Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Checkpoint protein rad17

Gene

rad17

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 119ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: PomBase
  • DNA clamp loader activity Source: InterPro

GO - Biological processi

  • DNA repair Source: GO_Central
  • intra-S DNA damage checkpoint Source: PomBase
  • mitotic DNA damage checkpoint Source: PomBase
  • mitotic DNA replication checkpoint Source: PomBase
  • mitotic G2 DNA damage checkpoint Source: PomBase
  • telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Checkpoint protein rad17
Gene namesi
Name:rad17
ORF Names:SPAC14C4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC14C4.13.
PomBaseiSPAC14C4.13. rad17.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nuclear chromatin Source: PomBase
  • nuclear replication fork Source: PomBase
  • nucleus Source: PomBase
  • Rad17 RFC-like complex Source: PomBase
  • subtelomeric heterochromatin Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099521 – 606Checkpoint protein rad17Add BLAST606

Proteomic databases

MaxQBiP50531.
PRIDEiP50531.

PTM databases

SwissPalmiP50531.

Interactioni

Subunit structurei

Interacts with mug40.1 Publication

Protein-protein interaction databases

BioGridi278139. 97 interactors.

Structurei

3D structure databases

ProteinModelPortaliP50531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rad17/RAD24 family.Curated

Phylogenomic databases

InParanoidiP50531.
KOiK06662.
OMAiYNKREGD.
OrthoDBiEOG092C3K1W.
PhylomeDBiP50531.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR004582. Checkpoint_prot_Rad17_Rad24.
IPR027417. P-loop_NTPase.
IPR018324. Rad17/Rad24_fun/met.
[Graphical view]
PANTHERiPTHR12172. PTHR12172. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00602. rad24. 1 hit.

Sequencei

Sequence statusi: Complete.

P50531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRQLSFHES TKRSLKKKKI RKIEKPSLVS KTSRDKNASI TDIHEEDIEA
60 70 80 90 100
FSDEENKIVH LNNLKEDRFQ LWFEKYIPQK AADLAVHKSK ISAIKQWMLT
110 120 130 140 150
DSLESRLLLI CGPSGCGKST AVQVLAKELG YSLIEWLNPM NLKEPSNQES
160 170 180 190 200
DTLSLTEKFS RFMSLCETYP ELELMDSNNI QKRGKNAQGK KKFIFLDEIP
210 220 230 240 250
HLSKFNGSLD AFRNVIRTAL TSRGAFSIIM VLTEIQLNNL EGINSQDRNS
260 270 280 290 300
FNSVQIMGND LLQDPRVTVL QFNPIAPTYM KKCLGSILRK EGVPKSPKLL
310 320 330 340 350
SLVENICSAS EGDLRSAINS LQLSISQSFE KKGTKNIREV KEGKGKGNDF
360 370 380 390 400
SLEAAQVLER LSKSDSEAYA RFKNYKSAYI PKSDKNENSF FKKDVGLGMM
410 420 430 440 450
HAIGKVVWNK REGDDEVLKA SSQQTGNSER IKGVKVSKSQ ENKNCISLKS
460 470 480 490 500
DQRERMLNVD QCFTSKRRSL VDIESTINQS GLSGSVFRYG LFENYVDSCV
510 520 530 540 550
TTDEAFNVCD LLSISDCLSH DFPYSYTGDE ISTWFSVQGT LFYLPSPVPR
560 570 580 590 600
KWRQLRFQQW NNEGIVRGIF DDYMVIYGKR SVSDPVIEAH EDQVLEDIDD

PIEDED
Length:606
Mass (Da):68,882
Last modified:October 1, 1996 - v1
Checksum:i7D2A31E4F27D455C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91889 Genomic DNA. Translation: CAA62993.1.
CU329670 Genomic DNA. Translation: CAB11206.1.
PIRiS60090.
RefSeqiNP_594918.1. NM_001020350.2.

Genome annotation databases

EnsemblFungiiSPAC14C4.13.1; SPAC14C4.13.1:pep; SPAC14C4.13.
GeneIDi2541643.
KEGGispo:SPAC14C4.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91889 Genomic DNA. Translation: CAA62993.1.
CU329670 Genomic DNA. Translation: CAB11206.1.
PIRiS60090.
RefSeqiNP_594918.1. NM_001020350.2.

3D structure databases

ProteinModelPortaliP50531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278139. 97 interactors.

PTM databases

SwissPalmiP50531.

Proteomic databases

MaxQBiP50531.
PRIDEiP50531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC14C4.13.1; SPAC14C4.13.1:pep; SPAC14C4.13.
GeneIDi2541643.
KEGGispo:SPAC14C4.13.

Organism-specific databases

EuPathDBiFungiDB:SPAC14C4.13.
PomBaseiSPAC14C4.13. rad17.

Phylogenomic databases

InParanoidiP50531.
KOiK06662.
OMAiYNKREGD.
OrthoDBiEOG092C3K1W.
PhylomeDBiP50531.

Miscellaneous databases

PROiP50531.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR004582. Checkpoint_prot_Rad17_Rad24.
IPR027417. P-loop_NTPase.
IPR018324. Rad17/Rad24_fun/met.
[Graphical view]
PANTHERiPTHR12172. PTHR12172. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00602. rad24. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRAD17_SCHPO
AccessioniPrimary (citable) accession number: P50531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.