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Protein

Hsc70-interacting protein

Gene

St13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.1 Publication

GO - Molecular functioni

  • chaperone binding Source: RGD
  • dATP binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • identical protein binding Source: RGD
  • protein complex binding Source: RGD
  • protein domain specific binding Source: RGD
  • unfolded protein binding Source: RGD

GO - Biological processi

  • chaperone cofactor-dependent protein refolding Source: RGD
  • negative regulation of protein refolding Source: RGD
  • protein folding Source: RGD
  • protein homooligomerization Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Hsc70-interacting protein
Short name:
Hip
Alternative name(s):
Protein FAM10A1
Protein ST13 homolog
Gene namesi
Name:St13
Synonyms:Fam10a1, Hip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621312. St13.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001908141 – 368Hsc70-interacting proteinAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei345Phosphoserine; by GRK5By similarity1
Modified residuei352N6-acetyllysineBy similarity1
Modified residuei359N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50503.
PRIDEiP50503.

PTM databases

iPTMnetiP50503.
PhosphoSitePlusiP50503.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019070.
GenevisibleiP50503. RN.

Interactioni

Subunit structurei

Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • identical protein binding Source: RGD
  • protein complex binding Source: RGD
  • protein domain specific binding Source: RGD
  • unfolded protein binding Source: RGD

Protein-protein interaction databases

DIPiDIP-37019N.
IntActiP50503. 1 interactor.
STRINGi10116.ENSRNOP00000025925.

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 18Combined sources16
Helixi20 – 24Combined sources5
Helixi26 – 28Combined sources3
Helixi29 – 37Combined sources9
Helixi107 – 124Combined sources18
Turni125 – 127Combined sources3
Helixi129 – 142Combined sources14
Helixi147 – 159Combined sources13
Helixi163 – 176Combined sources14
Helixi182 – 194Combined sources13
Helixi197 – 210Combined sources14
Helixi214 – 240Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J8CX-ray1.10A/B1-44[»]
4J8DX-ray2.80A/B/C/D78-247[»]
4J8EX-ray2.60A/B78-247[»]
4J8FX-ray2.70A77-247[»]
ProteinModelPortaliP50503.
SMRiP50503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 146TPR 1Add BLAST34
Repeati147 – 180TPR 2Add BLAST34
Repeati181 – 214TPR 3Add BLAST34
Domaini318 – 357STI1Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 311Gly/Met/Pro-richAdd BLAST34

Sequence similaritiesi

Belongs to the FAM10 family.Curated
Contains 1 STI1 domain.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1308. Eukaryota.
ENOG410XR19. LUCA.
GeneTreeiENSGT00390000001347.
HOGENOMiHOG000001586.
HOVERGENiHBG002482.
InParanoidiP50503.
KOiK09560.
OMAiVQPKANK.
OrthoDBiEOG091G0KXF.
PhylomeDBiP50503.
TreeFamiTF313244.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRKVSELR AFVKMCRQDP SVLHTEEMRF LREWVESMGG KVPPATHKAK
60 70 80 90 100
SEENTKEEKR DKTTEDNIKT EEPSSEESDL EIDNEGVIEA DTDAPQEMGD
110 120 130 140 150
ENAEITEAMM DEANEKKGAA IDALNDGELQ KAIDLFTDAI KLNPRLAILY
160 170 180 190 200
AKRASVFVKL QKPNAAIRDC DRAIEINPDS AQPYKWRGKA HRLLGHWEEA
210 220 230 240 250
ARDLALACKL DYDEDASAML REVQPRAQKI AEHRRKYERK REEREIKERI
260 270 280 290 300
ERVKKAREEH EKAQREEEAR RQSGSQFGSF PGGFPGGMPG NFPGGMPGMG
310 320 330 340 350
GAMPGMAGMP GLNEILSDPE VLAAMQDPEV MVAFQDVAQN PSNMSKYQNN
360
PKVMNLISKL SAKFGGHS
Length:368
Mass (Da):41,280
Last modified:October 1, 1996 - v1
Checksum:i1AEBFC0526AE5CE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82021 mRNA. Translation: CAA57546.1.
BC078804 mRNA. Translation: AAH78804.1.
RefSeqiNP_112384.1. NM_031122.1.
UniGeneiRn.119613.
Rn.8796.

Genome annotation databases

EnsembliENSRNOT00000025925; ENSRNOP00000025925; ENSRNOG00000019070.
GeneIDi81800.
KEGGirno:81800.
UCSCiRGD:621312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82021 mRNA. Translation: CAA57546.1.
BC078804 mRNA. Translation: AAH78804.1.
RefSeqiNP_112384.1. NM_031122.1.
UniGeneiRn.119613.
Rn.8796.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J8CX-ray1.10A/B1-44[»]
4J8DX-ray2.80A/B/C/D78-247[»]
4J8EX-ray2.60A/B78-247[»]
4J8FX-ray2.70A77-247[»]
ProteinModelPortaliP50503.
SMRiP50503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-37019N.
IntActiP50503. 1 interactor.
STRINGi10116.ENSRNOP00000025925.

PTM databases

iPTMnetiP50503.
PhosphoSitePlusiP50503.

Proteomic databases

PaxDbiP50503.
PRIDEiP50503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025925; ENSRNOP00000025925; ENSRNOG00000019070.
GeneIDi81800.
KEGGirno:81800.
UCSCiRGD:621312. rat.

Organism-specific databases

CTDi6767.
RGDi621312. St13.

Phylogenomic databases

eggNOGiKOG1308. Eukaryota.
ENOG410XR19. LUCA.
GeneTreeiENSGT00390000001347.
HOGENOMiHOG000001586.
HOVERGENiHBG002482.
InParanoidiP50503.
KOiK09560.
OMAiVQPKANK.
OrthoDBiEOG091G0KXF.
PhylomeDBiP50503.
TreeFamiTF313244.

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiP50503.

Gene expression databases

BgeeiENSRNOG00000019070.
GenevisibleiP50503. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF10A1_RAT
AccessioniPrimary (citable) accession number: P50503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.