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P50502

- F10A1_HUMAN

UniProt

P50502 - F10A1_HUMAN

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Protein
Hsc70-interacting protein
Gene
ST13, AAG2, FAM10A1, HIP, SNC6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins By similarity.

GO - Molecular functioni

  1. dATP binding Source: Ensembl
  2. protein binding Source: IntAct
  3. protein binding, bridging Source: ProtInc

GO - Biological processi

  1. chaperone cofactor-dependent protein refolding Source: Ensembl
  2. negative regulation of protein refolding Source: Ensembl
  3. protein folding Source: ProtInc
  4. protein homooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Hsc70-interacting protein
Short name:
Hip
Alternative name(s):
Aging-associated protein 2
Progesterone receptor-associated p48 protein
Protein FAM10A1
Putative tumor suppressor ST13
Renal carcinoma antigen NY-REN-33
Suppression of tumorigenicity 13 protein
Gene namesi
Name:ST13
Synonyms:AAG2, FAM10A1, HIP, SNC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:11343. ST13.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Hsc70-interacting protein
PRO_0000190811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei346 – 3461Phosphoserine; by GRK51 Publication
Modified residuei353 – 3531N6-acetyllysine By similarity
Modified residuei360 – 3601N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP50502.
PaxDbiP50502.
PeptideAtlasiP50502.
PRIDEiP50502.

2D gel databases

OGPiP50502.
REPRODUCTION-2DPAGEIPI00032826.

PTM databases

PhosphoSiteiP50502.

Miscellaneous databases

PMAP-CutDBP50502.

Expressioni

Gene expression databases

ArrayExpressiP50502.
BgeeiP50502.
CleanExiHS_ST13.
GenevestigatoriP50502.

Organism-specific databases

HPAiHPA043233.
HPA046412.
HPA047114.
HPA047116.

Interactioni

Subunit structurei

Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 By similarity. Interacts (via the C-terminus 303- 319 AA) with GRK5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APOEP026493EBI-357285,EBI-1222467
NOS3P294743EBI-357285,EBI-1391623
PSEN1P497683EBI-357285,EBI-297277

Protein-protein interaction databases

BioGridi112644. 34 interactions.
IntActiP50502. 21 interactions.
MINTiMINT-4999606.
STRINGi9606.ENSP00000216218.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UZSmodel-A98-244[»]
ProteinModelPortaliP50502.
SMRiP50502. Positions 1-44, 78-275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati114 – 14734TPR 1
Add
BLAST
Repeati148 – 18134TPR 2
Add
BLAST
Repeati182 – 21534TPR 3
Add
BLAST
Domaini319 – 35840STI1
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi279 – 31234Gly/Met/Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM10 family.
Contains 1 STI1 domain.
Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG260098.
HOGENOMiHOG000001586.
HOVERGENiHBG002482.
InParanoidiP50502.
KOiK09560.
OMAiQANEKKM.
OrthoDBiEOG77M8P3.
PhylomeDBiP50502.
TreeFamiTF313244.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50502-1 [UniParc]FASTAAdd to Basket

« Hide

MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK    50
SEENTKEEKP DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG 100
DENAEITEEM MDQANDKKVA AIEALNDGEL QKAIDLFTDA IKLNPRLAIL 150
YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK AHRLLGHWEE 200
AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER 250
IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM 300
GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS 350
NPKVMNLISK LSAKFGGQA 369
Length:369
Mass (Da):41,332
Last modified:May 30, 2000 - v2
Checksum:i98FCC65BEE14CDD7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti297 – 2971M → I.
Corresponds to variant rs710193 [ dbSNP | Ensembl ].
VAR_011900

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241H → Y in AAB38382. 1 Publication
Sequence conflicti38 – 381M → I in AAB38382. 1 Publication
Sequence conflicti50 – 501K → I in AAB38382. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28918 mRNA. Translation: AAB38382.1.
U17714 mRNA. Translation: AAC97526.1.
AY513286 mRNA. Translation: AAT08039.1.
CR456586 mRNA. Translation: CAG30472.1.
Z98048 Genomic DNA. Translation: CAB10844.1.
CH471095 Genomic DNA. Translation: EAW60394.1.
BC052982 mRNA. Translation: AAH52982.1.
BC071629 mRNA. Translation: AAH71629.1.
BC139724 mRNA. Translation: AAI39725.1.
CCDSiCCDS14006.1.
RefSeqiNP_003923.2. NM_003932.4.
UniGeneiHs.712713.

