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P50506

- HXK_SCHOC

UniProt

P50506 - HXK_SCHOC

Protein

Hexokinase

Gene

HXK

Organism
Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase (EC:2.7.1.1)
    Gene namesi
    Name:HXK
    OrganismiSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
    Taxonomic identifieri27300 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSchwanniomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478HexokinasePRO_0000197606Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP50506.
    SMRiP50506. Positions 15-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 222200Hexokinase type-1Add
    BLAST
    Domaini225 – 469245Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 17727Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50506-1 [UniParc]FASTAAdd to Basket

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    MVHLGPKPPQ HRKGSFLDVP EYLLKELTEL EGLLTVSGET LRKITDHFIS    50
    ELEKGLSKQG GNIPMIPGWV MDFPTGKEMG DYLAIDLGGT NLRVVLVKLG 100
    GNRDFDTTQS KFALPENMRT AKSEELWEFI AECLQKFVEE EFRNGVLSNL 150
    PLGFTFSYPA SQGSINEGYL QRWTKGFDIE GVEGHDVVPM LQAAIEKRKV 200
    PIEVVALIND TTGTLVASMY TDPEAKMGLF SGTGCNGAYY DVVDNIPKLE 250
    GKVPDDIKSS SPMAINCEYG AFDNEHIILP RTKYDIQIDE ESPRPGQQAF 300
    EKMISGYYLG EVLRLILLDL TSKQLIFKDQ DLSKLQVPFI LDTSIPARIE 350
    EDPFENLSDV QELFQEILGI QTTSPERKII RRLAELIGER SARLSICGIA 400
    AICKKRGYKT AHCAADGSVY NKYPGFKERA AKGLRDIFQW ESEEDPIVIV 450
    PAEDGLGAGA AIIAALTEKR LKDGLPLV 478
    Length:478
    Mass (Da):53,067
    Last modified:October 1, 1996 - v1
    Checksum:i080D5F9134478ABA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78714 Genomic DNA. Translation: AAB34892.1.
    PIRiS57203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78714 Genomic DNA. Translation: AAB34892.1 .
    PIRi S57203.

    3D structure databases

    ProteinModelPortali P50506.
    SMRi P50506. Positions 15-477.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis."
      Rose M.
      Curr. Genet. 27:330-338(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 2322 / CBS 819 / JCM 8123 / NBRC 1841 / NRRL Y-10 / BCRC 22052.

    Entry informationi

    Entry nameiHXK_SCHOC
    AccessioniPrimary (citable) accession number: P50506
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3