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Protein

Gamma-aminobutyric acid receptor subunit rho-3

Gene

Gabrr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-RNO-975298. Ligand-gated ion channel transport.
R-RNO-977442. GABA A (rho) receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-3
Alternative name(s):
GABA(A) receptor subunit rho-3
GABA(C) receptor
Gene namesi
Name:Gabrr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621564. Gabrr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 264243ExtracellularCuratedAdd
BLAST
Transmembranei265 – 28824HelicalCuratedAdd
BLAST
Transmembranei292 – 31423HelicalCuratedAdd
BLAST
Transmembranei326 – 34823HelicalCuratedAdd
BLAST
Topological domaini349 – 44294CytoplasmicCuratedAdd
BLAST
Transmembranei443 – 46422HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 464443Gamma-aminobutyric acid receptor subunit rho-3PRO_0000000491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi181 ↔ 195By similarity
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50573.

Expressioni

Tissue specificityi

Retina.

Gene expression databases

GenevisibleiP50573. RN.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi251384. 1 interaction.
STRINGi10116.ENSRNOP00000002281.

Structurei

3D structure databases

ProteinModelPortaliP50573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 445102Interaction with SQSTM1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50573.
KOiK05190.
OMAiMDFTMTF.
OrthoDBiEOG712TVZ.
PhylomeDBiP50573.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAFWLAFF TYTWITLMLD ASAVKEPHQQ CLSSPKQTRI RETRMRKDDL
60 70 80 90 100
TKVWPLKREQ LLHIEDHDFS TRPGFGGSPV PVGIDVQVES IDSISEVNMD
110 120 130 140 150
FTMTFYLRHY WKDERLSFPS TTNKSMTFDR RLIQKIWVPD IFFVHSKRSF
160 170 180 190 200
IHDTTVENIM LRVHPDGNVL FSLRITVSAM CFMDFSRFPL DTQNCSLELE
210 220 230 240 250
SYAYNEEDLM LYWKHGNKSL NTEEHISLSQ FFIEEFSASS GLAFYSSTGW
260 270 280 290 300
YYRLFINFVL RRHIFFFVLQ TYFPAMLMVM LSWVSFWIDR RAVPARVSLG
310 320 330 340 350
ITTVLTMSTI VTGVSASMPQ VSYVKAVDVY MWVSSLFVFL SVIEYAAVNY
360 370 380 390 400
LTTVEEWKQL NRRGKISGMY NIDAVQAMAF DGCYHDGETD VDQTSFFLHS
410 420 430 440 450
EEDSMRTKFT GSPCADSSQI KRKSLGGNVG RIILENNHVI DTYSRIVFPV
460
VYIIFNLFYW GIYV
Length:464
Mass (Da):54,031
Last modified:October 1, 1996 - v1
Checksum:iFC86BE7E8DA5ACE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50671 mRNA. Translation: BAA09322.1.
PIRiS65756.
RefSeqiNP_620252.1. NM_138897.1.
UniGeneiRn.10670.

Genome annotation databases

EnsembliENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679.
GeneIDi192258.
KEGGirno:192258.
UCSCiRGD:621564. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50671 mRNA. Translation: BAA09322.1.
PIRiS65756.
RefSeqiNP_620252.1. NM_138897.1.
UniGeneiRn.10670.

3D structure databases

ProteinModelPortaliP50573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251384. 1 interaction.
STRINGi10116.ENSRNOP00000002281.

Proteomic databases

PaxDbiP50573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002281; ENSRNOP00000002281; ENSRNOG00000001679.
GeneIDi192258.
KEGGirno:192258.
UCSCiRGD:621564. rat.

Organism-specific databases

CTDi200959.
RGDi621564. Gabrr3.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50573.
KOiK05190.
OMAiMDFTMTF.
OrthoDBiEOG712TVZ.
PhylomeDBiP50573.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-RNO-975298. Ligand-gated ion channel transport.
R-RNO-977442. GABA A (rho) receptor activation.

Miscellaneous databases

PROiP50573.

Gene expression databases

GenevisibleiP50573. RN.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA."
    Ogurusu T., Shingai R.
    Biochim. Biophys. Acta 1305:15-18(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Retina.
  2. "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2."
    Croci C., Brandstaetter J.H., Enz R.
    J. Biol. Chem. 278:6128-6135(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1 AND PRKCZ, DOMAIN.

Entry informationi

Entry nameiGBRR3_RAT
AccessioniPrimary (citable) accession number: P50573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.