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Protein

Gamma-aminobutyric acid receptor subunit rho-1

Gene

Gabrr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: InterPro
  • GABA receptor activity Source: RGD
  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • visual perception Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
Gene namesi
Name:Gabrr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61900. Gabrr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 282ExtracellularCuratedAdd BLAST261
Transmembranei283 – 306HelicalCuratedAdd BLAST24
Transmembranei310 – 332HelicalCuratedAdd BLAST23
Transmembranei344 – 366HelicalCuratedAdd BLAST23
Topological domaini367 – 458CytoplasmicCuratedAdd BLAST92
Transmembranei459 – 480HelicalCuratedAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000048722 – 480Gamma-aminobutyric acid receptor subunit rho-1Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi199 ↔ 213By similarity
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50572.
PRIDEiP50572.

PTM databases

iPTMnetiP50572.
PhosphoSitePlusiP50572.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010172.

Structurei

3D structure databases

ProteinModelPortaliP50572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50572.
PhylomeDBiP50572.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVRNMKFG IFLLWWGWVL AAESTVHWPG REVHEPSKKG SRPQRQRRGA
60 70 80 90 100
HDDAHKQGSP ILKRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV
110 120 130 140 150
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSTN NLSMTFDGRL
160 170 180 190 200
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN
210 220 230 240 250
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL
260 270 280 290 300
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
310 320 330 340 350
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW
360 370 380 390 400
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS
410 420 430 440 450
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK SQRGSYVSMR
460 470 480
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
Length:480
Mass (Da):55,532
Last modified:February 10, 2009 - v2
Checksum:i18998C6C86CDC93C
GO

Sequence cautioni

The sequence AAA87730 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA64832 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21070 mRNA. Translation: AAA87730.1. Different initiation.
X95579 mRNA. Translation: CAA64832.1. Different initiation.
UniGeneiRn.33552.

Genome annotation databases

UCSCiRGD:61900. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21070 mRNA. Translation: AAA87730.1. Different initiation.
X95579 mRNA. Translation: CAA64832.1. Different initiation.
UniGeneiRn.33552.

3D structure databases

ProteinModelPortaliP50572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010172.

Chemistry databases

GuidetoPHARMACOLOGYi420.

PTM databases

iPTMnetiP50572.
PhosphoSitePlusiP50572.

Proteomic databases

PaxDbiP50572.
PRIDEiP50572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61900. rat.

Organism-specific databases

RGDi61900. Gabrr1.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50572.
PhylomeDBiP50572.

Miscellaneous databases

PROiP50572.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRR1_RAT
AccessioniPrimary (citable) accession number: P50572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.