P50549 (ETV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ETS translocation variant 1

Alternative name(s):
Ets-related protein 81

Gene names

Name:	ETV1
Synonyms:	ER81

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Subcellular location	Nucleus Probable.
Tissue specificity	Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.
Post-translational modification	Sumoylated. Ref.12 Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity. Ref.10 Ref.11
Involvement in disease	Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain.
Sequence caution	The sequence BAD92439.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara mechanosensory behavior Inferred from electronic annotation. Source: Compara muscle organ development Inferred from electronic annotation. Source: Compara peripheral nervous system neuron development Traceable author statement PubMed 20096094. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRKDC	P78527	2	EBI-3905068,EBI-352053

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P50549-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P50549-2)

The sequence of this isoform differs from the canonical sequence as follows:
     61-79: AQVPDNDEQFVPDYQAESL → V

Isoform 3 (identifier: P50549-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: P50549-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     122-184: Missing.

Isoform 5 (identifier: P50549-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     61-79: AQVPDNDEQFVPDYQAESL → V

Note: No experimental confirmation available.

Isoform 6 (identifier: P50549-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 477

477

ETS translocation variant 1

PRO_0000204110

Regions

DNA binding

335 – 415

81

ETS

Amino acid modifications

Modified residue

191

1

Phosphoserine; by RPS6KA1 and RPS6KA5 Ref.10 Ref.11

Modified residue

216

1

Phosphoserine; by RPS6KA1 and RPS6KA5 Ref.10 Ref.11

Natural variations

Alternative sequence

1 – 60

60

MDGFY…TWLAE → MLQDLSASVFFPPCSQHRTL in isoform 4, isoform 5 and isoform 6.

VSP_043808

Alternative sequence

61 – 79

19

AQVPD…QAESL → V in isoform 2 and isoform 5.

VSP_001472

Alternative sequence

122 – 184

63

Missing in isoform 4.

VSP_043809

Alternative sequence

268 – 290

23

Missing in isoform 3.

VSP_043750

Natural variant

100

1

S → G. Ref.4 Ref.5
Corresponds to variant rs9639168 [ dbSNP | Ensembl ].

VAR_048948

Experimental info

Mutagenesis

191

1

S → A: Loss of phosphorylation by RPS6KA5. Ref.11

Mutagenesis

216

1

S → A: Loss of phosphorylation by RPS6KA5. Ref.11

Sequence conflict

39

1

L → V in CAA60642. Ref.2

Sequence conflict

117

1

C → S in AAA79844. Ref.1

Sequence conflict

127

1

K → N in AAA79844. Ref.1

Sequence conflict

253

1

Missing in CAA60642. Ref.2

Sequence conflict

349

1

S → A in CAA60642. Ref.2

Sequence conflict

445

1

E → G in CAH10484. Ref.6

Sequence conflict

471

1

Y → C in BAH13104. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

477

Helix Strand Turn

Details...

Helix

337 – 346

10

Helix

348 – 350

3

Turn

351 – 353

3

Beta strand

354 – 356

3

Beta strand

362 – 367

6

Helix

368 – 378

11

Helix

386 – 399

14

Beta strand

401 – 404

4

Beta strand

409 – 414

6

Helix

418 – 425

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: BE95FA3F07196F06	FASTA	477	55,131
	10 20 30 40 50 60 MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 70 80 90 100 110 120 AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS SACSQEQPFK FSYGEKCLYN 130 140 150 160 170 180 VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY 190 200 210 220 230 240 PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT 250 260 270 280 290 300 MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 310 320 330 340 350 360 FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG 370 380 390 400 410 420 MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA 430 440 450 460 470 LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM PEGGCCNPHP YNEGYVY
	Isoform 2 [UniParc]. Checksum: 558A574E5B53979B	FASTA	459	53,083
	10 20 30 40 50 60 MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 70 80 90 100 110 120 VAFHGLPLKI KKEPHSPCSE ISSACSQEQP FKFSYGEKCL YNVSAYDQKP QVGMRPSNPP 130 140 150 160 170 180 TPSSTPVSPL HHASPNSTHT PKPDRAFPAH LPPSQSIPDS SYPMDHRFRR QLSEPCNSFP 190 200 210 220 230 240 PLPTMPREGR PMYQRQMSEP NIPFPPQGFK QEYHDPVYEH NTMVGSAASQ SFPPPLMIKQ 250 260 270 280 290 300 EPRDFAYDSE VPSCHSIYMR QEGFLAHPSR TEGCMFEKGP RQFYDDTCVV PEKFDGDIKQ 310 320 330 340 350 360 EPGMYREGPT YQRRGSLQLW QFLVALLDDP SNSHFIAWTG RGMEFKLIEP EEVARRWGIQ 370 380 390 400 410 420 KNRPAMNYDK LSRSLRYYYE KGIMQKVAGE RYVYKFVCDP EALFSMAFPD NQRPLLKTDM 430 440 450 ERHINEEDTV PLSHFDESMA YMPEGGCCNP HPYNEGYVY
	Isoform 3 [UniParc]. Checksum: F0BB1A4835FCF45D	FASTA	454	52,474
	10 20 30 40 50 60 MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 70 80 90 100 110 120 AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS SACSQEQPFK FSYGEKCLYN 130 140 150 160 170 180 VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY 190 200 210 220 230 240 PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT 250 260 270 280 290 300 MVGSAASQSF PPPLMIKQEP RDFAYDSGCM FEKGPRQFYD DTCVVPEKFD GDIKQEPGMY 310 320 330 340 350 360 REGPTYQRRG SLQLWQFLVA LLDDPSNSHF IAWTGRGMEF KLIEPEEVAR RWGIQKNRPA 370 380 390 400 410 420 MNYDKLSRSL RYYYEKGIMQ KVAGERYVYK FVCDPEALFS MAFPDNQRPL LKTDMERHIN 430 440 450 EEDTVPLSHF DESMAYMPEG GCCNPHPYNE GYVY
	Isoform 4 [UniParc]. Checksum: E493CC2364AD60C2	FASTA	374	43,455
	10 20 30 40 50 60 MLQDLSASVF FPPCSQHRTL AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS 70 80 90 100 110 120 SACSQEQPFK FSYGEKCLYN VRFRRQLSEP CNSFPPLPTM PREGRPMYQR QMSEPNIPFP 130 140 150 160 170 180 PQGFKQEYHD PVYEHNTMVG SAASQSFPPP LMIKQEPRDF AYDSEVPSCH SIYMRQEGFL 190 200 210 220 230 240 AHPSRTEGCM FEKGPRQFYD DTCVVPEKFD GDIKQEPGMY REGPTYQRRG SLQLWQFLVA 250 260 270 280 290 300 LLDDPSNSHF IAWTGRGMEF KLIEPEEVAR RWGIQKNRPA MNYDKLSRSL RYYYEKGIMQ 310 320 330 340 350 360 KVAGERYVYK FVCDPEALFS MAFPDNQRPL LKTDMERHIN EEDTVPLSHF DESMAYMPEG 370 GCCNPHPYNE GYVY
	Isoform 5 [UniParc]. Checksum: 24285CFD0B256971	FASTA	419	48,168
	10 20 30 40 50 60 MLQDLSASVF FPPCSQHRTL VAFHGLPLKI KKEPHSPCSE ISSACSQEQP FKFSYGEKCL 70 80 90 100 110 120 YNVSAYDQKP QVGMRPSNPP TPSSTPVSPL HHASPNSTHT PKPDRAFPAH LPPSQSIPDS 130 140 150 160 170 180 SYPMDHRFRR QLSEPCNSFP PLPTMPREGR PMYQRQMSEP NIPFPPQGFK QEYHDPVYEH 190 200 210 220 230 240 NTMVGSAASQ SFPPPLMIKQ EPRDFAYDSE VPSCHSIYMR QEGFLAHPSR TEGCMFEKGP 250 260 270 280 290 300 RQFYDDTCVV PEKFDGDIKQ EPGMYREGPT YQRRGSLQLW QFLVALLDDP SNSHFIAWTG 310 320 330 340 350 360 RGMEFKLIEP EEVARRWGIQ KNRPAMNYDK LSRSLRYYYE KGIMQKVAGE RYVYKFVCDP 370 380 390 400 410 EALFSMAFPD NQRPLLKTDM ERHINEEDTV PLSHFDESMA YMPEGGCCNP HPYNEGYVY
	Isoform 6 [UniParc]. Checksum: 37A55122A463957C	FASTA	437	50,217
	10 20 30 40 50 60 MLQDLSASVF FPPCSQHRTL AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS 70 80 90 100 110 120 SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK 130 140 150 160 170 180 PDRAFPAHLP PSQSIPDSSY PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI 190 200 210 220 230 240 PFPPQGFKQE YHDPVYEHNT MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE 250 260 270 280 290 300 GFLAHPSRTE GCMFEKGPRQ FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF 310 320 330 340 350 360 LVALLDDPSN SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG 370 380 390 400 410 420 IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM 430 PEGGCCNPHP YNEGYVY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1." Jeon I.-S., Davis J.N., Braun B.S., Sublett J.E., Roussel M.F., Denny C.T., Shapiro D.N. Oncogene 10:1229-1234(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Molecular characterization of the ets-related human transcription factor ER81." Monte D., Coutte L., Baert J.-L., Angeli I., Stehelin D., de Launoit Y. Oncogene 11:771-779(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Kidney.
[3]	"Characterization of the human and mouse ER81/ETV1 transcription factor genes. Role of the two human alternatively spliced isoforms." Coutte L., Monte D., Pouilly L., Dewitte F., Vidaud M., Baert J.-L., de Launoit Y. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5), VARIANT GLY-100. Tissue: Brain and Trachea.
[5]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-100. Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Seminoma.
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]	"Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A." Wu J., Janknecht R. J. Biol. Chem. 277:42669-42679(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-191 AND SER-216.
[11]	"Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)." Janknecht R. Oncogene 22:746-755(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-191 AND SER-216, MUTAGENESIS OF SER-191 AND SER-216.
[12]	"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates." Gocke C.B., Yu H., Kang J. J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUMOYLATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U17163 mRNA. Translation: AAA79844.1.
X87175 mRNA. Translation: CAA60642.1.
AF109632 , AF109621, AF109622, AF109623, AF109624, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29877.1.
AF109632 , AF109621, AF109622, AF109623, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29878.1.
AK294755 mRNA. Translation: BAH11870.1.
AK299693 mRNA. Translation: BAH13104.1.
AK312863 mRNA. Translation: BAG35715.1.
AK316007 mRNA. Translation: BAH14378.1.
AB209202 mRNA. Translation: BAD92439.1. Different initiation.
CR627389 mRNA. Translation: CAH10484.1.
AC004857 Genomic DNA. Translation: AAC62435.1.
AC004909 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24294.1.
BC098403 mRNA. Translation: AAH98403.1.
BC106762 mRNA. Translation: AAI06763.1.
BC106763 mRNA. Translation: AAI06764.1.

