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Protein

Histone H4

Gene

H4-I

more
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:H4-I
AND
Name:H4-II
AND
Name:H4-III
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001582992 – 103Histone H4Add BLAST102

Proteomic databases

PRIDEiP50566.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP50566.
SMRiP50566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
KOiK11254.
OMAiYEEVRVV.

Family and domain databases

CDDicd00076. H4. 1 hit.
InterProiView protein in InterPro
IPR035425. CENP-T/H4_C.
IPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
PfamiView protein in Pfam
PF15511. CENP-T_C. 1 hit.
PRINTSiPR00623. HISTONEH4.
SMARTiView protein in SMART
SM00417. H4. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00047. HISTONE_H4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRTVLK TFLENVIRDS VTYTEHARRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,457
Last modified:January 23, 2007 - v2
Checksum:i62973B661293637F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41841 Genomic DNA. Translation: AAA99966.1.
U16724 Genomic DNA. Translation: AAA98445.1.
U16725 Genomic DNA. Translation: AAA98449.1.
U16825 Genomic DNA. Translation: AAA98456.1.
PIRiS59586.
RefSeqiXP_001690685.1. XM_001690633.1.
XP_001690721.1. XM_001690669.1.
XP_001690810.1. XM_001690758.1.
XP_001690828.1. XM_001690776.1.
XP_001690996.1. XM_001690944.1.
XP_001691002.1. XM_001690950.1.
XP_001691010.1. XM_001690958.1.
XP_001691527.1. XM_001691475.1.
XP_001691544.1. XM_001691492.1.
XP_001691698.1. XM_001691646.1.
XP_001696174.1. XM_001696122.1.
XP_001696191.1. XM_001696139.1.
XP_001696262.1. XM_001696210.1.
XP_001696277.1. XM_001696225.1.
XP_001696279.1. XM_001696227.1.
XP_001696285.1. XM_001696233.1.
XP_001696452.1. XM_001696400.1.
XP_001696459.1. XM_001696407.1.
XP_001696488.1. XM_001696436.1.
XP_001696520.1. XM_001696468.1.
XP_001696524.1. XM_001696472.1.
XP_001696553.1. XM_001696501.1.
XP_001698167.1. XM_001698115.1.
XP_001698253.1. XM_001698201.1.
XP_001700398.1. XM_001700346.1.
XP_001700408.1. XM_001700356.1.
XP_001700424.1. XM_001700372.1.
XP_001700455.1. XM_001700403.1.
XP_001702964.1. XM_001702912.1.
XP_001703063.1. XM_001703011.1.
UniGeneiCre.5997.

