Reviewed,
UniProtKB/Swiss-Prot P50596 (LEP_RAT)
Last modified
November 25, 2008.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Leptin Alternative name(s): Obesity factor | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 167 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Subcellular location | SecretedProbable. |
| Sequence similarities | Belongs to the leptin family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Disease | Obesity |
| Domain | Signal |
Gene Ontology (GO) | |
| Biological process | adult feeding behavior Inferred from sequence or structural similarity. Source: HGNC negative regulation of appetiteInferred from sequence or structural similarity. Source: HGNC signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Inferred from direct assay. Source: HGNC |
| Molecular function | hormone activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | |||||||
| Chain | 22 – 167 | 146 | Leptin | PRO_0000017690 | ||||||
Amino acid modifications | ||||||||||
| Disulfide bond | 117 ↔ 167 | By similarity | ||||||||
Experimental info | ||||||||||
| Sequence conflict | 32 | 1 | K → T Ref.2 | |||||||
| Sequence conflict | 163 | 1 | L → V in AAC52514. Ref.4 | |||||||
Sequences
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References
| [1] | "Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats." Ogawa Y., Masuzaki H., Isse N., Okazaki T., Mori K., Shigemoto M., Satoh N., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K. J. Clin. Invest. 96:1647-1652(1995) [PubMed: 7657834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [2] | "Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats." Funahashi T., Shimomura I., Hiraoka H., Arai T., Takahashi M., Nakamura T., Nozaki S., Yamashita S., Takemura K., Tokunaga K. Biochem. Biophys. Res. Commun. 211:469-475(1995) [PubMed: 7794258] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Adipose tissue. |
| [3] | "Cloning of rat obese cDNA and its expression in obese rats." Murakami T., Shima K. Biochem. Biophys. Res. Commun. 209:944-952(1995) [PubMed: 7733988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Leto, OLETF and Zucker. Tissue: Adipose tissue. |
| [4] | Donohoue P.A., Sivitz W.I., Bailey H.L. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-167. Strain: Sprague-Dawley. Tissue: Adipose tissue. |
Cross-references
Sequence databases | |
|---|---|
| D45862 mRNA. Translation: BAA08296.1. S78586 mRNA. Translation: AAB34657.2. D49653 mRNA. Translation: BAA08529.1. U48849 mRNA. Translation: AAC52514.1. | |
| PIR | LTRT. PC4034. |
| RefSeq | NP_037208.1. |
| UniGene | Rn.44444 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AX8 based on UniProtKB P41159. |
| SMR | P50596. Positions 24-167. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000006059. Rattus norvegicus. [Contig view] |
| GeneID | 25608. |
| KEGG | rno:25608. |
Organism-specific databases | |
| RGD | 3000. Lep. |
Phylogenomic databases | |
| HOVERGEN | P50596. |
Gene expression databases | |
| ArrayExpress | P50596. |
| GermOnline | ENSRNOG00000006059. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR012351. 4_helix_cytokine_core. IPR000065. Leptin. [Graphical view] |
| Gene3D | G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit. |
| PANTHER | PTHR11724. Leptin. 1 hit. |
| Pfam | PF02024. Leptin. 1 hit. [Graphical view] |
| PIRSF | PIRSF001837. Leptin. 1 hit. |
| PRINTS | PR00495. LEPTIN. |
| ProDom | PD005698. Leptin. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 607339. |
Entry information
| Entry name | LEP_RAT | ||||||||
| Accession | Primary (citable) accession number: P50596 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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