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Protein

V-type proton ATPase subunit E 1

Gene

Atp6v1e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 1
Short name:
V-ATPase subunit E 1
Alternative name(s):
V-ATPase 31 kDa subunit
Short name:
p31
Vacuolar proton pump subunit E 1
Gene namesi
Name:Atp6v1e1
Synonyms:Atp6e, Atp6e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:894326 Atp6v1e1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001172962 – 226V-type proton ATPase subunit E 1Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP50518
MaxQBiP50518
PaxDbiP50518
PeptideAtlasiP50518
PRIDEiP50518

PTM databases

iPTMnetiP50518
PhosphoSitePlusiP50518

Expressioni

Tissue specificityi

Expressed within the midpiece of sperm tail (at protein level). Ubiquitous.2 Publications

Gene expression databases

BgeeiENSMUSG00000019210
CleanExiMM_ATP6V1E1
ExpressionAtlasiP50518 baseline and differential
GenevisibleiP50518 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with ALDOC. Interacts with RAB11B (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP50518, 7 interactors
MINTiP50518
STRINGi10090.ENSMUSP00000019354

Structurei

3D structure databases

ProteinModelPortaliP50518
SMRiP50518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiKOG1664 Eukaryota
COG1390 LUCA
GeneTreeiENSGT00390000002730
HOGENOMiHOG000202506
HOVERGENiHBG002309
InParanoidiP50518
KOiK02150
OMAiSEMNKMV
OrthoDBiEOG091G0OGO
PhylomeDBiP50518
TreeFamiTF313479

Family and domain databases

Gene3Di3.30.2320.30, 1 hit
HAMAPiMF_00311 ATP_synth_E_arch, 1 hit
InterProiView protein in InterPro
IPR038495 ATPase_E_C
IPR002842 ATPase_V1_Esu
PfamiView protein in Pfam
PF01991 vATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ
110 120 130 140 150
RLSKVVKDTT RYQVLLDGLV LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK
160 170 180 190 200
AIPMYKIATK KDVDVQIDQE AYLPEEIAGG VEIYNGDRKI KVSNTLESRL
210 220
DLIAQQMMPE VRGALFGANA NRKFLD
Length:226
Mass (Da):26,157
Last modified:April 3, 2007 - v2
Checksum:i5DD7B0EAB181EA08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 5ALSD → GLRH in AAC52412 (PubMed:8741845).Curated4
Sequence conflicti29E → EE in AAC52412 (PubMed:8741845).Curated1
Sequence conflicti46 – 47VQ → LE in AAC52412 (PubMed:8741845).Curated2
Sequence conflicti65E → R in AAC52412 (PubMed:8741845).Curated1
Sequence conflicti67Q → QQ in AAC52412 (PubMed:8741845).Curated1
Sequence conflicti86A → T in BAB92084 (PubMed:11872743).Curated1
Sequence conflicti103S → M in AAC52412 (PubMed:8741845).Curated1
Sequence conflicti153P → T in BAE26943 (PubMed:16141072).Curated1
Sequence conflicti161K → R in AAC52412 (PubMed:8741845).Curated1
Sequence conflicti171 – 176AYLPEE → PTCLRN in AAC52412 (PubMed:8741845).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13841 Genomic DNA Translation: AAC52412.1
AB074758 mRNA Translation: BAB92084.1
AK146162 mRNA Translation: BAE26943.1
AK149356 mRNA Translation: BAE28832.1
AK167644 mRNA Translation: BAE39695.1
AK169854 mRNA Translation: BAE41412.1
BC003421 mRNA Translation: AAH03421.1
BC055438 mRNA Translation: AAH55438.1
CCDSiCCDS20484.1
RefSeqiNP_031536.2, NM_007510.2
UniGeneiMm.29045

Genome annotation databases

EnsembliENSMUST00000019354; ENSMUSP00000019354; ENSMUSG00000019210
GeneIDi11973
KEGGimmu:11973
UCSCiuc009dnr.1 mouse

Entry informationi

Entry nameiVATE1_MOUSE
AccessioniPrimary (citable) accession number: P50518
Secondary accession number(s): Q3UK59, Q8K5D6, Q99LD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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