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P50464

- UNC97_CAEEL

UniProt

P50464 - UNC97_CAEEL

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Protein

LIM domain-containing protein unc-97

Gene

unc-97

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.

GO - Molecular functioni

  1. myosin binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell-cell junction organization Source: WormBase
  2. muscle organ development Source: WormBase
  3. sensory perception of mechanical stimulus Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein unc-97
Alternative name(s):
PINCH homolog
Uncoordinated protein 97
Gene namesi
Name:unc-97
ORF Names:F14D12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF14D12.2; CE04392; WBGene00006826; unc-97.

Subcellular locationi

GO - Cellular componenti

  1. adherens junction Source: WormBase
  2. M band Source: WormBase
  3. nucleus Source: WormBase
  4. striated muscle dense body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348LIM domain-containing protein unc-97PRO_0000075909Add
BLAST

Proteomic databases

PaxDbiP50464.

Expressioni

Tissue specificityi

Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.

Interactioni

Subunit structurei

Interacts with unc-98.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rsu-1Q094975EBI-319593,EBI-319599

Protein-protein interaction databases

BioGridi45760. 8 interactions.
DIPiDIP-24818N.
IntActiP50464. 5 interactions.
MINTiMINT-1050203.
STRINGi6239.F14D12.2.1.

Structurei

3D structure databases

ProteinModelPortaliP50464.
SMRiP50464. Positions 14-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7353LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini82 – 13251LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 19651LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST
Domaini205 – 25551LIM zinc-binding 4PROSITE-ProRule annotationAdd
BLAST
Domaini264 – 31552LIM zinc-binding 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG263350.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000253950.
InParanoidiP50464.
OMAiECFRCEL.
OrthoDBiEOG7GBFX3.
PhylomeDBiP50464.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24210. PTHR24210. 1 hit.
PfamiPF00412. LIM. 5 hits.
[Graphical view]
PIRSFiPIRSF038003. PINCH. 1 hit.
SMARTiSM00132. LIM. 5 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50464-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDHNHING DLAHGFENMV CVRCNDGFSM QDQMVNSSGQ VWHSECFVCA
60 70 80 90 100
QCFEPFPDGI YFEYEGRKYC EHDFHVLFSP CCGKCNEFIV GRVIKAMNAS
110 120 130 140 150
WHPGCFCCEI CNKQLADVGF LRNAGRALCR ECNEREKAAG HGRYVCHKCH
160 170 180 190 200
AMIDDGQHIK FRGDSFHPYH FKCKRCNNEL TTASREVNGE LYCLRCHDTM
210 220 230 240 250
GIPICGACHR PIEERVIAAL GKHWHVEHFV CSVCEKPFLG HRHYERKGLP
260 270 280 290 300
YCEQHFHKLF GNLCFKCGDP CCGEVFQALQ KTWCVKCFSC SFCDKKLDQK
310 320 330 340
TKFYEFDMKP TCKRCYDRFP TELKKRISES LKDRDVENQR RSMSPGPK
Length:348
Mass (Da):40,308
Last modified:October 1, 1996 - v1
Checksum:i0CD22C39628ECEDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035583 mRNA. Translation: AAD09435.1.
FO080820 Genomic DNA. Translation: CCD83467.1.
PIRiT16076.
RefSeqiNP_508943.3. NM_076542.5.
UniGeneiCel.19566.

Genome annotation databases

EnsemblMetazoaiF14D12.2.1; F14D12.2.1; WBGene00006826.
F14D12.2.2; F14D12.2.2; WBGene00006826.
GeneIDi180827.
KEGGicel:CELE_F14D12.2.
UCSCiF14D12.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035583 mRNA. Translation: AAD09435.1 .
FO080820 Genomic DNA. Translation: CCD83467.1 .
PIRi T16076.
RefSeqi NP_508943.3. NM_076542.5.
UniGenei Cel.19566.

3D structure databases

ProteinModelPortali P50464.
SMRi P50464. Positions 14-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45760. 8 interactions.
DIPi DIP-24818N.
IntActi P50464. 5 interactions.
MINTi MINT-1050203.
STRINGi 6239.F14D12.2.1.

Proteomic databases

PaxDbi P50464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F14D12.2.1 ; F14D12.2.1 ; WBGene00006826 .
F14D12.2.2 ; F14D12.2.2 ; WBGene00006826 .
GeneIDi 180827.
KEGGi cel:CELE_F14D12.2.
UCSCi F14D12.2.1. c. elegans.

Organism-specific databases

CTDi 180827.
WormBasei F14D12.2 ; CE04392 ; WBGene00006826 ; unc-97.

Phylogenomic databases

eggNOGi NOG263350.
GeneTreei ENSGT00760000118910.
HOGENOMi HOG000253950.
InParanoidi P50464.
OMAi ECFRCEL.
OrthoDBi EOG7GBFX3.
PhylomeDBi P50464.

Miscellaneous databases

NextBioi 911142.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view ]
PANTHERi PTHR24210. PTHR24210. 1 hit.
Pfami PF00412. LIM. 5 hits.
[Graphical view ]
PIRSFi PIRSF038003. PINCH. 1 hit.
SMARTi SM00132. LIM. 5 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans."
    Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G.
    J. Cell Biol. 144:45-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes."
    Mercer K.B., Flaherty D.B., Miller R.K., Qadota H., Tinley T.L., Moerman D.G., Benian G.M.
    Mol. Biol. Cell 14:2492-2507(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UNC-98.

Entry informationi

Entry nameiUNC97_CAEEL
AccessioniPrimary (citable) accession number: P50464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3