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P50548

- ERF_HUMAN

UniProt

P50548 - ERF_HUMAN

Protein

ETS domain-containing transcription factor ERF

Gene

ERF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment By similarity. May be important for regulating trophoblast stem cell differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi27 – 10781ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB
    2. cell differentiation Source: RefGenome
    3. chorio-allantoic fusion Source: Ensembl
    4. ectodermal cell differentiation Source: Ensembl
    5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. transcription from RNA polymerase II promoter Source: GOC
    7. trophoblast giant cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_169325. Oncogene Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS domain-containing transcription factor ERF
    Alternative name(s):
    Ets2 repressor factor
    PE-2
    Gene namesi
    Name:ERF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3444. ERF.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleoplasm Source: Reactome
    3. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Craniosynostosis 4 (CRS4) [MIM:600775]: A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651R → Q in CRS4. 1 Publication
    VAR_070098
    Natural varianti86 – 861R → C in CRS4. 1 Publication
    VAR_070099

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi526 – 5261T → A: Loss of a phosphorylation site. 1 Publication

    Keywords - Diseasei

    Craniosynostosis, Disease mutation

    Organism-specific databases

    MIMi600775. phenotype.
    Orphaneti207. Crouzon disease.
    3267. Familial lambdoid synostosis.
    2343. Isolated cloverleaf skull syndrome.
    35093. Isolated scaphocephaly.
    PharmGKBiPA27857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548ETS domain-containing transcription factor ERFPRO_0000204101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei3 – 31Phosphothreonine1 Publication
    Modified residuei7 – 71Phosphothreonine1 Publication
    Modified residuei20 – 201Phosphoserine1 Publication
    Modified residuei185 – 1851Phosphoserine1 Publication
    Modified residuei190 – 1901Phosphoserine1 Publication
    Modified residuei327 – 3271Phosphoserine2 Publications
    Modified residuei431 – 4311Phosphoserine2 Publications
    Modified residuei435 – 4351Phosphoserine1 Publication
    Modified residuei441 – 4411Phosphothreonine1 Publication
    Modified residuei444 – 4441Phosphoserine2 Publications
    Modified residuei526 – 5261Phosphothreonine; by MAPK12 Publications
    Modified residuei531 – 5311Phosphoserine1 Publication
    Modified residuei548 – 5481Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP50548.
    PaxDbiP50548.
    PeptideAtlasiP50548.
    PRIDEiP50548.

    PTM databases

    PhosphoSiteiP50548.

    Expressioni

    Tissue specificityi

    Highest levels in testis, ovary, pancreas, and heart.1 Publication

    Gene expression databases

    ArrayExpressiP50548.
    BgeeiP50548.
    CleanExiHS_ERF.
    GenevestigatoriP50548.

    Interactioni

    Protein-protein interaction databases

    BioGridi108388. 4 interactions.
    MINTiMINT-240265.
    STRINGi9606.ENSP00000222329.

    Structurei

    3D structure databases

    ProteinModelPortaliP50548.
    SMRiP50548. Positions 24-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi166 – 1716Poly-Ser
    Compositional biasi290 – 2934Poly-Gly
    Compositional biasi362 – 37312Poly-SerAdd
    BLAST
    Compositional biasi418 – 4236Poly-Pro
    Compositional biasi496 – 4994Poly-Gly

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG331846.
    HOGENOMiHOG000070246.
    HOVERGENiHBG005183.
    InParanoidiP50548.
    KOiK09434.
    OMAiGASQCMP.
    OrthoDBiEOG71P2BB.
    PhylomeDBiP50548.
    TreeFamiTF351065.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P50548-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG    50
    DYGEFVIKDP DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK 100
    RFTYKFNFNK LVLVNYPFID VGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS 150
    EVLSPTEDPR SPPACSSSSS SLFSAVVARR LGRGSVSDCS DGTSELEEPL 200
    GEDPRARPPG PPDLGAFRGP PLARLPHDPG VFRVYPRPRG GPEPLSPFPV 250
    SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG 300
    SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL 350
    PPMAPETPPV PSSASSSSSS SSSPFKFKLQ PPPLGRRQRA AGEKAVAGAD 400
    KSGGSAGGLA EGAGALAPPP PPPQIKVEPI SEGESEEVEV TDISDEDEED 450
    GEVFKTPRAP PAPPKPEPGE APGASQCMPL KLRFKRRWSE DCRLEGGGGP 500
    AGGFEDEGED KKVRGEGPGE AGGPLTPRRV SSDLQHATAQ LSLEHRDS 548
    Length:548
    Mass (Da):58,703
    Last modified:July 19, 2004 - v2
    Checksum:i01242339B8D328ED
    GO
    Isoform 2 (identifier: P50548-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:473
    Mass (Da):49,965
    Checksum:iD6811CCDE51F53C9
    GO

    Sequence cautioni

    The sequence BAD92508.1 differs from that shown. Reason: The sequence differs from that shown because it seems to be derived from a pre-mRNA.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811P → R in AAA86686. (PubMed:7588608)Curated
    Sequence conflicti398 – 3981G → A in AAA86686. (PubMed:7588608)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651R → Q in CRS4. 1 Publication
    VAR_070098
    Natural varianti86 – 861R → C in CRS4. 1 Publication
    VAR_070099
    Natural varianti205 – 2051R → H.
    Corresponds to variant rs1053655 [ dbSNP | Ensembl ].
    VAR_048947

