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P50571

- GBRB1_MOUSE

UniProt

P50571 - GBRB1_MOUSE

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Protein
Gamma-aminobutyric acid receptor subunit beta-1
Gene
Gabrb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. GABA-A receptor activity Source: InterPro
  2. chloride channel activity Source: UniProtKB-KW
  3. extracellular ligand-gated ion channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit beta-1
    Alternative name(s):
    GABA(A) receptor subunit beta-1
    Gene namesi
    Name:Gabrb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95619. Gabrb1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 245220Extracellular Inferred
    Add
    BLAST
    Transmembranei246 – 26722Helical; Inferred
    Add
    BLAST
    Transmembranei271 – 29323Helical; Inferred
    Add
    BLAST
    Transmembranei305 – 32723Helical; Inferred
    Add
    BLAST
    Topological domaini328 – 451124Cytoplasmic Inferred
    Add
    BLAST
    Transmembranei452 – 47322Helical; Inferred
    Add
    BLAST

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 Reviewed prediction
    Add
    BLAST
    Chaini26 – 474449Gamma-aminobutyric acid receptor subunit beta-1
    PRO_0000000457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi161 ↔ 175 By similarity
    Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP50571.
    PaxDbiP50571.
    PRIDEiP50571.

    PTM databases

    PhosphoSiteiP50571.

    Expressioni

    Gene expression databases

    ArrayExpressiP50571.
    BgeeiP50571.
    GenevestigatoriP50571.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12, KCTD12B and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.2 Publications

    Protein-protein interaction databases

    BioGridi199802. 2 interactions.
    STRINGi10090.ENSMUSP00000031122.

    Structurei

    3D structure databases

    ProteinModelPortaliP50571.
    SMRiP50571. Positions 47-346.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77438.
    HOGENOMiHOG000231335.
    HOVERGENiHBG051707.
    InParanoidiP50571.
    KOiK05181.
    OMAiDSASIHY.
    OrthoDBiEOG712TVZ.
    PhylomeDBiP50571.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR002289. GABAAb_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01160. GABAARBETA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI    50
    RLRPDFGGPP VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS 100
    GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL 150
    YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWNGGEGAV 200
    TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK RNIGYFILQT 250
    YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 300
    PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE 350
    KNRLEMNKVQ VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA 400
    SIQYRKPLSS REGFGRGLDR HGVPGKGRIR RRASQLKVKI PDLTDVNSID 450
    KWSRMFFPIT FSLFNVVYWL YYVH 474
    Length:474
    Mass (Da):54,100
    Last modified:October 1, 1996 - v1
    Checksum:i986C47E4BD663763
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14418 mRNA. Translation: AAA79973.1.
    CCDSiCCDS19329.1.
    PIRiS53530.
    RefSeqiNP_032095.1. NM_008069.4.
    UniGeneiMm.38567.

    Genome annotation databases

    EnsembliENSMUST00000031122; ENSMUSP00000031122; ENSMUSG00000029212.
    GeneIDi14400.
    KEGGimmu:14400.
    UCSCiuc008xrb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14418 mRNA. Translation: AAA79973.1 .
    CCDSi CCDS19329.1.
    PIRi S53530.
    RefSeqi NP_032095.1. NM_008069.4.
    UniGenei Mm.38567.

    3D structure databases

    ProteinModelPortali P50571.
    SMRi P50571. Positions 47-346.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 199802. 2 interactions.
    STRINGi 10090.ENSMUSP00000031122.

    Chemistry

    BindingDBi P50571.
    ChEMBLi CHEMBL2094133.
    GuidetoPHARMACOLOGYi 410.

    PTM databases

    PhosphoSitei P50571.

    Proteomic databases

    MaxQBi P50571.
    PaxDbi P50571.
    PRIDEi P50571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031122 ; ENSMUSP00000031122 ; ENSMUSG00000029212 .
    GeneIDi 14400.
    KEGGi mmu:14400.
    UCSCi uc008xrb.1. mouse.

    Organism-specific databases

    CTDi 2560.
    MGIi MGI:95619. Gabrb1.

    Phylogenomic databases

    eggNOGi NOG77438.
    HOGENOMi HOG000231335.
    HOVERGENi HBG051707.
    InParanoidi P50571.
    KOi K05181.
    OMAi DSASIHY.
    OrthoDBi EOG712TVZ.
    PhylomeDBi P50571.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Miscellaneous databases

    ChiTaRSi GABRB1. mouse.
    NextBioi 285945.
    PROi P50571.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50571.
    Bgeei P50571.
    Genevestigatori P50571.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR002289. GABAAb_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01160. GABAARBETA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice."
      Kamatchi G.L., Kofuji P., Wang J.B., Fernando J.C., Liu Z., Mathura J.R., Burt D.R.
      Biochim. Biophys. Acta 1261:134-142(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J and DBA/2J.
      Tissue: Brain.
    2. "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
      Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
      Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBQLN1.
    3. Cited for: INTERACTION WITH KCTD8; KCTD12; KCTD12B AND KCTD16.

    Entry informationi

    Entry nameiGBRB1_MOUSE
    AccessioniPrimary (citable) accession number: P50571
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: September 3, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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