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Protein

Protein BTG3

Gene

Btg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG3
Alternative name(s):
Abundant in neuroepithelium area protein
BTG family member 3
Protein Tob5
Gene namesi
Name:Btg3
Synonyms:Ana, Tob5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 16, Chromosome 17

Organism-specific databases

MGIiMGI:109532. Btg3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438081 – 252Protein BTG3Add BLAST252

Proteomic databases

PaxDbiP50615.
PRIDEiP50615.

PTM databases

PhosphoSitePlusiP50615.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000022863.
CleanExiMM_BTG3.
ExpressionAtlasiP50615. baseline and differential.
GenevisibleiP50615. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61989N.
STRINGi10090.ENSMUSP00000053997.

Structurei

3D structure databases

ProteinModelPortaliP50615.
SMRiP50615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Ser6

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiP50615.
KOiK14443.
OMAiCEVCCRR.
OrthoDBiEOG091G0U1P.
PhylomeDBiP50615.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTQILQE KYKNHWYPEK
60 70 80 90 100
PSKGQAYRCI RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE
110 120 130 140 150
VCCRYGEKNN AFIVASFENE DENKDEISKK VSRALDKVTS DYHSGSSSSD
160 170 180 190 200
EDTSKEVDVK PSSVAATPSP VYQISELIFP PLPMWHPLPR KKPGMYRGSG
210 220 230 240 250
HQTHYPPPVP FAYPNPGRKN KPFRPIPVTW VPPPGMHCDR NHWINPHMLA

PH
Length:252
Mass (Da):28,983
Last modified:October 1, 1996 - v1
Checksum:i15C4F8EFFF3B4A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72000 mRNA. Translation: CAA96519.1.
D83745 mRNA. Translation: BAA29058.1.
BC012705 mRNA. Translation: AAH12705.1.
CCDSiCCDS28277.1.
RefSeqiNP_001284676.1. NM_001297747.1.
NP_033900.1. NM_009770.3.
UniGeneiMm.392910.

Genome annotation databases

EnsembliENSMUST00000023570; ENSMUSP00000023570; ENSMUSG00000022863.
ENSMUST00000061681; ENSMUSP00000053997; ENSMUSG00000044645.
GeneIDi12228.
KEGGimmu:12228.
UCSCiuc007zsp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72000 mRNA. Translation: CAA96519.1.
D83745 mRNA. Translation: BAA29058.1.
BC012705 mRNA. Translation: AAH12705.1.
CCDSiCCDS28277.1.
RefSeqiNP_001284676.1. NM_001297747.1.
NP_033900.1. NM_009770.3.
UniGeneiMm.392910.

3D structure databases

ProteinModelPortaliP50615.
SMRiP50615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61989N.
STRINGi10090.ENSMUSP00000053997.

PTM databases

PhosphoSitePlusiP50615.

Proteomic databases

PaxDbiP50615.
PRIDEiP50615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023570; ENSMUSP00000023570; ENSMUSG00000022863.
ENSMUST00000061681; ENSMUSP00000053997; ENSMUSG00000044645.
GeneIDi12228.
KEGGimmu:12228.
UCSCiuc007zsp.2. mouse.

Organism-specific databases

CTDi10950.
MGIiMGI:109532. Btg3.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiP50615.
KOiK14443.
OMAiCEVCCRR.
OrthoDBiEOG091G0U1P.
PhylomeDBiP50615.
TreeFamiTF105272.

Miscellaneous databases

PROiP50615.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022863.
CleanExiMM_BTG3.
ExpressionAtlasiP50615. baseline and differential.
GenevisibleiP50615. MM.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTG3_MOUSE
AccessioniPrimary (citable) accession number: P50615
Secondary accession number(s): Q62328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.