SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P50464

- UNC97_CAEEL

UniProt

P50464 - UNC97_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
LIM domain-containing protein unc-97
Gene
unc-97, F14D12.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.

GO - Molecular functioni

  1. myosin binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell-cell junction organization Source: WormBase
  2. muscle organ development Source: WormBase
  3. sensory perception of mechanical stimulus Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein unc-97
Alternative name(s):
PINCH homolog
Uncoordinated protein 97
Gene namesi
Name:unc-97
ORF Names:F14D12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF14D12.2; CE04392; WBGene00006826; unc-97.

Subcellular locationi

GO - Cellular componenti

  1. M band Source: WormBase
  2. adherens junction Source: WormBase
  3. nucleus Source: WormBase
  4. striated muscle dense body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348LIM domain-containing protein unc-97
PRO_0000075909Add
BLAST

Proteomic databases

PaxDbiP50464.

Expressioni

Tissue specificityi

Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.

Interactioni

Subunit structurei

Interacts with unc-98.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rsu-1Q094975EBI-319593,EBI-319599

Protein-protein interaction databases

BioGridi45760. 8 interactions.
DIPiDIP-24818N.
IntActiP50464. 5 interactions.
MINTiMINT-1050203.
STRINGi6239.F14D12.2.1.

Structurei

3D structure databases

ProteinModelPortaliP50464.
SMRiP50464. Positions 14-317.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7353LIM zinc-binding 1
Add
BLAST
Domaini82 – 13251LIM zinc-binding 2
Add
BLAST
Domaini146 – 19651LIM zinc-binding 3
Add
BLAST
Domaini205 – 25551LIM zinc-binding 4
Add
BLAST
Domaini264 – 31552LIM zinc-binding 5
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG263350.
GeneTreeiENSGT00740000115292.
HOGENOMiHOG000253950.
InParanoidiP50464.
OMAiECFRCEL.
OrthoDBiEOG7GBFX3.
PhylomeDBiP50464.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24210. PTHR24210. 1 hit.
PfamiPF00412. LIM. 5 hits.
[Graphical view]
PIRSFiPIRSF038003. PINCH. 1 hit.
SMARTiSM00132. LIM. 5 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50464-1 [UniParc]FASTAAdd to Basket

« Hide

MDSDHNHING DLAHGFENMV CVRCNDGFSM QDQMVNSSGQ VWHSECFVCA    50
QCFEPFPDGI YFEYEGRKYC EHDFHVLFSP CCGKCNEFIV GRVIKAMNAS 100
WHPGCFCCEI CNKQLADVGF LRNAGRALCR ECNEREKAAG HGRYVCHKCH 150
AMIDDGQHIK FRGDSFHPYH FKCKRCNNEL TTASREVNGE LYCLRCHDTM 200
GIPICGACHR PIEERVIAAL GKHWHVEHFV CSVCEKPFLG HRHYERKGLP 250
YCEQHFHKLF GNLCFKCGDP CCGEVFQALQ KTWCVKCFSC SFCDKKLDQK 300
TKFYEFDMKP TCKRCYDRFP TELKKRISES LKDRDVENQR RSMSPGPK 348
Length:348
Mass (Da):40,308
Last modified:October 1, 1996 - v1
Checksum:i0CD22C39628ECEDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035583 mRNA. Translation: AAD09435.1.
FO080820 Genomic DNA. Translation: CCD83467.1.
PIRiT16076.
RefSeqiNP_508943.3. NM_076542.5.
UniGeneiCel.19566.

Genome annotation databases

EnsemblMetazoaiF14D12.2.1; F14D12.2.1; WBGene00006826.
F14D12.2.2; F14D12.2.2; WBGene00006826.
GeneIDi180827.
KEGGicel:CELE_F14D12.2.
UCSCiF14D12.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035583 mRNA. Translation: AAD09435.1 .
FO080820 Genomic DNA. Translation: CCD83467.1 .
PIRi T16076.
RefSeqi NP_508943.3. NM_076542.5.
UniGenei Cel.19566.

3D structure databases

ProteinModelPortali P50464.
SMRi P50464. Positions 14-317.
ModBasei Search...

Protein-protein interaction databases

BioGridi 45760. 8 interactions.
DIPi DIP-24818N.
IntActi P50464. 5 interactions.
MINTi MINT-1050203.
STRINGi 6239.F14D12.2.1.

Proteomic databases

PaxDbi P50464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F14D12.2.1 ; F14D12.2.1 ; WBGene00006826 .
F14D12.2.2 ; F14D12.2.2 ; WBGene00006826 .
GeneIDi 180827.
KEGGi cel:CELE_F14D12.2.
UCSCi F14D12.2.1. c. elegans.

Organism-specific databases

CTDi 180827.
WormBasei F14D12.2 ; CE04392 ; WBGene00006826 ; unc-97.

Phylogenomic databases

eggNOGi NOG263350.
GeneTreei ENSGT00740000115292.
HOGENOMi HOG000253950.
InParanoidi P50464.
OMAi ECFRCEL.
OrthoDBi EOG7GBFX3.
PhylomeDBi P50464.

Miscellaneous databases

NextBioi 911142.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view ]
PANTHERi PTHR24210. PTHR24210. 1 hit.
Pfami PF00412. LIM. 5 hits.
[Graphical view ]
PIRSFi PIRSF038003. PINCH. 1 hit.
SMARTi SM00132. LIM. 5 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans."
    Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G.
    J. Cell Biol. 144:45-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes."
    Mercer K.B., Flaherty D.B., Miller R.K., Qadota H., Tinley T.L., Moerman D.G., Benian G.M.
    Mol. Biol. Cell 14:2492-2507(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UNC-98.

Entry informationi

Entry nameiUNC97_CAEEL
AccessioniPrimary (citable) accession number: P50464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi