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P50571

- GBRB1_MOUSE

UniProt

P50571 - GBRB1_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit beta-1

Gene

Gabrb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251AgonistBy similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: UniProtKB
  4. ligand-gated ion channel activity Source: UniProtKB

GO - Biological processi

  1. cellular response to histamine Source: UniProtKB
  2. ion transmembrane transport Source: GOC
  3. ion transport Source: UniProtKB
  4. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-1
Alternative name(s):
GABA(A) receptor subunit beta-1
Gene namesi
Name:Gabrb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:95619. Gabrb1.

Subcellular locationi

Cell junctionsynapsepostsynaptic cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. GABA-A receptor complex Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 474449Gamma-aminobutyric acid receptor subunit beta-1PRO_0000000457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 175By similarity
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP50571.
PaxDbiP50571.
PRIDEiP50571.

PTM databases

PhosphoSiteiP50571.

Expressioni

Gene expression databases

BgeeiP50571.
ExpressionAtlasiP50571. baseline and differential.
GenevestigatoriP50571.

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Binds UBQLN1. Interacts with KCTD8, KCTD12, KCTD12B and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.2 Publications

Protein-protein interaction databases

BioGridi199802. 2 interactions.
STRINGi10090.ENSMUSP00000031122.

Structurei

3D structure databases

ProteinModelPortaliP50571.
SMRiP50571. Positions 27-473.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 245220ExtracellularCuratedAdd
BLAST
Topological domaini328 – 451124CytoplasmicCuratedAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei246 – 26722HelicalCuratedAdd
BLAST
Transmembranei271 – 29323HelicalCuratedAdd
BLAST
Transmembranei305 – 32723HelicalCuratedAdd
BLAST
Transmembranei452 – 47322HelicalCuratedAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1223Agonist bindingBy similarity
Regioni180 – 1823Agonist bindingBy similarity
Regioni290 – 31122Allosteric effector bindingBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50571.
KOiK05181.
OMAiDSASIHY.
OrthoDBiEOG712TVZ.
PhylomeDBiP50571.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50571-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI
60 70 80 90 100
RLRPDFGGPP VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS
110 120 130 140 150
GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL
160 170 180 190 200
YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWNGGEGAV
210 220 230 240 250
TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK RNIGYFILQT
260 270 280 290 300
YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI
310 320 330 340 350
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE
360 370 380 390 400
KNRLEMNKVQ VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA
410 420 430 440 450
SIQYRKPLSS REGFGRGLDR HGVPGKGRIR RRASQLKVKI PDLTDVNSID
460 470
KWSRMFFPIT FSLFNVVYWL YYVH
Length:474
Mass (Da):54,100
Last modified:October 1, 1996 - v1
Checksum:i986C47E4BD663763
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14418 mRNA. Translation: AAA79973.1.
CCDSiCCDS19329.1.
PIRiS53530.
RefSeqiNP_032095.1. NM_008069.4.
UniGeneiMm.38567.

Genome annotation databases

EnsembliENSMUST00000031122; ENSMUSP00000031122; ENSMUSG00000029212.
GeneIDi14400.
KEGGimmu:14400.
UCSCiuc008xrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14418 mRNA. Translation: AAA79973.1 .
CCDSi CCDS19329.1.
PIRi S53530.
RefSeqi NP_032095.1. NM_008069.4.
UniGenei Mm.38567.

3D structure databases

ProteinModelPortali P50571.
SMRi P50571. Positions 27-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199802. 2 interactions.
STRINGi 10090.ENSMUSP00000031122.

Chemistry

BindingDBi P50571.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 410.

PTM databases

PhosphoSitei P50571.

Proteomic databases

MaxQBi P50571.
PaxDbi P50571.
PRIDEi P50571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031122 ; ENSMUSP00000031122 ; ENSMUSG00000029212 .
GeneIDi 14400.
KEGGi mmu:14400.
UCSCi uc008xrb.1. mouse.

Organism-specific databases

CTDi 2560.
MGIi MGI:95619. Gabrb1.

Phylogenomic databases

eggNOGi NOG77438.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P50571.
KOi K05181.
OMAi DSASIHY.
OrthoDBi EOG712TVZ.
PhylomeDBi P50571.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Miscellaneous databases

ChiTaRSi GABRB1. mouse.
NextBioi 285945.
PROi P50571.
SOURCEi Search...

Gene expression databases

Bgeei P50571.
ExpressionAtlasi P50571. baseline and differential.
Genevestigatori P50571.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice."
    Kamatchi G.L., Kofuji P., Wang J.B., Fernando J.C., Liu Z., Mathura J.R., Burt D.R.
    Biochim. Biophys. Acta 1261:134-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  2. "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
    Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
    Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN1.
  3. Cited for: INTERACTION WITH KCTD8; KCTD12; KCTD12B AND KCTD16, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGBRB1_MOUSE
AccessioniPrimary (citable) accession number: P50571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3