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Protein

Hsc70-interacting protein

Gene

ST13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Hsc70-interacting protein
Short name:
Hip
Alternative name(s):
Aging-associated protein 2
Progesterone receptor-associated p48 protein
Protein FAM10A1
Putative tumor suppressor ST13
Renal carcinoma antigen NY-REN-33
Suppression of tumorigenicity 13 protein
Gene namesi
Name:ST13
Synonyms:AAG2, FAM10A1, HIP, SNC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100380.12
HGNCiHGNC:11343 ST13
MIMi606796 gene
neXtProtiNX_P50502

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6767
OpenTargetsiENSG00000100380
PharmGKBiPA36167

Polymorphism and mutation databases

DMDMi6686278

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001908111 – 369Hsc70-interacting proteinAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei346Phosphoserine; by GRK51 Publication1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei360N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP50502
PaxDbiP50502
PeptideAtlasiP50502
PRIDEiP50502

2D gel databases

OGPiP50502
REPRODUCTION-2DPAGEIPI00032826

PTM databases

iPTMnetiP50502
PhosphoSitePlusiP50502
SwissPalmiP50502

Miscellaneous databases

PMAP-CutDBP50502

Expressioni

Gene expression databases

BgeeiENSG00000100380
CleanExiHS_ST13
ExpressionAtlasiP50502 baseline and differential
GenevisibleiP50502 HS

Organism-specific databases

HPAiHPA043233
HPA046412
HPA047114
HPA047116

Interactioni

Subunit structurei

Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112644, 46 interactors
CORUMiP50502
IntActiP50502, 23 interactors
MINTiP50502
STRINGi9606.ENSP00000216218

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UZSmodel-A98-244[»]
ProteinModelPortaliP50502
SMRiP50502
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati114 – 147TPR 1Add BLAST34
Repeati148 – 181TPR 2Add BLAST34
Repeati182 – 215TPR 3Add BLAST34
Domaini319 – 358STI1Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi279 – 312Gly/Met/Pro-richAdd BLAST34

Sequence similaritiesi

Belongs to the FAM10 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1308 Eukaryota
ENOG410XR19 LUCA
GeneTreeiENSGT00390000001347
HOGENOMiHOG000001586
HOVERGENiHBG002482
InParanoidiP50502
KOiK09560
OMAiTVLNMPQ
OrthoDBiEOG091G0KXF
PhylomeDBiP50502
TreeFamiTF313244

Family and domain databases

CDDicd14438 Hip_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034649 Hip_N
IPR006636 STI1_HS-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P50502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK
60 70 80 90 100
SEENTKEEKP DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG
110 120 130 140 150
DENAEITEEM MDQANDKKVA AIEALNDGEL QKAIDLFTDA IKLNPRLAIL
160 170 180 190 200
YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK AHRLLGHWEE
210 220 230 240 250
AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER
260 270 280 290 300
IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM
310 320 330 340 350
GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS
360
NPKVMNLISK LSAKFGGQA
Length:369
Mass (Da):41,332
Last modified:May 30, 2000 - v2
Checksum:i98FCC65BEE14CDD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24H → Y in AAB38382 (PubMed:8721986).Curated1
Sequence conflicti38M → I in AAB38382 (PubMed:8721986).Curated1
Sequence conflicti50K → I in AAB38382 (PubMed:8721986).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011900297M → I. Corresponds to variant dbSNP:rs710193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28918 mRNA Translation: AAB38382.1
U17714 mRNA Translation: AAC97526.1
AY513286 mRNA Translation: AAT08039.1
CR456586 mRNA Translation: CAG30472.1
Z98048 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60394.1
BC052982 mRNA Translation: AAH52982.1
BC071629 mRNA Translation: AAH71629.1
BC139724 mRNA Translation: AAI39725.1
CCDSiCCDS14006.1
RefSeqiNP_003923.2, NM_003932.4
UniGeneiHs.712713

Genome annotation databases

EnsembliENST00000216218; ENSP00000216218; ENSG00000100380
GeneIDi6767
KEGGihsa:6767
UCSCiuc003aze.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF10A1_HUMAN
AccessioniPrimary (citable) accession number: P50502
Secondary accession number(s): O14999, Q2TU77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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