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Protein

26S proteasome regulatory subunit rpn12

Gene

rpn12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn12
Gene namesi
Name:rpn12
Synonyms:mts3
ORF Names:SPBC16G5.01, SPBC342.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.01
PomBaseiSPBC16G5.01 rpn12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738501 – 27026S proteasome regulatory subunit rpn12Add BLAST270

Proteomic databases

MaxQBiP50524
PaxDbiP50524
PRIDEiP50524

PTM databases

iPTMnetiP50524

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cut8P389372EBI-1152607,EBI-1152591

Protein-protein interaction databases

BioGridi276569, 19 interactors
IntActiP50524, 2 interactors
STRINGi4896.SPBC16G5.01.1

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 14Combined sources8
Helixi18 – 34Combined sources17
Helixi44 – 63Combined sources20
Helixi67 – 81Combined sources15
Helixi91 – 104Combined sources14
Helixi108 – 117Combined sources10
Helixi123 – 126Combined sources4
Helixi128 – 141Combined sources14
Helixi145 – 153Combined sources9
Helixi158 – 160Combined sources3
Helixi161 – 182Combined sources22
Beta strandi184 – 187Combined sources4
Helixi188 – 194Combined sources7
Helixi200 – 210Combined sources11
Beta strandi213 – 215Combined sources3
Beta strandi218 – 220Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B0ZX-ray1.58A/B1-224[»]
ProteinModelPortaliP50524
SMRiP50524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 237PCIPROSITE-ProRule annotationAdd BLAST173

Sequence similaritiesi

Belongs to the proteasome subunit S14 family.Curated

Phylogenomic databases

HOGENOMiHOG000196008
InParanoidiP50524
KOiK03031
OMAiLEIGAFW
OrthoDBiEOG092C40NW
PhylomeDBiP50524

Family and domain databases

InterProiView protein in InterPro
IPR006746 26S_Psome_Rpn12
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR12387 PTHR12387, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

P50524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLDLNHLA DLYDRKDWNA CKKELLKLKV ELAKQNLFVP TSDKEKASFA
60 70 80 90 100
RNVFEYGVLV SIQTCDIESF ARYASQVIPF YHDSLVPSSR MGLVTGLNLL
110 120 130 140 150
YLLSENRIAE FHTALESVPD KSLFERDPYV EWVISLEQNV MEGAFDKVAS
160 170 180 190 200
MIRSCNFPEF SYFMKIVMSM VRNEIATCAE KVYSEIPLSN ATSLLYLENT
210 220 230 240 250
KETEKLAEER GWDIRDGVIY FPKEANALET EDGMLIDEED ELELPPTASK
260 270
HTISSIRQLL SYTSELEQIV
Length:270
Mass (Da):30,899
Last modified:October 1, 1996 - v1
Checksum:iC1BC6571722A034D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92682 mRNA Translation: CAA63366.1
CU329671 Genomic DNA Translation: CAB46777.1
PIRiT40280
RefSeqiNP_596750.2, NM_001023770.2

Genome annotation databases

EnsemblFungiiSPBC16G5.01.1; SPBC16G5.01.1:pep; SPBC16G5.01
GeneIDi2540025
KEGGispo:SPBC16G5.01

Similar proteinsi

Entry informationi

Entry nameiRPN12_SCHPO
AccessioniPrimary (citable) accession number: P50524
Secondary accession number(s): Q9UUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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