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P50549 (ETV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS translocation variant 1
Alternative name(s):
Ets-related protein 81
Gene names
Name:ETV1
Synonyms:ER81
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Subcellular location

Nucleus Probable.

Tissue specificity

Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.

Post-translational modification

Sumoylated. Ref.12

Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity. Ref.10 Ref.11

Involvement in disease

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Sequence caution

The sequence BAD92439.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
Polymorphism
   DiseaseProto-oncogene
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

mechanosensory behavior

Inferred from electronic annotation. Source: Ensembl

muscle organ development

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system neuron development

Traceable author statement PubMed 20096094. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentnucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 21575865. Source: IntAct

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRKDCP785272EBI-3905068,EBI-352053

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P50549-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P50549-2)

The sequence of this isoform differs from the canonical sequence as follows:
     61-79: AQVPDNDEQFVPDYQAESL → V
Isoform 3 (identifier: P50549-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: P50549-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     122-184: Missing.
Isoform 5 (identifier: P50549-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
     61-79: AQVPDNDEQFVPDYQAESL → V
Note: No experimental confirmation available.
Isoform 6 (identifier: P50549-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MDGFYDQQVP...SQLQETWLAE → MLQDLSASVFFPPCSQHRTL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477ETS translocation variant 1
PRO_0000204110

Regions

DNA binding335 – 41581ETS

Amino acid modifications

Modified residue1911Phosphoserine; by RPS6KA1 and RPS6KA5 Ref.10 Ref.11
Modified residue2161Phosphoserine; by RPS6KA1 and RPS6KA5 Ref.10 Ref.11

Natural variations

Alternative sequence1 – 6060MDGFY…TWLAE → MLQDLSASVFFPPCSQHRTL in isoform 4, isoform 5 and isoform 6.
VSP_043808
Alternative sequence61 – 7919AQVPD…QAESL → V in isoform 2 and isoform 5.
VSP_001472
Alternative sequence122 – 18463Missing in isoform 4.
VSP_043809
Alternative sequence268 – 29023Missing in isoform 3.
VSP_043750
Natural variant1001S → G. Ref.4 Ref.5
Corresponds to variant rs9639168 [ dbSNP | Ensembl ].
VAR_048948

Experimental info

Mutagenesis1911S → A: Loss of phosphorylation by RPS6KA5. Ref.11
Mutagenesis2161S → A: Loss of phosphorylation by RPS6KA5. Ref.11
Sequence conflict391L → V in CAA60642. Ref.2
Sequence conflict1171C → S in AAA79844. Ref.1
Sequence conflict1271K → N in AAA79844. Ref.1
Sequence conflict2531Missing in CAA60642. Ref.2
Sequence conflict3491S → A in CAA60642. Ref.2
Sequence conflict4451E → G in CAH10484. Ref.6
Sequence conflict4711Y → C in BAH13104. Ref.4

Secondary structure

.................. 477
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 24, 2001. Version 2.
Checksum: BE95FA3F07196F06

FASTA47755,131
        10         20         30         40         50         60 
MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 

        70         80         90        100        110        120 
AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS SACSQEQPFK FSYGEKCLYN 

       130        140        150        160        170        180 
VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY 

       190        200        210        220        230        240 
PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT 

       250        260        270        280        290        300 
MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 

       310        320        330        340        350        360 
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG 

       370        380        390        400        410        420 
MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA 

       430        440        450        460        470 
LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM PEGGCCNPHP YNEGYVY 

« Hide

Isoform 2 [UniParc].

Checksum: 558A574E5B53979B
Show »

FASTA45953,083
Isoform 3 [UniParc].

Checksum: F0BB1A4835FCF45D
Show »

FASTA45452,474
Isoform 4 [UniParc].

Checksum: E493CC2364AD60C2
Show »

FASTA37443,455
Isoform 5 [UniParc].

Checksum: 24285CFD0B256971
Show »

FASTA41948,168
Isoform 6 [UniParc].

Checksum: 37A55122A463957C
Show »

