P50504 (PUR6_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole carboxylase
EC=4.1.1.21

Alternative name(s):
AIR carboxylase
Short name=AIRC

Gene names

Name:

ADE2

Organism

Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)

Taxonomic identifier

27300 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Schwanniomyces

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	In the C-terminal section; belongs to the AIR carboxylase family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ligase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Phosphoribosylaminoimidazole carboxylase		PRO_0000075026
Regions
	Domain	108 – 296	189	ATP-grasp
	Nucleotide binding	136 – 191	56	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50504 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: EE5338090FC2E41A	FASTA	557	61,338
	10 20 30 40 50 60 MDNKIVGILG GGQLGRMIVE AANRLNIKTV VLDVPNSPAK QINSNEHVDG SFTDLKSIIQ 70 80 90 100 110 120 LAEKCDILTV EIEHVDVEAL KYVKEKFGVE IYPLPDTIKL IQDKYLQKEH LIQHGISVTE 130 140 150 160 170 180 SVAVPSNDEQ SLIEIGNKFN YPFMLKSRTL AYDGRGNYVV KTKESIPEAL EFLKDRPLYA 190 200 210 220 230 240 EKWCPFNKEL AVMVVRSIEG EVFAYPTVET IHKNNICHVV YAPARVSDSI AVKASVLAKN 250 260 270 280 290 300 AVKSFPGCGI FGVEMFLLPN NEILINEIAP RPHNSGHYTI DACVTSQFEA HVRAVVGLPM 310 320 330 340 350 360 PKNFTSLSTT TTNAIMLNVL GDEESNKELE ICRRALETPN ASVYLYGKST RPNRKMGHIN 370 380 390 400 410 420 IVSSSMEDCE SRLDYIIGKS SKIPENLIPK EKPLVSIIMG SDSDLPVMSV GANILKRFGV 430 440 450 460 470 480 PFELTIVSAH RTPHRMTQYA IEAPKRGLKV IIAGAGGAAH LPGMVAAMTP LPVIGVPVKG 490 500 510 520 530 540 STLDGVDSLH SIVQMPRGIP VATVAINNST NAALLAVRIL GAYDYKWLNE MNQYMNNMEN 550 EVLAKAERLE EVGYEKY

References

[1]	"Sequence analysis of the ADE2 gene coding for phosphoribosylaminoimidazole carboxylase in Schwanniomyces occidentalis." Gourdon P., Janatova I., Meilhoc E., Klein R.D., Costaglioli P., Masson J.-M. Yeast 11:1289-1293(1995) [PubMed: 8553700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23210 Genomic DNA. Translation: AAA96380.1.
PIR	S60392.
3D structure databases
ProteinModelPortal	P50504.
SMR	P50504. Positions 393-557.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR000031. N5-CAIR_Mutase_PurE_dom. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR011054. Rudment_hybrid_motif. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit. G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
Pfam	PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view]
PIRSF	PIRSF001340. AIR_carboxylase. 1 hit.
SMART	SM01001. AIRC. 1 hit. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 1 hit. SSF52440. PreATP-grasp-like. 1 hit. SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMs	TIGR01162. PurE. 1 hit. TIGR01161. PurK. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR6_SCHOC

Accession

Primary (citable) accession number: P50504

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program