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P50506 (HXK_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase

EC=2.7.1.1
Gene names
Name:HXK
OrganismSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Taxonomic identifier27300 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSchwanniomyces

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termAllosteric enzyme
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Hexokinase
PRO_0000197606

Regions

Domain23 – 222200Hexokinase type-1
Domain225 – 469245Hexokinase type-2
Region151 – 17727Glucose-binding Potential

Sites

Binding site1111ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P50506 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 080D5F9134478ABA

FASTA47853,067
        10         20         30         40         50         60 
MVHLGPKPPQ HRKGSFLDVP EYLLKELTEL EGLLTVSGET LRKITDHFIS ELEKGLSKQG 

        70         80         90        100        110        120 
GNIPMIPGWV MDFPTGKEMG DYLAIDLGGT NLRVVLVKLG GNRDFDTTQS KFALPENMRT 

       130        140        150        160        170        180 
AKSEELWEFI AECLQKFVEE EFRNGVLSNL PLGFTFSYPA SQGSINEGYL QRWTKGFDIE 

       190        200        210        220        230        240 
GVEGHDVVPM LQAAIEKRKV PIEVVALIND TTGTLVASMY TDPEAKMGLF SGTGCNGAYY 

       250        260        270        280        290        300 
DVVDNIPKLE GKVPDDIKSS SPMAINCEYG AFDNEHIILP RTKYDIQIDE ESPRPGQQAF 

       310        320        330        340        350        360 
EKMISGYYLG EVLRLILLDL TSKQLIFKDQ DLSKLQVPFI LDTSIPARIE EDPFENLSDV 

       370        380        390        400        410        420 
QELFQEILGI QTTSPERKII RRLAELIGER SARLSICGIA AICKKRGYKT AHCAADGSVY 

       430        440        450        460        470 
NKYPGFKERA AKGLRDIFQW ESEEDPIVIV PAEDGLGAGA AIIAALTEKR LKDGLPLV 

« Hide

References

[1]"Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis."
Rose M.
Curr. Genet. 27:330-338(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 2322 / CBS 819 / JCM 8123 / NBRC 1841 / NRRL Y-10 / BCRC 22052.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S78714 Genomic DNA. Translation: AAB34892.1.
PIRS57203.

3D structure databases

ProteinModelPortalP50506.
SMRP50506. Positions 15-477.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXK_SCHOC
AccessionPrimary (citable) accession number: P50506
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways