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Protein

Fibromodulin

Gene

Fmod

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).By similarity

GO - Biological processi

  • odontogenesis Source: RGD
  • wound healing Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Fibromodulin
Short name:
FM
Alternative name(s):
Collagen-binding 59 kDa protein
Keratan sulfate proteoglycan fibromodulin
Short name:
KSPG fibromodulin
Gene namesi
Name:Fmod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619769 Fmod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000003274119 – 376FibromodulinAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei20SulfotyrosineBy similarity1
Modified residuei38SulfotyrosineBy similarity1
Modified residuei53SulfotyrosineBy similarity1
Modified residuei55SulfotyrosineBy similarity1
Modified residuei63SulfotyrosineBy similarity1
Modified residuei65SulfotyrosineBy similarity1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi166N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi201N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi291N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Disulfide bondi334 ↔ 367By similarity
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP50609
PRIDEiP50609

Interactioni

Subunit structurei

Binds to type I and type II collagen.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004382

Structurei

3D structure databases

ProteinModelPortaliP50609
SMRiP50609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 105LRRNTAdd BLAST39
Repeati106 – 127LRR 1Add BLAST22
Repeati130 – 143LRR 2Add BLAST14
Repeati156 – 176LRR 3Add BLAST21
Repeati177 – 198LRR 4Add BLAST22
Repeati201 – 222LRR 5Add BLAST22
Repeati224 – 245LRR 6Add BLAST22
Repeati246 – 266LRR 7Add BLAST21
Repeati269 – 289LRR 8Add BLAST21
Repeati294 – 315LRR 9Add BLAST22
Repeati316 – 335LRR 10Add BLAST20
Repeati344 – 367LRR 11Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 73Poly-Pro6
Compositional biasi76 – 92Cys-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiP50609
KOiK08121
PhylomeDBiP50609

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR027215 Fibromodulin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PANTHERiPTHR24373:SF127 PTHR24373:SF127, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWASILLLR GLCSLSQGQY EEDSHWWLQY LRNQQSTYYD PYDTYPYETS
60 70 80 90 100
DPYPYEVEEG PAYAYGAPPP PEPRDCPQEC DCPPNFPTAM YCDNRNLKYL
110 120 130 140 150
PFVPSRMKYV YFQNNQIAAI QEGVFDNATG LLWIALHGNQ ITSDKIGRKV
160 170 180 190 200
FSKLRHLERL YLDHNNLTRM PGPLPRSLRE LHLDHNQISR VPNNALEGLE
210 220 230 240 250
NLTALYLHHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD GLPSALEQLY
260 270 280 290 300
LEHNNVYTVP DSYFRGSPKL LYVRLSHNSL TNNGLATNTF NSSSLLELDL
310 320 330 340 350
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVM NFSKLQVLRL
360 370
DGNEIKRSAM PVDAPLCLRL ASLIEI
Length:376
Mass (Da):43,219
Last modified:October 1, 1996 - v1
Checksum:i9C3298675CE3714A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82152 mRNA Translation: CAA57648.1
RefSeqiNP_542429.1, NM_080698.1
UniGeneiRn.8778

Genome annotation databases

GeneIDi64507
KEGGirno:64507
UCSCiRGD:619769 rat

Similar proteinsi

Entry informationi

Entry nameiFMOD_RAT
AccessioniPrimary (citable) accession number: P50609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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