – 56Combined sources4
Beta strandi58 – 64Combined sources7
Helixi66 – 73Combined sources8
Turni74 – 76Combined sources3
Helixi79 – 85Combined sources7
Beta strandi90 – 95Combined sources6
Beta strandi98 – 104Combined sources7
Beta strandi109 – 114Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D5RX-ray2.50B1-115[»]
2Z15X-ray2.30A/B/C/D1-117[»]
5CI8X-ray2.33A1-345[»]
5CI9X-ray2.30A1-345[»]
DisProtiDP00794
ProteinModelPortaliP50616
SMRiP50616
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50616

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 92Important for nuclear localizationBy similarityAdd BLAST11
Regioni161 – 218Required for interaction with CPEB31 PublicationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 39Bipartite nuclear localization signalBy similarityAdd BLAST18
Motifi226 – 234Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi237 – 245Poly-Gln9
Compositional biasi249 – 256Poly-Pro8
Compositional biasi257 – 262Poly-Gln6

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000253939
HOVERGENiHBG006617
InParanoidiP50616
KOiK14443
OMAiGLGPLQY
OrthoDBiEOG091G0LEQ
PhylomeDBiP50616
TreeFamiTF105274

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR015677 Tob1
IPR015676 Tob1/2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF6 PTHR17537:SF6, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY
60 70 80 90 100
KGSGFRCIHI GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS
110 120 130 140 150
YQIGEKGPVK VLYVDDNNEN GCELDKEIKN SFNPEAQVFM PISDPASSVS
160 170 180 190 200
SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSNK
210 220 230 240 250
VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP QQQQQPAQPP
260 270 280 290 300
PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP
310 320 330 340
LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN
Length:345
Mass (Da):38,155
Last modified:October 1, 1996 - v1
Checksum:i3C8AC51B49E1E69F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037840319K → R. Corresponds to variant dbSNP:rs3316Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38305 mRNA Translation: BAA07423.1
CR536487 mRNA Translation: CAG38726.1
CR541686 mRNA Translation: CAG46487.1
BT019380 mRNA Translation: AAV38187.1
BT019381 mRNA Translation: AAV38188.1
AK313904 mRNA Translation: BAG36627.1
CH471109 Genomic DNA Translation: EAW94577.1
CH471109 Genomic DNA Translation: EAW94578.1
BC031406 mRNA Translation: AAH31406.1
BC070493 mRNA Translation: AAH70493.1
BC098415 mRNA Translation: AAH98415.1
CCDSiCCDS11576.1
RefSeqiNP_001230806.1, NM_001243877.1
NP_001230814.1, NM_001243885.1
NP_005740.1, NM_005749.3
UniGeneiHs.703321
Hs.744946

Genome annotation databases

EnsembliENST00000268957; ENSP00000268957; ENSG00000141232
ENST00000499247; ENSP00000427695; ENSG00000141232
GeneIDi10140
KEGGihsa:10140
UCSCiuc002isw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTOB1_HUMAN
AccessioniPrimary (citable) accession number: P50616
Secondary accession number(s): B2R9T0, D3DTY3, Q4KMQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health