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Protein

Protein S100-A11

Gene

S100a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Endothelial monocyte-activating polypeptide
Short name:
EMAP
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100a11
Synonyms:S100c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338798. S100a11.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: Ensembl
  • cytoplasm Source: MGI
  • extracellular exosome Source: Ensembl
  • extracellular space Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
  • ruffle Source: Ensembl

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440101 – 98Protein S100-A11Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineBy similarity1
Disulfide bondi8InterchainBy similarity
Modified residuei22N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-5 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP50543.
MaxQBiP50543.
PaxDbiP50543.
PeptideAtlasiP50543.
PRIDEiP50543.
TopDownProteomicsiP50543.

PTM databases

iPTMnetiP50543.
PhosphoSitePlusiP50543.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027907.
CleanExiMM_S100A11.
GenevisibleiP50543. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi203050. 1 interactor.
IntActiP50543. 4 interactors.
MINTiMINT-4133618.
STRINGi10090.ENSMUSP00000029515.

Structurei

3D structure databases

ProteinModelPortaliP50543.
SMRiP50543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST37
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP50543.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
PhylomeDBiP50543.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
PANTHERiPTHR11639:SF85. PTHR11639:SF85. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P50543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTETERCIE SLIAVFQKYS GKDGNNTQLS KTEFLSFMNT ELAAFTKNQK
60 70 80 90
DPGVLDRMMK KLDLNCDGQL DFQEFLNLIG GLAIACHDSF IQTSQKRI
Length:98
Mass (Da):11,083
Last modified:October 1, 1996 - v1
Checksum:i2385424BCAA8CB82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41341 mRNA. Translation: AAA85181.1.
AK002490 mRNA. Translation: BAB22139.1.
AK003889 mRNA. Translation: BAB23059.1.
AK164352 mRNA. Translation: BAE37754.1.
BC021916 mRNA. Translation: AAH21916.1.
BC086903 mRNA. Translation: AAH86903.1.
CCDSiCCDS38525.1.
RefSeqiNP_058020.1. NM_016740.3.
UniGeneiMm.280038.

Genome annotation databases

EnsembliENSMUST00000029515; ENSMUSP00000029515; ENSMUSG00000027907.
GeneIDi20195.
KEGGimmu:20195.
UCSCiuc008qfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41341 mRNA. Translation: AAA85181.1.
AK002490 mRNA. Translation: BAB22139.1.
AK003889 mRNA. Translation: BAB23059.1.
AK164352 mRNA. Translation: BAE37754.1.
BC021916 mRNA. Translation: AAH21916.1.
BC086903 mRNA. Translation: AAH86903.1.
CCDSiCCDS38525.1.
RefSeqiNP_058020.1. NM_016740.3.
UniGeneiMm.280038.

3D structure databases

ProteinModelPortaliP50543.
SMRiP50543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203050. 1 interactor.
IntActiP50543. 4 interactors.
MINTiMINT-4133618.
STRINGi10090.ENSMUSP00000029515.

PTM databases

iPTMnetiP50543.
PhosphoSitePlusiP50543.

Proteomic databases

EPDiP50543.
MaxQBiP50543.
PaxDbiP50543.
PeptideAtlasiP50543.
PRIDEiP50543.
TopDownProteomicsiP50543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029515; ENSMUSP00000029515; ENSMUSG00000027907.
GeneIDi20195.
KEGGimmu:20195.
UCSCiuc008qfj.1. mouse.

Organism-specific databases

CTDi6282.
MGIiMGI:1338798. S100a11.

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP50543.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
PhylomeDBiP50543.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiPR:P50543.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027907.
CleanExiMM_S100A11.
GenevisibleiP50543. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
PANTHERiPTHR11639:SF85. PTHR11639:SF85. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10AB_MOUSE
AccessioniPrimary (citable) accession number: P50543
Secondary accession number(s): Q545S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 15, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.