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P50571

- GBRB1_MOUSE

UniProt

P50571 - GBRB1_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit beta-1

Gene
Gabrb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-1
Alternative name(s):
GABA(A) receptor subunit beta-1
Gene namesi
Name:Gabrb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:95619. Gabrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 245220Extracellular InferredAdd
BLAST
Transmembranei246 – 26722Helical; InferredAdd
BLAST
Transmembranei271 – 29323Helical; InferredAdd
BLAST
Transmembranei305 – 32723Helical; InferredAdd
BLAST
Topological domaini328 – 451124Cytoplasmic InferredAdd
BLAST
Transmembranei452 – 47322Helical; InferredAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 474449Gamma-aminobutyric acid receptor subunit beta-1PRO_0000000457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 175 By similarity
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP50571.
PaxDbiP50571.
PRIDEiP50571.

PTM databases

PhosphoSiteiP50571.

Expressioni

Gene expression databases

ArrayExpressiP50571.
BgeeiP50571.
GenevestigatoriP50571.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12, KCTD12B and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.2 Publications

Protein-protein interaction databases

BioGridi199802. 2 interactions.
STRINGi10090.ENSMUSP00000031122.

Structurei

3D structure databases

ProteinModelPortaliP50571.
SMRiP50571. Positions 47-346.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP50571.
KOiK05181.
OMAiDSASIHY.
OrthoDBiEOG712TVZ.
PhylomeDBiP50571.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50571-1 [UniParc]FASTAAdd to Basket

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MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI    50
RLRPDFGGPP VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS 100
GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL 150
YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWNGGEGAV 200
TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK RNIGYFILQT 250
YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI 300
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE 350
KNRLEMNKVQ VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA 400
SIQYRKPLSS REGFGRGLDR HGVPGKGRIR RRASQLKVKI PDLTDVNSID 450
KWSRMFFPIT FSLFNVVYWL YYVH 474
Length:474
Mass (Da):54,100
Last modified:October 1, 1996 - v1
Checksum:i986C47E4BD663763
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14418 mRNA. Translation: AAA79973.1.
CCDSiCCDS19329.1.
PIRiS53530.
RefSeqiNP_032095.1. NM_008069.4.
UniGeneiMm.38567.

Genome annotation databases

EnsembliENSMUST00000031122; ENSMUSP00000031122; ENSMUSG00000029212.
GeneIDi14400.
KEGGimmu:14400.
UCSCiuc008xrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14418 mRNA. Translation: AAA79973.1 .
CCDSi CCDS19329.1.
PIRi S53530.
RefSeqi NP_032095.1. NM_008069.4.
UniGenei Mm.38567.

3D structure databases

ProteinModelPortali P50571.
SMRi P50571. Positions 47-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199802. 2 interactions.
STRINGi 10090.ENSMUSP00000031122.

Chemistry

BindingDBi P50571.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 410.

PTM databases

PhosphoSitei P50571.

Proteomic databases

MaxQBi P50571.
PaxDbi P50571.
PRIDEi P50571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031122 ; ENSMUSP00000031122 ; ENSMUSG00000029212 .
GeneIDi 14400.
KEGGi mmu:14400.
UCSCi uc008xrb.1. mouse.

Organism-specific databases

CTDi 2560.
MGIi MGI:95619. Gabrb1.

Phylogenomic databases

eggNOGi NOG77438.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P50571.
KOi K05181.
OMAi DSASIHY.
OrthoDBi EOG712TVZ.
PhylomeDBi P50571.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.

Miscellaneous databases

ChiTaRSi GABRB1. mouse.
NextBioi 285945.
PROi P50571.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50571.
Bgeei P50571.
Genevestigatori P50571.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice."
    Kamatchi G.L., Kofuji P., Wang J.B., Fernando J.C., Liu Z., Mathura J.R., Burt D.R.
    Biochim. Biophys. Acta 1261:134-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  2. "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1."
    Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., Wisden W., Triller A., Smart T.G., Moss S.J.
    Nat. Neurosci. 4:908-916(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN1.
  3. Cited for: INTERACTION WITH KCTD8; KCTD12; KCTD12B AND KCTD16.

Entry informationi

Entry nameiGBRB1_MOUSE
AccessioniPrimary (citable) accession number: P50571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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