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P50610 (FLGE_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Flagellar hook protein FlgE
Gene names
Name:flgE
Ordered Locus Names:HP_0870
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length718 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

A flexible structure which links the flagellar filament to the drive apparatus in the basal body. Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility. Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.

Subcellular location

Bacterial flagellum basal body.

Miscellaneous

The N-terminal amino acid sequence was from strain CCUG 951; the DNA sequence was from strain CCUG 17874. Disruption and subcellular localization experiments were performed for both strains. The apparent pI for the hook protein was 5.1.

Sequence similarities

Belongs to the flagella basal body rod proteins family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 718718Flagellar hook protein FlgE
PRO_0000180828

Experimental info

Sequence conflict1061S → N in AAA92803. Ref.1
Sequence conflict2371C → Y in AAA92803. Ref.1
Sequence conflict2591A → P in AAA92803. Ref.1
Sequence conflict373 – 3742DI → NS in AAA92803. Ref.1
Sequence conflict413 – 4142SV → TI in AAA92803. Ref.1
Sequence conflict5091E → D in AAA92803. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50610 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: F36EB60684AD1333

FASTA71876,207
        10         20         30         40         50         60 
MLRSLWSGVN GMQAHQIALD IESNNIANVN TTGFKYSRAS FVDMLSQVKL IATAPYKNGL 

        70         80         90        100        110        120 
AGQNDFSVGL GVGVDATTKI FSQGNIQNTD VKTDLAIQGD GFFIISPDRG ITRNFTRDGE 

       130        140        150        160        170        180 
FLFDSQGSLV TTGGLVVQGW VRNGSDTGNK GSDTDALKVD NTGPLENIRI DPGMVMPARA 

       190        200        210        220        230        240 
SNRISMRANL NAGRHADQTA AIFALDSSAK TPSDGINPVY DSGTNLAQVA EDMGSLCNED 

       250        260        270        280        290        300 
GDALLLNENQ GIWVSYKSAK MVKDILPSAE NSTLELNGVK ISFTNDSAVS RTSSLVAAKN 

       310        320        330        340        350        360 
AINAVKSQTG IEAYLDGKQL RLENTNELDG DEKLKNIVVT QAGTGAFANF LDGDKDVTAF 

       370        380        390        400        410        420 
KYSYTHSISP NADIGQFRTT EDLRALIQHD ANIVKDPSLA DNYQDSAASI GVSVNQYGMF 

       430        440        450        460        470        480 
EINNKDNKNV IKENLNIFVS GYSSDSVTNN VLFKNAMKGL NTASLIEGGA SASSSKFTHA 

       490        500        510        520        530        540 
THATSIDVID SLGTKHAMRI EFYRSGGAEW NFRVIVPEPG ELVGGSAARP NVFEGGRLHF 

       550        560        570        580        590        600 
NNDGSLAGMN PPLLQFDPKN GADAPQRINL AFGSSGSFDG LTSVDKISET YAIEQNGYQA 

       610        620        630        640        650        660 
GDLMDVRFDS DGVLLGAFSN GRTLALAQVA LANFANDAGL QALGGNVFSQ TGNSGQALIG 

       670        680        690        700        710 
AANTGRRGSI SGSKLESSNV DLSRSLTNLI VVQRGFQANS KAVTTSDQIL NTLLNLKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09549 Genomic DNA. Translation: AAA92803.1.
AE000511 Genomic DNA. Translation: AAD07911.1.
PIRF64628.
RefSeqNP_207664.1. NC_000915.1.
YP_006934784.1. NC_018939.1.

3D structure databases

ProteinModelPortalP50610.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3456N.
IntActP50610. 6 interactions.
MINTMINT-162602.
STRING85962.HP0870.

PTM databases

PhosSiteP11041018.

Proteomic databases

PRIDEP50610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07911; AAD07911; HP_0870.
GeneID13870054.
899399.
KEGGheo:C694_04455.
hpy:HP0870.
PATRIC20593029. VBIHelPyl33062_0902.

Phylogenomic databases

eggNOGCOG1749.
KOK02390.
OMAGEFTNGK.
OrthoDBEOG6G7R1D.
ProtClustDBPRK08425.

Enzyme and pathway databases

BioCycHPY:HP0870-MONOMER.

Family and domain databases

InterProIPR011491. Falgellar_basal_body_FlaE.
IPR001444. Flag_bb_rod_N.
IPR020013. Flagellar_FlgE/F/G.
IPR010810. Flagellin_hook_IN_motif.
IPR010930. Flg_bb/hook_C_dom.
IPR012835. FlgE_epsilon.
[Graphical view]
PfamPF07559. FlaE. 1 hit.
PF07196. Flagellin_IN. 1 hit.
PF00460. Flg_bb_rod. 1 hit.
PF06429. Flg_bbr_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR02489. flgE_epsilon. 1 hit.
TIGR03506. FlgEFG_subfam. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFLGE_HELPY
AccessionPrimary (citable) accession number: P50610
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names