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Protein

Tumor necrosis factor ligand superfamily member 10

Gene

Tnfsf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi240Zinc; shared with trimeric partnersBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processApoptosis
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-MMU-3371378. Regulation by c-FLIP.
R-MMU-5213460. RIPK1-mediated regulated necrosis.
R-MMU-5218900. CASP8 activity is inhibited.
R-MMU-69416. Dimerization of procaspase-8.
R-MMU-75158. TRAIL signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 10
Alternative name(s):
TNF-related apoptosis-inducing ligand
Short name:
Protein TRAIL
CD_antigen: CD253
Gene namesi
Name:Tnfsf10
Synonyms:Trail
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:107414. Tnfsf10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 291ExtracellularSequence analysisAdd BLAST253

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855041 – 291Tumor necrosis factor ligand superfamily member 10Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Tyrosine phosphorylated by PKDCC/VLK.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP50592.
PRIDEiP50592.

PTM databases

iPTMnetiP50592.
PhosphoSitePlusiP50592.

Expressioni

Tissue specificityi

Widespread.

Gene expression databases

BgeeiENSMUSG00000039304.
ExpressionAtlasiP50592. baseline and differential.
GenevisibleiP50592. MM.

Interactioni

Subunit structurei

Homotrimer. One TNFSF10 homotrimer interacts with three TNFSF10A mononers. One TNFSF10 homotrimer interacts with three TNFSF10B mononers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4996803.
STRINGi10090.ENSMUSP00000040271.

Structurei

3D structure databases

ProteinModelPortaliP50592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIX7. Eukaryota.
ENOG410YS4F. LUCA.
GeneTreeiENSGT00530000063443.
HOGENOMiHOG000133003.
HOVERGENiHBG059007.
InParanoidiP50592.
KOiK04721.
OMAiNKQMVQY.
OrthoDBiEOG091G0F3S.
PhylomeDBiP50592.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P50592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ
60 70 80 90 100
DNYSKIGLAC FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF
110 120 130 140 150
QDTISTVPEK QLSTPPLPRG GRPQKVAAHI TGITRRSNSA LIPISKDGKT
160 170 180 190 200
LGQKIESWES SRKGHSFLNH VLFRNGELVI EQEGLYYIYS QTYFRFQEAE
210 220 230 240 250
DASKMVSKDK VRTKQLVQYI YKYTSYPDPI VLMKSARNSC WSRDAEYGLY
260 270 280 290
SIYQGGLFEL KKNDRIFVSV TNEHLMDLDQ EASFFGAFLI N
Length:291
Mass (Da):33,477
Last modified:October 1, 1996 - v1
Checksum:i3FEACAB9F0D7D802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37522 mRNA. Translation: AAC52345.1.
CCDSiCCDS17272.1.
RefSeqiNP_033451.1. NM_009425.2.
UniGeneiMm.1062.

Genome annotation databases

EnsembliENSMUST00000046383; ENSMUSP00000040271; ENSMUSG00000039304.
GeneIDi22035.
KEGGimmu:22035.
UCSCiuc008otm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTNF10_MOUSE
AccessioniPrimary (citable) accession number: P50592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families