Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P50610

- FLGE_HELPY

UniProt

P50610 - FLGE_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Flagellar hook protein FlgE

Gene

flgE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

A flexible structure which links the flagellar filament to the drive apparatus in the basal body. Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility. Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.

GO - Biological processi

  1. bacterial-type flagellum-dependent cell motility Source: InterPro
  2. bacterial-type flagellum organization Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciHPY:HP0870-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar hook protein FlgE
Gene namesi
Name:flgE
Ordered Locus Names:HP_0870
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. bacterial-type flagellum basal body, rod Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Flagellar hook protein FlgEPRO_0000180828Add
BLAST

Proteomic databases

PRIDEiP50610.

PTM databases

PhosSiteiP11041018.

Interactioni

Protein-protein interaction databases

DIPiDIP-3456N.
IntActiP50610. 6 interactions.
MINTiMINT-162602.
STRINGi85962.HP0870.

Structurei

3D structure databases

ProteinModelPortaliP50610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1749.
KOiK02390.
OMAiGEFTNGK.
OrthoDBiEOG6G7R1D.

Family and domain databases

InterProiIPR011491. Falgellar_basal_body_FlaE.
IPR001444. Flag_bb_rod_N.
IPR020013. Flagellar_FlgE/F/G.
IPR010810. Flagellin_hook_IN_motif.
IPR010930. Flg_bb/hook_C_dom.
IPR012835. FlgE_epsilon.
[Graphical view]
PfamiPF07559. FlaE. 1 hit.
PF07196. Flagellin_IN. 1 hit.
PF00460. Flg_bb_rod. 1 hit.
PF06429. Flg_bbr_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02489. flgE_epsilon. 1 hit.
TIGR03506. FlgEFG_subfam. 2 hits.

Sequencei

Sequence statusi: Complete.

P50610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSLWSGVN GMQAHQIALD IESNNIANVN TTGFKYSRAS FVDMLSQVKL
60 70 80 90 100
IATAPYKNGL AGQNDFSVGL GVGVDATTKI FSQGNIQNTD VKTDLAIQGD
110 120 130 140 150
GFFIISPDRG ITRNFTRDGE FLFDSQGSLV TTGGLVVQGW VRNGSDTGNK
160 170 180 190 200
GSDTDALKVD NTGPLENIRI DPGMVMPARA SNRISMRANL NAGRHADQTA
210 220 230 240 250
AIFALDSSAK TPSDGINPVY DSGTNLAQVA EDMGSLCNED GDALLLNENQ
260 270 280 290 300
GIWVSYKSAK MVKDILPSAE NSTLELNGVK ISFTNDSAVS RTSSLVAAKN
310 320 330 340 350
AINAVKSQTG IEAYLDGKQL RLENTNELDG DEKLKNIVVT QAGTGAFANF
360 370 380 390 400
LDGDKDVTAF KYSYTHSISP NADIGQFRTT EDLRALIQHD ANIVKDPSLA
410 420 430 440 450
DNYQDSAASI GVSVNQYGMF EINNKDNKNV IKENLNIFVS GYSSDSVTNN
460 470 480 490 500
VLFKNAMKGL NTASLIEGGA SASSSKFTHA THATSIDVID SLGTKHAMRI
510 520 530 540 550
EFYRSGGAEW NFRVIVPEPG ELVGGSAARP NVFEGGRLHF NNDGSLAGMN
560 570 580 590 600
PPLLQFDPKN GADAPQRINL AFGSSGSFDG LTSVDKISET YAIEQNGYQA
610 620 630 640 650
GDLMDVRFDS DGVLLGAFSN GRTLALAQVA LANFANDAGL QALGGNVFSQ
660 670 680 690 700
TGNSGQALIG AANTGRRGSI SGSKLESSNV DLSRSLTNLI VVQRGFQANS
710
KAVTTSDQIL NTLLNLKQ
Length:718
Mass (Da):76,207
Last modified:November 1, 1997 - v2
Checksum:iF36EB60684AD1333
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061S → N in AAA92803. (PubMed:7891557)Curated
Sequence conflicti237 – 2371C → Y in AAA92803. (PubMed:7891557)Curated
Sequence conflicti259 – 2591A → P in AAA92803. (PubMed:7891557)Curated
Sequence conflicti373 – 3742DI → NS in AAA92803. (PubMed:7891557)Curated
Sequence conflicti413 – 4142SV → TI in AAA92803. (PubMed:7891557)Curated
Sequence conflicti509 – 5091E → D in AAA92803. (PubMed:7891557)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09549 Genomic DNA. Translation: AAA92803.1.
AE000511 Genomic DNA. Translation: AAD07911.1.
PIRiF64628.
RefSeqiNP_207664.1. NC_000915.1.
YP_006934784.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07911; AAD07911; HP_0870.
GeneIDi13870054.
899399.
KEGGiheo:C694_04455.
hpy:HP0870.
PATRICi20593029. VBIHelPyl33062_0902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09549 Genomic DNA. Translation: AAA92803.1 .
AE000511 Genomic DNA. Translation: AAD07911.1 .
PIRi F64628.
RefSeqi NP_207664.1. NC_000915.1.
YP_006934784.1. NC_018939.1.

3D structure databases

ProteinModelPortali P50610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3456N.
IntActi P50610. 6 interactions.
MINTi MINT-162602.
STRINGi 85962.HP0870.

PTM databases

PhosSitei P11041018.

Proteomic databases

PRIDEi P50610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07911 ; AAD07911 ; HP_0870 .
GeneIDi 13870054.
899399.
KEGGi heo:C694_04455.
hpy:HP0870.
PATRICi 20593029. VBIHelPyl33062_0902.

Phylogenomic databases

eggNOGi COG1749.
KOi K02390.
OMAi GEFTNGK.
OrthoDBi EOG6G7R1D.

Enzyme and pathway databases

BioCyci HPY:HP0870-MONOMER.

Family and domain databases

InterProi IPR011491. Falgellar_basal_body_FlaE.
IPR001444. Flag_bb_rod_N.
IPR020013. Flagellar_FlgE/F/G.
IPR010810. Flagellin_hook_IN_motif.
IPR010930. Flg_bb/hook_C_dom.
IPR012835. FlgE_epsilon.
[Graphical view ]
Pfami PF07559. FlaE. 1 hit.
PF07196. Flagellin_IN. 1 hit.
PF00460. Flg_bb_rod. 1 hit.
PF06429. Flg_bbr_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02489. flgE_epsilon. 1 hit.
TIGR03506. FlgEFG_subfam. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production."
    O'Toole P.W., Kostrzynska M., Trust T.J.
    Mol. Microbiol. 14:691-703(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, CHARACTERIZATION.
    Strain: CCUG 951 and DSM 4867 / CCUG 17874 / NCTC 11638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFLGE_HELPY
AccessioniPrimary (citable) accession number: P50610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The N-terminal amino acid sequence was from strain CCUG 951; the DNA sequence was from strain CCUG 17874. Disruption and subcellular localization experiments were performed for both strains. The apparent pI for the hook protein was 5.1.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3