FASTA43750,217

References

« Hide 'large scale' references
[1]"A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1."
Jeon I.-S., Davis J.N., Braun B.S., Sublett J.E., Roussel M.F., Denny C.T., Shapiro D.N.
Oncogene 10:1229-1234(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Molecular characterization of the ets-related human transcription factor ER81."
Monte D., Coutte L., Baert J.-L., Angeli I., Stehelin D., de Launoit Y.
Oncogene 11:771-779(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Kidney.
[3]"Characterization of the human and mouse ER81/ETV1 transcription factor genes. Role of the two human alternatively spliced isoforms."
Coutte L., Monte D., Pouilly L., Dewitte F., Vidaud M., Baert J.-L., de Launoit Y.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5), VARIANT GLY-100.
Tissue: Brain and Trachea.
[5]"Homo sapiens protein coding cDNA."
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-100.
Tissue: Brain.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Seminoma.
[7]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[10]"Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A."
Wu J., Janknecht R.
J. Biol. Chem. 277:42669-42679(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-191 AND SER-216.
[11]"Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)."
Janknecht R.
Oncogene 22:746-755(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-191 AND SER-216, MUTAGENESIS OF SER-191 AND SER-216.
[12]"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
Gocke C.B., Yu H., Kang J.
J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17163 mRNA. Translation: AAA79844.1.
X87175 mRNA. Translation: CAA60642.1.
AF109632 expand/collapse EMBL AC list , AF109621, AF109622, AF109623, AF109624, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29877.1.
AF109632 expand/collapse EMBL AC list , AF109621, AF109622, AF109623, AF109625, AF109626, AF109627, AF109628, AF109629, AF109630, AF109631 Genomic DNA. Translation: AAD29878.1.
AK294755 mRNA. Translation: BAH11870.1.
AK299693 mRNA. Translation: BAH13104.1.
AK312863 mRNA. Translation: BAG35715.1.
AK316007 mRNA. Translation: BAH14378.1.
AB209202 mRNA. Translation: BAD92439.1. Different initiation.
CR627389 mRNA. Translation: CAH10484.1.
AC004857 Genomic DNA. Translation: AAC62435.1.
AC004909 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24294.1.
BC098403 mRNA. Translation: AAH98403.1.
BC106762 mRNA. Translation: AAI06763.1.
BC106763 mRNA. Translation: AAI06764.1.
CCDSCCDS55083.1. [P50549-5]
CCDS55084.1. [P50549-4]
CCDS55085.1. [P50549-6]
CCDS55086.1. [P50549-2]
CCDS55087.1. [P50549-3]
CCDS55088.1. [P50549-1]
PIRI38893.
RefSeqNP_001156619.1. NM_001163147.1. [P50549-3]
NP_001156620.1. NM_001163148.1. [P50549-2]
NP_001156621.1. NM_001163149.1. [P50549-2]
NP_001156622.1. NM_001163150.1. [P50549-6]
NP_001156623.1. NM_001163151.1. [P50549-5]
NP_001156624.1. NM_001163152.1. [P50549-4]
NP_004947.2. NM_004956.4. [P50549-1]
XP_005249692.1. XM_005249635.2. [P50549-1]
XP_005249693.1. XM_005249636.2. [P50549-1]
UniGeneHs.22634.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVPX-ray1.82A/B/C/D326-429[»]
4BNCX-ray2.90A326-429[»]
ProteinModelPortalP50549.
SMRP50549. Positions 334-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108416. 14 interactions.
DIPDIP-60463N.
IntActP50549. 5 interactions.
STRING9606.ENSP00000384085.

Chemistry

ChEMBLCHEMBL2010626.

PTM databases

PhosphoSiteP50549.

Polymorphism databases

DMDM12643411.

Proteomic databases

MaxQBP50549.
PaxDbP50549.
PRIDEP50549.

Protocols and materials databases

DNASU2115.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242066; ENSP00000242066; ENSG00000006468. [P50549-2]
ENST00000343495; ENSP00000340853; ENSG00000006468. [P50549-2]
ENST00000399357; ENSP00000382293; ENSG00000006468. [P50549-4]
ENST00000403527; ENSP00000384138; ENSG00000006468. [P50549-6]
ENST00000403685; ENSP00000385686; ENSG00000006468. [P50549-2]
ENST00000405192; ENSP00000385381; ENSG00000006468. [P50549-3]
ENST00000405218; ENSP00000385551; ENSG00000006468. [P50549-1]
ENST00000420159; ENSP00000411626; ENSG00000006468. [P50549-5]
ENST00000430479; ENSP00000405327; ENSG00000006468. [P50549-1]
GeneID2115.
KEGGhsa:2115.
UCSCuc003ssw.4. human. [P50549-3]
uc021zzu.1. human. [P50549-4]
uc021zzz.1. human. [P50549-1]
uc022aaa.1. human. [P50549-2]

Organism-specific databases

CTD2115.
GeneCardsGC07M013897.
HGNCHGNC:3490. ETV1.
MIM600541. gene.
612219. phenotype.
neXtProtNX_P50549.
Orphanet319. Ewing sarcoma.
PharmGKBPA27904.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG258471.
HOGENOMHOG000230986.
HOVERGENHBG000231.
KOK09431.
OrthoDBEOG7K9K2M.
PhylomeDBP50549.
TreeFamTF316214.

Gene expression databases

ArrayExpressP50549.
BgeeP50549.
CleanExHS_ETV1.
GenevestigatorP50549.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSETV1. human.
GeneWikiETV1.
GenomeRNAi2115.
NextBio13627645.
PROP50549.
SOURCESearch...

Entry information

Entry nameETV1_HUMAN
AccessionPrimary (citable) accession number: P50549
Secondary accession number(s): A4D118 expand/collapse secondary AC list , B2R768, B7Z2I4, B7Z618, B7Z9P2, C9JT37, E9PHB1, F5GXR2, O75849, Q4KMQ6, Q59GA7, Q6AI30, Q9UQ71, Q9Y636
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 24, 2001
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM