Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-aminobutyric acid receptor subunit rho-3

Gene

Gabrr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-RNO-975298. Ligand-gated ion channel transport.
R-RNO-977442. GABA A (rho) receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-3
Alternative name(s):
GABA(A) receptor subunit rho-3
GABA(C) receptor
Gene namesi
Name:Gabrr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621564. Gabrr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 264ExtracellularCuratedAdd BLAST243
Transmembranei265 – 288HelicalCuratedAdd BLAST24
Transmembranei292 – 314HelicalCuratedAdd BLAST23
Transmembranei326 – 348HelicalCuratedAdd BLAST23
Topological domaini349 – 442CytoplasmicCuratedAdd BLAST94
Transmembranei443 – 464HelicalCuratedAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000049122 – 464Gamma-aminobutyric acid receptor subunit rho-3Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi181 ↔ 195By similarity
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50573.
PRIDEiP50573.

PTM databases

PhosphoSitePlusiP50573.

Expressioni

Tissue specificityi

Retina.

Gene expression databases

GenevisibleiP50573. RN.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi251384. 1 interactor.
STRINGi10116.ENSRNOP00000002281.

Structurei

3D structure databases

ProteinModelPortaliP50573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 445Interaction with SQSTM11 PublicationAdd BLAST102

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50573.
KOiK05190.
OMAiMDFTMTF.
OrthoDBiEOG091G0805.
PhylomeDBiP50573.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAFWLAFF TYTWITLMLD ASAVKEPHQQ CLSSPKQTRI RETRMRKDDL
60 70 80 90 100
TKVWPLKREQ LLHIEDHDFS TRPGFGGSPV PVGIDVQVES IDSISEVNMD
110 120 130 140 150
FTMTFYLRHY WKDERLSFPS TTNKSMTFDR RLIQKIWVPD IFFVHSKRSF
160 170 180 190 200
IHDTTVENIM LRVHPDGNVL FSLRITVSAM CFMDFSRFPL DTQNCSLELE
210 220 230 240 250
SYAYNEEDLM LYWKHGNKSL NTEEHISLSQ FFIEEFSASS GLAFYSSTGW
260 270 280 290 300
YYRLFINFVL RRHIFFFVLQ TYFPAMLMVM LSWVSFWIDR RAVPARVSLG
310 320 330 340 350
ITTVLTMSTI VTGVSASMPQ VSYVKAVDVY MWVSSLFVFL SVIEYAAVNY
360 370 380 390 400
LTTVEEWKQL NRRGKISGMY NIDAVQAMAF DGCYHDGETD VDQTSFFLHS
410 420 430 440 450
EEDSMRTKFT GSPCADSSQI KRKSLGGNVG RIILENNHVI DTYSRIVFPV
460
VYIIFNLFYW GIYV
Length:464
Mass (Da):54,031
Last modified:October 1, 1996 - v1
Checksum:iFC86BE7E8DA5ACE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50671 mRNA. Translation: BAA09322.1.
PIRiS65756.
RefSeqiNP_620252.1. NM_138897.1.
UniGeneiRn.10670.

Genome annotation databases

EnsembliENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679.
GeneIDi192258.
KEGGirno:192258.
UCSCiRGD:621564. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50671 mRNA. Translation: BAA09322.1.
PIRiS65756.
RefSeqiNP_620252.1. NM_138897.1.
UniGeneiRn.10670.

3D structure databases

ProteinModelPortaliP50573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251384. 1 interactor.
STRINGi10116.ENSRNOP00000002281.

PTM databases

PhosphoSitePlusiP50573.

Proteomic databases

PaxDbiP50573.
PRIDEiP50573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679.
GeneIDi192258.
KEGGirno:192258.
UCSCiRGD:621564. rat.

Organism-specific databases

CTDi200959.
RGDi621564. Gabrr3.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50573.
KOiK05190.
OMAiMDFTMTF.
OrthoDBiEOG091G0805.
PhylomeDBiP50573.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-RNO-975298. Ligand-gated ion channel transport.
R-RNO-977442. GABA A (rho) receptor activation.

Miscellaneous databases

PROiP50573.

Gene expression databases

GenevisibleiP50573. RN.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRR3_RAT
AccessioniPrimary (citable) accession number: P50573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.