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P50464 (UNC97_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM domain-containing protein unc-97
Alternative name(s):
PINCH homolog
Uncoordinated protein 97
Gene names
Name:unc-97
ORF Names:F14D12.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.

Subunit structure

Interacts with unc-98. Ref.3

Subcellular location

Cell junctionadherens junction. Nucleus.

Tissue specificity

Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.

Sequence similarities

Contains 5 LIM zinc-binding domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

rsu-1Q094975EBI-319593,EBI-319599

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348LIM domain-containing protein unc-97
PRO_0000075909

Regions

Domain21 – 7353LIM zinc-binding 1
Domain82 – 13251LIM zinc-binding 2
Domain146 – 19651LIM zinc-binding 3
Domain205 – 25551LIM zinc-binding 4
Domain264 – 31552LIM zinc-binding 5

Sequences

Sequence LengthMass (Da)Tools
P50464 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0CD22C39628ECEDA

FASTA34840,308
        10         20         30         40         50         60 
MDSDHNHING DLAHGFENMV CVRCNDGFSM QDQMVNSSGQ VWHSECFVCA QCFEPFPDGI 

        70         80         90        100        110        120 
YFEYEGRKYC EHDFHVLFSP CCGKCNEFIV GRVIKAMNAS WHPGCFCCEI CNKQLADVGF 

       130        140        150        160        170        180 
LRNAGRALCR ECNEREKAAG HGRYVCHKCH AMIDDGQHIK FRGDSFHPYH FKCKRCNNEL 

       190        200        210        220        230        240 
TTASREVNGE LYCLRCHDTM GIPICGACHR PIEERVIAAL GKHWHVEHFV CSVCEKPFLG 

       250        260        270        280        290        300 
HRHYERKGLP YCEQHFHKLF GNLCFKCGDP CCGEVFQALQ KTWCVKCFSC SFCDKKLDQK 

       310        320        330        340 
TKFYEFDMKP TCKRCYDRFP TELKKRISES LKDRDVENQR RSMSPGPK 

« Hide

References

« Hide 'large scale' references
[1]"A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans."
Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G.
J. Cell Biol. 144:45-57(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes."
Mercer K.B., Flaherty D.B., Miller R.K., Qadota H., Tinley T.L., Moerman D.G., Benian G.M.
Mol. Biol. Cell 14:2492-2507(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UNC-98.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF035583 mRNA. Translation: AAD09435.1.
FO080820 Genomic DNA. Translation: CCD83467.1.
PIRT16076.
RefSeqNP_508943.3. NM_076542.5.
UniGeneCel.19566.

3D structure databases

ProteinModelPortalP50464.
SMRP50464. Positions 14-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45760. 8 interactions.
DIPDIP-24818N.
IntActP50464. 5 interactions.
MINTMINT-1050203.
STRING6239.F14D12.2.1.

Proteomic databases

PaxDbP50464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF14D12.2.1; F14D12.2.1; WBGene00006826.
F14D12.2.2; F14D12.2.2; WBGene00006826.
GeneID180827.
KEGGcel:CELE_F14D12.2.
UCSCF14D12.2.1. c. elegans.

Organism-specific databases

CTD180827.
WormBaseF14D12.2; CE04392; WBGene00006826; unc-97.

Phylogenomic databases

eggNOGNOG263350.
GeneTreeENSGT00740000115292.
HOGENOMHOG000253950.
InParanoidP50464.
OMAECFRCEL.
OrthoDBEOG7GBFX3.
PhylomeDBP50464.

Family and domain databases

Gene3D2.10.110.10. 5 hits.
InterProIPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERPTHR24210. PTHR24210. 1 hit.
PfamPF00412. LIM. 5 hits.
[Graphical view]
PIRSFPIRSF038003. PINCH. 1 hit.
SMARTSM00132. LIM. 5 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio911142.

Entry information

Entry nameUNC97_CAEEL
AccessionPrimary (citable) accession number: P50464
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase