Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P50591

- TNF10_HUMAN

UniProt

P50591 - TNF10_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 10

Gene

TNFSF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

    Cofactori

    Binds 1 zinc ion per trimer.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi230 – 2301Zinc

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. receptor binding Source: ProtInc

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
    2. apoptotic process Source: Reactome
    3. apoptotic signaling pathway Source: Reactome
    4. cell-cell signaling Source: ProtInc
    5. immune response Source: InterPro
    6. male gonad development Source: Ensembl
    7. positive regulation of apoptotic process Source: UniProtKB
    8. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    9. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    11. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
    12. regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
    13. response to insulin Source: Ensembl
    14. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1503. Caspase-8 activation.
    REACT_164011. Regulation by c-FLIP.
    REACT_402. TRAIL signaling.
    REACT_832. Dimerization of procaspase-8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 10
    Alternative name(s):
    Apo-2 ligand
    Short name:
    Apo-2L
    TNF-related apoptosis-inducing ligand
    Short name:
    Protein TRAIL
    CD_antigen: CD253
    Gene namesi
    Name:TNFSF10
    Synonyms:APO2L, TRAIL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11925. TNFSF10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Tumor necrosis factor ligand superfamily member 10PRO_0000185503Add
    BLAST

    Proteomic databases

    MaxQBiP50591.
    PaxDbiP50591.
    PRIDEiP50591.

    PTM databases

    PhosphoSiteiP50591.

    Expressioni

    Tissue specificityi

    Widespread; most predominant in spleen, lung and prostate.

    Gene expression databases

    ArrayExpressiP50591.
    BgeeiP50591.
    CleanExiHS_TNFSF10.
    GenevestigatoriP50591.

    Organism-specific databases

    HPAiCAB002446.

    Interactioni

    Subunit structurei

    Homotrimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CUL3Q136182EBI-495373,EBI-456129
    TNFRSF10AO002204EBI-495373,EBI-518861
    TNFRSF10BO1476321EBI-495373,EBI-518882

    Protein-protein interaction databases

    BioGridi114280. 14 interactions.
    DIPiDIP-6230N.
    IntActiP50591. 17 interactions.
    MINTiMINT-109168.
    STRINGi9606.ENSP00000241261.

    Structurei

    Secondary structure

    1
    281
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi123 – 1275
    Turni137 – 1393
    Beta strandi144 – 1463
    Beta strandi148 – 1503
    Turni158 – 1614
    Beta strandi163 – 1708
    Beta strandi173 – 1786
    Beta strandi180 – 19314
    Beta strandi205 – 2139
    Beta strandi215 – 2184
    Beta strandi220 – 2289
    Beta strandi237 – 25014
    Beta strandi255 – 2628
    Helixi263 – 2653
    Turni270 – 2723
    Beta strandi273 – 2797

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D0GX-ray2.40A/B/D114-281[»]
    1D2QX-ray2.80A/B114-281[»]
    1D4VX-ray2.20B119-281[»]
    1DG6X-ray1.30A91-281[»]
    1DU3X-ray2.20D/E/F/J/K/L114-281[»]
    ProteinModelPortaliP50591.
    SMRiP50591. Positions 119-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP50591.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 281243ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46547.
    HOGENOMiHOG000230484.
    HOVERGENiHBG059007.
    KOiK04721.
    OMAiQTCVLIL.
    PhylomeDBiP50591.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P50591-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS    50
    KSGIACFLKE DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI 100
    STVQEKQQNI SPLVRERGPQ RVAAHITGTR GRSNTLSSPN SKNEKALGRK 150
    INSWESSRSG HSFLSNLHLR NGELVIHEKG FYYIYSQTYF RFQEEIKENT 200
    KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY SIYQGGIFEL 250
    KENDRIFVSV TNEHLIDMDH EASFFGAFLV G 281
    Length:281
    Mass (Da):32,509
    Last modified:October 1, 1996 - v1
    Checksum:iDDAAAF78DAAB2F6D
    GO
    Isoform 2 (identifier: P50591-2) [UniParc]FASTAAdd to Basket

    Also known as: TRAIL-short, TRAIL-s

    The sequence of this isoform differs from the canonical sequence as follows:
         91-101: MILRTSEETIS → TPRMKRLWAAK
         102-281: Missing.

    Note: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).

    Show »
    Length:101
    Mass (Da):11,746
    Checksum:i205B6BA004A7C104
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331V → I.
    Corresponds to variant rs6763816 [ dbSNP | Ensembl ].
    VAR_052584
    Natural varianti47 – 471D → E.
    Corresponds to variant rs16845759 [ dbSNP | Ensembl ].
    VAR_052585

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei91 – 10111MILRTSEETIS → TPRMKRLWAAK in isoform 2. 3 PublicationsVSP_043507Add
    BLAST
    Alternative sequencei102 – 281180Missing in isoform 2. 3 PublicationsVSP_043508Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37518 mRNA. Translation: AAC50332.1.
    U57059 mRNA. Translation: AAB01233.1.
    DQ848564 mRNA. Translation: ABI24016.1.
    EU183231 mRNA. Translation: ABW24658.1.
    AK296085 mRNA. Translation: BAG58840.1.
    AC007919 Genomic DNA. No translation available.
    AC016938 Genomic DNA. No translation available.
    BC032722 mRNA. Translation: AAH32722.1.
    CCDSiCCDS3219.1. [P50591-1]
    CCDS54680.1. [P50591-2]
    RefSeqiNP_001177871.1. NM_001190942.1. [P50591-2]
    NP_003801.1. NM_003810.3. [P50591-1]
    UniGeneiHs.478275.