Genome annotation databases

EnsemblPlantsiEDO95785; EDO95785; CHLREDRAFT_110341.
EDO95843; EDO95843; CHLREDRAFT_124889.
EDO95850; EDO95850; CHLREDRAFT_181346.
EDO96244; EDO96244; CHLREDRAFT_796.
EDO96260; EDO96260; CHLREDRAFT_123650.
EDO98087; EDO98087; CHLREDRAFT_121845.
EDO98097; EDO98097; CHLREDRAFT_653.
EDO98113; EDO98113; CHLREDRAFT_121805.
EDO98144; EDO98144; CHLREDRAFT_121757.
EDO99452; EDO99452; CHLREDRAFT_106054.
EDO99538; EDO99538; CHLREDRAFT_579.
EDP04635; EDP04635; CHLREDRAFT_115475.
EDP04652; EDP04652; CHLREDRAFT_100662.
EDP04806; EDP04806; CHLREDRAFT_100611.
EDP05256; EDP05256; CHLREDRAFT_114706.
EDP05274; EDP05274; CHLREDRAFT_144564.
EDP05442; EDP05442; CHLREDRAFT_99975.
EDP05448; EDP05448; CHLREDRAFT_99976.
EDP05456; EDP05456; CHLREDRAFT_100020.
EDP08151; EDP08151; CHLREDRAFT_97616.
EDP08168; EDP08168; CHLREDRAFT_97613.
EDP08239; EDP08239; CHLREDRAFT_167195.
EDP08254; EDP08254; CHLREDRAFT_112470.
EDP08256; EDP08256; CHLREDRAFT_98022.
EDP08262; EDP08262; CHLREDRAFT_97647.
EDP08429; EDP08429; CHLREDRAFT_112822.
EDP08436; EDP08436; CHLREDRAFT_97581.
EDP08465; EDP08465; CHLREDRAFT_97742.
EDP08497; EDP08497; CHLREDRAFT_112559.
EDP08501; EDP08501; CHLREDRAFT_167163.
EDP08530; EDP08530; CHLREDRAFT_98181.
GeneIDi5716266.
5716318.
5716449.
5716454.
5716466.
5716482.
5716484.
5717133.
5717168.
5717177.
5721749.
5721766.
5721776.
5721781.
5721835.
5721892.
5721901.
5721930.
5721954.
5721959.
5721962.
5721972.
5723807.
5723810.
5725955.
5726000.
5726011.
5726025.
5728507.
5728603.
GrameneiEDO95785; EDO95785; CHLREDRAFT_110341.
EDO95843; EDO95843; CHLREDRAFT_124889.
EDO95850; EDO95850; CHLREDRAFT_181346.
EDO96244; EDO96244; CHLREDRAFT_796.
EDO96260; EDO96260; CHLREDRAFT_123650.
EDO98087; EDO98087; CHLREDRAFT_121845.
EDO98097; EDO98097; CHLREDRAFT_653.
EDO98113; EDO98113; CHLREDRAFT_121805.
EDO98144; EDO98144; CHLREDRAFT_121757.
EDO99452; EDO99452; CHLREDRAFT_106054.
EDO99538; EDO99538; CHLREDRAFT_579.
EDP04635; EDP04635; CHLREDRAFT_115475.
EDP04652; EDP04652; CHLREDRAFT_100662.
EDP04806; EDP04806; CHLREDRAFT_100611.
EDP05256; EDP05256; CHLREDRAFT_114706.
EDP05274; EDP05274; CHLREDRAFT_144564.
EDP05442; EDP05442; CHLREDRAFT_99975.
EDP05448; EDP05448; CHLREDRAFT_99976.
EDP05456; EDP05456; CHLREDRAFT_100020.
EDP08151; EDP08151; CHLREDRAFT_97616.
EDP08168; EDP08168; CHLREDRAFT_97613.
EDP08239; EDP08239; CHLREDRAFT_167195.
EDP08254; EDP08254; CHLREDRAFT_112470.
EDP08256; EDP08256; CHLREDRAFT_98022.
EDP08262; EDP08262; CHLREDRAFT_97647.
EDP08429; EDP08429; CHLREDRAFT_112822.
EDP08436; EDP08436; CHLREDRAFT_97581.
EDP08465; EDP08465; CHLREDRAFT_97742.
EDP08497; EDP08497; CHLREDRAFT_112559.
EDP08501; EDP08501; CHLREDRAFT_167163.
EDP08530; EDP08530; CHLREDRAFT_98181.
KEGGicre:CHLREDRAFT_100020.
cre:CHLREDRAFT_100611.
cre:CHLREDRAFT_100662.
cre:CHLREDRAFT_106054.
cre:CHLREDRAFT_110341.
cre:CHLREDRAFT_112470.
cre:CHLREDRAFT_112559.
cre:CHLREDRAFT_112822.
cre:CHLREDRAFT_114706.
cre:CHLREDRAFT_115475.
cre:CHLREDRAFT_121757.
cre:CHLREDRAFT_121805.
cre:CHLREDRAFT_121845.
cre:CHLREDRAFT_123650.
cre:CHLREDRAFT_124889.
cre:CHLREDRAFT_144564.
cre:CHLREDRAFT_167163.
cre:CHLREDRAFT_167195.
cre:CHLREDRAFT_181346.
cre:CHLREDRAFT_579.
cre:CHLREDRAFT_653.
cre:CHLREDRAFT_97581.
cre:CHLREDRAFT_97613.
cre:CHLREDRAFT_97616.
cre:CHLREDRAFT_97647.
cre:CHLREDRAFT_97742.
cre:CHLREDRAFT_98022.
cre:CHLREDRAFT_98181.
cre:CHLREDRAFT_99975.
cre:CHLREDRAFT_99976.

Similar proteinsi

Entry informationi

Entry nameiH4_CHLRE
AccessioniPrimary (citable) accession number: P50566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: January 31, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families