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P50542

- PEX5_HUMAN

UniProt

P50542 - PEX5_HUMAN

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Protein
Peroxisomal targeting signal 1 receptor
Gene
PEX5, PXR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.3 Publications

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. peroxisome matrix targeting signal-1 binding Source: UniProtKB
  3. peroxisome targeting sequence binding Source: UniProtKB
  4. protein C-terminus binding Source: UniProtKB
  5. protein N-terminus binding Source: UniProtKB
  6. protein binding Source: UniProtKB
  7. small GTPase binding Source: UniProtKB

GO - Biological processi

  1. cell development Source: Ensembl
  2. cerebral cortex cell migration Source: Ensembl
  3. cerebral cortex neuron differentiation Source: Ensembl
  4. endoplasmic reticulum organization Source: Ensembl
  5. fatty acid beta-oxidation Source: Ensembl
  6. mitochondrial membrane organization Source: Ensembl
  7. negative regulation of protein homotetramerization Source: UniProtKB
  8. neuromuscular process Source: Ensembl
  9. neuron migration Source: Ensembl
  10. positive regulation of multicellular organism growth Source: Ensembl
  11. protein import into peroxisome matrix Source: UniProtKB
  12. protein import into peroxisome matrix, docking Source: UniProtKB
  13. protein import into peroxisome matrix, translocation Source: UniProtKB
  14. protein import into peroxisome membrane Source: UniProtKB
  15. protein targeting to peroxisome Source: UniProtKB
  16. protein tetramerization Source: UniProtKB
  17. very long-chain fatty acid metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:PEX5
Synonyms:PXR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9719. PEX5.

Subcellular locationi

Cytoplasm. Peroxisome membrane; Peripheral membrane protein
Note: Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).2 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. intracellular Source: GOC
  5. membrane Source: UniProtKB
  6. mitochondrion Source: GOC
  7. peroxisomal matrix Source: UniProtKB
  8. peroxisomal membrane Source: UniProtKB
  9. peroxisome Source: UniProtKB
  10. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

Pathology & Biotechi

Involvement in diseasei

Peroxisome biogenesis disorder 2A (PBD2A) [MIM:214110]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and characterized clinically by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Peroxisome biogenesis disorder 2B (PBD2B) [MIM:202370]: A peroxisome biogenesis disorder that includes neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), two milder manifestations of the Zellweger disease spectrum. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy and vision impairment. Children with the NALD presentation may reach their teens, while patients with the IRD presentation may reach adulthood. The clinical conditions are often slowly progressive in particular with respect to loss of hearing and vision. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti526 – 5261N → K in PBD2B; neonatal adrenoleukodystrophy; strongly affects peroxisomal protein import. 2 Publications
VAR_007543
Natural varianti600 – 6001S → W in PBD2B; infantile Refsum disease; mildly affects peroxisomal protein import. 1 Publication
VAR_031328

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi118 – 1181W → A: Strongly reduced interaction with PEX14. 1 Publication
Mutagenesisi122 – 1221F → A: Strongly reduced interaction with PEX14. 1 Publication

Keywords - Diseasei

Disease mutation, Peroxisome biogenesis disorder, Zellweger syndrome

Organism-specific databases

MIMi202370. phenotype.
214110. phenotype.
Orphaneti772. Infantile Refsum disease.
44. Neonatal adrenoleukodystrophy.
912. Zellweger syndrome.
PharmGKBiPA34063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Peroxisomal targeting signal 1 receptor
PRO_0000106305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling By similarity.

Keywords - PTMi

Thioester bond, Ubl conjugation

Proteomic databases

MaxQBiP50542.
PaxDbiP50542.
PRIDEiP50542.

PTM databases

PhosphoSiteiP50542.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.3 Publications

Gene expression databases

ArrayExpressiP50542.
BgeeiP50542.
CleanExiHS_PEX5.
GenevestigatoriP50542.

Organism-specific databases

HPAiHPA039259.
HPA039260.

Interactioni

Subunit structurei

Interacts with PEX7 and PEX13 By similarity. Interacts with PEX12 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX12O006234EBI-597835,EBI-594836
PEX14O7538113EBI-597835,EBI-594898

Protein-protein interaction databases

BioGridi111788. 66 interactions.
DIPiDIP-34654N.
IntActiP50542. 18 interactions.
MINTiMINT-241634.
STRINGi9606.ENSP00000407401.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi60 – 6910
Helixi109 – 12416
Helixi318 – 3214
Turni331 – 3344
Helixi338 – 34710
Helixi351 – 36313
Helixi369 – 38113
Helixi385 – 39814
Helixi403 – 41513
Helixi419 – 43113
Turni434 – 4363
Helixi437 – 4393
Helixi460 – 48122
Helixi488 – 50013
Helixi504 – 51714
Helixi522 – 53413
Helixi538 – 55114
Helixi556 – 56914
Helixi572 – 58716
Beta strandi593 – 5953
Helixi601 – 61414
Helixi617 – 6193
Helixi620 – 6245
Helixi628 – 6347

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FCHX-ray2.20A/B272-639[»]
2C0LX-ray2.30A335-639[»]
2C0MX-ray2.50A/B/C/F321-639[»]
2J9QX-ray2.65A/B315-639[»]
2W84NMR-B108-127[»]
3R9AX-ray2.35B/D315-639[»]
4BXUNMR-B57-71[»]
DisProtiDP00472.
ProteinModelPortaliP50542.
SMRiP50542. Positions 335-639.

Miscellaneous databases

EvolutionaryTraceiP50542.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati335 – 36834TPR 1
Add
BLAST
Repeati369 – 40234TPR 2
Add
BLAST
Repeati403 – 43634TPR 3
Add
BLAST
Repeati452 – 48534TPR 4
Add
BLAST
Repeati488 – 52134TPR 5
Add
BLAST
Repeati522 – 55534TPR 6
Add
BLAST
Repeati556 – 58934TPR 7
Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiP50542.
KOiK13342.
OrthoDBiEOG793B77.
PhylomeDBiP50542.
TreeFamiTF315044.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF00515. TPR_1. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P50542-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA    50
SKPLGVASED ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR 100
QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VTQDYNETDW SQEFISEVTD 150
PLSVSPARWA EEYLEQSEEK LWLGEPEGTA TDRWYDEYHP EEDLQHTASD 200
FVAKVDDPKL ANSEFLKFVR QIGEGQVSLE SGAGSGRAQA EQWAAEFIQQ 250
QGTSDAWVDQ FTRPVNTSAL DMEFERAKSA IESDVDFWDK LQAELEEMAK 300
RDAEAHPWLS DYDDLTSATY DKGYQFEEEN PLRDHPQPFE EGLRRLQEGD 350
LPNAVLLFEA AVQQDPKHME AWQYLGTTQA ENEQELLAIS ALRRCLELKP 400
DNQTALMALA VSFTNESLQR QACETLRDWL RYTPAYAHLV TPAEEGAGGA 450
GLGPSKRILG SLLSDSLFLE VKELFLAAVR LDPTSIDPDV QCGLGVLFNL 500
SGEYDKAVDC FTAALSVRPN DYLLWNKLGA TLANGNQSEE AVAAYRRALE 550
LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 600
ENIWSTLRLA LSMLGQSDAY GAADARDLST LLTMFGLPQ 639
Length:639
Mass (Da):70,865
Last modified:December 12, 2006 - v3
Checksum:i9D6951F58AED31AC
GO
Isoform 2 (identifier: P50542-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-251: Missing.

Show »
Length:602
Mass (Da):66,830
Checksum:iEA4E6FAAF5E11C55
GO
Isoform 3 (identifier: P50542-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-290: Missing.

Show »
Length:631
Mass (Da):69,872
Checksum:i9F3B705D888C484B
GO
Isoform 4 (identifier: P50542-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: P → PASEAVSVLEVESPGA

Note: No experimental confirmation available.

Show »
Length:654
Mass (Da):72,291
Checksum:iCF2055CBD6902BFE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti526 – 5261N → K in PBD2B; neonatal adrenoleukodystrophy; strongly affects peroxisomal protein import. 2 Publications
VAR_007543
Natural varianti600 – 6001S → W in PBD2B; infantile Refsum disease; mildly affects peroxisomal protein import. 1 Publication
VAR_031328

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 451P → PASEAVSVLEVESPGA in isoform 4.
VSP_043639
Alternative sequencei215 – 25137Missing in isoform 2.
VSP_021880Add
BLAST
Alternative sequencei283 – 2908Missing in isoform 3.
VSP_024106

