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Protein

26S proteasome regulatory subunit rpn12

Gene

rpn12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn12
Gene namesi
Name:rpn12
Synonyms:mts3
ORF Names:SPBC16G5.01, SPBC342.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.01.
PomBaseiSPBC16G5.01. rpn12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nuclear periphery Source: PomBase
  • nucleus Source: PomBase
  • proteasome regulatory particle, lid subcomplex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738501 – 27026S proteasome regulatory subunit rpn12Add BLAST270

Proteomic databases

MaxQBiP50524.
PRIDEiP50524.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cut8P389372EBI-1152607,EBI-1152591

Protein-protein interaction databases

BioGridi276569. 19 interactors.
IntActiP50524. 2 interactors.
MINTiMINT-4690673.

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 14Combined sources8
Helixi18 – 34Combined sources17
Helixi44 – 63Combined sources20
Helixi67 – 81Combined sources15
Helixi91 – 104Combined sources14
Helixi108 – 117Combined sources10
Helixi123 – 126Combined sources4
Helixi128 – 141Combined sources14
Helixi145 – 153Combined sources9
Helixi158 – 160Combined sources3
Helixi161 – 182Combined sources22
Beta strandi184 – 187Combined sources4
Helixi188 – 194Combined sources7
Helixi200 – 210Combined sources11
Beta strandi213 – 215Combined sources3
Beta strandi218 – 220Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B0ZX-ray1.58A/B1-224[»]
ProteinModelPortaliP50524.
SMRiP50524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proteasome subunit S14 family.Curated

Phylogenomic databases

HOGENOMiHOG000196008.
InParanoidiP50524.
KOiK03031.
OMAiYAGLHTR.
OrthoDBiEOG092C40NW.
PhylomeDBiP50524.

Family and domain databases

InterProiIPR006746. 26S_Psome_Rpn12.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR12387. PTHR12387. 2 hits.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLDLNHLA DLYDRKDWNA CKKELLKLKV ELAKQNLFVP TSDKEKASFA
60 70 80 90 100
RNVFEYGVLV SIQTCDIESF ARYASQVIPF YHDSLVPSSR MGLVTGLNLL
110 120 130 140 150
YLLSENRIAE FHTALESVPD KSLFERDPYV EWVISLEQNV MEGAFDKVAS
160 170 180 190 200
MIRSCNFPEF SYFMKIVMSM VRNEIATCAE KVYSEIPLSN ATSLLYLENT
210 220 230 240 250
KETEKLAEER GWDIRDGVIY FPKEANALET EDGMLIDEED ELELPPTASK
260 270
HTISSIRQLL SYTSELEQIV
Length:270
Mass (Da):30,899
Last modified:October 1, 1996 - v1
Checksum:iC1BC6571722A034D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92682 mRNA. Translation: CAA63366.1.
CU329671 Genomic DNA. Translation: CAB46777.1.
PIRiT40280.
RefSeqiNP_596750.2. NM_001023770.2.

Genome annotation databases

EnsemblFungiiSPBC16G5.01.1; SPBC16G5.01.1:pep; SPBC16G5.01.
GeneIDi2540025.
KEGGispo:SPBC16G5.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92682 mRNA. Translation: CAA63366.1.
CU329671 Genomic DNA. Translation: CAB46777.1.
PIRiT40280.
RefSeqiNP_596750.2. NM_001023770.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B0ZX-ray1.58A/B1-224[»]
ProteinModelPortaliP50524.
SMRiP50524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276569. 19 interactors.
IntActiP50524. 2 interactors.
MINTiMINT-4690673.

Proteomic databases

MaxQBiP50524.
PRIDEiP50524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16G5.01.1; SPBC16G5.01.1:pep; SPBC16G5.01.
GeneIDi2540025.
KEGGispo:SPBC16G5.01.

Organism-specific databases

EuPathDBiFungiDB:SPBC16G5.01.
PomBaseiSPBC16G5.01. rpn12.

Phylogenomic databases

HOGENOMiHOG000196008.
InParanoidiP50524.
KOiK03031.
OMAiYAGLHTR.
OrthoDBiEOG092C40NW.
PhylomeDBiP50524.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiP50524.

Family and domain databases

InterProiIPR006746. 26S_Psome_Rpn12.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR12387. PTHR12387. 2 hits.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPN12_SCHPO
AccessioniPrimary (citable) accession number: P50524
Secondary accession number(s): Q9UUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.