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Protein

Serpin B9

Gene

SERPINB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Granzyme B inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei340 – 3412Reactive bondBy similarity

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: GOC
  • cellular response to estrogen stimulus Source: UniProtKB
  • immune response Source: UniProtKB
  • mast cell mediated immunity Source: UniProtKB
  • negative regulation by symbiont of host apoptotic process Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  • negative regulation of endopeptidase activity Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • protection from natural killer cell mediated cytotoxicity Source: UniProtKB
  • response to bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.014.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B9
Alternative name(s):
Cytoplasmic antiproteinase 3
Short name:
CAP-3
Short name:
CAP3
Peptidase inhibitor 9
Short name:
PI-9
Gene namesi
Name:SERPINB9
Synonyms:PI9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8955. SERPINB9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intracellular Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35519.

Polymorphism and mutation databases

BioMutaiSERPINB9.
DMDMi1709896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Serpin B9PRO_0000094113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP50453.
PaxDbiP50453.
PeptideAtlasiP50453.
PRIDEiP50453.

2D gel databases

OGPiP50453.
REPRODUCTION-2DPAGEIPI00032139.

PTM databases

PhosphoSiteiP50453.

Expressioni

Gene expression databases

BgeeiP50453.
CleanExiHS_SERPINB9.
ExpressionAtlasiP50453. baseline and differential.
GenevisibleiP50453. HS.

Organism-specific databases

HPAiHPA030067.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF5O004633EBI-711626,EBI-523498

Protein-protein interaction databases

BioGridi111290. 30 interactions.
IntActiP50453. 26 interactions.
MINTiMINT-1368440.
STRINGi9606.ENSP00000370074.

Structurei

3D structure databases

ProteinModelPortaliP50453.
SMRiP50453. Positions 1-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP50453.
KOiK13963.
OMAiFYHTELE.
OrthoDBiEOG7327PB.
PhylomeDBiP50453.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT
60 70 80 90 100
ATQMAQALSL NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF
110 120 130 140 150
LSTFKESCLQ FYHAELKELS FIRAAEESRK HINTWVSKKT EGKIEELLPG
160 170 180 190 200
SSIDAETRLV LVNAIYFKGK WNEPFDETYT REMPFKINQE EQRPVQMMYQ
210 220 230 240 250
EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS TVEKSLTFEK
260 270 280 290 300
LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL
310 320 330 340 350
SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC
360 370
ADHPFLFFIR HNRANSILFC GRFSSP
Length:376
Mass (Da):42,404
Last modified:October 1, 1996 - v1
Checksum:iECBA80869B939753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40378 mRNA. Translation: AAC41940.1.
U71364 mRNA. Translation: AAC50793.1.
AB060690 mRNA. Translation: BAB91078.1.
AK314842 mRNA. Translation: BAG37360.1.
BT006673 mRNA. Translation: AAP35319.1.
CR407627 mRNA. Translation: CAG28555.1.
AL133351 Genomic DNA. Translation: CAI23290.1.
CH471087 Genomic DNA. Translation: EAW55093.1.
BC002538 mRNA. Translation: AAH02538.1.
CCDSiCCDS4478.1.
PIRiB59273.
RefSeqiNP_004146.1. NM_004155.5.
XP_005249241.1. XM_005249184.3.
UniGeneiHs.104879.

Genome annotation databases

EnsembliENST00000380698; ENSP00000370074; ENSG00000170542.
GeneIDi5272.
KEGGihsa:5272.
UCSCiuc003mug.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40378 mRNA. Translation: AAC41940.1.
U71364 mRNA. Translation: AAC50793.1.
AB060690 mRNA. Translation: BAB91078.1.
AK314842 mRNA. Translation: BAG37360.1.
BT006673 mRNA. Translation: AAP35319.1.
CR407627 mRNA. Translation: CAG28555.1.
AL133351 Genomic DNA. Translation: CAI23290.1.
CH471087 Genomic DNA. Translation: EAW55093.1.
BC002538 mRNA. Translation: AAH02538.1.
CCDSiCCDS4478.1.
PIRiB59273.
RefSeqiNP_004146.1. NM_004155.5.
XP_005249241.1. XM_005249184.3.
UniGeneiHs.104879.

3D structure databases

ProteinModelPortaliP50453.
SMRiP50453. Positions 1-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111290. 30 interactions.
IntActiP50453. 26 interactions.
MINTiMINT-1368440.
STRINGi9606.ENSP00000370074.

Protein family/group databases

MEROPSiI04.014.

PTM databases

PhosphoSiteiP50453.

Polymorphism and mutation databases

BioMutaiSERPINB9.
DMDMi1709896.

2D gel databases

OGPiP50453.
REPRODUCTION-2DPAGEIPI00032139.

Proteomic databases

MaxQBiP50453.
PaxDbiP50453.
PeptideAtlasiP50453.
PRIDEiP50453.

Protocols and materials databases

DNASUi5272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380698; ENSP00000370074; ENSG00000170542.
GeneIDi5272.
KEGGihsa:5272.
UCSCiuc003mug.4. human.

Organism-specific databases

CTDi5272.
GeneCardsiGC06M002887.
H-InvDBHIX0057760.
HGNCiHGNC:8955. SERPINB9.
HPAiHPA030067.
MIMi601799. gene.
neXtProtiNX_P50453.
PharmGKBiPA35519.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP50453.
KOiK13963.
OMAiFYHTELE.
OrthoDBiEOG7327PB.
PhylomeDBiP50453.
TreeFamiTF352619.

Miscellaneous databases

GeneWikiiSERPINB9.
GenomeRNAii5272.
NextBioi20372.
PROiP50453.
SOURCEiSearch...

Gene expression databases

BgeeiP50453.
CleanExiHS_SERPINB9.
ExpressionAtlasiP50453. baseline and differential.
GenevisibleiP50453. HS.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors."
    Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W.
    J. Biol. Chem. 270:29854-29861(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes."
    Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., Jong T.A., Trapani J.A., Bird P.I.
    J. Biol. Chem. 271:27802-27809(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow and Placenta.
  3. "Serine proteinase inhibitor 9 as a tumor antigen recognized by cytotoxic T lymphocytes of epithelial cancer patients."
    Tanaka K., Harashima N., Shichijo S., Harada M., Itoh K.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSPB9_HUMAN
AccessioniPrimary (citable) accession number: P50453
Secondary accession number(s): B2RBW3, Q5TD03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.