IPI

IPI00221065.
IPI00306430.
IPI00744316.
IPI00892607.
IPI00892613.

PIR

I38893.

RefSeq

NP_001156619.1. NM_001163147.1.
NP_001156620.1. NM_001163148.1.
NP_001156621.1. NM_001163149.1.
NP_001156622.1. NM_001163150.1.
NP_001156623.1. NM_001163151.1.
NP_001156624.1. NM_001163152.1.
NP_004947.2. NM_004956.4.

UniGene

Hs.22634.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AVP	X-ray	1.82	A/B/C/D	326-429	[»]
4B06	X-ray	2.90	A	326-429	[»]

ProteinModelPortal

P50549.

ModBase

Search...

Protein-protein interaction databases

IntAct

P50549. 5 interactions.

STRING

9606.ENSP00000384085.

PTM databases

PhosphoSite

P50549.

Polymorphism databases

DMDM

12643411.

Proteomic databases

PaxDb

P50549.

PRIDE

P50549.

Protocols and materials databases

DNASU

2115.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000242066; ENSP00000242066; ENSG00000006468.
ENST00000343495; ENSP00000340853; ENSG00000006468.
ENST00000399357; ENSP00000382293; ENSG00000006468.
ENST00000403527; ENSP00000384138; ENSG00000006468.
ENST00000403685; ENSP00000385686; ENSG00000006468.
ENST00000405192; ENSP00000385381; ENSG00000006468.
ENST00000405218; ENSP00000385551; ENSG00000006468.
ENST00000420159; ENSP00000411626; ENSG00000006468.
ENST00000430479; ENSP00000405327; ENSG00000006468.

GeneID

2115.

KEGG

hsa:2115.

UCSC

uc021zzz.1. human.
uc022aaa.1. human.

Organism-specific databases

CTD

2115.

GeneCards

GC07M013897.

HGNC

HGNC:3490. ETV1.

MIM

600541. gene.
612219. phenotype.

neXtProt

NX_P50549.

Orphanet

319. Ewing sarcoma.

PharmGKB

PA27904.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG258471.

HOGENOM

HOG000230986.

HOVERGEN

HBG000231.

KO

K09431.

OrthoDB

EOG45X7W5.

Enzyme and pathway databases

Pathway_Interaction_DB

p38_mk2pathway. p38 signaling mediated by MAPKAP kinases.

Gene expression databases

ArrayExpress

P50549.

Bgee

P50549.

CleanEx

HS_ETV1.

Genevestigator

P50549.

GermOnline

ENSG00000006468. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.

InterPro

IPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]

PRINTS

PR00454. ETSDOMAIN.

SMART

SM00413. ETS. 1 hit.
[Graphical view]

PROSITE

PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ETV1. human.

GenomeRNAi

2115.

NextBio

13627645.

SOURCE

Search...

Entry information

Entry name

ETV1_HUMAN

Accession

Primary (citable) accession number: P50549
Secondary accession number(s): A4D118 , B2R768, B7Z2I4, B7Z618, B7Z9P2, C9JT37, E9PHB1, F5GXR2, O75849, Q4KMQ6, Q59GA7, Q6AI30, Q9UQ71, Q9Y636

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 24, 2001
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.