P50458 (LHX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LIM/homeobox protein Lhx2
Short name=Homeobox protein LH-2
Short name=LIM homeobox protein 2

Gene names

Name:	LHX2
Synonyms:	LH2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types By similarity.
Subunit structure	interacts (via LIM domains) with CITED2 By similarity.
Subcellular location	Nucleus Probable.
Domain	LIM domains are necessary for transcription activation By similarity.
Sequence similarities	Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains.
Sequence caution	The sequence BAC04371.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox LIM domain Repeat
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara mesoderm development Inferred from electronic annotation. Source: Compara negative regulation of transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB telencephalon regionalization Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein binding transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	LIM/homeobox protein Lhx2		PRO_0000075778
Regions
	Domain	53 – 105	53	LIM zinc-binding 1
	Domain	115 – 168	54	LIM zinc-binding 2
	DNA binding	266 – 325	60	Homeobox
	Motif	307 – 323	17	Nuclear localization signal Potential
	Compositional bias	187 – 196	10	Poly-Ala
Experimental info
	Sequence conflict	22 – 28	7	AKSEAPA → QERGSR in AAB08752. Ref.1
	Sequence conflict	54	1	A → G in AAB08752. Ref.1
	Sequence conflict	107	1	Y → YSPSLHGPY Ref.3
	Sequence conflict	187	1	A → Q Ref.1
	Sequence conflict	190 – 192	3	AAA → RAR Ref.1
	Sequence conflict	196	1	Missing Ref.1
	Sequence conflict	241 – 242	2	NA → TR in AAB08752. Ref.1
	Sequence conflict	391 – 406	16	GHEPH…LTNLF → AMSLTAPHKRLLPTFSNDSQ PPHPTISLKKKLSLV in AAB08752. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P50458 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: DF73AAC81867D30D	FASTA	406	44,373
	10 20 30 40 50 60 MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA ALCAGCGGKI 70 80 90 100 110 120 SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI YCKEDYYRRF SVQRCARCHL 130 140 150 160 170 180 GISASEMVMR ARDLVYHLNC FTCTTCNKML TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH 190 200 210 220 230 240 FNHADVAAAA AAAAAAKSAG LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY 250 260 270 280 290 300 NAALSCNEND AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 310 320 330 340 350 360 QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA SELSNASLSP 370 380 390 400 SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT TLTNLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1." Wu H.-K., Heng H.H.Q., Siderovski D.P., Dong W.-F., Okuno Y., Shi X.-M., Tsui L.-C., Minden M.D. Oncogene 12:1205-1212(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-406. Tissue: Brain cortex.
[4]	"Conservation of the expression and function of apterous orthologs in Drosophila and mammals." Rincon-Limas D.E., Lu C.-H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J.-C., Botas J. Proc. Natl. Acad. Sci. U.S.A. 96:2165-2170(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-406.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11701 mRNA. Translation: AAB08752.1. BC093662 mRNA. Translation: AAH93662.1. BC112185 mRNA. Translation: AAI12186.1. AK094511 mRNA. Translation: BAC04371.1. Different initiation. AF124735 mRNA. Translation: AAD20013.1.
IPI	IPI00032144.
RefSeq	NP_004780.3. NM_004789.3.
UniGene	Hs.696425.
3D structure databases
ProteinModelPortal	P50458.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000362717.
PTM databases
PhosphoSite	P50458.
Polymorphism databases
DMDM	8247936.
Proteomic databases
PaxDb	P50458.
PRIDE	P50458.
Protocols and materials databases
DNASU	9355.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373615; ENSP00000362717; ENSG00000106689.
GeneID	9355.
KEGG	hsa:9355.
UCSC	uc004boe.1. human.
Organism-specific databases
CTD	9355.
GeneCards	GC09P126763.
HGNC	HGNC:6594. LHX2.
MIM	603759. gene.
neXtProt	NX_P50458.
PharmGKB	PA30365.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5576.
HOGENOM	HOG000034022.
HOVERGEN	HBG006262.
InParanoid	P50458.
KO	K09373.
OrthoDB	EOG4G4GQK.
PhylomeDB	P50458.
Gene expression databases
ArrayExpress	P50458.
Bgee	P50458.
CleanEx	HS_LHX2.
Genevestigator	P50458.
GermOnline	ENSG00000106689. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LHX2. human.
GenomeRNAi	9355.
NextBio	35033.
SOURCE	Search...

Entry information

Entry name

LHX2_HUMAN

Accession

Primary (citable) accession number: P50458
Secondary accession number(s): O95860, Q52M57, Q8N1Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.