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P50571 (GBRB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit beta-1
Alternative name(s):
GABA(A) receptor subunit beta-1
Gene names
Name:Gabrb1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12, KCTD12B and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents. Ref.2 Ref.3

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainSignal
Transmembrane
Transmembrane helix
   LigandChloride
   Molecular functionChloride channel
Ion channel
Ligand-gated ion channel
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentral nervous system neuron development

Inferred from electronic annotation. Source: Compara

ovulation cycle

Inferred from electronic annotation. Source: Compara

response to progesterone stimulus

Inferred from electronic annotation. Source: Compara

response to toxin

Inferred from electronic annotation. Source: Compara

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

chloride channel complex

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from electronic annotation. Source: Compara

dendrite

Inferred from electronic annotation. Source: Compara

nuclear envelope

Inferred from electronic annotation. Source: Compara

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

receptor complex

Inferred from electronic annotation. Source: Compara

   Molecular_functionGABA-A receptor activity

Inferred from electronic annotation. Source: Compara

chloride channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular ligand-gated ion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 474449Gamma-aminobutyric acid receptor subunit beta-1
PRO_0000000457

Regions

Topological domain26 – 245220Extracellular Probable
Transmembrane246 – 26722Helical; Probable
Transmembrane271 – 29323Helical; Probable
Transmembrane305 – 32723Helical; Probable
Topological domain328 – 451124Cytoplasmic Probable
Transmembrane452 – 47322Helical; Probable

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Disulfide bond161 ↔ 175 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50571 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 986C47E4BD663763

FASTA47454,100
        10         20         30         40         50         60 
MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP 

        70         80         90        100        110        120 
VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD 

       130        140        150        160        170        180 
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 

       190        200        210        220        230        240 
SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK 

       250        260        270        280        290        300 
RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 

       310        320        330        340        350        360 
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE KNRLEMNKVQ 

       370        380        390        400        410        420 
VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA SIQYRKPLSS REGFGRGLDR 

       430        440        450        460        470 
HGVPGKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH

« Hide

References

[1]"GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice."
Kamatchi G.L., Kofuji P., Wang J.B., Fernando J.C., Liu Z., Mathura J.R., Burt D.R.
Biochim. Biophys. Acta 1261:134-142(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J and DBA/2J.
Tissue: Brain.
[2]"GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBQLN1.
[3]"Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits."
Schwenk J., Metz M., Zolles G., Turecek R., Fritzius T., Bildl W., Tarusawa E., Kulik A., Unger A., Ivankova K., Seddik R., Tiao J.Y., Rajalu M., Trojanova J., Rohde V., Gassmann M., Schulte U., Fakler B., Bettler B.
Nature 465:231-235(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KCTD8; KCTD12; KCTD12B AND KCTD16.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U14418 mRNA. Translation: AAA79973.1.
IPIIPI00119283.
PIRS53530.
RefSeqNP_032095.1. NM_008069.4.
UniGeneMm.38567.

3D structure databases

ProteinModelPortalP50571.
SMRP50571. Positions 47-330.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000031122.

PTM databases

PhosphoSiteP50571.

Proteomic databases

PaxDbP50571.
PRIDEP50571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031122; ENSMUSP00000031122; ENSMUSG00000029212.
GeneID14400.
KEGGmmu:14400.

Organism-specific databases

CTD2560.
MGIMGI:95619. Gabrb1.

Phylogenomic databases

eggNOGNOG77438.
HOGENOMHOG000231335.
HOVERGENHBG051707.
InParanoidP50571.
KOK05181.
OMAYRKPMSS.
OrthoDBEOG45756F.

Gene expression databases

ArrayExpressP50571.
BgeeP50571.
GenevestigatorP50571.
GermOnlineENSMUSG00000029212. Mus musculus.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP50571.
ChEMBLCHEMBL2839.
ChiTaRSGABRB1. mouse.
NextBio285945.
SOURCESearch...

Entry information

Entry nameGBRB1_MOUSE
AccessionPrimary (citable) accession number: P50571
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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