ID   LEP_RAT                 Reviewed;         167 AA.
AC   P50596;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 66.
DE   RecName: Full=Leptin;
DE   AltName: Full=Obesity factor;
DE   Flags: Precursor;
GN   Name=Lep; Synonyms=Ob;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   MEDLINE=95386724; PubMed=7657834;
RA   Ogawa Y., Masuzaki H., Isse N., Okazaki T., Mori K., Shigemoto M.,
RA   Satoh N., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T.,
RA   Nakao K.;
RT   "Molecular cloning of rat obese cDNA and augmented gene expression in
RT   genetically obese Zucker fatty (fa/fa) rats.";
RL   J. Clin. Invest. 96:1647-1652(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Adipose tissue;
RX   MEDLINE=95314614; PubMed=7794258; DOI=10.1006/bbrc.1995.1837;
RA   Funahashi T., Shimomura I., Hiraoka H., Arai T., Takahashi M.,
RA   Nakamura T., Nozaki S., Yamashita S., Takemura K., Tokunaga K.;
RT   "Enhanced expression of rat obese (ob) gene in adipose tissues of
RT   ventromedial hypothalamus (VMH)-lesioned rats.";
RL   Biochem. Biophys. Res. Commun. 211:469-475(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Leto, OLETF, and Zucker; TISSUE=Adipose tissue;
RX   MEDLINE=95251725; PubMed=7733988; DOI=10.1006/bbrc.1995.1589;
RA   Murakami T., Shima K.;
RT   "Cloning of rat obese cDNA and its expression in obese rats.";
RL   Biochem. Biophys. Res. Commun. 209:944-952(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-167.
RC   STRAIN=Sprague-Dawley; TISSUE=Adipose tissue;
RA   Donohoue P.A., Sivitz W.I., Bailey H.L.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as part of a signaling pathway that acts to
CC       regulate the size of the body fat depot. An increase in the level
CC       of Lep may act directly or indirectly on the CNS to inhibit food
CC       intake and/or regulate energy expenditure as part of a homeostatic
CC       mechanism to maintain constancy of the adipose mass.
CC   -!- SUBCELLULAR LOCATION: Secreted (Probable).
CC   -!- SIMILARITY: Belongs to the leptin family.
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DR   EMBL; D45862; BAA08296.1; -; mRNA.
DR   EMBL; S78586; AAB34657.2; -; mRNA.
DR   EMBL; D49653; BAA08529.1; -; mRNA.
DR   EMBL; U48849; AAC52514.1; -; mRNA.
DR   IPI; IPI00199521; -.
DR   PIR; PC4034; LTRT.
DR   RefSeq; NP_037208.1; -.
DR   UniGene; Rn.44444; -.
DR   HSSP; P41159; 1AX8.
DR   SMR; P50596; 24-167.
DR   Ensembl; ENSRNOG00000006059; Rattus norvegicus.
DR   GeneID; 25608; -.
DR   KEGG; rno:25608; -.
DR   RGD; 3000; Lep.
DR   HOVERGEN; P50596; -.
DR   OMA; P50596; GLDFIPG.
DR   NextBio; 607339; -.
DR   ArrayExpress; P50596; -.
DR   GermOnline; ENSRNOG00000006059; Rattus norvegicus.
DR   GO; GO:0005615; C:extracellular space; IDA:HGNC.
DR   GO; GO:0005125; F:cytokine activity; TAS:RGD.
DR   GO; GO:0005179; F:hormone activity; IDA:RGD.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IDA:RGD.
DR   GO; GO:0008343; P:adult feeding behavior; ISS:HGNC.
DR   GO; GO:0019933; P:cAMP-mediated signaling; TAS:RGD.
DR   GO; GO:0006112; P:energy reserve metabolic process; IDA:RGD.
DR   GO; GO:0009062; P:fatty acid catabolic process; IDA:RGD.
DR   GO; GO:0007259; P:JAK-STAT cascade; TAS:RGD.
DR   GO; GO:0033210; P:leptin-mediated signaling pathway; IDA:RGD.
DR   GO; GO:0032099; P:negative regulation of appetite; ISS:HGNC.
DR   GO; GO:0009892; P:negative regulation of metabolic process; IDA:RGD.
DR   GO; GO:0001542; P:ovulation from ovarian follicle; IDA:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPKKK cascade; IDA:RGD.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000065; Leptin.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11724; Leptin; 1.
DR   Pfam; PF02024; Leptin; 1.
DR   PIRSF; PIRSF001837; Leptin; 1.
DR   PRINTS; PR00495; LEPTIN.
DR   ProDom; PD005698; Leptin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Secreted; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    167       Leptin.
FT                                /FTId=PRO_0000017690.
FT   DISULFID    117    167       By similarity.
FT   CONFLICT     32     32       K -> T (in Ref. 2).
FT   CONFLICT    163    163       L -> V (in Ref. 4; AAC52514).
SQ   SEQUENCE   167 AA;  18866 MW;  3B5B563DA42EC84E CRC64;
     MCWRPLCRFL WLWSYLSYVQ AVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL
     DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP
     QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC
//