    Genome annotation databases

    EnsembliENST00000241261; ENSP00000241261; ENSG00000121858. [P50591-1]
    ENST00000420541; ENSP00000389931; ENSG00000121858. [P50591-2]
    GeneIDi8743.
    KEGGihsa:8743.
    UCSCiuc003fid.3. human. [P50591-1]
    uc003fie.3. human. [P50591-2]

    Polymorphism databases

    DMDMi1730015.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37518 mRNA. Translation: AAC50332.1 .
    U57059 mRNA. Translation: AAB01233.1 .
    DQ848564 mRNA. Translation: ABI24016.1 .
    EU183231 mRNA. Translation: ABW24658.1 .
    AK296085 mRNA. Translation: BAG58840.1 .
    AC007919 Genomic DNA. No translation available.
    AC016938 Genomic DNA. No translation available.
    BC032722 mRNA. Translation: AAH32722.1 .
    CCDSi CCDS3219.1. [P50591-1 ]
    CCDS54680.1. [P50591-2 ]
    RefSeqi NP_001177871.1. NM_001190942.1. [P50591-2 ]
    NP_003801.1. NM_003810.3. [P50591-1 ]
    UniGenei Hs.478275.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D0G X-ray 2.40 A/B/D 114-281 [» ]
    1D2Q X-ray 2.80 A/B 114-281 [» ]
    1D4V X-ray 2.20 B 119-281 [» ]
    1DG6 X-ray 1.30 A 91-281 [» ]
    1DU3 X-ray 2.20 D/E/F/J/K/L 114-281 [» ]
    ProteinModelPortali P50591.
    SMRi P50591. Positions 119-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114280. 14 interactions.
    DIPi DIP-6230N.
    IntActi P50591. 17 interactions.
    MINTi MINT-109168.
    STRINGi 9606.ENSP00000241261.

    Chemistry

    BindingDBi P50591.
    ChEMBLi CHEMBL5813.

    PTM databases

    PhosphoSitei P50591.

    Polymorphism databases

    DMDMi 1730015.

    Proteomic databases

    MaxQBi P50591.
    PaxDbi P50591.
    PRIDEi P50591.

    Protocols and materials databases

    DNASUi 8743.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241261 ; ENSP00000241261 ; ENSG00000121858 . [P50591-1 ]
    ENST00000420541 ; ENSP00000389931 ; ENSG00000121858 . [P50591-2 ]
    GeneIDi 8743.
    KEGGi hsa:8743.
    UCSCi uc003fid.3. human. [P50591-1 ]
    uc003fie.3. human. [P50591-2 ]

    Organism-specific databases

    CTDi 8743.
    GeneCardsi GC03M172223.
    HGNCi HGNC:11925. TNFSF10.
    HPAi CAB002446.
    MIMi 603598. gene.
    neXtProti NX_P50591.
    PharmGKBi PA36618.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46547.
    HOGENOMi HOG000230484.
    HOVERGENi HBG059007.
    KOi K04721.
    OMAi QTCVLIL.
    PhylomeDBi P50591.
    TreeFami TF332169.

    Enzyme and pathway databases

    Reactomei REACT_1503. Caspase-8 activation.
    REACT_164011. Regulation by c-FLIP.
    REACT_402. TRAIL signaling.
    REACT_832. Dimerization of procaspase-8.

    Miscellaneous databases

    ChiTaRSi TNFSF10. human.
    EvolutionaryTracei P50591.
    GeneWikii TRAIL.
    GenomeRNAii 8743.
    NextBioi 32805.
    PROi P50591.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50591.
    Bgeei P50591.
    CleanExi HS_TNFSF10.
    Genevestigatori P50591.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038013. TNF10_TNF11. 1 hit.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new member of the TNF family that induces apoptosis."
      Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.
      Immunity 3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family."
      Pitti R.M., Marsters S.A., Ruppert S., Donahue C.J., Moore A., Ashkenazi A.
      J. Biol. Chem. 271:12687-12690(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    4. "Novel TRAIL splice variant TRAIL-delta."
      Woods D.C., Haugen M.J., Johnson A.L.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thalamus.
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    8. "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
      Hymowitz S.G., Christinger H.W., Fuh G., Ultsch M., O'Connell M., Kelley R.F., Ashkenazi A., de Vos A.M.
      Mol. Cell 4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 114-281.
    9. "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
      Mongkolsapaya J., Grimes J.M., Chen N., Xu X.-N., Stuart D.I., Jones E.Y., Screaton G.R.
      Nat. Struct. Biol. 6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 119-281.
    10. "2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity."
      Cha S.-S., Kim M.S., Choi Y.H., Sung B.J., Shin N.K., Shin H.C., Sung Y.C., Oh B.-H.
      Immunity 11:253-261(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 114-281.

    Entry informationi

    Entry nameiTNF10_HUMAN
    AccessioniPrimary (citable) accession number: P50591
    Secondary accession number(s): A1Y9B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3