Reviewed,
UniProtKB/Swiss-Prot P50529 (STHA_VIBCH)
Last modified
June 16, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Soluble pyridine nucleotide transhydrogenase Short name=STH EC=1.6.1.1 Alternative name(s): NAD(P)(+) transhydrogenase [B-specific] | ||||||
| Gene names |
| ||||||
| Organism | Vibrio cholerae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 666 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. |
| Catalytic activity | NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247 |
| Cofactor | Binds 1 FAD per subunit By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasisInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247 | PRO_0000068075 | |||||
Regions | |||||||||
| Nucleotide binding | 36 – 45 | 10 | FAD By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. Fraser C.M.Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1. |
| [2] | "The rpoH gene encoding sigma 32 homolog of Vibrio cholerae." Sahu G.K., Chowdhury R., Das J. Gene 189:203-207(1997) [PubMed: 9168128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 421-466. Strain: ATCC 25870 / Classical Inaba 569B / Serotype O1. |
Cross-references
Sequence databases | |
|---|---|
| AE003852 Genomic DNA. Translation: AAF93328.1. U44432 Genomic DNA. Translation: AAC45342.1. | |
| PIR | E82357. |
| RefSeq | NP_229809.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 3LAD based on UniProtKB P18925. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2614850. |
| GenomeReviews | Gene locus VC_0151 in contig AE003852_GR. |
| KEGG | vch:VC0151. |
| TIGR | VC_0151. |
Phylogenomic databases | |
| HOGENOM | P50529. |
| OMA | P50529. GEGNTIE. |
Enzyme and pathway databases | |
| BRENDA | 1.6.1.1. 19019. |
Family and domain databases | |
| HAMAP | MF_00247. [Tree] |
| InterPro | IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view] |
| Gene3D | G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit. |
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. PR00945. HGRDTASE. |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | STHA_VIBCH | ||||||||
| Accession | Primary (citable) accession number: P50529 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


