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P50592

- TNF10_MOUSE

UniProt

P50592 - TNF10_MOUSE

Protein

Tumor necrosis factor ligand superfamily member 10

Gene

Tnfsf10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

    GO - Molecular functioni

    1. tumor necrosis factor receptor superfamily binding Source: MGI

    GO - Biological processi

    1. immune response Source: InterPro
    2. male gonad development Source: Ensembl
    3. positive regulation of apoptotic process Source: Ensembl
    4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    5. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    7. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    8. response to insulin Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_215122. Regulation by c-FLIP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 10
    Alternative name(s):
    TNF-related apoptosis-inducing ligand
    Short name:
    Protein TRAIL
    CD_antigen: CD253
    Gene namesi
    Name:Tnfsf10
    Synonyms:Trail
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:107414. Tnfsf10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Tumor necrosis factor ligand superfamily member 10PRO_0000185504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP50592.

    PTM databases

    PhosphoSiteiP50592.

    Expressioni

    Tissue specificityi

    Widespread.

    Gene expression databases

    ArrayExpressiP50592.
    BgeeiP50592.
    GenevestigatoriP50592.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    MINTiMINT-4996803.
    STRINGi10090.ENSMUSP00000040271.

    Structurei

    3D structure databases

    ProteinModelPortaliP50592.
    SMRiP50592. Positions 123-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 291253ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46547.
    HOGENOMiHOG000133003.
    HOVERGENiHBG059007.
    InParanoidiP50592.
    KOiK04721.
    OMAiQTCVLIL.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiP50592.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ    50
    DNYSKIGLAC FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF 100
    QDTISTVPEK QLSTPPLPRG GRPQKVAAHI TGITRRSNSA LIPISKDGKT 150
    LGQKIESWES SRKGHSFLNH VLFRNGELVI EQEGLYYIYS QTYFRFQEAE 200
    DASKMVSKDK VRTKQLVQYI YKYTSYPDPI VLMKSARNSC WSRDAEYGLY 250
    SIYQGGLFEL KKNDRIFVSV TNEHLMDLDQ EASFFGAFLI N 291
    Length:291
    Mass (Da):33,477
    Last modified:October 1, 1996 - v1
    Checksum:i3FEACAB9F0D7D802
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37522 mRNA. Translation: AAC52345.1.
    CCDSiCCDS17272.1.
    RefSeqiNP_033451.1. NM_009425.2.
    UniGeneiMm.1062.

    Genome annotation databases

    EnsembliENSMUST00000046383; ENSMUSP00000040271; ENSMUSG00000039304.
    GeneIDi22035.
    KEGGimmu:22035.
    UCSCiuc008otm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37522 mRNA. Translation: AAC52345.1 .
    CCDSi CCDS17272.1.
    RefSeqi NP_033451.1. NM_009425.2.
    UniGenei Mm.1062.

    3D structure databases

    ProteinModelPortali P50592.
    SMRi P50592. Positions 123-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996803.
    STRINGi 10090.ENSMUSP00000040271.

    PTM databases

    PhosphoSitei P50592.

    Proteomic databases

    PRIDEi P50592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046383 ; ENSMUSP00000040271 ; ENSMUSG00000039304 .
    GeneIDi 22035.
    KEGGi mmu:22035.
    UCSCi uc008otm.1. mouse.

    Organism-specific databases

    CTDi 8743.
    MGIi MGI:107414. Tnfsf10.

    Phylogenomic databases

    eggNOGi NOG46547.
    HOGENOMi HOG000133003.
    HOVERGENi HBG059007.
    InParanoidi P50592.
    KOi K04721.
    OMAi QTCVLIL.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi P50592.
    TreeFami TF332169.

    Enzyme and pathway databases

    Reactomei REACT_215122. Regulation by c-FLIP.

    Miscellaneous databases

    NextBioi 301802.
    PROi P50592.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50592.
    Bgeei P50592.
    Genevestigatori P50592.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038013. TNF10_TNF11. 1 hit.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new member of the TNF family that induces apoptosis."
      Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.
      Immunity 3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTNF10_MOUSE
    AccessioniPrimary (citable) accession number: P50592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3