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Protein

LIM domain-containing protein unc-97

Gene

unc-97

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • myosin binding Source: UniProtKB

GO - Biological processi

  • cell-cell junction organization Source: WormBase
  • muscle organ development Source: WormBase
  • sensory perception of mechanical stimulus Source: WormBase

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein unc-97
Alternative name(s):
PINCH homolog
Uncoordinated protein 97
Gene namesi
Name:unc-97
ORF Names:F14D12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF14D12.2 ; CE04392 ; WBGene00006826 ; unc-97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759091 – 348LIM domain-containing protein unc-97Add BLAST348

Proteomic databases

EPDiP50464
PaxDbiP50464
PeptideAtlasiP50464
PRIDEiP50464

Expressioni

Tissue specificityi

Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.

Gene expression databases

BgeeiWBGene00006826

Interactioni

Subunit structurei

Interacts with unc-98.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rsu-1Q094975EBI-319593,EBI-319599

GO - Molecular functioni

  • myosin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi45760, 8 interactors
DIPiDIP-24818N
IntActiP50464, 10 interactors
STRINGi6239.F14D12.2.1

Structurei

3D structure databases

ProteinModelPortaliP50464
SMRiP50464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 73LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini82 – 132LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST51
Domaini146 – 196LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini205 – 255LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST51
Domaini264 – 315LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
InParanoidiP50464
OMAiCRECNER
OrthoDBiEOG091G08K3
PhylomeDBiP50464

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

P50464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDHNHING DLAHGFENMV CVRCNDGFSM QDQMVNSSGQ VWHSECFVCA
60 70 80 90 100
QCFEPFPDGI YFEYEGRKYC EHDFHVLFSP CCGKCNEFIV GRVIKAMNAS
110 120 130 140 150
WHPGCFCCEI CNKQLADVGF LRNAGRALCR ECNEREKAAG HGRYVCHKCH
160 170 180 190 200
AMIDDGQHIK FRGDSFHPYH FKCKRCNNEL TTASREVNGE LYCLRCHDTM
210 220 230 240 250
GIPICGACHR PIEERVIAAL GKHWHVEHFV CSVCEKPFLG HRHYERKGLP
260 270 280 290 300
YCEQHFHKLF GNLCFKCGDP CCGEVFQALQ KTWCVKCFSC SFCDKKLDQK
310 320 330 340
TKFYEFDMKP TCKRCYDRFP TELKKRISES LKDRDVENQR RSMSPGPK
Length:348
Mass (Da):40,308
Last modified:October 1, 1996 - v1
Checksum:i0CD22C39628ECEDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035583 mRNA Translation: AAD09435.1
FO080820 Genomic DNA Translation: CCD83467.1
PIRiT16076
RefSeqiNP_508943.3, NM_076542.5
UniGeneiCel.19566

Genome annotation databases

EnsemblMetazoaiF14D12.2.1; F14D12.2.1; WBGene00006826
F14D12.2.2; F14D12.2.2; WBGene00006826
GeneIDi180827
KEGGicel:CELE_F14D12.2
UCSCiF14D12.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiUNC97_CAEEL
AccessioniPrimary (citable) accession number: P50464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health