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti425 – 4251T → I in AAC50103. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19721 mRNA. Translation: AAC50103.1.
Z48054 mRNA. Translation: CAA88131.1.
X84899 mRNA. Translation: CAA59324.1.
AK292256 mRNA. Translation: BAF84945.1.
AK302742 mRNA. Translation: BAG63957.1.
AK316250 mRNA. Translation: BAH14621.1.
AC018653 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88671.1.
CH471116 Genomic DNA. Translation: EAW88674.1.
CH471116 Genomic DNA. Translation: EAW88672.1.
BC010621 mRNA. Translation: AAH10621.1.
CCDSiCCDS44822.1. [P50542-4]
CCDS44823.1. [P50542-1]
CCDS44824.1. [P50542-2]
CCDS8576.1. [P50542-3]
PIRiA56126.
RefSeqiNP_000310.2. NM_000319.4. [P50542-3]
NP_001124495.1. NM_001131023.1. [P50542-4]
NP_001124496.1. NM_001131024.1. [P50542-2]
NP_001124497.1. NM_001131025.1. [P50542-1]
NP_001124498.1. NM_001131026.1. [P50542-1]
XP_006719194.1. XM_006719131.1. [P50542-1]
UniGeneiHs.567327.

Genome annotation databases

EnsembliENST00000266563; ENSP00000266563; ENSG00000139197. [P50542-2]
ENST00000266564; ENSP00000266564; ENSG00000139197. [P50542-3]
ENST00000420616; ENSP00000410159; ENSG00000139197. [P50542-1]
ENST00000434354; ENSP00000407401; ENSG00000139197. [P50542-4]
ENST00000455147; ENSP00000400647; ENSG00000139197. [P50542-1]
GeneIDi5830.
KEGGihsa:5830.
UCSCiuc001qsu.3. human. [P50542-2]
uc001qsv.3. human. [P50542-3]
uc001qsw.3. human. [P50542-1]
uc010sgc.2. human. [P50542-4]

Polymorphism databases

DMDMi119364633.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19721 mRNA. Translation: AAC50103.1 .
Z48054 mRNA. Translation: CAA88131.1 .
X84899 mRNA. Translation: CAA59324.1 .
AK292256 mRNA. Translation: BAF84945.1 .
AK302742 mRNA. Translation: BAG63957.1 .
AK316250 mRNA. Translation: BAH14621.1 .
AC018653 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88671.1 .
CH471116 Genomic DNA. Translation: EAW88674.1 .
CH471116 Genomic DNA. Translation: EAW88672.1 .
BC010621 mRNA. Translation: AAH10621.1 .
CCDSi CCDS44822.1. [P50542-4 ]
CCDS44823.1. [P50542-1 ]
CCDS44824.1. [P50542-2 ]
CCDS8576.1. [P50542-3 ]
PIRi A56126.
RefSeqi NP_000310.2. NM_000319.4. [P50542-3 ]
NP_001124495.1. NM_001131023.1. [P50542-4 ]
NP_001124496.1. NM_001131024.1. [P50542-2 ]
NP_001124497.1. NM_001131025.1. [P50542-1 ]
NP_001124498.1. NM_001131026.1. [P50542-1 ]
XP_006719194.1. XM_006719131.1. [P50542-1 ]
UniGenei Hs.567327.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FCH X-ray 2.20 A/B 272-639 [» ]
2C0L X-ray 2.30 A 335-639 [» ]
2C0M X-ray 2.50 A/B/C/F 321-639 [» ]
2J9Q X-ray 2.65 A/B 315-639 [» ]
2W84 NMR - B 108-127 [» ]
3R9A X-ray 2.35 B/D 315-639 [» ]
4BXU NMR - B 57-71 [» ]
DisProti DP00472.
ProteinModelPortali P50542.
SMRi P50542. Positions 335-639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111788. 66 interactions.
DIPi DIP-34654N.
IntActi P50542. 18 interactions.
MINTi MINT-241634.
STRINGi 9606.ENSP00000407401.

PTM databases

PhosphoSitei P50542.

Polymorphism databases

DMDMi 119364633.

Proteomic databases

MaxQBi P50542.
PaxDbi P50542.
PRIDEi P50542.

Protocols and materials databases

DNASUi 5830.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266563 ; ENSP00000266563 ; ENSG00000139197 . [P50542-2 ]
ENST00000266564 ; ENSP00000266564 ; ENSG00000139197 . [P50542-3 ]
ENST00000420616 ; ENSP00000410159 ; ENSG00000139197 . [P50542-1 ]
ENST00000434354 ; ENSP00000407401 ; ENSG00000139197 . [P50542-4 ]
ENST00000455147 ; ENSP00000400647 ; ENSG00000139197 . [P50542-1 ]
GeneIDi 5830.
KEGGi hsa:5830.
UCSCi uc001qsu.3. human. [P50542-2 ]
uc001qsv.3. human. [P50542-3 ]
uc001qsw.3. human. [P50542-1 ]
uc010sgc.2. human. [P50542-4 ]

Organism-specific databases

CTDi 5830.
GeneCardsi GC12P007341.
GeneReviewsi PEX5.
HGNCi HGNC:9719. PEX5.
HPAi HPA039259.
HPA039260.
MIMi 202370. phenotype.
214110. phenotype.
600414. gene.
neXtProti NX_P50542.
Orphaneti 772. Infantile Refsum disease.
44. Neonatal adrenoleukodystrophy.
912. Zellweger syndrome.
PharmGKBi PA34063.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000158146.
HOVERGENi HBG053575.
InParanoidi P50542.
KOi K13342.
OrthoDBi EOG793B77.
PhylomeDBi P50542.
TreeFami TF315044.

Miscellaneous databases

ChiTaRSi PEX5. human.
EvolutionaryTracei P50542.
GeneWikii PEX5.
GenomeRNAii 5830.
NextBioi 22716.
PROi P50542.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50542.
Bgeei P50542.
CleanExi HS_PEX5.
Genevestigatori P50542.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10130. PTHR10130. 1 hit.
Pfami PF00515. TPR_1. 3 hits.
[Graphical view ]
SMARTi SM00028. TPR. 4 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders."
    Dodt G., Braverman N., Wong C., Moser A., Moser H.W., Watkins P., Valle D., Gould S.J.
    Nat. Genet. 9:115-125(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INVOLVEMENT IN PBD2A, VARIANT PBD2B LYS-526, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders."
    Wiemer E.A.C., Nuttley W.M., Bertolaet B.L., Li X., Francke U., Wheelock M.J., Anne U.K., Johnson K.R., Subramani S.
    J. Cell Biol. 130:51-65(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Liver.
  3. "Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor."
    Fransen M., Brees C., Baumgart E., Vanhooren J.C.T., Baes M., Mannaerts G.P., van Veldhoven P.P.
    J. Biol. Chem. 270:7731-7736(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Testis.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  8. "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import."
    Chang C.C., Warren D.S., Sacksteder K.A., Gould S.J.
    J. Cell Biol. 147:761-774(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PEX12.
  9. "The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14."
    Saidowsky J., Dodt G., Kirchberg K., Wegner A., Nastainczyk W., Kunau W.-H., Schliebs W.
    J. Biol. Chem. 276:34524-34529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PEX14, MUTAGENESIS OF TRP-118 AND PHE-122.
  10. "AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase."
    Miyata N., Okumoto K., Mukai S., Noguchi M., Fujiki Y.
    Traffic 13:168-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFAND6.
  11. "Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5."
    Gatto G.J. Jr., Geisbrecht B.V., Gould S.J., Berg J.M.
    Nat. Struct. Biol. 7:1091-1095(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 272-639 IN COMPLEX WITH TARGETING PEPTIDE.
  12. "Recognition of a functional peroxisome type 1 target by the dynamic import receptor Pex5p."
    Stanley W.A., Filipp F.V., Kursula P., Schueller N., Erdmann R., Schliebs W., Sattler M., Wilmanns M.
    Mol. Cell 24:653-663(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 321-639 IN COMPLEX WITH TARGETING PEPTIDE.
  13. "A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding."
    Stanley W.A., Pursiainen N.V., Garman E.F., Juffer A.H., Wilmanns M., Kursula P.
    BMC Struct. Biol. 7:24-24(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 315-639, BINDING TO C-TERMINAL TARGETING PEPTIDES.
  14. "Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19."
    Neufeld C., Filipp F.V., Simon B., Neuhaus A., Schueller N., David C., Kooshapur H., Madl T., Erdmann R., Schliebs W., Wilmanns M., Sattler M.
    EMBO J. 28:745-754(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 108-127 IN COMPLEX WITH PEX14.
  15. "Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients."
    Shimozawa N., Zhang Z., Suzuki Y., Imamura A., Tsukamoto T., Osumi T., Fujiki Y., Orii T., Barth P.G., Wanders R.J., Kondo N.
    Biochem. Biophys. Res. Commun. 262:504-508(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PBD2B LYS-526 AND TRP-600, CHARACTERIZATION OF VARIANTS PBD2B LYS-526 AND TRP-600.

Entry informationi

Entry nameiPEX5_HUMAN
AccessioniPrimary (citable) accession number: P50542
Secondary accession number(s): A8K891
, B4DZ45, B7ZAD5, D3DUT8, Q15115, Q15266, Q96FN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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