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P50514 (ARLZ_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argx
ORF Names:SPBC1539.03c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

urea cycle

Inferred by curator. Source: GeneDB_Spombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionargininosuccinate lyase activity

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Probable argininosuccinate lyase
PRO_0000137726

Sequences

Sequence LengthMass (Da)Tools
P50514 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7E17C506557D7D0A

FASTA46051,572
        10         20         30         40         50         60 
MASSQKLWGG RFTGATDPLM TAYNESIHYD KRMFNADIDG SKAYAKALEQ RGIISADELD 

        70         80         90        100        110        120 
KMLDGLEAVR DEWKTNKFTL QPSDEDIHTA NERRLGEIIG TGIAGKLHTG RSRNDQVTTD 

       130        140        150        160        170        180 
MRLWLRDELD IIQKSLVGLL QVFVARAESD LDIIMPGYTH LQRAQPIRWS HFLLSHAFSI 

       190        200        210        220        230        240 
LNDLDRLKQI YSRVNRLPLG AGALAGNPFA VDRKFLQKEL GFEGVIMNSM NAVADRDYVI 

       250        260        270        280        290        300 
EFMFWASMVM THISRLAEDL IIYSTSEFNF VTLSDAYSTG SSIMPQKKNP DSLELLRGKS 

       310        320        330        340        350        360 
GRVFGNMMGF MVSVKGIPST YNKDLQEDKE PLFDSSKTVL DSIQILTGVL STLTVNPENI 

       370        380        390        400        410        420 
AKSLTADMLA TDLAEYLVRK GVPFRETHHI SGSAVRMAEE RNTTIDKLSV EDFKSLHPLY 

       430        440        450        460 
EEDVADVFNY ESSVEKRCAI GGTAKSCVLE QIQTIKKALE

« Hide

References

« Hide 'large scale' references
[1]Shpakovski G.V.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U13259 Genomic DNA. Translation: AAA58961.1.
CU329671 Genomic DNA. Translation: CAB51335.1.
PIRT39462.
RefSeqNP_596817.1. NM_001023837.1.

3D structure databases

ProteinModelPortalP50514.
SMRP50514. Positions 19-460.
ModBaseSearch...

Protein-protein interaction databases

STRINGP50514.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1539.03c.1; SPBC1539.03c.1:pep; SPBC1539.03c.
GeneID2539950.
GenomeReviewsGene locus argx in contig CU329671_GR.
KEGGspo:SPBC1539.03c.
NMPDRfig|4896.1.peg.2683.

Organism-specific databases

GeneDB_SpombeSPBC1539.03c.

Phylogenomic databases

eggNOGfuNOG04635.
GeneTreeEFGT00050000004720.
HOGENOMHBG539632.
OMAMAEDLIF.
OrthoDBEOG4VMJQ2.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004795-MONOMER.

Gene expression databases

ArrayExpressP50514.

Family and domain databases

InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLZ_SCHPO
AccessionPrimary (citable) accession number: P50514
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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