Reviewed,
UniProtKB/Swiss-Prot P50453 (SPB9_HUMAN)
Last modified
November 25, 2008.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Serpin B9 Alternative name(s): Cytoplasmic antiproteinase 3 Short name=CAP-3 Short name=CAP3 Proteinase inhibitor 9 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Granzyme B inhibitor. |
| Subcellular location | |
| Sequence similarities | Belongs to the serpin family. Ov-serpin subfamily. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Protease inhibitor Serine protease inhibitor |
Gene Ontology (GO) | |
| Biological process | anti-apoptosis Traceable author statement. Source: UniProtKB signal transductionTraceable author statement. Source: UniProtKB |
| Cellular component | cytosol Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Ref.2 Traceable author statement. Source: ProtInc serine-type endopeptidase inhibitor activity Ref.2Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors." Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W. J. Biol. Chem. 270:29854-29861(1995) [PubMed: 8530382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes." Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., Jong T.A., Trapani J.A., Bird P.I. J. Biol. Chem. 271:27802-27809(1996) [PubMed: 8910377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow and Placenta. |
| [3] | "Serine proteinase inhibitor 9 as a tumor antigen recognized by cytotoxic T lymphocytes of epithelial cancer patients." Tanaka K., Harashima N., Shichijo S., Harada M., Itoh K. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
Cross-references
Sequence databases | |
|---|---|
| L40378 mRNA. Translation: AAC41940.1. U71364 mRNA. Translation: AAC50793.1. AB060690 mRNA. Translation: BAB91078.1. BT006673 mRNA. Translation: AAP35319.1. CR407627 mRNA. Translation: CAG28555.1. AL133351 Genomic DNA. Translation: CAI23290.1. CH471087 Genomic DNA. Translation: EAW55093.1. BC002538 mRNA. Translation: AAH02538.1. | |
| PIR | B59273. |
| RefSeq | NP_004146.1. |
| UniGene | Hs.104879 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JRR based on UniProtKB P05120. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P50453. |
Protein family/group databases | |
| MEROPS | I04.014. |
PTM databases | |
| PhosphoSite | P50453. |
2-D gel databases | |
| OGP | P50453. |
| REPRODUCTION-2DPAGE | IPI00032139. |
Proteomic databases | |
| PeptideAtlas | P50453. |
Genome annotation databases | |
| Ensembl | ENSG00000170542. Homo sapiens. [Contig view] |
| GeneID | 5272. |
| KEGG | hsa:5272. |
Organism-specific databases | |
| H-InvDB | HIX0005533. HIX0057760. |
| HGNC | HGNC:8955. SERPINB9. |
| MIM | 601799. gene. |
| PharmGKB | PA35519. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P50453. |
| HOVERGEN | P50453. |
Gene expression databases | |
| ArrayExpress | P50453. |
| CleanEx | HS_SERPINB9. |
| GermOnline | ENSG00000170542. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000215. Protease_inhib_I4_serpin. IPR000240. SerpinB9_Maspin. [Graphical view] |
| PANTHER | PTHR11461. Prot_inh_serpin. 1 hit. |
| Pfam | PF00079. Serpin. 1 hit. [Graphical view] |
| PRINTS | PR00676. MASPIN. |
| SMART | SM00093. SERPIN. 1 hit. [Graphical view] |
| PROSITE | PS00284. SERPIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P50453. |
| NextBio | 20372. |
| SOURCE | Search... |
Entry information
| Entry name | SPB9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P50453 Secondary accession number(s): Q5TD03 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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