Reviewed, UniProtKB/Swiss-Prot P50453 (SPB9_HUMAN)

Names and origin

Protein names

Recommended name:
    Serpin B9
Alternative name(s):
    Cytoplasmic antiproteinase 3
      Short name=CAP-3
      Short name=CAP3
    Proteinase inhibitor 9

Gene names

Name:	SERPINB9
Synonyms:	PI9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Granzyme B inhibitor.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Protease inhibitor Serine protease inhibitor
Gene Ontology (GO)
Biological process	anti-apoptosis Traceable author statement. Source: UniProtKB signal transduction Traceable author statement. Source: UniProtKB
Cellular component	cytosol Ref.2 Traceable author statement. Source: ProtInc
Molecular function	protein binding Ref.2 Traceable author statement. Source: ProtInc serine-type endopeptidase inhibitor activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Serpin B9		PRO_0000094113
Sites
	Site	340 – 341	2	Reactive bond By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50453-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: ECBA80869B939753	FASTA	376	42,404
	10 20 30 40 50 60 METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT ATQMAQALSL 70 80 90 100 110 120 NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF LSTFKESCLQ FYHAELKELS 130 140 150 160 170 180 FIRAAEESRK HINTWVSKKT EGKIEELLPG SSIDAETRLV LVNAIYFKGK WNEPFDETYT 190 200 210 220 230 240 REMPFKINQE EQRPVQMMYQ EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS 250 260 270 280 290 300 TVEKSLTFEK LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL 310 320 330 340 350 360 SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC ADHPFLFFIR 370 HNRANSILFC GRFSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors." Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W. J. Biol. Chem. 270:29854-29861(1995) [PubMed: 8530382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes." Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., Jong T.A., Trapani J.A., Bird P.I. J. Biol. Chem. 271:27802-27809(1996) [PubMed: 8910377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow and Placenta.
[3]	"Serine proteinase inhibitor 9 as a tumor antigen recognized by cytotoxic T lymphocytes of epithelial cancer patients." Tanaka K., Harashima N., Shichijo S., Harada M., Itoh K. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L40378 mRNA. Translation: AAC41940.1. U71364 mRNA. Translation: AAC50793.1. AB060690 mRNA. Translation: BAB91078.1. BT006673 mRNA. Translation: AAP35319.1. CR407627 mRNA. Translation: CAG28555.1. AL133351 Genomic DNA. Translation: CAI23290.1. CH471087 Genomic DNA. Translation: EAW55093.1. BC002538 mRNA. Translation: AAH02538.1.
PIR	B59273.
RefSeq	NP_004146.1.
UniGene	Hs.104879
3D structure databases
HSSP	HSSP built from PDB template 1JRR based on UniProtKB P05120.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50453.
Protein family/group databases
MEROPS	I04.014.
PTM databases
PhosphoSite	P50453.
2-D gel databases
OGP	P50453.
REPRODUCTION-2DPAGE	IPI00032139.
Proteomic databases
PeptideAtlas	P50453.
Genome annotation databases
Ensembl	ENSG00000170542. Homo sapiens. [Contig view]
GeneID	5272.
KEGG	hsa:5272.
Organism-specific databases
H-InvDB	HIX0005533. HIX0057760.
HGNC	HGNC:8955. SERPINB9.
MIM	601799. gene.
PharmGKB	PA35519.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P50453.
HOVERGEN	P50453.
Gene expression databases
ArrayExpress	P50453.
CleanEx	HS_SERPINB9.
GermOnline	ENSG00000170542. Homo sapiens.
Family and domain databases
InterPro	IPR000215. Protease_inhib_I4_serpin. IPR000240. SerpinB9_Maspin. [Graphical view]
PANTHER	PTHR11461. Prot_inh_serpin. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
PRINTS	PR00676. MASPIN.
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P50453.
NextBio	20372.
SOURCE	Search...

Entry information

Entry name

SPB9_HUMAN

Accession

Primary (citable) accession number: P50453
Secondary accession number(s): Q5TD03

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)