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Protein

ETS translocation variant 1

Gene

ETV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi335 – 41581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: Ensembl
  • cell differentiation Source: GO_Central
  • mechanosensory behavior Source: Ensembl
  • muscle organ development Source: Ensembl
  • peripheral nervous system neuron development Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 1
Alternative name(s):
Ets-related protein 81
Gene namesi
Name:ETV1
Synonyms:ER81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:3490. ETV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES)

The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.

Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.

See also OMIM:612219

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi191 – 1911S → A: Loss of phosphorylation by RPS6KA5. 1 Publication
Mutagenesisi216 – 2161S → A: Loss of phosphorylation by RPS6KA5. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi612219. phenotype.
Orphaneti319. Ewing sarcoma.
PharmGKBiPA27904.

Polymorphism and mutation databases

BioMutaiETV1.
DMDMi12643411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477ETS translocation variant 1PRO_0000204110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei191 – 1911Phosphoserine; by RPS6KA1 and RPS6KA52 Publications
Modified residuei216 – 2161Phosphoserine; by RPS6KA1 and RPS6KA52 Publications

Post-translational modificationi

Sumoylated.1 Publication
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP50549.
PaxDbiP50549.
PRIDEiP50549.

PTM databases

PhosphoSiteiP50549.

Expressioni

Tissue specificityi

Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.

Gene expression databases

BgeeiP50549.
CleanExiHS_ETV1.
ExpressionAtlasiP50549. baseline and differential.
GenevisibleiP50549. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKDCP785272EBI-3905068,EBI-352053

Protein-protein interaction databases

BioGridi108416. 18 interactions.
DIPiDIP-60463N.
IntActiP50549. 6 interactions.
STRINGi9606.ENSP00000385551.

Structurei

Secondary structure

1
477
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi337 – 34610Combined sources
Helixi348 – 3503Combined sources
Turni351 – 3533Combined sources
Beta strandi354 – 3563Combined sources
Beta strandi362 – 3676Combined sources
Helixi368 – 37811Combined sources
Helixi386 – 39914Combined sources
Beta strandi401 – 4044Combined sources
Beta strandi409 – 4146Combined sources
Helixi418 – 4258Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVPX-ray1.82A/B/C/D326-429[»]
4BNCX-ray2.90A326-429[»]
ProteinModelPortaliP50549.
SMRiP50549. Positions 334-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258471.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiP50549.
KOiK09431.
OrthoDBiEOG7K9K2M.
PhylomeDBiP50549.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50549-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL
60 70 80 90 100
SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS
110 120 130 140 150
SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH
160 170 180 190 200
ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY PMDHRFRRQL SEPCNSFPPL
210 220 230 240 250
PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT MVGSAASQSF
260 270 280 290 300
PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ
310 320 330 340 350
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN
360 370 380 390 400
SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG
410 420 430 440 450
IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL
460 470
SHFDESMAYM PEGGCCNPHP YNEGYVY
Length:477
Mass (Da):55,131
Last modified:January 24, 2001 - v2
Checksum:iBE95FA3F07196F06
GO
Isoform 2 (identifier: P50549-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-79: AQVPDNDEQFVPDYQAESL → V

Show »
Length:459
Mass (Da):53,083
Checksum:i558A574E5B53979B
GO
Isoform 3 (identifier: P50549-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: Missing.

Note: No experimental confirmation available.
Show »
Length:454
Mass (Da):52,474
Checksum:iF0BB1A4835FCF45D
GO
Isoform 4 (identifier: P50549-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     122-184: Missing.

Show »
Length:374
Mass (Da):43,455
Checksum:iE493CC2364AD60C2
GO
Isoform 5 (identifier: P50549-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     61-79: AQVPDNDEQFVPDYQAESL → V

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):48,168
Checksum:i24285CFD0B256971
GO
Isoform 6 (identifier: P50549-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):50,217
Checksum:i37A55122A463957C
GO

Sequence cautioni

The sequence BAD92439.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391L → V in CAA60642 (PubMed:7651741).Curated
Sequence conflicti117 – 1171C → S in AAA79844 (PubMed:7700648).Curated
Sequence conflicti127 – 1271K → N in AAA79844 (PubMed:7700648).Curated
Sequence conflicti253 – 2531Missing in CAA60642 (PubMed:7651741).Curated
Sequence conflicti349 – 3491S → A in CAA60642 (PubMed:7651741).Curated
Sequence conflicti445 – 4451E → G in CAH10484 (PubMed:17974005).Curated
Sequence conflicti471 – 4711Y → C in BAH13104 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001S → G.2 Publications
Corresponds to variant rs9639168 [ dbSNP | Ensembl ].
VAR_048948

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060MDGFY…TWLAE → MLQDLSASVFFPPCSQHRTL in isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_043808Add
BLAST
Alternative sequencei61 – 7919AQVPD…QAESL → V in isoform 2 and isoform 5. 2 PublicationsVSP_001472Add
BLAST
Alternative sequencei122 – 18463Missing in isoform 4. 1 PublicationVSP_043809Add
BLAST
Alternative sequencei268 – 29023Missing in isoform 3. 1 PublicationVSP_043750Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17163 mRNA. Translation: AAA79844.1.
X87175 mRNA. Translation: CAA60642.1.
AF109632
, AF109621, AF109622, AF109623, AF109624, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29877.1.
AF109632
, AF109621, AF109622, AF109623, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29878.1.
AK294755 mRNA. Translation: BAH11870.1.
AK299693 mRNA. Translation: BAH13104.1.
AK312863 mRNA. Translation: BAG35715.1.
AK316007 mRNA. Translation: BAH14378.1.
AB209202 mRNA. Translation: BAD92439.1. Different initiation.
CR627389 mRNA. Translation: CAH10484.1.
AC004857 Genomic DNA. Translation: AAC62435.1.
AC004909 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24294.1.
BC098403 mRNA. Translation: AAH98403.1.
BC106762 mRNA. Translation: AAI06763.1.
BC106763 mRNA. Translation: AAI06764.1.
CCDSiCCDS55083.1. [P50549-5]
CCDS55084.1. [P50549-4]
CCDS55085.1. [P50549-6]
CCDS55086.1. [P50549-2]
CCDS55087.1. [P50549-3]
CCDS55088.1. [P50549-1]
PIRiI38893.
RefSeqiNP_001156619.1. NM_001163147.1. [P50549-3]
NP_001156620.1. NM_001163148.1. [P50549-2]
NP_001156621.1. NM_001163149.1. [P50549-2]
NP_001156622.1. NM_001163150.1. [P50549-6]
NP_001156623.1. NM_001163151.1. [P50549-5]
NP_001156624.1. NM_001163152.1. [P50549-4]
NP_004947.2. NM_004956.4. [P50549-1]
XP_005249692.1. XM_005249635.3. [P50549-1]
XP_005249693.1. XM_005249636.3. [P50549-1]
XP_011513470.1. XM_011515168.1. [P50549-1]
XP_011513473.1. XM_011515171.1. [P50549-2]
XP_011513474.1. XM_011515172.1. [P50549-2]
UniGeneiHs.22634.

Genome annotation databases

EnsembliENST00000242066; ENSP00000242066; ENSG00000006468. [P50549-2]
ENST00000399357; ENSP00000382293; ENSG00000006468. [P50549-4]
ENST00000403527; ENSP00000384138; ENSG00000006468. [P50549-6]
ENST00000403685; ENSP00000385686; ENSG00000006468. [P50549-2]
ENST00000405192; ENSP00000385381; ENSG00000006468. [P50549-3]
ENST00000405218; ENSP00000385551; ENSG00000006468.
ENST00000420159; ENSP00000411626; ENSG00000006468. [P50549-5]
ENST00000430479; ENSP00000405327; ENSG00000006468.
GeneIDi2115.
KEGGihsa:2115.
UCSCiuc003ssw.4. human. [P50549-3]
uc021zzu.1. human. [P50549-4]
uc021zzz.1. human. [P50549-1]
uc022aaa.1. human. [P50549-2]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17163 mRNA. Translation: AAA79844.1.
X87175 mRNA. Translation: CAA60642.1.
AF109632
, AF109621, AF109622, AF109623, AF109624, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29877.1.
AF109632
, AF109621, AF109622, AF109623, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29878.1.
AK294755 mRNA. Translation: BAH11870.1.
AK299693 mRNA. Translation: BAH13104.1.
AK312863 mRNA. Translation: BAG35715.1.
AK316007 mRNA. Translation: BAH14378.1.
AB209202 mRNA. Translation: BAD92439.1. Different initiation.
CR627389 mRNA. Translation: CAH10484.1.
AC004857 Genomic DNA. Translation: AAC62435.1.
AC004909 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24294.1.
BC098403 mRNA. Translation: AAH98403.1.
BC106762 mRNA. Translation: AAI06763.1.
BC106763 mRNA. Translation: AAI06764.1.
CCDSiCCDS55083.1. [P50549-5]
CCDS55084.1. [P50549-4]
CCDS55085.1. [P50549-6]
CCDS55086.1. [P50549-2]
CCDS55087.1. [P50549-3]
CCDS55088.1. [P50549-1]
PIRiI38893.
RefSeqiNP_001156619.1. NM_001163147.1. [P50549-3]
NP_001156620.1. NM_001163148.1. [P50549-2]
NP_001156621.1. NM_001163149.1. [P50549-2]
NP_001156622.1. NM_001163150.1. [P50549-6]
NP_001156623.1. NM_001163151.1. [P50549-5]
NP_001156624.1. NM_001163152.1. [P50549-4]
NP_004947.2. NM_004956.4. [P50549-1]
XP_005249692.1. XM_005249635.3. [P50549-1]
XP_005249693.1. XM_005249636.3. [P50549-1]
XP_011513470.1. XM_011515168.1. [P50549-1]
XP_011513473.1. XM_011515171.1. [P50549-2]
XP_011513474.1. XM_011515172.1. [P50549-2]
UniGeneiHs.22634.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVPX-ray1.82A/B/C/D326-429[»]
4BNCX-ray2.90A326-429[»]
ProteinModelPortaliP50549.
SMRiP50549. Positions 334-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108416. 18 interactions.
DIPiDIP-60463N.
IntActiP50549. 6 interactions.
STRINGi9606.ENSP00000385551.

Chemistry

BindingDBiP50549.
ChEMBLiCHEMBL2010626.

PTM databases

PhosphoSiteiP50549.

Polymorphism and mutation databases

BioMutaiETV1.
DMDMi12643411.

Proteomic databases

MaxQBiP50549.
PaxDbiP50549.
PRIDEiP50549.

Protocols and materials databases

DNASUi2115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242066; ENSP00000242066; ENSG00000006468. [P50549-2]
ENST00000399357; ENSP00000382293; ENSG00000006468. [P50549-4]
ENST00000403527; ENSP00000384138; ENSG00000006468. [P50549-6]
ENST00000403685; ENSP00000385686; ENSG00000006468. [P50549-2]
ENST00000405192; ENSP00000385381; ENSG00000006468. [P50549-3]
ENST00000405218; ENSP00000385551; ENSG00000006468.
ENST00000420159; ENSP00000411626; ENSG00000006468. [P50549-5]
ENST00000430479; ENSP00000405327; ENSG00000006468.
GeneIDi2115.
KEGGihsa:2115.
UCSCiuc003ssw.4. human. [P50549-3]
uc021zzu.1. human. [P50549-4]
uc021zzz.1. human. [P50549-1]
uc022aaa.1. human. [P50549-2]

Organism-specific databases

CTDi2115.
GeneCardsiGC07M013897.
HGNCiHGNC:3490. ETV1.
MIMi600541. gene.
612219. phenotype.
neXtProtiNX_P50549.
Orphaneti319. Ewing sarcoma.
PharmGKBiPA27904.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258471.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiP50549.
KOiK09431.
OrthoDBiEOG7K9K2M.
PhylomeDBiP50549.
TreeFamiTF316214.

Miscellaneous databases

ChiTaRSiETV1. human.
GeneWikiiETV1.
GenomeRNAii2115.
NextBioi13627645.
PROiP50549.
SOURCEiSearch...

Gene expression databases

BgeeiP50549.
CleanExiHS_ETV1.
ExpressionAtlasiP50549. baseline and differential.
GenevisibleiP50549. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1."
    Jeon I.-S., Davis J.N., Braun B.S., Sublett J.E., Roussel M.F., Denny C.T., Shapiro D.N.
    Oncogene 10:1229-1234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular characterization of the ets-related human transcription factor ER81."
    Monte D., Coutte L., Baert J.-L., Angeli I., Stehelin D., de Launoit Y.
    Oncogene 11:771-779(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Kidney.
  3. "Characterization of the human and mouse ER81/ETV1 transcription factor genes. Role of the two human alternatively spliced isoforms."
    Coutte L., Monte D., Pouilly L., Dewitte F., Vidaud M., Baert J.-L., de Launoit Y.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5), VARIANT GLY-100.
    Tissue: Brain and Trachea.
  5. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-100.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Seminoma.
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A."
    Wu J., Janknecht R.
    J. Biol. Chem. 277:42669-42679(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-191 AND SER-216.
  11. "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)."
    Janknecht R.
    Oncogene 22:746-755(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-191 AND SER-216, MUTAGENESIS OF SER-191 AND SER-216.
  12. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
    Gocke C.B., Yu H., Kang J.
    J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.

Entry informationi

Entry nameiETV1_HUMAN
AccessioniPrimary (citable) accession number: P50549
Secondary accession number(s): A4D118
, B2R768, B7Z2I4, B7Z618, B7Z9P2, C9JT37, E9PHB1, F5GXR2, O75849, Q4KMQ6, Q59GA7, Q6AI30, Q9UQ71, Q9Y636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 24, 2001
Last modified: July 22, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.