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P50505 (HAK1_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
High affinity potassium transporter
Gene names
Name:HAK1
OrganismSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Taxonomic identifier27300 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Schwanniomyces

Protein attributes

Sequence length821 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major high-affinity potassium uptake protein.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the HAK/KUP transporter (TC 2.A.72) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpotassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 821821High affinity potassium transporter
PRO_0000209105

Regions

Topological domain1 – 5757Cytoplasmic Potential
Transmembrane58 – 7821Helical; Potential
Topological domain79 – 10123Extracellular Potential
Transmembrane102 – 12221Helical; Potential
Topological domain123 – 19068Cytoplasmic Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 23827Extracellular Potential
Transmembrane239 – 25921Helical; Potential
Topological domain2601Cytoplasmic Potential
Transmembrane261 – 28121Helical; Potential
Topological domain282 – 30625Extracellular Potential
Transmembrane307 – 32721Helical; Potential
Topological domain328 – 34013Cytoplasmic Potential
Transmembrane341 – 36121Helical; Potential
Topological domain362 – 38625Extracellular Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 43427Cytoplasmic Potential
Transmembrane435 – 45521Helical; Potential
Topological domain456 – 4638Extracellular Potential
Transmembrane464 – 48421Helical; Potential
Topological domain485 – 4917Cytoplasmic Potential
Transmembrane492 – 51221Helical; Potential
Topological domain513 – 5164Extracellular Potential
Transmembrane517 – 53721Helical; Potential
Topological domain538 – 821284Cytoplasmic Potential

Amino acid modifications

Glycosylation4601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P50505 [UniParc].

Last modified July 11, 2001. Version 2.
Checksum: ECAEA760603F63C2

FASTA82191,935
        10         20         30         40         50         60 
MSDSQSNKQN QGEDDNNVSS SIESNENYPF RLNDEESEPQ SSTTESMLKA KKQSWRQVLM 

        70         80         90        100        110        120 
LGFSSLGAIY GDIGTSPLYV LNSIKYPNSS PTEEDIYGAI SIIFYLFTFI VIFKYILIVL 

       130        140        150        160        170        180 
FLGTNDGEGG QVAIYAKIAR SLKIGPKGVH IPGSPEKTDL ELLARAETSS SFKSSNLFLN 

       190        200        210        220        230        240 
KASGFKTNPK LIKFISKFIL FGCFFGCSLV MSDGLLTPTT SVLSAIAGIQ IANPSFNDVL 

       250        260        270        280        290        300 
AVSEVVLIVL FLIQQFGSNK ISFTFAPIIF LWLIGLIISG IYNIVKFHPA VFKSLSPYYA 

       310        320        330        340        350        360 
IQLLKHSGID VFSGAMLSIT GTEAMFADVG HFGRLPIQLT LTLFVYPALI ICYLGQGAYI 

       370        380        390        400        410        420 
IKHPEALSNP FFYSIPGGLN SWIYWVMFVL ATLSTIIASQ ALILGVFSIT SQLINLDCFP 

       430        440        450        460        470        480 
NFKIIHVSKK YAGKVYIPAI NWLLMIGVCA TTAGFKNSNN VTAAYGLGIT LDFLVTSSLI 

       490        500        510        520        530        540 
MVCMTYVYNW NILIPITYAL IFLPLEVIMV ISNLKKITHG AWFPLMMSGI FMMFLSFWRW 

       550        560        570        580        590        600 
ARSRKVNQDF KTRIRIGDLY PELKKQPPQS ETVDLNDRGR PMSIVNSSNE ELVEYGVTLP 

       610        620        630        640        650        660 
KILKTNNNQL KVQSKFGLMN LKKYDGIAIM YNDSSVHTLN SPNTVPQVYG KLVSSFSSIP 

       670        680        690        700        710        720 
SVFIFCSIRV LSIPTVPNDE RVLIGSMKIP GHYRCIIRYG FMEEILIDKE LNNHILNSIP 

       730        740        750        760        770        780 
DINELAIKFN LNNKCILTKP CTIPILHIFE NNLIRSHDYS SEEHETKNPL VKCKRFIRKI 

       790        800        810        820 
LINHIFSPIY SDFQSNGKFL KISDEDEESE KKMFLGGVVR I

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References

[1]Rodriguez-Navarro A.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A potassium transporter of the yeast Schwanniomyces occidentalis homologous to the Kup system of Escherichia coli has a high concentrative capacity."
Banuelos M.A., Klein R.D., Alexander-Bowman S.J., Rodriguez-Navarro A.
EMBO J. 14:3021-3027(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-821.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U22945 Genomic DNA. Translation: AAB17122.2.
PIRS56141.

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB2.A.72.2.1. K+ uptake permease (KUP) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003855. K+_transporter.
[Graphical view]
PfamPF02705. K_trans. 1 hit.
[Graphical view]
TIGRFAMsTIGR00794. kup. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAK1_SCHOC
AccessionPrimary (citable) accession number: P50505
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: April 3, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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