P50506 (HXK_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase
EC=2.7.1.1

Gene names

Name:

HXK

Organism

Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)

Taxonomic identifier

27300 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Schwanniomyces

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Hexokinase		PRO_0000197606
Regions
	Region	151 – 177	27	Glucose-binding Potential
Sites
	Binding site	111	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50506 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 080D5F9134478ABA	FASTA	478	53,067
	10 20 30 40 50 60 MVHLGPKPPQ HRKGSFLDVP EYLLKELTEL EGLLTVSGET LRKITDHFIS ELEKGLSKQG 70 80 90 100 110 120 GNIPMIPGWV MDFPTGKEMG DYLAIDLGGT NLRVVLVKLG GNRDFDTTQS KFALPENMRT 130 140 150 160 170 180 AKSEELWEFI AECLQKFVEE EFRNGVLSNL PLGFTFSYPA SQGSINEGYL QRWTKGFDIE 190 200 210 220 230 240 GVEGHDVVPM LQAAIEKRKV PIEVVALIND TTGTLVASMY TDPEAKMGLF SGTGCNGAYY 250 260 270 280 290 300 DVVDNIPKLE GKVPDDIKSS SPMAINCEYG AFDNEHIILP RTKYDIQIDE ESPRPGQQAF 310 320 330 340 350 360 EKMISGYYLG EVLRLILLDL TSKQLIFKDQ DLSKLQVPFI LDTSIPARIE EDPFENLSDV 370 380 390 400 410 420 QELFQEILGI QTTSPERKII RRLAELIGER SARLSICGIA AICKKRGYKT AHCAADGSVY 430 440 450 460 470 NKYPGFKERA AKGLRDIFQW ESEEDPIVIV PAEDGLGAGA AIIAALTEKR LKDGLPLV

References

[1]

"Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis." Rose M. Curr. Genet. 27:330-338(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 2322 / CBS 819 / JCM 8123 / NBRC 1841 / NRRL Y-10 / BCRC 22052.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S78714 Genomic DNA. Translation: AAB34892.1.
PIR	S57203.
3D structure databases
ProteinModelPortal	P50506.
SMR	P50506. Positions 15-477.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00242.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK_SCHOC

Accession

Primary (citable) accession number: P50506

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program