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P50458

- LHX2_HUMAN

UniProt

P50458 - LHX2_HUMAN

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Protein

LIM/homeobox protein Lhx2

Gene
LHX2, LH2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi266 – 32560HomeoboxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. cerebral cortex development Source: Ensembl
  3. dorsal/ventral pattern formation Source: Ensembl
  4. mesoderm development Source: Ensembl
  5. negative regulation of transcription regulatory region DNA binding Source: Ensembl
  6. neural tube closure Source: Ensembl
  7. olfactory bulb development Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. telencephalon regionalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx2
Short name:
Homeobox protein LH-2
Short name:
LIM homeobox protein 2
Gene namesi
Name:LHX2
Synonyms:LH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:6594. LHX2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406LIM/homeobox protein Lhx2PRO_0000075778Add
BLAST

Proteomic databases

PaxDbiP50458.
PRIDEiP50458.

PTM databases

PhosphoSiteiP50458.

Expressioni

Gene expression databases

ArrayExpressiP50458.
BgeeiP50458.
CleanExiHS_LHX2.
GenevestigatoriP50458.

Interactioni

Subunit structurei

interacts (via LIM domains) with CITED2 By similarity.

Protein-protein interaction databases

BioGridi114758. 4 interactions.
MINTiMINT-112470.
STRINGi9606.ENSP00000362717.

Structurei

3D structure databases

ProteinModelPortaliP50458.
SMRiP50458. Positions 53-165, 262-333.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 10553LIM zinc-binding 1Add
BLAST
Domaini115 – 16854LIM zinc-binding 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 32317Nuclear localization signal Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 19610Poly-Ala

Domaini

LIM domains are necessary for transcription activation By similarity.

Sequence similaritiesi

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiCOG5576.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiP50458.
KOiK09373.
PhylomeDBiP50458.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50458-1 [UniParc]FASTAAdd to Basket

« Hide

MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA    50
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI 100
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML 150
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG 200
LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND 250
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 300
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA 350
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT 400
TLTNLF 406
Length:406
Mass (Da):44,373
Last modified:May 30, 2000 - v2
Checksum:iDF73AAC81867D30D
GO

Sequence cautioni

The sequence BAC04371.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 287AKSEAPA → QERGSR in AAB08752. 1 Publication
Sequence conflicti54 – 541A → G in AAB08752. 1 Publication
Sequence conflicti107 – 1071Y → YSPSLHGPY1 Publication
Sequence conflicti187 – 1871A → Q1 Publication
Sequence conflicti190 – 1923AAA → RAR1 Publication
Sequence conflicti196 – 1961Missing1 Publication
Sequence conflicti241 – 2422NA → TR in AAB08752. 1 Publication
Sequence conflicti391 – 40616GHEPH…LTNLF → AMSLTAPHKRLLPTFSNDSQ PPHPTISLKKKLSLV in AAB08752. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11701 mRNA. Translation: AAB08752.1.
BC093662 mRNA. Translation: AAH93662.1.
BC112185 mRNA. Translation: AAI12186.1.
AK094511 mRNA. Translation: BAC04371.1. Different initiation.
AF124735 mRNA. Translation: AAD20013.1.
CCDSiCCDS6853.1.
RefSeqiNP_004780.3. NM_004789.3.
UniGeneiHs.696425.

Genome annotation databases

EnsembliENST00000373615; ENSP00000362717; ENSG00000106689.
GeneIDi9355.
KEGGihsa:9355.
UCSCiuc004boe.1. human.

Polymorphism databases

DMDMi8247936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11701 mRNA. Translation: AAB08752.1 .
BC093662 mRNA. Translation: AAH93662.1 .
BC112185 mRNA. Translation: AAI12186.1 .
AK094511 mRNA. Translation: BAC04371.1 . Different initiation.
AF124735 mRNA. Translation: AAD20013.1 .
CCDSi CCDS6853.1.
RefSeqi NP_004780.3. NM_004789.3.
UniGenei Hs.696425.

3D structure databases

ProteinModelPortali P50458.
SMRi P50458. Positions 53-165, 262-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114758. 4 interactions.
MINTi MINT-112470.
STRINGi 9606.ENSP00000362717.

PTM databases

PhosphoSitei P50458.

Polymorphism databases

DMDMi 8247936.

Proteomic databases

PaxDbi P50458.
PRIDEi P50458.

Protocols and materials databases

DNASUi 9355.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373615 ; ENSP00000362717 ; ENSG00000106689 .
GeneIDi 9355.
KEGGi hsa:9355.
UCSCi uc004boe.1. human.

Organism-specific databases

CTDi 9355.
GeneCardsi GC09P126763.
HGNCi HGNC:6594. LHX2.
MIMi 603759. gene.
neXtProti NX_P50458.
PharmGKBi PA30365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5576.
HOGENOMi HOG000034022.
HOVERGENi HBG006262.
InParanoidi P50458.
KOi K09373.
PhylomeDBi P50458.
TreeFami TF315442.

Miscellaneous databases

ChiTaRSi LHX2. human.
GeneWikii LHX2.
GenomeRNAii 9355.
NextBioi 35033.
PROi P50458.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50458.
Bgeei P50458.
CleanExi HS_LHX2.
Genevestigatori P50458.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1."
    Wu H.-K., Heng H.H.Q., Siderovski D.P., Dong W.-F., Okuno Y., Shi X.-M., Tsui L.-C., Minden M.D.
    Oncogene 12:1205-1212(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-406.
    Tissue: Brain cortex.
  4. "Conservation of the expression and function of apterous orthologs in Drosophila and mammals."
    Rincon-Limas D.E., Lu C.-H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J.-C., Botas J.
    Proc. Natl. Acad. Sci. U.S.A. 96:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-406.

Entry informationi

Entry nameiLHX2_HUMAN
AccessioniPrimary (citable) accession number: P50458
Secondary accession number(s): O95860, Q52M57, Q8N1Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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