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Protein

Fibromodulin

Gene

Fmod

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).By similarity

GO - Biological processi

  1. odontogenesis Source: RGD
  2. wound healing Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fibromodulin
Short name:
FM
Alternative name(s):
Collagen-binding 59 kDa protein
Keratan sulfate proteoglycan fibromodulin
Short name:
KSPG fibromodulin
Gene namesi
Name:Fmod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619769. Fmod.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: RGD
  2. extracellular region Source: RGD
  3. intracellular Source: RGD
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 376358FibromodulinPRO_0000032741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
Modified residuei20 – 201SulfotyrosineBy similarity
Modified residuei38 – 381SulfotyrosineBy similarity
Modified residuei53 – 531SulfotyrosineBy similarity
Modified residuei55 – 551SulfotyrosineBy similarity
Modified residuei63 – 631SulfotyrosineBy similarity
Modified residuei65 – 651SulfotyrosineBy similarity
Glycosylationi127 – 1271N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi166 – 1661N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) (keratan sulfate)By similarity
Disulfide bondi334 ↔ 367By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP50609.
PRIDEiP50609.

Expressioni

Gene expression databases

GenevestigatoriP50609.

Interactioni

Subunit structurei

Binds to type I and type II collagen.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004382.

Structurei

3D structure databases

ProteinModelPortaliP50609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 10539LRRNTAdd
BLAST
Repeati106 – 12722LRR 1Add
BLAST
Repeati130 – 14314LRR 2Add
BLAST
Repeati156 – 17621LRR 3Add
BLAST
Repeati177 – 19822LRR 4Add
BLAST
Repeati201 – 22222LRR 5Add
BLAST
Repeati224 – 24522LRR 6Add
BLAST
Repeati246 – 26621LRR 7Add
BLAST
Repeati269 – 28921LRR 8Add
BLAST
Repeati294 – 31522LRR 9Add
BLAST
Repeati316 – 33520LRR 10Add
BLAST
Repeati344 – 36724LRR 11Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 736Poly-Pro
Compositional biasi76 – 9217Cys-richAdd
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP50609.
KOiK08121.
PhylomeDBiP50609.

Family and domain databases

InterProiIPR027215. Fibromodulin.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24371:SF11. PTHR24371:SF11. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50609-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQWASILLLR GLCSLSQGQY EEDSHWWLQY LRNQQSTYYD PYDTYPYETS
60 70 80 90 100
DPYPYEVEEG PAYAYGAPPP PEPRDCPQEC DCPPNFPTAM YCDNRNLKYL
110 120 130 140 150
PFVPSRMKYV YFQNNQIAAI QEGVFDNATG LLWIALHGNQ ITSDKIGRKV
160 170 180 190 200
FSKLRHLERL YLDHNNLTRM PGPLPRSLRE LHLDHNQISR VPNNALEGLE
210 220 230 240 250
NLTALYLHHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD GLPSALEQLY
260 270 280 290 300
LEHNNVYTVP DSYFRGSPKL LYVRLSHNSL TNNGLATNTF NSSSLLELDL
310 320 330 340 350
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVM NFSKLQVLRL
360 370
DGNEIKRSAM PVDAPLCLRL ASLIEI
Length:376
Mass (Da):43,219
Last modified:October 1, 1996 - v1
Checksum:i9C3298675CE3714A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82152 mRNA. Translation: CAA57648.1.
RefSeqiNP_542429.1. NM_080698.1.
UniGeneiRn.8778.

Genome annotation databases

GeneIDi64507.
KEGGirno:64507.
UCSCiRGD:619769. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82152 mRNA. Translation: CAA57648.1.
RefSeqiNP_542429.1. NM_080698.1.
UniGeneiRn.8778.

3D structure databases

ProteinModelPortaliP50609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004382.

Proteomic databases

PaxDbiP50609.
PRIDEiP50609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64507.
KEGGirno:64507.
UCSCiRGD:619769. rat.

Organism-specific databases

CTDi2331.
RGDi619769. Fmod.

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP50609.
KOiK08121.
PhylomeDBiP50609.

Miscellaneous databases

NextBioi613278.
PROiP50609.

Gene expression databases

GenevestigatoriP50609.

Family and domain databases

InterProiIPR027215. Fibromodulin.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24371:SF11. PTHR24371:SF11. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Krull N.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFMOD_RAT
AccessioniPrimary (citable) accession number: P50609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.