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P50453

- SPB9_HUMAN

UniProt

P50453 - SPB9_HUMAN

Protein

Serpin B9

Gene

SERPINB9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Granzyme B inhibitor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei340 – 3412Reactive bondBy similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    2. protease binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to estrogen stimulus Source: UniProtKB
    2. immune response Source: UniProtKB
    3. mast cell mediated immunity Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
    6. negative regulation of endopeptidase activity Source: RefGenome
    7. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B9
    Alternative name(s):
    Cytoplasmic antiproteinase 3
    Short name:
    CAP-3
    Short name:
    CAP3
    Peptidase inhibitor 9
    Short name:
    PI-9
    Gene namesi
    Name:SERPINB9
    Synonyms:PI9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8955. SERPINB9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35519.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Serpin B9PRO_0000094113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP50453.
    PaxDbiP50453.
    PeptideAtlasiP50453.
    PRIDEiP50453.

    2D gel databases

    OGPiP50453.
    REPRODUCTION-2DPAGEIPI00032139.

    PTM databases

    PhosphoSiteiP50453.

    Expressioni

    Gene expression databases

    ArrayExpressiP50453.
    BgeeiP50453.
    CleanExiHS_SERPINB9.
    GenevestigatoriP50453.

    Organism-specific databases

    HPAiHPA030067.

    Interactioni

    Protein-protein interaction databases

    BioGridi111290. 29 interactions.
    IntActiP50453. 25 interactions.
    MINTiMINT-1368440.
    STRINGi9606.ENSP00000370074.

    Structurei

    3D structure databases

    ProteinModelPortaliP50453.
    SMRiP50453. Positions 1-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP50453.
    KOiK13963.
    OMAiCLQFYRA.
    OrthoDBiEOG7327PB.
    PhylomeDBiP50453.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00676. MASPIN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50453-1 [UniParc]FASTAAdd to Basket

    « Hide

    METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT    50
    ATQMAQALSL NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF 100
    LSTFKESCLQ FYHAELKELS FIRAAEESRK HINTWVSKKT EGKIEELLPG 150
    SSIDAETRLV LVNAIYFKGK WNEPFDETYT REMPFKINQE EQRPVQMMYQ 200
    EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS TVEKSLTFEK 250
    LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL 300
    SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC 350
    ADHPFLFFIR HNRANSILFC GRFSSP 376
    Length:376
    Mass (Da):42,404
    Last modified:October 1, 1996 - v1
    Checksum:iECBA80869B939753
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40378 mRNA. Translation: AAC41940.1.
    U71364 mRNA. Translation: AAC50793.1.
    AB060690 mRNA. Translation: BAB91078.1.
    AK314842 mRNA. Translation: BAG37360.1.
    BT006673 mRNA. Translation: AAP35319.1.
    CR407627 mRNA. Translation: CAG28555.1.
    AL133351 Genomic DNA. Translation: CAI23290.1.
    CH471087 Genomic DNA. Translation: EAW55093.1.
    BC002538 mRNA. Translation: AAH02538.1.
    CCDSiCCDS4478.1.
    PIRiB59273.
    RefSeqiNP_004146.1. NM_004155.5.
    XP_005249241.1. XM_005249184.2.
    UniGeneiHs.104879.

    Genome annotation databases

    EnsembliENST00000380698; ENSP00000370074; ENSG00000170542.
    GeneIDi5272.
    KEGGihsa:5272.
    UCSCiuc003mug.4. human.

    Polymorphism databases

    DMDMi1709896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40378 mRNA. Translation: AAC41940.1 .
    U71364 mRNA. Translation: AAC50793.1 .
    AB060690 mRNA. Translation: BAB91078.1 .
    AK314842 mRNA. Translation: BAG37360.1 .
    BT006673 mRNA. Translation: AAP35319.1 .
    CR407627 mRNA. Translation: CAG28555.1 .
    AL133351 Genomic DNA. Translation: CAI23290.1 .
    CH471087 Genomic DNA. Translation: EAW55093.1 .
    BC002538 mRNA. Translation: AAH02538.1 .
    CCDSi CCDS4478.1.
    PIRi B59273.
    RefSeqi NP_004146.1. NM_004155.5.
    XP_005249241.1. XM_005249184.2.
    UniGenei Hs.104879.

    3D structure databases

    ProteinModelPortali P50453.
    SMRi P50453. Positions 1-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111290. 29 interactions.
    IntActi P50453. 25 interactions.
    MINTi MINT-1368440.
    STRINGi 9606.ENSP00000370074.

    Protein family/group databases

    MEROPSi I04.014.

    PTM databases

    PhosphoSitei P50453.

    Polymorphism databases

    DMDMi 1709896.

    2D gel databases

    OGPi P50453.
    REPRODUCTION-2DPAGE IPI00032139.

    Proteomic databases

    MaxQBi P50453.
    PaxDbi P50453.
    PeptideAtlasi P50453.
    PRIDEi P50453.

    Protocols and materials databases

    DNASUi 5272.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380698 ; ENSP00000370074 ; ENSG00000170542 .
    GeneIDi 5272.
    KEGGi hsa:5272.
    UCSCi uc003mug.4. human.

    Organism-specific databases

    CTDi 5272.
    GeneCardsi GC06M002887.
    H-InvDB HIX0057760.
    HGNCi HGNC:8955. SERPINB9.
    HPAi HPA030067.
    MIMi 601799. gene.
    neXtProti NX_P50453.
    PharmGKBi PA35519.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P50453.
    KOi K13963.
    OMAi CLQFYRA.
    OrthoDBi EOG7327PB.
    PhylomeDBi P50453.
    TreeFami TF352619.

    Miscellaneous databases

    ChiTaRSi SERPINB9. human.
    GeneWikii SERPINB9.
    GenomeRNAii 5272.
    NextBioi 20372.
    PROi P50453.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50453.
    Bgeei P50453.
    CleanExi HS_SERPINB9.
    Genevestigatori P50453.

    Family and domain databases

    InterProi IPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00676. MASPIN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors."
      Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W.
      J. Biol. Chem. 270:29854-29861(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes."
      Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., Jong T.A., Trapani J.A., Bird P.I.
      J. Biol. Chem. 271:27802-27809(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow and Placenta.
    3. "Serine proteinase inhibitor 9 as a tumor antigen recognized by cytotoxic T lymphocytes of epithelial cancer patients."
      Tanaka K., Harashima N., Shichijo S., Harada M., Itoh K.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPB9_HUMAN
    AccessioniPrimary (citable) accession number: P50453
    Secondary accession number(s): B2RBW3, Q5TD03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3