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Protein

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Gene

NUDT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Catalytic activityi

P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal ions.By similarity

GO - Molecular functioni

  • bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Source: UniProtKB
  • bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • nucleobase-containing compound metabolic process Source: ProtInc
  • response to reactive oxygen species Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09170-MONOMER.
BRENDAi3.6.1.17. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
SABIO-RKP50583.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC:3.6.1.17)
Alternative name(s):
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name:
Ap4A hydrolase
Short name:
Ap4Aase
Short name:
Diadenosine tetraphosphatase
Nucleoside diphosphate-linked moiety X motif 2
Short name:
Nudix motif 2
Gene namesi
Name:NUDT2
Synonyms:APAH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8049. NUDT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi318.
OpenTargetsiENSG00000164978.
PharmGKBiPA31833.

Polymorphism and mutation databases

BioMutaiNUDT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000571022 – 147Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP50583.
MaxQBiP50583.
PaxDbiP50583.
PeptideAtlasiP50583.
PRIDEiP50583.
TopDownProteomicsiP50583.

PTM databases

iPTMnetiP50583.
PhosphoSitePlusiP50583.

Expressioni

Gene expression databases

BgeeiENSG00000164978.
CleanExiHS_NUDT2.
GenevisibleiP50583. HS.

Organism-specific databases

HPAiCAB004684.
HPA044903.
HPA058623.
HPA067639.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MCM6Q145663EBI-10096247,EBI-374900

Protein-protein interaction databases

BioGridi106815. 1 interactor.
IntActiP50583. 2 interactors.
STRINGi9606.ENSP00000338397.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Turni17 – 19Combined sources3
Beta strandi23 – 33Combined sources11
Beta strandi42 – 44Combined sources3
Beta strandi47 – 49Combined sources3
Helixi51 – 63Combined sources13
Helixi67 – 69Combined sources3
Beta strandi70 – 84Combined sources15
Beta strandi87 – 99Combined sources13
Beta strandi111 – 117Combined sources7
Helixi119 – 126Combined sources8
Helixi129 – 147Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSANMR-A1-147[»]
1XSBNMR-A1-147[»]
1XSCNMR-A2-147[»]
3U53X-ray2.70A/B/C/D1-147[»]
4ICKX-ray2.10A/B1-147[»]
4IJXX-ray2.10A/B1-147[»]
ProteinModelPortaliP50583.
SMRiP50583.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 139Nudix hydrolasePROSITE-ProRule annotationAdd BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 64Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00390000002416.
HOGENOMiHOG000261976.
HOVERGENiHBG002853.
KOiK01518.
OMAiHQDYRWA.
OrthoDBiEOG091G0S47.
PhylomeDBiP50583.
TreeFamiTF105958.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR003565. Tetra_PHTase.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01405. TETRPHPHTASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED
60 70 80 90 100
DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD
110 120 130 140
YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA
Length:147
Mass (Da):16,829
Last modified:January 23, 2007 - v3
Checksum:i3599B12719F94AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30313 mRNA. Translation: AAC50277.1.
AL356494 Genomic DNA. Translation: CAI15964.1.
CH471071 Genomic DNA. Translation: EAW58461.1.
CH471071 Genomic DNA. Translation: EAW58462.1.
CH471071 Genomic DNA. Translation: EAW58463.1.
BC004926 mRNA. Translation: AAH04926.1.
CCDSiCCDS6552.1.
PIRiS60111.
RefSeqiNP_001152.1. NM_001161.4.
NP_001231319.1. NM_001244390.1.
NP_671701.1. NM_147172.2.
NP_671702.1. NM_147173.2.
UniGeneiHs.493767.
Hs.731743.

Genome annotation databases

EnsembliENST00000346365; ENSP00000344187; ENSG00000164978.
ENST00000379155; ENSP00000368452; ENSG00000164978.
ENST00000379158; ENSP00000368455; ENSG00000164978.
ENST00000618590; ENSP00000482384; ENSG00000164978.
GeneIDi318.
KEGGihsa:318.
UCSCiuc003zub.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30313 mRNA. Translation: AAC50277.1.
AL356494 Genomic DNA. Translation: CAI15964.1.
CH471071 Genomic DNA. Translation: EAW58461.1.
CH471071 Genomic DNA. Translation: EAW58462.1.
CH471071 Genomic DNA. Translation: EAW58463.1.
BC004926 mRNA. Translation: AAH04926.1.
CCDSiCCDS6552.1.
PIRiS60111.
RefSeqiNP_001152.1. NM_001161.4.
NP_001231319.1. NM_001244390.1.
NP_671701.1. NM_147172.2.
NP_671702.1. NM_147173.2.
UniGeneiHs.493767.
Hs.731743.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSANMR-A1-147[»]
1XSBNMR-A1-147[»]
1XSCNMR-A2-147[»]
3U53X-ray2.70A/B/C/D1-147[»]
4ICKX-ray2.10A/B1-147[»]
4IJXX-ray2.10A/B1-147[»]
ProteinModelPortaliP50583.
SMRiP50583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106815. 1 interactor.
IntActiP50583. 2 interactors.
STRINGi9606.ENSP00000338397.

PTM databases

iPTMnetiP50583.
PhosphoSitePlusiP50583.

Polymorphism and mutation databases

BioMutaiNUDT2.

Proteomic databases

EPDiP50583.
MaxQBiP50583.
PaxDbiP50583.
PeptideAtlasiP50583.
PRIDEiP50583.
TopDownProteomicsiP50583.

Protocols and materials databases

DNASUi318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346365; ENSP00000344187; ENSG00000164978.
ENST00000379155; ENSP00000368452; ENSG00000164978.
ENST00000379158; ENSP00000368455; ENSG00000164978.
ENST00000618590; ENSP00000482384; ENSG00000164978.
GeneIDi318.
KEGGihsa:318.
UCSCiuc003zub.3. human.

Organism-specific databases

CTDi318.
DisGeNETi318.
GeneCardsiNUDT2.
HGNCiHGNC:8049. NUDT2.
HPAiCAB004684.
HPA044903.
HPA058623.
HPA067639.
MIMi602852. gene.
neXtProtiNX_P50583.
OpenTargetsiENSG00000164978.
PharmGKBiPA31833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00390000002416.
HOGENOMiHOG000261976.
HOVERGENiHBG002853.
KOiK01518.
OMAiHQDYRWA.
OrthoDBiEOG091G0S47.
PhylomeDBiP50583.
TreeFamiTF105958.

Enzyme and pathway databases

BioCyciZFISH:HS09170-MONOMER.
BRENDAi3.6.1.17. 2681.
ReactomeiR-HSA-3299685. Detoxification of Reactive Oxygen Species.
SABIO-RKP50583.

Miscellaneous databases

ChiTaRSiNUDT2. human.
EvolutionaryTraceiP50583.
GeneWikiiNUDT2.
GenomeRNAii318.
PROiP50583.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164978.
CleanExiHS_NUDT2.
GenevisibleiP50583. HS.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR003565. Tetra_PHTase.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01405. TETRPHPHTASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP4A_HUMAN
AccessioniPrimary (citable) accession number: P50583
Secondary accession number(s): D3DRM0, Q5T589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.