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Protein

Protein S100-A11

Gene

S100a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Endothelial monocyte-activating polypeptide
Short name:
EMAP
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100a11
Synonyms:S100c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338798. S100a11.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: Ensembl
  • cytoplasm Source: MGI
  • extracellular exosome Source: Ensembl
  • extracellular space Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
  • ruffle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440101 – 98Protein S100-A11Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineBy similarity1
Disulfide bondi8InterchainBy similarity
Modified residuei22N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP50543.
MaxQBiP50543.
PaxDbiP50543.
PeptideAtlasiP50543.
PRIDEiP50543.
TopDownProteomicsiP50543.

PTM databases

iPTMnetiP50543.
PhosphoSitePlusiP50543.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027907.
CleanExiMM_S100A11.
GenevisibleiP50543. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi203050. 1 interactor.
IntActiP50543. 4 interactors.
MINTiMINT-4133618.
STRINGi10090.ENSMUSP00000029515.

Structurei

3D structure databases

ProteinModelPortaliP50543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST37
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP50543.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
PhylomeDBiP50543.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETERCIE SLIAVFQKYS GKDGNNTQLS KTEFLSFMNT ELAAFTKNQK
60 70 80 90
DPGVLDRMMK KLDLNCDGQL DFQEFLNLIG GLAIACHDSF IQTSQKRI
Length:98
Mass (Da):11,083
Last modified:October 1, 1996 - v1
Checksum:i2385424BCAA8CB82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41341 mRNA. Translation: AAA85181.1.
AK002490 mRNA. Translation: BAB22139.1.
AK003889 mRNA. Translation: BAB23059.1.
AK164352 mRNA. Translation: BAE37754.1.
BC021916 mRNA. Translation: AAH21916.1.
BC086903 mRNA. Translation: AAH86903.1.
CCDSiCCDS38525.1.
RefSeqiNP_058020.1. NM_016740.3.
UniGeneiMm.280038.

Genome annotation databases

EnsembliENSMUST00000029515; ENSMUSP00000029515; ENSMUSG00000027907.
GeneIDi20195.
KEGGimmu:20195.
UCSCiuc008qfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41341 mRNA. Translation: AAA85181.1.
AK002490 mRNA. Translation: BAB22139.1.
AK003889 mRNA. Translation: BAB23059.1.
AK164352 mRNA. Translation: BAE37754.1.
BC021916 mRNA. Translation: AAH21916.1.
BC086903 mRNA. Translation: AAH86903.1.
CCDSiCCDS38525.1.
RefSeqiNP_058020.1. NM_016740.3.
UniGeneiMm.280038.

3D structure databases

ProteinModelPortaliP50543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203050. 1 interactor.
IntActiP50543. 4 interactors.
MINTiMINT-4133618.
STRINGi10090.ENSMUSP00000029515.

PTM databases

iPTMnetiP50543.
PhosphoSitePlusiP50543.

Proteomic databases

EPDiP50543.
MaxQBiP50543.
PaxDbiP50543.
PeptideAtlasiP50543.
PRIDEiP50543.
TopDownProteomicsiP50543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029515; ENSMUSP00000029515; ENSMUSG00000027907.
GeneIDi20195.
KEGGimmu:20195.
UCSCiuc008qfj.1. mouse.

Organism-specific databases

CTDi6282.
MGIiMGI:1338798. S100a11.

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP50543.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
PhylomeDBiP50543.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP50543.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027907.
CleanExiMM_S100A11.
GenevisibleiP50543. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AB_MOUSE
AccessioniPrimary (citable) accession number: P50543
Secondary accession number(s): Q545S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.