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P50464

- UNC97_CAEEL

UniProt

P50464 - UNC97_CAEEL

Protein

LIM domain-containing protein unc-97

Gene

unc-97

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.

    GO - Molecular functioni

    1. myosin binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell-cell junction organization Source: WormBase
    2. muscle organ development Source: WormBase
    3. sensory perception of mechanical stimulus Source: WormBase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM domain-containing protein unc-97
    Alternative name(s):
    PINCH homolog
    Uncoordinated protein 97
    Gene namesi
    Name:unc-97
    ORF Names:F14D12.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF14D12.2; CE04392; WBGene00006826; unc-97.

    Subcellular locationi

    GO - Cellular componenti

    1. adherens junction Source: WormBase
    2. M band Source: WormBase
    3. nucleus Source: WormBase
    4. striated muscle dense body Source: WormBase

    Keywords - Cellular componenti

    Cell junction, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348LIM domain-containing protein unc-97PRO_0000075909Add
    BLAST

    Proteomic databases

    PaxDbiP50464.

    Expressioni

    Tissue specificityi

    Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.

    Interactioni

    Subunit structurei

    Interacts with unc-98.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    rsu-1Q094975EBI-319593,EBI-319599

    Protein-protein interaction databases

    BioGridi45760. 8 interactions.
    DIPiDIP-24818N.
    IntActiP50464. 5 interactions.
    MINTiMINT-1050203.
    STRINGi6239.F14D12.2.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP50464.
    SMRiP50464. Positions 14-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 7353LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini82 – 13251LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini146 – 19651LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 25551LIM zinc-binding 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini264 – 31552LIM zinc-binding 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG263350.
    GeneTreeiENSGT00740000115292.
    HOGENOMiHOG000253950.
    InParanoidiP50464.
    OMAiECFRCEL.
    OrthoDBiEOG7GBFX3.
    PhylomeDBiP50464.

    Family and domain databases

    Gene3Di2.10.110.10. 5 hits.
    InterProiIPR017351. PINCH.
    IPR001781. Znf_LIM.
    [Graphical view]
    PANTHERiPTHR24210. PTHR24210. 1 hit.
    PfamiPF00412. LIM. 5 hits.
    [Graphical view]
    PIRSFiPIRSF038003. PINCH. 1 hit.
    SMARTiSM00132. LIM. 5 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50464-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDHNHING DLAHGFENMV CVRCNDGFSM QDQMVNSSGQ VWHSECFVCA    50
    QCFEPFPDGI YFEYEGRKYC EHDFHVLFSP CCGKCNEFIV GRVIKAMNAS 100
    WHPGCFCCEI CNKQLADVGF LRNAGRALCR ECNEREKAAG HGRYVCHKCH 150
    AMIDDGQHIK FRGDSFHPYH FKCKRCNNEL TTASREVNGE LYCLRCHDTM 200
    GIPICGACHR PIEERVIAAL GKHWHVEHFV CSVCEKPFLG HRHYERKGLP 250
    YCEQHFHKLF GNLCFKCGDP CCGEVFQALQ KTWCVKCFSC SFCDKKLDQK 300
    TKFYEFDMKP TCKRCYDRFP TELKKRISES LKDRDVENQR RSMSPGPK 348
    Length:348
    Mass (Da):40,308
    Last modified:October 1, 1996 - v1
    Checksum:i0CD22C39628ECEDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035583 mRNA. Translation: AAD09435.1.
    FO080820 Genomic DNA. Translation: CCD83467.1.
    PIRiT16076.
    RefSeqiNP_508943.3. NM_076542.5.
    UniGeneiCel.19566.

    Genome annotation databases

    EnsemblMetazoaiF14D12.2.1; F14D12.2.1; WBGene00006826.
    F14D12.2.2; F14D12.2.2; WBGene00006826.
    GeneIDi180827.
    KEGGicel:CELE_F14D12.2.
    UCSCiF14D12.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035583 mRNA. Translation: AAD09435.1 .
    FO080820 Genomic DNA. Translation: CCD83467.1 .
    PIRi T16076.
    RefSeqi NP_508943.3. NM_076542.5.
    UniGenei Cel.19566.

    3D structure databases

    ProteinModelPortali P50464.
    SMRi P50464. Positions 14-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45760. 8 interactions.
    DIPi DIP-24818N.
    IntActi P50464. 5 interactions.
    MINTi MINT-1050203.
    STRINGi 6239.F14D12.2.1.

    Proteomic databases

    PaxDbi P50464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F14D12.2.1 ; F14D12.2.1 ; WBGene00006826 .
    F14D12.2.2 ; F14D12.2.2 ; WBGene00006826 .
    GeneIDi 180827.
    KEGGi cel:CELE_F14D12.2.
    UCSCi F14D12.2.1. c. elegans.

    Organism-specific databases

    CTDi 180827.
    WormBasei F14D12.2 ; CE04392 ; WBGene00006826 ; unc-97.

    Phylogenomic databases

    eggNOGi NOG263350.
    GeneTreei ENSGT00740000115292.
    HOGENOMi HOG000253950.
    InParanoidi P50464.
    OMAi ECFRCEL.
    OrthoDBi EOG7GBFX3.
    PhylomeDBi P50464.

    Miscellaneous databases

    NextBioi 911142.

    Family and domain databases

    Gene3Di 2.10.110.10. 5 hits.
    InterProi IPR017351. PINCH.
    IPR001781. Znf_LIM.
    [Graphical view ]
    PANTHERi PTHR24210. PTHR24210. 1 hit.
    Pfami PF00412. LIM. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF038003. PINCH. 1 hit.
    SMARTi SM00132. LIM. 5 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans."
      Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G.
      J. Cell Biol. 144:45-57(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes."
      Mercer K.B., Flaherty D.B., Miller R.K., Qadota H., Tinley T.L., Moerman D.G., Benian G.M.
      Mol. Biol. Cell 14:2492-2507(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UNC-98.

    Entry informationi

    Entry nameiUNC97_CAEEL
    AccessioniPrimary (citable) accession number: P50464
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3