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P50458

- LHX2_HUMAN

UniProt

P50458 - LHX2_HUMAN

Protein

LIM/homeobox protein Lhx2

Gene

LHX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. cerebral cortex development Source: Ensembl
    3. dorsal/ventral pattern formation Source: Ensembl
    4. mesoderm development Source: Ensembl
    5. negative regulation of transcription regulatory region DNA binding Source: Ensembl
    6. neural tube closure Source: Ensembl
    7. olfactory bulb development Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. telencephalon regionalization Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM/homeobox protein Lhx2
    Short name:
    Homeobox protein LH-2
    Short name:
    LIM homeobox protein 2
    Gene namesi
    Name:LHX2
    Synonyms:LH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:6594. LHX2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406LIM/homeobox protein Lhx2PRO_0000075778Add
    BLAST

    Proteomic databases

    PaxDbiP50458.
    PRIDEiP50458.

    PTM databases

    PhosphoSiteiP50458.

    Expressioni

    Gene expression databases

    ArrayExpressiP50458.
    BgeeiP50458.
    CleanExiHS_LHX2.
    GenevestigatoriP50458.

    Interactioni

    Subunit structurei

    interacts (via LIM domains) with CITED2.By similarity

    Protein-protein interaction databases

    BioGridi114758. 4 interactions.
    MINTiMINT-112470.
    STRINGi9606.ENSP00000362717.

    Structurei

    3D structure databases

    ProteinModelPortaliP50458.
    SMRiP50458. Positions 53-165, 262-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 10553LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini115 – 16854LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi307 – 32317Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi187 – 19610Poly-Ala

    Domaini

    LIM domains are necessary for transcription activation.By similarity

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiCOG5576.
    HOGENOMiHOG000034022.
    HOVERGENiHBG006262.
    InParanoidiP50458.
    KOiK09373.
    PhylomeDBiP50458.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50458-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA    50
    ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI 100
    YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML 150
    TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG 200
    LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND 250
    AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 300
    QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA 350
    SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT 400
    TLTNLF 406
    Length:406
    Mass (Da):44,373
    Last modified:May 30, 2000 - v2
    Checksum:iDF73AAC81867D30D
    GO

    Sequence cautioni

    The sequence BAC04371.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 287AKSEAPA → QERGSR in AAB08752. (PubMed:8649822)Curated
    Sequence conflicti54 – 541A → G in AAB08752. (PubMed:8649822)Curated
    Sequence conflicti107 – 1071Y → YSPSLHGPY(PubMed:14702039)Curated
    Sequence conflicti187 – 1871A → Q(PubMed:8649822)Curated
    Sequence conflicti190 – 1923AAA → RAR(PubMed:8649822)Curated
    Sequence conflicti196 – 1961Missing(PubMed:8649822)Curated
    Sequence conflicti241 – 2422NA → TR in AAB08752. (PubMed:8649822)Curated
    Sequence conflicti391 – 40616GHEPH…LTNLF → AMSLTAPHKRLLPTFSNDSQ PPHPTISLKKKLSLV in AAB08752. (PubMed:8649822)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11701 mRNA. Translation: AAB08752.1.
    BC093662 mRNA. Translation: AAH93662.1.
    BC112185 mRNA. Translation: AAI12186.1.
    AK094511 mRNA. Translation: BAC04371.1. Different initiation.
    AF124735 mRNA. Translation: AAD20013.1.
    CCDSiCCDS6853.1.
    RefSeqiNP_004780.3. NM_004789.3.
    UniGeneiHs.696425.

    Genome annotation databases

    EnsembliENST00000373615; ENSP00000362717; ENSG00000106689.
    GeneIDi9355.
    KEGGihsa:9355.
    UCSCiuc004boe.1. human.

    Polymorphism databases

    DMDMi8247936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11701 mRNA. Translation: AAB08752.1 .
    BC093662 mRNA. Translation: AAH93662.1 .
    BC112185 mRNA. Translation: AAI12186.1 .
    AK094511 mRNA. Translation: BAC04371.1 . Different initiation.
    AF124735 mRNA. Translation: AAD20013.1 .
    CCDSi CCDS6853.1.
    RefSeqi NP_004780.3. NM_004789.3.
    UniGenei Hs.696425.

    3D structure databases

    ProteinModelPortali P50458.
    SMRi P50458. Positions 53-165, 262-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114758. 4 interactions.
    MINTi MINT-112470.
    STRINGi 9606.ENSP00000362717.

    PTM databases

    PhosphoSitei P50458.

    Polymorphism databases

    DMDMi 8247936.

    Proteomic databases

    PaxDbi P50458.
    PRIDEi P50458.

    Protocols and materials databases

    DNASUi 9355.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373615 ; ENSP00000362717 ; ENSG00000106689 .
    GeneIDi 9355.
    KEGGi hsa:9355.
    UCSCi uc004boe.1. human.

    Organism-specific databases

    CTDi 9355.
    GeneCardsi GC09P126763.
    HGNCi HGNC:6594. LHX2.
    MIMi 603759. gene.
    neXtProti NX_P50458.
    PharmGKBi PA30365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5576.
    HOGENOMi HOG000034022.
    HOVERGENi HBG006262.
    InParanoidi P50458.
    KOi K09373.
    PhylomeDBi P50458.
    TreeFami TF315442.

    Miscellaneous databases

    ChiTaRSi LHX2. human.
    GeneWikii LHX2.
    GenomeRNAii 9355.
    NextBioi 35033.
    PROi P50458.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50458.
    Bgeei P50458.
    CleanExi HS_LHX2.
    Genevestigatori P50458.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1."
      Wu H.-K., Heng H.H.Q., Siderovski D.P., Dong W.-F., Okuno Y., Shi X.-M., Tsui L.-C., Minden M.D.
      Oncogene 12:1205-1212(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-406.
      Tissue: Brain cortex.
    4. "Conservation of the expression and function of apterous orthologs in Drosophila and mammals."
      Rincon-Limas D.E., Lu C.-H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J.-C., Botas J.
      Proc. Natl. Acad. Sci. U.S.A. 96:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-406.

    Entry informationi

    Entry nameiLHX2_HUMAN
    AccessioniPrimary (citable) accession number: P50458
    Secondary accession number(s): O95860, Q52M57, Q8N1Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3