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P50610

- FLGE_HELPY

UniProt

P50610 - FLGE_HELPY

Protein

Flagellar hook protein FlgE

Gene

flgE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    A flexible structure which links the flagellar filament to the drive apparatus in the basal body. Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility. Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.

    GO - Biological processi

    1. bacterial-type flagellum-dependent cell motility Source: InterPro
    2. bacterial-type flagellum organization Source: InterPro

    Enzyme and pathway databases

    BioCyciHPY:HP0870-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellar hook protein FlgE
    Gene namesi
    Name:flgE
    Ordered Locus Names:HP_0870
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. bacterial-type flagellum basal body, rod Source: InterPro

    Keywords - Cellular componenti

    Bacterial flagellum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 718718Flagellar hook protein FlgEPRO_0000180828Add
    BLAST

    Proteomic databases

    PRIDEiP50610.

    PTM databases

    PhosSiteiP11041018.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3456N.
    IntActiP50610. 6 interactions.
    MINTiMINT-162602.
    STRINGi85962.HP0870.

    Structurei

    3D structure databases

    ProteinModelPortaliP50610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1749.
    KOiK02390.
    OMAiGEFTNGK.
    OrthoDBiEOG6G7R1D.

    Family and domain databases

    InterProiIPR011491. Falgellar_basal_body_FlaE.
    IPR001444. Flag_bb_rod_N.
    IPR020013. Flagellar_FlgE/F/G.
    IPR010810. Flagellin_hook_IN_motif.
    IPR010930. Flg_bb/hook_C_dom.
    IPR012835. FlgE_epsilon.
    [Graphical view]
    PfamiPF07559. FlaE. 1 hit.
    PF07196. Flagellin_IN. 1 hit.
    PF00460. Flg_bb_rod. 1 hit.
    PF06429. Flg_bbr_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02489. flgE_epsilon. 1 hit.
    TIGR03506. FlgEFG_subfam. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P50610-1 [UniParc]FASTAAdd to Basket

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    MLRSLWSGVN GMQAHQIALD IESNNIANVN TTGFKYSRAS FVDMLSQVKL    50
    IATAPYKNGL AGQNDFSVGL GVGVDATTKI FSQGNIQNTD VKTDLAIQGD 100
    GFFIISPDRG ITRNFTRDGE FLFDSQGSLV TTGGLVVQGW VRNGSDTGNK 150
    GSDTDALKVD NTGPLENIRI DPGMVMPARA SNRISMRANL NAGRHADQTA 200
    AIFALDSSAK TPSDGINPVY DSGTNLAQVA EDMGSLCNED GDALLLNENQ 250
    GIWVSYKSAK MVKDILPSAE NSTLELNGVK ISFTNDSAVS RTSSLVAAKN 300
    AINAVKSQTG IEAYLDGKQL RLENTNELDG DEKLKNIVVT QAGTGAFANF 350
    LDGDKDVTAF KYSYTHSISP NADIGQFRTT EDLRALIQHD ANIVKDPSLA 400
    DNYQDSAASI GVSVNQYGMF EINNKDNKNV IKENLNIFVS GYSSDSVTNN 450
    VLFKNAMKGL NTASLIEGGA SASSSKFTHA THATSIDVID SLGTKHAMRI 500
    EFYRSGGAEW NFRVIVPEPG ELVGGSAARP NVFEGGRLHF NNDGSLAGMN 550
    PPLLQFDPKN GADAPQRINL AFGSSGSFDG LTSVDKISET YAIEQNGYQA 600
    GDLMDVRFDS DGVLLGAFSN GRTLALAQVA LANFANDAGL QALGGNVFSQ 650
    TGNSGQALIG AANTGRRGSI SGSKLESSNV DLSRSLTNLI VVQRGFQANS 700
    KAVTTSDQIL NTLLNLKQ 718
    Length:718
    Mass (Da):76,207
    Last modified:November 1, 1997 - v2
    Checksum:iF36EB60684AD1333
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061S → N in AAA92803. (PubMed:7891557)Curated
    Sequence conflicti237 – 2371C → Y in AAA92803. (PubMed:7891557)Curated
    Sequence conflicti259 – 2591A → P in AAA92803. (PubMed:7891557)Curated
    Sequence conflicti373 – 3742DI → NS in AAA92803. (PubMed:7891557)Curated
    Sequence conflicti413 – 4142SV → TI in AAA92803. (PubMed:7891557)Curated
    Sequence conflicti509 – 5091E → D in AAA92803. (PubMed:7891557)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09549 Genomic DNA. Translation: AAA92803.1.
    AE000511 Genomic DNA. Translation: AAD07911.1.
    PIRiF64628.
    RefSeqiNP_207664.1. NC_000915.1.
    YP_006934784.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07911; AAD07911; HP_0870.
    GeneIDi13870054.
    899399.
    KEGGiheo:C694_04455.
    hpy:HP0870.
    PATRICi20593029. VBIHelPyl33062_0902.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09549 Genomic DNA. Translation: AAA92803.1 .
    AE000511 Genomic DNA. Translation: AAD07911.1 .
    PIRi F64628.
    RefSeqi NP_207664.1. NC_000915.1.
    YP_006934784.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P50610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3456N.
    IntActi P50610. 6 interactions.
    MINTi MINT-162602.
    STRINGi 85962.HP0870.

    PTM databases

    PhosSitei P11041018.

    Proteomic databases

    PRIDEi P50610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07911 ; AAD07911 ; HP_0870 .
    GeneIDi 13870054.
    899399.
    KEGGi heo:C694_04455.
    hpy:HP0870.
    PATRICi 20593029. VBIHelPyl33062_0902.

    Phylogenomic databases

    eggNOGi COG1749.
    KOi K02390.
    OMAi GEFTNGK.
    OrthoDBi EOG6G7R1D.

    Enzyme and pathway databases

    BioCyci HPY:HP0870-MONOMER.

    Family and domain databases

    InterProi IPR011491. Falgellar_basal_body_FlaE.
    IPR001444. Flag_bb_rod_N.
    IPR020013. Flagellar_FlgE/F/G.
    IPR010810. Flagellin_hook_IN_motif.
    IPR010930. Flg_bb/hook_C_dom.
    IPR012835. FlgE_epsilon.
    [Graphical view ]
    Pfami PF07559. FlaE. 1 hit.
    PF07196. Flagellin_IN. 1 hit.
    PF00460. Flg_bb_rod. 1 hit.
    PF06429. Flg_bbr_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02489. flgE_epsilon. 1 hit.
    TIGR03506. FlgEFG_subfam. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production."
      O'Toole P.W., Kostrzynska M., Trust T.J.
      Mol. Microbiol. 14:691-703(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, CHARACTERIZATION.
      Strain: CCUG 951 and DSM 4867 / CCUG 17874 / NCTC 11638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFLGE_HELPY
    AccessioniPrimary (citable) accession number: P50610
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The N-terminal amino acid sequence was from strain CCUG 951; the DNA sequence was from strain CCUG 17874. Disruption and subcellular localization experiments were performed for both strains. The apparent pI for the hook protein was 5.1.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3