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Protein

Hexokinase

Gene

HXK

Organism
Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
Gene namesi
Name:HXK
OrganismiSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Taxonomic identifieri27300 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSchwanniomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478HexokinasePRO_0000197606Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP50506.
SMRiP50506. Positions 15-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 222200Hexokinase type-1Add
BLAST
Domaini225 – 469245Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 17727Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50506-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHLGPKPPQ HRKGSFLDVP EYLLKELTEL EGLLTVSGET LRKITDHFIS
60 70 80 90 100
ELEKGLSKQG GNIPMIPGWV MDFPTGKEMG DYLAIDLGGT NLRVVLVKLG
110 120 130 140 150
GNRDFDTTQS KFALPENMRT AKSEELWEFI AECLQKFVEE EFRNGVLSNL
160 170 180 190 200
PLGFTFSYPA SQGSINEGYL QRWTKGFDIE GVEGHDVVPM LQAAIEKRKV
210 220 230 240 250
PIEVVALIND TTGTLVASMY TDPEAKMGLF SGTGCNGAYY DVVDNIPKLE
260 270 280 290 300
GKVPDDIKSS SPMAINCEYG AFDNEHIILP RTKYDIQIDE ESPRPGQQAF
310 320 330 340 350
EKMISGYYLG EVLRLILLDL TSKQLIFKDQ DLSKLQVPFI LDTSIPARIE
360 370 380 390 400
EDPFENLSDV QELFQEILGI QTTSPERKII RRLAELIGER SARLSICGIA
410 420 430 440 450
AICKKRGYKT AHCAADGSVY NKYPGFKERA AKGLRDIFQW ESEEDPIVIV
460 470
PAEDGLGAGA AIIAALTEKR LKDGLPLV
Length:478
Mass (Da):53,067
Last modified:October 1, 1996 - v1
Checksum:i080D5F9134478ABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78714 Genomic DNA. Translation: AAB34892.1.
PIRiS57203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78714 Genomic DNA. Translation: AAB34892.1.
PIRiS57203.

3D structure databases

ProteinModelPortaliP50506.
SMRiP50506. Positions 15-477.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00242.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis."
    Rose M.
    Curr. Genet. 27:330-338(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 2322 / CBS 819 / JCM 8123 / NBRC 1841 / NRRL Y-10 / BCRC 22052.

Entry informationi

Entry nameiHXK_SCHOC
AccessioniPrimary (citable) accession number: P50506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.