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P50609

- FMOD_RAT

UniProt

P50609 - FMOD_RAT

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Protein
Fibromodulin
Gene
Fmod
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis By similarity.

GO - Biological processi

  1. odontogenesis Source: RGD
  2. wound healing Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fibromodulin
Short name:
FM
Alternative name(s):
Collagen-binding 59 kDa protein
Keratan sulfate proteoglycan fibromodulin
Short name:
KSPG fibromodulin
Gene namesi
Name:Fmod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619769. Fmod.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: RGD
  2. extracellular region Source: RGD
  3. intracellular Source: RGD
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Chaini19 – 376358Fibromodulin
PRO_0000032741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid By similarity
Modified residuei20 – 201Sulfotyrosine By similarity
Modified residuei38 – 381Sulfotyrosine By similarity
Modified residuei53 – 531Sulfotyrosine By similarity
Modified residuei55 – 551Sulfotyrosine By similarity
Modified residuei63 – 631Sulfotyrosine By similarity
Modified residuei65 – 651Sulfotyrosine By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...) (keratan sulfate) By similarity
Glycosylationi166 – 1661N-linked (GlcNAc...) (keratan sulfate) By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...) (keratan sulfate) By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) (keratan sulfate) By similarity
Disulfide bondi334 ↔ 367 By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Binds keratan sulfate chains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP50609.
PRIDEiP50609.

Expressioni

Gene expression databases

GenevestigatoriP50609.

Interactioni

Subunit structurei

Binds to type I and type II collagen By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004382.

Structurei

3D structure databases

ProteinModelPortaliP50609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 10539LRRNT
Add
BLAST
Repeati106 – 12722LRR 1
Add
BLAST
Repeati130 – 14314LRR 2
Add
BLAST
Repeati156 – 17621LRR 3
Add
BLAST
Repeati177 – 19822LRR 4
Add
BLAST
Repeati201 – 22222LRR 5
Add
BLAST
Repeati224 – 24522LRR 6
Add
BLAST
Repeati246 – 26621LRR 7
Add
BLAST
Repeati269 – 28921LRR 8
Add
BLAST
Repeati294 – 31522LRR 9
Add
BLAST
Repeati316 – 33520LRR 10
Add
BLAST
Repeati344 – 36724LRR 11
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 736Poly-Pro
Compositional biasi76 – 9217Cys-rich
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP50609.
KOiK08121.
PhylomeDBiP50609.

Family and domain databases

InterProiIPR027215. Fibromodulin.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24371:SF11. PTHR24371:SF11. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50609-1 [UniParc]FASTAAdd to Basket

« Hide

MQWASILLLR GLCSLSQGQY EEDSHWWLQY LRNQQSTYYD PYDTYPYETS    50
DPYPYEVEEG PAYAYGAPPP PEPRDCPQEC DCPPNFPTAM YCDNRNLKYL 100
PFVPSRMKYV YFQNNQIAAI QEGVFDNATG LLWIALHGNQ ITSDKIGRKV 150
FSKLRHLERL YLDHNNLTRM PGPLPRSLRE LHLDHNQISR VPNNALEGLE 200
NLTALYLHHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD GLPSALEQLY 250
LEHNNVYTVP DSYFRGSPKL LYVRLSHNSL TNNGLATNTF NSSSLLELDL 300
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVM NFSKLQVLRL 350
DGNEIKRSAM PVDAPLCLRL ASLIEI 376
Length:376
Mass (Da):43,219
Last modified:October 1, 1996 - v1
Checksum:i9C3298675CE3714A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82152 mRNA. Translation: CAA57648.1.
RefSeqiNP_542429.1. NM_080698.1.
UniGeneiRn.8778.

Genome annotation databases

GeneIDi64507.
KEGGirno:64507.
UCSCiRGD:619769. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82152 mRNA. Translation: CAA57648.1 .
RefSeqi NP_542429.1. NM_080698.1.
UniGenei Rn.8778.

3D structure databases

ProteinModelPortali P50609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004382.

Proteomic databases

PaxDbi P50609.
PRIDEi P50609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64507.
KEGGi rno:64507.
UCSCi RGD:619769. rat.

Organism-specific databases

CTDi 2331.
RGDi 619769. Fmod.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000234447.
HOVERGENi HBG108061.
InParanoidi P50609.
KOi K08121.
PhylomeDBi P50609.

Miscellaneous databases

NextBioi 613278.
PROi P50609.

Gene expression databases

Genevestigatori P50609.

Family and domain databases

InterProi IPR027215. Fibromodulin.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
PANTHERi PTHR24371:SF11. PTHR24371:SF11. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Krull N.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFMOD_RAT
AccessioniPrimary (citable) accession number: P50609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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