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P50592

- TNF10_MOUSE

UniProt

P50592 - TNF10_MOUSE

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Protein

Tumor necrosis factor ligand superfamily member 10

Gene

Tnfsf10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

GO - Molecular functioni

  1. tumor necrosis factor receptor superfamily binding Source: MGI

GO - Biological processi

  1. immune response Source: InterPro
  2. male gonad development Source: Ensembl
  3. positive regulation of apoptotic process Source: Ensembl
  4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  5. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  7. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  8. response to insulin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_215122. Regulation by c-FLIP.
REACT_241657. Caspase-8 activation by cleavage.
REACT_243608. Dimerization of procaspase-8.
REACT_253999. TRAIL signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 10
Alternative name(s):
TNF-related apoptosis-inducing ligand
Short name:
Protein TRAIL
CD_antigen: CD253
Gene namesi
Name:Tnfsf10
Synonyms:Trail
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:107414. Tnfsf10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 291253ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Tumor necrosis factor ligand superfamily member 10PRO_0000185504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Tyrosine phosphorylated by PKDCC/VLK.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP50592.

PTM databases

PhosphoSiteiP50592.

Expressioni

Tissue specificityi

Widespread.

Gene expression databases

BgeeiP50592.
ExpressionAtlasiP50592. baseline and differential.
GenevestigatoriP50592.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

MINTiMINT-4996803.
STRINGi10090.ENSMUSP00000040271.

Structurei

3D structure databases

ProteinModelPortaliP50592.
SMRiP50592. Positions 123-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46547.
HOGENOMiHOG000133003.
HOVERGENiHBG059007.
InParanoidiP50592.
KOiK04721.
OMAiQTCVLIL.
OrthoDBiEOG7V4B0Q.
PhylomeDBiP50592.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50592-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ
60 70 80 90 100
DNYSKIGLAC FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF
110 120 130 140 150
QDTISTVPEK QLSTPPLPRG GRPQKVAAHI TGITRRSNSA LIPISKDGKT
160 170 180 190 200
LGQKIESWES SRKGHSFLNH VLFRNGELVI EQEGLYYIYS QTYFRFQEAE
210 220 230 240 250
DASKMVSKDK VRTKQLVQYI YKYTSYPDPI VLMKSARNSC WSRDAEYGLY
260 270 280 290
SIYQGGLFEL KKNDRIFVSV TNEHLMDLDQ EASFFGAFLI N
Length:291
Mass (Da):33,477
Last modified:October 1, 1996 - v1
Checksum:i3FEACAB9F0D7D802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37522 mRNA. Translation: AAC52345.1.
CCDSiCCDS17272.1.
RefSeqiNP_033451.1. NM_009425.2.
UniGeneiMm.1062.

Genome annotation databases

EnsembliENSMUST00000046383; ENSMUSP00000040271; ENSMUSG00000039304.
GeneIDi22035.
KEGGimmu:22035.
UCSCiuc008otm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37522 mRNA. Translation: AAC52345.1 .
CCDSi CCDS17272.1.
RefSeqi NP_033451.1. NM_009425.2.
UniGenei Mm.1062.

3D structure databases

ProteinModelPortali P50592.
SMRi P50592. Positions 123-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996803.
STRINGi 10090.ENSMUSP00000040271.

PTM databases

PhosphoSitei P50592.

Proteomic databases

PRIDEi P50592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046383 ; ENSMUSP00000040271 ; ENSMUSG00000039304 .
GeneIDi 22035.
KEGGi mmu:22035.
UCSCi uc008otm.1. mouse.

Organism-specific databases

CTDi 8743.
MGIi MGI:107414. Tnfsf10.

Phylogenomic databases

eggNOGi NOG46547.
HOGENOMi HOG000133003.
HOVERGENi HBG059007.
InParanoidi P50592.
KOi K04721.
OMAi QTCVLIL.
OrthoDBi EOG7V4B0Q.
PhylomeDBi P50592.
TreeFami TF332169.

Enzyme and pathway databases

Reactomei REACT_215122. Regulation by c-FLIP.
REACT_241657. Caspase-8 activation by cleavage.
REACT_243608. Dimerization of procaspase-8.
REACT_253999. TRAIL signaling.

Miscellaneous databases

NextBioi 301802.
PROi P50592.
SOURCEi Search...

Gene expression databases

Bgeei P50592.
ExpressionAtlasi P50592. baseline and differential.
Genevestigatori P50592.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PIRSFi PIRSF038013. TNF10_TNF11. 1 hit.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a new member of the TNF family that induces apoptosis."
    Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.
    Immunity 3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTNF10_MOUSE
AccessioniPrimary (citable) accession number: P50592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3