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_055487Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15655 mRNA. Translation: AAA86686.1.
    AK297666 mRNA. Translation: BAH12646.1.
    AK314278 mRNA. Translation: BAG36938.1.
    AB209271 Transcribed RNA. Translation: BAD92508.1. Sequence problems.
    AC006486 Genomic DNA. Translation: AAD11987.1.
    CH471126 Genomic DNA. Translation: EAW57116.1.
    CH471126 Genomic DNA. Translation: EAW57118.1.
    BC022231 mRNA. Translation: AAH22231.1.
    CCDSiCCDS12600.1.
    PIRiS59133.
    RefSeqiNP_006485.2. NM_006494.2.
    UniGeneiHs.655969.

    Genome annotation databases

    EnsembliENST00000222329; ENSP00000222329; ENSG00000105722. [P50548-1]
    ENST00000440177; ENSP00000388173; ENSG00000105722. [P50548-2]
    GeneIDi2077.
    KEGGihsa:2077.
    UCSCiuc002otd.4. human.

    Polymorphism databases

    DMDMi50403684.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15655 mRNA. Translation: AAA86686.1 .
    AK297666 mRNA. Translation: BAH12646.1 .
    AK314278 mRNA. Translation: BAG36938.1 .
    AB209271 Transcribed RNA. Translation: BAD92508.1 . Sequence problems.
    AC006486 Genomic DNA. Translation: AAD11987.1 .
    CH471126 Genomic DNA. Translation: EAW57116.1 .
    CH471126 Genomic DNA. Translation: EAW57118.1 .
    BC022231 mRNA. Translation: AAH22231.1 .
    CCDSi CCDS12600.1.
    PIRi S59133.
    RefSeqi NP_006485.2. NM_006494.2.
    UniGenei Hs.655969.

    3D structure databases

    ProteinModelPortali P50548.
    SMRi P50548. Positions 24-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108388. 4 interactions.
    MINTi MINT-240265.
    STRINGi 9606.ENSP00000222329.

    PTM databases

    PhosphoSitei P50548.

    Polymorphism databases

    DMDMi 50403684.

    Proteomic databases

    MaxQBi P50548.
    PaxDbi P50548.
    PeptideAtlasi P50548.
    PRIDEi P50548.

    Protocols and materials databases

    DNASUi 2077.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222329 ; ENSP00000222329 ; ENSG00000105722 . [P50548-1 ]
    ENST00000440177 ; ENSP00000388173 ; ENSG00000105722 . [P50548-2 ]
    GeneIDi 2077.
    KEGGi hsa:2077.
    UCSCi uc002otd.4. human.

    Organism-specific databases

    CTDi 2077.
    GeneCardsi GC19M042751.
    HGNCi HGNC:3444. ERF.
    MIMi 600775. phenotype.
    611888. gene.
    neXtProti NX_P50548.
    Orphaneti 207. Crouzon disease.
    3267. Familial lambdoid synostosis.
    2343. Isolated cloverleaf skull syndrome.
    35093. Isolated scaphocephaly.
    PharmGKBi PA27857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331846.
    HOGENOMi HOG000070246.
    HOVERGENi HBG005183.
    InParanoidi P50548.
    KOi K09434.
    OMAi GASQCMP.
    OrthoDBi EOG71P2BB.
    PhylomeDBi P50548.
    TreeFami TF351065.

    Enzyme and pathway databases

    Reactomei REACT_169325. Oncogene Induced Senescence.

    Miscellaneous databases

    ChiTaRSi ERF. human.
    GeneWikii ERF_(gene).
    GenomeRNAii 2077.
    NextBioi 8443.
    PROi P50548.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50548.
    Bgeei P50548.
    CleanExi HS_ERF.
    Genevestigatori P50548.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation."
      Sgouras D.N., Athanasiou M.A., Beal G.J. Jr., Fisher R.J., Blair D.G., Mavrothalassitis G.J.
      EMBO J. 14:4781-4793(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PHOSPHORYLATION AT THR-526, MUTAGENESIS OF THR-526.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Heart.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Duodenum.
    7. Bienvenut W.V., Lempens A., Norman J.C.
      Submitted (OCT-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 102-110; 206-218; 313-347; 377-386; 402-426 AND 515-528, PHOSPHORYLATION AT SER-327, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    8. "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)."
      de Castro C.M., Rabe S.M., Langdon S.D., Fleenor D.E., Slentz-Kesler K., Ahmed M.N., Qumsiyeh M.B., Kaufman R.E.
      Genomics 42:227-235(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3; THR-7; SER-20; SER-185; SER-327; SER-431; SER-435; THR-441; SER-444; SER-531 AND SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431; SER-444 AND THR-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANTS CRS4 GLN-65 AND CYS-86.

    Entry informationi

    Entry nameiERF_HUMAN
    AccessioniPrimary (citable) accession number: P50548
    Secondary accession number(s): B2RAP1
    , B7Z4R0, Q59G38, Q9UPI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3