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Protein

Checkpoint protein rad17

Gene

rad17

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 119ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: PomBase
  • DNA clamp loader activity Source: InterPro

GO - Biological processi

  • DNA repair Source: GO_Central
  • intra-S DNA damage checkpoint Source: PomBase
  • mitotic DNA replication checkpoint Source: PomBase
  • mitotic G2 DNA damage checkpoint Source: PomBase
  • telomere maintenance Source: PomBase

Keywordsi

Biological processCell cycle, DNA damage
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Checkpoint protein rad17
Gene namesi
Name:rad17
ORF Names:SPAC14C4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC14C4.13
PomBaseiSPAC14C4.13 rad17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099521 – 606Checkpoint protein rad17Add BLAST606

Proteomic databases

MaxQBiP50531
PaxDbiP50531
PRIDEiP50531

PTM databases

iPTMnetiP50531
SwissPalmiP50531

Interactioni

Subunit structurei

Interacts with mug40.1 Publication

Protein-protein interaction databases

BioGridi278139, 97 interactors
STRINGi4896.SPAC14C4.13.1

Structurei

3D structure databases

ProteinModelPortaliP50531
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rad17/RAD24 family.Curated

Phylogenomic databases

InParanoidiP50531
KOiK06662
OrthoDBiEOG092C3K1W
PhylomeDBiP50531

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004582 Checkpoint_prot_Rad17_Rad24
IPR027417 P-loop_NTPase
IPR018324 Rad17/Rad24_fun/met
PANTHERiPTHR12172 PTHR12172, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00602 rad24, 1 hit

Sequencei

Sequence statusi: Complete.

P50531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRQLSFHES TKRSLKKKKI RKIEKPSLVS KTSRDKNASI TDIHEEDIEA
60 70 80 90 100
FSDEENKIVH LNNLKEDRFQ LWFEKYIPQK AADLAVHKSK ISAIKQWMLT
110 120 130 140 150
DSLESRLLLI CGPSGCGKST AVQVLAKELG YSLIEWLNPM NLKEPSNQES
160 170 180 190 200
DTLSLTEKFS RFMSLCETYP ELELMDSNNI QKRGKNAQGK KKFIFLDEIP
210 220 230 240 250
HLSKFNGSLD AFRNVIRTAL TSRGAFSIIM VLTEIQLNNL EGINSQDRNS
260 270 280 290 300
FNSVQIMGND LLQDPRVTVL QFNPIAPTYM KKCLGSILRK EGVPKSPKLL
310 320 330 340 350
SLVENICSAS EGDLRSAINS LQLSISQSFE KKGTKNIREV KEGKGKGNDF
360 370 380 390 400
SLEAAQVLER LSKSDSEAYA RFKNYKSAYI PKSDKNENSF FKKDVGLGMM
410 420 430 440 450
HAIGKVVWNK REGDDEVLKA SSQQTGNSER IKGVKVSKSQ ENKNCISLKS
460 470 480 490 500
DQRERMLNVD QCFTSKRRSL VDIESTINQS GLSGSVFRYG LFENYVDSCV
510 520 530 540 550
TTDEAFNVCD LLSISDCLSH DFPYSYTGDE ISTWFSVQGT LFYLPSPVPR
560 570 580 590 600
KWRQLRFQQW NNEGIVRGIF DDYMVIYGKR SVSDPVIEAH EDQVLEDIDD

PIEDED
Length:606
Mass (Da):68,882
Last modified:October 1, 1996 - v1
Checksum:i7D2A31E4F27D455C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91889 Genomic DNA Translation: CAA62993.1
CU329670 Genomic DNA Translation: CAB11206.1
PIRiS60090
RefSeqiNP_594918.1, NM_001020350.2

Genome annotation databases

EnsemblFungiiSPAC14C4.13.1; SPAC14C4.13.1:pep; SPAC14C4.13
GeneIDi2541643
KEGGispo:SPAC14C4.13

Entry informationi

Entry nameiRAD17_SCHPO
AccessioniPrimary (citable) accession number: P50531
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health