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P50592 (TNF10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 10
Alternative name(s):
TNF-related apoptosis-inducing ligand
Short name=Protein TRAIL
CD_antigen=CD253
Gene names
Name:Tnfsf10
Synonyms:Trail
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Subunit structure

Homotrimer By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Widespread.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Tumor necrosis factor ligand superfamily member 10
PRO_0000185504

Regions

Topological domain1 – 1717Cytoplasmic Potential
Transmembrane18 – 3821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain39 – 291253Extracellular Potential

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P50592 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 3FEACAB9F0D7D802

FASTA29133,477
        10         20         30         40         50         60 
MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ DNYSKIGLAC 

        70         80         90        100        110        120 
FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF QDTISTVPEK QLSTPPLPRG 

       130        140        150        160        170        180 
GRPQKVAAHI TGITRRSNSA LIPISKDGKT LGQKIESWES SRKGHSFLNH VLFRNGELVI 

       190        200        210        220        230        240 
EQEGLYYIYS QTYFRFQEAE DASKMVSKDK VRTKQLVQYI YKYTSYPDPI VLMKSARNSC 

       250        260        270        280        290 
WSRDAEYGLY SIYQGGLFEL KKNDRIFVSV TNEHLMDLDQ EASFFGAFLI N 

« Hide

References

[1]"Identification and characterization of a new member of the TNF family that induces apoptosis."
Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.
Immunity 3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37522 mRNA. Translation: AAC52345.1.
CCDSCCDS17272.1.
RefSeqNP_033451.1. NM_009425.2.
UniGeneMm.1062.

3D structure databases

ProteinModelPortalP50592.
SMRP50592. Positions 123-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996803.
STRING10090.ENSMUSP00000040271.

PTM databases

PhosphoSiteP50592.

Proteomic databases

PRIDEP50592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046383; ENSMUSP00000040271; ENSMUSG00000039304.
GeneID22035.
KEGGmmu:22035.
UCSCuc008otm.1. mouse.

Organism-specific databases

CTD8743.
MGIMGI:107414. Tnfsf10.

Phylogenomic databases

eggNOGNOG46547.
HOGENOMHOG000133003.
HOVERGENHBG059007.
InParanoidP50592.
KOK04721.
OMAQTCVLIL.
OrthoDBEOG7V4B0Q.
PhylomeDBP50592.
TreeFamTF332169.

Gene expression databases

ArrayExpressP50592.
BgeeP50592.
GenevestigatorP50592.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
PIRSFPIRSF038013. TNF10_TNF11. 1 hit.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301802.
PROP50592.
SOURCESearch...

Entry information

Entry nameTNF10_MOUSE
AccessionPrimary (citable) accession number: P50592
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot