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P50549

- ETV1_HUMAN

UniProt

P50549 - ETV1_HUMAN

Protein

ETS translocation variant 1

Gene

ETV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi335 – 41581ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    5. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. cell differentiation Source: RefGenome
    3. mechanosensory behavior Source: Ensembl
    4. muscle organ development Source: Ensembl
    5. peripheral nervous system neuron development Source: BHF-UCL
    6. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    7. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    8. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS translocation variant 1
    Alternative name(s):
    Ets-related protein 81
    Gene namesi
    Name:ETV1
    Synonyms:ER81
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:3490. ETV1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
    Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi191 – 1911S → A: Loss of phosphorylation by RPS6KA5. 1 Publication
    Mutagenesisi216 – 2161S → A: Loss of phosphorylation by RPS6KA5. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi612219. phenotype.
    Orphaneti319. Ewing sarcoma.
    PharmGKBiPA27904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477ETS translocation variant 1PRO_0000204110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei191 – 1911Phosphoserine; by RPS6KA1 and RPS6KA52 Publications
    Modified residuei216 – 2161Phosphoserine; by RPS6KA1 and RPS6KA52 Publications

    Post-translational modificationi

    Sumoylated.1 Publication
    Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.2 Publications

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP50549.
    PaxDbiP50549.
    PRIDEiP50549.

    PTM databases

    PhosphoSiteiP50549.

    Expressioni

    Tissue specificityi

    Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.

    Gene expression databases

    ArrayExpressiP50549.
    BgeeiP50549.
    CleanExiHS_ETV1.
    GenevestigatoriP50549.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKDCP785272EBI-3905068,EBI-352053

    Protein-protein interaction databases

    BioGridi108416. 14 interactions.
    DIPiDIP-60463N.
    IntActiP50549. 5 interactions.
    STRINGi9606.ENSP00000384085.

    Structurei

    Secondary structure

    1
    477
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi337 – 34610
    Helixi348 – 3503
    Turni351 – 3533
    Beta strandi354 – 3563
    Beta strandi362 – 3676
    Helixi368 – 37811
    Helixi386 – 39914
    Beta strandi401 – 4044
    Beta strandi409 – 4146
    Helixi418 – 4258

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AVPX-ray1.82A/B/C/D326-429[»]
    4BNCX-ray2.90A326-429[»]
    ProteinModelPortaliP50549.
    SMRiP50549. Positions 334-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258471.
    HOGENOMiHOG000230986.
    HOVERGENiHBG000231.
    KOiK09431.
    OrthoDBiEOG7K9K2M.
    PhylomeDBiP50549.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P50549-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL    50
    SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS 100
    SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH 150
    ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY PMDHRFRRQL SEPCNSFPPL 200
    PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT MVGSAASQSF 250
    PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 300
    FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN 350
    SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG 400
    IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL 450
    SHFDESMAYM PEGGCCNPHP YNEGYVY 477
    Length:477
    Mass (Da):55,131
    Last modified:January 24, 2001 - v2
    Checksum:iBE95FA3F07196F06
    GO
    Isoform 2 (identifier: P50549-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-79: AQVPDNDEQFVPDYQAESL → V

    Show »
    Length:459
    Mass (Da):53,083
    Checksum:i558A574E5B53979B
    GO
    Isoform 3 (identifier: P50549-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-290: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:454
    Mass (Da):52,474
    Checksum:iF0BB1A4835FCF45D
    GO
    Isoform 4 (identifier: P50549-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
         122-184: Missing.

    Show »
    Length:374
    Mass (Da):43,455
    Checksum:iE493CC2364AD60C2
    GO
    Isoform 5 (identifier: P50549-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
         61-79: AQVPDNDEQFVPDYQAESL → V

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):48,168
    Checksum:i24285CFD0B256971
    GO
    Isoform 6 (identifier: P50549-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL

    Note: No experimental confirmation available.

    Show »
    Length:437
    Mass (Da):50,217
    Checksum:i37A55122A463957C
    GO

    Sequence cautioni

    The sequence BAD92439.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391L → V in CAA60642. (PubMed:7651741)Curated
    Sequence conflicti117 – 1171C → S in AAA79844. (PubMed:7700648)Curated
    Sequence conflicti127 – 1271K → N in AAA79844. (PubMed:7700648)Curated
    Sequence conflicti253 – 2531Missing in CAA60642. (PubMed:7651741)Curated
    Sequence conflicti349 – 3491S → A in CAA60642. (PubMed:7651741)Curated
    Sequence conflicti445 – 4451E → G in CAH10484. (PubMed:17974005)Curated
    Sequence conflicti471 – 4711Y → C in BAH13104. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001S → G.2 Publications
    Corresponds to variant rs9639168 [ dbSNP | Ensembl ].
    VAR_048948

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060MDGFY…TWLAE → MLQDLSASVFFPPCSQHRTL in isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_043808Add
    BLAST
    Alternative sequencei61 – 7919AQVPD…QAESL → V in isoform 2 and isoform 5. 2 PublicationsVSP_001472Add
    BLAST
    Alternative sequencei122 – 18463Missing in isoform 4. 1 PublicationVSP_043809Add
    BLAST
    Alternative sequencei268 – 29023Missing in isoform 3. 1 PublicationVSP_043750Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17163 mRNA. Translation: AAA79844.1.
    X87175 mRNA. Translation: CAA60642.1.
    AF109632
    , AF109621, AF109622, AF109623, AF109624, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29877.1.
    AF109632
    , AF109621, AF109622, AF109623, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29878.1.
    AK294755 mRNA. Translation: BAH11870.1.
    AK299693 mRNA. Translation: BAH13104.1.
    AK312863 mRNA. Translation: BAG35715.1.
    AK316007 mRNA. Translation: BAH14378.1.
    AB209202 mRNA. Translation: BAD92439.1. Different initiation.
    CR627389 mRNA. Translation: CAH10484.1.
    AC004857 Genomic DNA. Translation: AAC62435.1.
    AC004909 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24294.1.
    BC098403 mRNA. Translation: AAH98403.1.
    BC106762 mRNA. Translation: AAI06763.1.
    BC106763 mRNA. Translation: AAI06764.1.
    CCDSiCCDS55083.1. [P50549-5]
    CCDS55084.1. [P50549-4]
    CCDS55085.1. [P50549-6]
    CCDS55086.1. [P50549-2]
    CCDS55087.1. [P50549-3]
    CCDS55088.1. [P50549-1]
    PIRiI38893.
    RefSeqiNP_001156619.1. NM_001163147.1. [P50549-3]
    NP_001156620.1. NM_001163148.1. [P50549-2]
    NP_001156621.1. NM_001163149.1. [P50549-2]
    NP_001156622.1. NM_001163150.1. [P50549-6]
    NP_001156623.1. NM_001163151.1. [P50549-5]
    NP_001156624.1. NM_001163152.1. [P50549-4]
    NP_004947.2. NM_004956.4. [P50549-1]
    XP_005249692.1. XM_005249635.2. [P50549-1]
    XP_005249693.1. XM_005249636.2. [P50549-1]
    UniGeneiHs.22634.

    Genome annotation databases

    EnsembliENST00000242066; ENSP00000242066; ENSG00000006468. [P50549-2]
    ENST00000399357; ENSP00000382293; ENSG00000006468. [P50549-4]
    ENST00000403527; ENSP00000384138; ENSG00000006468. [P50549-6]
    ENST00000403685; ENSP00000385686; ENSG00000006468. [P50549-2]
    ENST00000405192; ENSP00000385381; ENSG00000006468. [P50549-3]
    ENST00000405218; ENSP00000385551; ENSG00000006468. [P50549-1]
    ENST00000420159; ENSP00000411626; ENSG00000006468. [P50549-5]
    ENST00000430479; ENSP00000405327; ENSG00000006468. [P50549-1]
    GeneIDi2115.
    KEGGihsa:2115.
    UCSCiuc003ssw.4. human. [P50549-3]
    uc021zzu.1. human. [P50549-4]
    uc021zzz.1. human. [P50549-1]
    uc022aaa.1. human. [P50549-2]

    Polymorphism databases

    DMDMi12643411.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17163 mRNA. Translation: AAA79844.1 .
    X87175 mRNA. Translation: CAA60642.1 .
    AF109632
    , AF109621 , AF109622 , AF109623 , AF109624 , AF109625 , AF109626 , AF109627 , AF109628 , AF109629 , AF109630 , AF109631 Genomic DNA. Translation: AAD29877.1 .
    AF109632
    , AF109621 , AF109622 , AF109623 , AF109625 , AF109626 , AF109627 , AF109628 , AF109629 , AF109630 , AF109631 Genomic DNA. Translation: AAD29878.1 .
    AK294755 mRNA. Translation: BAH11870.1 .
    AK299693 mRNA. Translation: BAH13104.1 .
    AK312863 mRNA. Translation: BAG35715.1 .
    AK316007 mRNA. Translation: BAH14378.1 .
    AB209202 mRNA. Translation: BAD92439.1 . Different initiation.
    CR627389 mRNA. Translation: CAH10484.1 .
    AC004857 Genomic DNA. Translation: AAC62435.1 .
    AC004909 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24294.1 .
    BC098403 mRNA. Translation: AAH98403.1 .
    BC106762 mRNA. Translation: AAI06763.1 .
    BC106763 mRNA. Translation: AAI06764.1 .
    CCDSi CCDS55083.1. [P50549-5 ]
    CCDS55084.1. [P50549-4 ]
    CCDS55085.1. [P50549-6 ]
    CCDS55086.1. [P50549-2 ]
    CCDS55087.1. [P50549-3 ]
    CCDS55088.1. [P50549-1 ]
    PIRi I38893.
    RefSeqi NP_001156619.1. NM_001163147.1. [P50549-3 ]
    NP_001156620.1. NM_001163148.1. [P50549-2 ]
    NP_001156621.1. NM_001163149.1. [P50549-2 ]
    NP_001156622.1. NM_001163150.1. [P50549-6 ]
    NP_001156623.1. NM_001163151.1. [P50549-5 ]
    NP_001156624.1. NM_001163152.1. [P50549-4 ]
    NP_004947.2. NM_004956.4. [P50549-1 ]
    XP_005249692.1. XM_005249635.2. [P50549-1 ]
    XP_005249693.1. XM_005249636.2. [P50549-1 ]
    UniGenei Hs.22634.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AVP X-ray 1.82 A/B/C/D 326-429 [» ]
    4BNC X-ray 2.90 A 326-429 [» ]
    ProteinModelPortali P50549.
    SMRi P50549. Positions 334-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108416. 14 interactions.
    DIPi DIP-60463N.
    IntActi P50549. 5 interactions.
    STRINGi 9606.ENSP00000384085.

    Chemistry

    ChEMBLi CHEMBL2010626.

    PTM databases

    PhosphoSitei P50549.

    Polymorphism databases

    DMDMi 12643411.

    Proteomic databases

    MaxQBi P50549.
    PaxDbi P50549.
    PRIDEi P50549.

    Protocols and materials databases

    DNASUi 2115.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242066 ; ENSP00000242066 ; ENSG00000006468 . [P50549-2 ]
    ENST00000399357 ; ENSP00000382293 ; ENSG00000006468 . [P50549-4 ]
    ENST00000403527 ; ENSP00000384138 ; ENSG00000006468 . [P50549-6 ]
    ENST00000403685 ; ENSP00000385686 ; ENSG00000006468 . [P50549-2 ]
    ENST00000405192 ; ENSP00000385381 ; ENSG00000006468 . [P50549-3 ]
    ENST00000405218 ; ENSP00000385551 ; ENSG00000006468 . [P50549-1 ]
    ENST00000420159 ; ENSP00000411626 ; ENSG00000006468 . [P50549-5 ]
    ENST00000430479 ; ENSP00000405327 ; ENSG00000006468 . [P50549-1 ]
    GeneIDi 2115.
    KEGGi hsa:2115.
    UCSCi uc003ssw.4. human. [P50549-3 ]
    uc021zzu.1. human. [P50549-4 ]
    uc021zzz.1. human. [P50549-1 ]
    uc022aaa.1. human. [P50549-2 ]

    Organism-specific databases

    CTDi 2115.
    GeneCardsi GC07M013897.
    HGNCi HGNC:3490. ETV1.
    MIMi 600541. gene.
    612219. phenotype.
    neXtProti NX_P50549.
    Orphaneti 319. Ewing sarcoma.
    PharmGKBi PA27904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258471.
    HOGENOMi HOG000230986.
    HOVERGENi HBG000231.
    KOi K09431.
    OrthoDBi EOG7K9K2M.
    PhylomeDBi P50549.
    TreeFami TF316214.

    Miscellaneous databases

    ChiTaRSi ETV1. human.
    GeneWikii ETV1.
    GenomeRNAii 2115.
    NextBioi 13627645.
    PROi P50549.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50549.
    Bgeei P50549.
    CleanExi HS_ETV1.
    Genevestigatori P50549.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1."
      Jeon I.-S., Davis J.N., Braun B.S., Sublett J.E., Roussel M.F., Denny C.T., Shapiro D.N.
      Oncogene 10:1229-1234(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular characterization of the ets-related human transcription factor ER81."
      Monte D., Coutte L., Baert J.-L., Angeli I., Stehelin D., de Launoit Y.
      Oncogene 11:771-779(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. "Characterization of the human and mouse ER81/ETV1 transcription factor genes. Role of the two human alternatively spliced isoforms."
      Coutte L., Monte D., Pouilly L., Dewitte F., Vidaud M., Baert J.-L., de Launoit Y.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5), VARIANT GLY-100.
      Tissue: Brain and Trachea.
    5. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-100.
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Seminoma.
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A."
      Wu J., Janknecht R.
      J. Biol. Chem. 277:42669-42679(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-191 AND SER-216.
    11. "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)."
      Janknecht R.
      Oncogene 22:746-755(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-191 AND SER-216, MUTAGENESIS OF SER-191 AND SER-216.
    12. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
      Gocke C.B., Yu H., Kang J.
      J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION.

    Entry informationi

    Entry nameiETV1_HUMAN
    AccessioniPrimary (citable) accession number: P50549
    Secondary accession number(s): A4D118
    , B2R768, B7Z2I4, B7Z618, B7Z9P2, C9JT37, E9PHB1, F5GXR2, O75849, Q4KMQ6, Q59GA7, Q6AI30, Q9UQ71, Q9Y636
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3