Genome annotation databases

EnsembliENST00000216218; ENSP00000216218; ENSG00000100380.
GeneIDi6767.
KEGGihsa:6767.
UCSCiuc003aze.3. human.

Polymorphism databases

DMDMi6686278.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28918 mRNA. Translation: AAB38382.1 .
U17714 mRNA. Translation: AAC97526.1 .
AY513286 mRNA. Translation: AAT08039.1 .
CR456586 mRNA. Translation: CAG30472.1 .
Z98048 Genomic DNA. Translation: CAB10844.1 .
CH471095 Genomic DNA. Translation: EAW60394.1 .
BC052982 mRNA. Translation: AAH52982.1 .
BC071629 mRNA. Translation: AAH71629.1 .
BC139724 mRNA. Translation: AAI39725.1 .
CCDSi CCDS14006.1.
RefSeqi NP_003923.2. NM_003932.4.
UniGenei Hs.712713.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UZS model - A 98-244 [» ]
ProteinModelPortali P50502.
SMRi P50502. Positions 1-44, 78-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112644. 34 interactions.
IntActi P50502. 21 interactions.
MINTi MINT-4999606.
STRINGi 9606.ENSP00000216218.

PTM databases

PhosphoSitei P50502.

Polymorphism databases

DMDMi 6686278.

2D gel databases

OGPi P50502.
REPRODUCTION-2DPAGE IPI00032826.

Proteomic databases

MaxQBi P50502.
PaxDbi P50502.
PeptideAtlasi P50502.
PRIDEi P50502.

Protocols and materials databases

DNASUi 6767.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216218 ; ENSP00000216218 ; ENSG00000100380 .
GeneIDi 6767.
KEGGi hsa:6767.
UCSCi uc003aze.3. human.

Organism-specific databases

CTDi 6767.
GeneCardsi GC22M041220.
HGNCi HGNC:11343. ST13.
HPAi HPA043233.
HPA046412.
HPA047114.
HPA047116.
MIMi 606796. gene.
neXtProti NX_P50502.
PharmGKBi PA36167.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260098.
HOGENOMi HOG000001586.
HOVERGENi HBG002482.
InParanoidi P50502.
KOi K09560.
OMAi QANEKKM.
OrthoDBi EOG77M8P3.
PhylomeDBi P50502.
TreeFami TF313244.

Miscellaneous databases

ChiTaRSi ST13. human.
GeneWikii ST13.
GenomeRNAii 6767.
NextBioi 26408.
PMAP-CutDB P50502.
PROi P50502.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50502.
Bgeei P50502.
CleanExi HS_ST13.
Genevestigatori P50502.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view ]
SMARTi SM00727. STI1. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein."
    Prapapanich V., Chen S., Nair S.C., Rimerman R.A., Smith D.F.
    Mol. Endocrinol. 10:420-431(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa."
    Mo Y., Zheng S., Shen D.
    Zhonghua Zhong Liu Za Zhi 18:241-243(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon mucosa.
  3. "Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening."
    Cao J., Cai X., Zheng L., Geng L., Shi Z., Pao C.C., Zheng S.
    J. Cancer Res. Clin. Oncol. 123:447-451(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon mucosa.
  4. "Identification of human aging-associated gene."
    Kim J.W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Testis.
  9. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 119-142; 147-153; 174-186 AND 211-222, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  10. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4."
    Barker B.L., Benovic J.L.
    Biochemistry 50:6933-6941(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-346, INTERACTION WITH GRK5.

Entry informationi

Entry nameiF10A1_HUMAN
AccessioniPrimary (citable) accession number: P50502
Secondary accession number(s): O14999, Q2TU77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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