P50452 (SPB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin B8

Alternative name(s):
Cytoplasmic antiproteinase 2
Short name=CAP-2
Short name=CAP2
Peptidase inhibitor 8
Short name=PI-8

Gene names

Name:	SERPINB8
Synonyms:	PI8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Protease inhibitor Serine protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	cytosol Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB serine-type endopeptidase inhibitor activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Serpin B8		PRO_0000094111
Sites
	Site	339 – 340	2	Reactive bond By similarity
Natural variations
	Natural variant	68	1	R → Q. Corresponds to variant rs1944270 [ dbSNP | Ensembl ].		VAR_047110
	Natural variant	158	1	K → N. Corresponds to variant rs1648493 [ dbSNP | Ensembl ].		VAR_047111
	Natural variant	304	1	T → A. Ref.2 Corresponds to variant rs3169983 [ dbSNP | Ensembl ].		VAR_051947
	Natural variant	359	1	H → R. Ref.1 Corresponds to variant rs3826616 [ dbSNP | Ensembl ].		VAR_051948

Sequences

	Sequence		Length	Mass (Da)
	P50452 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 7235A033519AC612	FASTA	374	42,767
	10 20 30 40 50 60 MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL 70 80 90 100 110 120 YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS 130 140 150 160 170 180 FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT 190 200 210 220 230 240 RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV 250 260 270 280 290 300 VEKALTYEKF KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS 310 320 330 340 350 360 GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD HPFLFFIRHH 370 KTNCILFCGR FSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors." Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W. J. Biol. Chem. 270:29854-29861(1995) [PubMed: 8530382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-359. Tissue: Placenta.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-304. Tissue: Oesophagus.
[3]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40377 mRNA. Translation: AAC41939.1. BX571754 mRNA. Translation: CAE11879.1. AC009802 Genomic DNA. No translation available.
IPI	IPI00032134.
PIR	A59273.
RefSeq	NP_002631.3. NM_002640.3. NP_942130.1. NM_198833.1.
UniGene	Hs.368077.
3D structure databases
ProteinModelPortal	P50452.
SMR	P50452. Positions 1-374.
ModBase	Search...
Protein-protein interaction databases
STRING	P50452.
Protein family/group databases
MEROPS	I04.013.
PTM databases
PhosphoSite	P50452.
Polymorphism databases
DMDM	212276474.
Proteomic databases
PRIDE	P50452.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000353706; ENSP00000331368; ENSG00000166401. ENST00000397985; ENSP00000381072; ENSG00000166401.
GeneID	5271.
KEGG	hsa:5271.
Organism-specific databases
CTD	5271.
GeneCards	GC18P061637.
H-InvDB	HIX0027371.
HGNC	HGNC:8952. SERPINB8.
HPA	CAB034300.
MIM	601697. gene.
neXtProt	NX_P50452.
PharmGKB	PA35517.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08889.
GeneTree	ENSGT00580000081427.
HOGENOM	HBG714743.
HOVERGEN	HBG005957.
InParanoid	P50452.
OMA	AKFKMGY.
OrthoDB	EOG412M5X.
PhylomeDB	P50452.
Gene expression databases
ArrayExpress	P50452.
Bgee	P50452.
CleanEx	HS_SERPINB8.
Genevestigator	P50452.
GermOnline	ENSG00000166401. Homo sapiens.
Family and domain databases
InterPro	IPR000215. Protease_inhib_I4_serpin. IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Sepin_dom. [Graphical view]
KO	K13965.
PANTHER	PTHR11461. Prot_inh_serpin. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

SPB8_HUMAN

Accession

Primary (citable) accession number: P50452
Secondary accession number(s): Q7Z2V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 4, 2008
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.