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Protein

LIM/homeobox protein Lhx2

Gene

LHX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP50458.

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:LHX2
Synonyms:LH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:6594. LHX2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9355.
OpenTargetsiENSG00000106689.
PharmGKBiPA30365.

Polymorphism and mutation databases

BioMutaiLHX2.
DMDMi8247936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757781 – 406LIM/homeobox protein Lhx2Add BLAST406

Proteomic databases

PaxDbiP50458.
PeptideAtlasiP50458.
PRIDEiP50458.

PTM databases

iPTMnetiP50458.
PhosphoSitePlusiP50458.

Expressioni

Gene expression databases

BgeeiENSG00000106689.
CleanExiHS_LHX2.
ExpressionAtlasiP50458. baseline and differential.
GenevisibleiP50458. HS.

Organism-specific databases

HPAiHPA000838.

Interactioni

Subunit structurei

Interacts (via LIM domains) with CITED2. Interacts with POU4F2.By similarity

Protein-protein interaction databases

BioGridi114758. 5 interactors.
IntActiP50458. 24 interactors.
MINTiMINT-112470.
STRINGi9606.ENSP00000362717.

Structurei

3D structure databases

ProteinModelPortaliP50458.
SMRiP50458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini115 – 168LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 323Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 196Poly-Ala10

Domaini

LIM domains are necessary for transcription activation.By similarity

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiP50458.
KOiK09373.
PhylomeDBiP50458.
TreeFamiTF315442.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P50458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,373
Last modified:May 30, 2000 - v2
Checksum:iDF73AAC81867D30D
GO

Sequence cautioni

The sequence BAC04371 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 28AKSEAPA → QERGSR in AAB08752 (PubMed:8649822).Curated7
Sequence conflicti54A → G in AAB08752 (PubMed:8649822).Curated1
Sequence conflicti107Y → YSPSLHGPY (PubMed:14702039).Curated1
Sequence conflicti187A → Q (PubMed:8649822).Curated1
Sequence conflicti190 – 192AAA → RAR (PubMed:8649822).Curated3
Sequence conflicti196Missing (PubMed:8649822).Curated1
Sequence conflicti241 – 242NA → TR in AAB08752 (PubMed:8649822).Curated2
Sequence conflicti391 – 406GHEPH…LTNLF → AMSLTAPHKRLLPTFSNDSQ PPHPTISLKKKLSLV in AAB08752 (PubMed:8649822).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11701 mRNA. Translation: AAB08752.1.
BC093662 mRNA. Translation: AAH93662.1.
BC112185 mRNA. Translation: AAI12186.1.
AK094511 mRNA. Translation: BAC04371.1. Different initiation.
AF124735 mRNA. Translation: AAD20013.1.
CCDSiCCDS6853.1.
RefSeqiNP_004780.3. NM_004789.3.
UniGeneiHs.696425.

Genome annotation databases

EnsembliENST00000373615; ENSP00000362717; ENSG00000106689.
GeneIDi9355.
KEGGihsa:9355.
UCSCiuc004boe.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11701 mRNA. Translation: AAB08752.1.
BC093662 mRNA. Translation: AAH93662.1.
BC112185 mRNA. Translation: AAI12186.1.
AK094511 mRNA. Translation: BAC04371.1. Different initiation.
AF124735 mRNA. Translation: AAD20013.1.
CCDSiCCDS6853.1.
RefSeqiNP_004780.3. NM_004789.3.
UniGeneiHs.696425.

3D structure databases

ProteinModelPortaliP50458.
SMRiP50458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114758. 5 interactors.
IntActiP50458. 24 interactors.
MINTiMINT-112470.
STRINGi9606.ENSP00000362717.

PTM databases

iPTMnetiP50458.
PhosphoSitePlusiP50458.

Polymorphism and mutation databases

BioMutaiLHX2.
DMDMi8247936.

Proteomic databases

PaxDbiP50458.
PeptideAtlasiP50458.
PRIDEiP50458.

Protocols and materials databases

DNASUi9355.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373615; ENSP00000362717; ENSG00000106689.
GeneIDi9355.
KEGGihsa:9355.
UCSCiuc004boe.2. human.

Organism-specific databases

CTDi9355.
DisGeNETi9355.
GeneCardsiLHX2.
HGNCiHGNC:6594. LHX2.
HPAiHPA000838.
MIMi603759. gene.
neXtProtiNX_P50458.
OpenTargetsiENSG00000106689.
PharmGKBiPA30365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiP50458.
KOiK09373.
PhylomeDBiP50458.
TreeFamiTF315442.

Enzyme and pathway databases

SIGNORiP50458.

Miscellaneous databases

ChiTaRSiLHX2. human.
GeneWikiiLHX2.
GenomeRNAii9355.
PROiPR:P50458.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106689.
CleanExiHS_LHX2.
ExpressionAtlasiP50458. baseline and differential.
GenevisibleiP50458. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiLHX2_HUMAN
AccessioniPrimary (citable) accession number: P50458
Secondary accession number(s): O95860, Q52M57, Q8N1Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: May 10, 2017
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.