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P50452

- SPB8_HUMAN

UniProt

P50452 - SPB8_HUMAN

Protein

Serpin B8

Gene

SERPINB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei339 – 3402Reactive bondBy similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: UniProtKB
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_641. Dissolution of Fibrin Clot.

    Protein family/group databases

    MEROPSiI04.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B8
    Alternative name(s):
    Cytoplasmic antiproteinase 2
    Short name:
    CAP-2
    Short name:
    CAP2
    Peptidase inhibitor 8
    Short name:
    PI-8
    Gene namesi
    Name:SERPINB8
    Synonyms:PI8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:8952. SERPINB8.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Serpin B8PRO_0000094111Add
    BLAST

    Proteomic databases

    MaxQBiP50452.
    PaxDbiP50452.
    PRIDEiP50452.

    PTM databases

    PhosphoSiteiP50452.

    Expressioni

    Gene expression databases

    ArrayExpressiP50452.
    BgeeiP50452.
    CleanExiHS_SERPINB8.
    GenevestigatoriP50452.

    Organism-specific databases

    HPAiCAB034300.

    Interactioni

    Protein-protein interaction databases

    BioGridi111289. 6 interactions.
    STRINGi9606.ENSP00000331368.

    Structurei

    3D structure databases

    ProteinModelPortaliP50452.
    SMRiP50452. Positions 1-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP50452.
    KOiK13965.
    OMAiIRHHKTN.
    OrthoDBiEOG7327PB.
    PhylomeDBiP50452.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P50452-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST    50
    AAQMSQALCL YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF 100
    LPDFKEYCQK FYQAELEELS FAEDTEECRK HINDWVAEKT EGKISEVLDA 150
    GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE 200
    AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV VEKALTYEKF 250
    KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS 300
    GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD 350
    HPFLFFIRHH KTNCILFCGR FSSP 374
    Length:374
    Mass (Da):42,767
    Last modified:November 4, 2008 - v2
    Checksum:i7235A033519AC612
    GO
    Isoform 2 (identifier: P50452-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-374: VEKALTYEKF...ILFCGRFSSP → KE

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):27,673
    Checksum:iB7CF7D13B3129681
    GO
    Isoform 3 (identifier: P50452-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-182: Missing.

    Show »
    Length:192
    Mass (Da):22,134
    Checksum:iEBDED15A48B73B5D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681R → Q.
    Corresponds to variant rs1944270 [ dbSNP | Ensembl ].
    VAR_047110
    Natural varianti158 – 1581K → N.
    Corresponds to variant rs1648493 [ dbSNP | Ensembl ].
    VAR_047111
    Natural varianti304 – 3041T → A.1 Publication
    Corresponds to variant rs3169983 [ dbSNP | Ensembl ].
    VAR_051947
    Natural varianti359 – 3591H → R.1 Publication
    Corresponds to variant rs3826616 [ dbSNP | Ensembl ].
    VAR_051948

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 182182Missing in isoform 3. 1 PublicationVSP_055135Add
    BLAST
    Alternative sequencei241 – 374134VEKAL…RFSSP → KE in isoform 2. 1 PublicationVSP_043097Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40377 mRNA. Translation: AAC41939.1.
    AK300391 mRNA. Translation: BAG62124.1.
    BX571754 mRNA. Translation: CAE11879.1.
    AC009802 Genomic DNA. No translation available.
    BC034528 mRNA. Translation: AAH34528.1.
    CCDSiCCDS11991.1. [P50452-1]
    CCDS42442.1. [P50452-2]
    CCDS62460.1. [P50452-3]
    PIRiA59273.
    RefSeqiNP_001027018.1. NM_001031848.1. [P50452-2]
    NP_001263419.1. NM_001276490.1.
    NP_002631.3. NM_002640.3. [P50452-1]
    NP_942130.1. NM_198833.1. [P50452-1]
    UniGeneiHs.368077.

    Genome annotation databases

    EnsembliENST00000353706; ENSP00000331368; ENSG00000166401. [P50452-1]
    ENST00000397985; ENSP00000381072; ENSG00000166401. [P50452-1]
    ENST00000397988; ENSP00000381075; ENSG00000166401. [P50452-2]
    ENST00000542677; ENSP00000438328; ENSG00000166401. [P50452-3]
    GeneIDi5271.
    KEGGihsa:5271.
    UCSCiuc002ljt.3. human. [P50452-2]
    uc002lju.3. human. [P50452-1]

    Polymorphism databases

    DMDMi212276474.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40377 mRNA. Translation: AAC41939.1 .
    AK300391 mRNA. Translation: BAG62124.1 .
    BX571754 mRNA. Translation: CAE11879.1 .
    AC009802 Genomic DNA. No translation available.
    BC034528 mRNA. Translation: AAH34528.1 .
    CCDSi CCDS11991.1. [P50452-1 ]
    CCDS42442.1. [P50452-2 ]
    CCDS62460.1. [P50452-3 ]
    PIRi A59273.
    RefSeqi NP_001027018.1. NM_001031848.1. [P50452-2 ]
    NP_001263419.1. NM_001276490.1.
    NP_002631.3. NM_002640.3. [P50452-1 ]
    NP_942130.1. NM_198833.1. [P50452-1 ]
    UniGenei Hs.368077.

    3D structure databases

    ProteinModelPortali P50452.
    SMRi P50452. Positions 1-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111289. 6 interactions.
    STRINGi 9606.ENSP00000331368.

    Protein family/group databases

    MEROPSi I04.013.

    PTM databases

    PhosphoSitei P50452.

    Polymorphism databases

    DMDMi 212276474.

    Proteomic databases

    MaxQBi P50452.
    PaxDbi P50452.
    PRIDEi P50452.

    Protocols and materials databases

    DNASUi 5271.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353706 ; ENSP00000331368 ; ENSG00000166401 . [P50452-1 ]
    ENST00000397985 ; ENSP00000381072 ; ENSG00000166401 . [P50452-1 ]
    ENST00000397988 ; ENSP00000381075 ; ENSG00000166401 . [P50452-2 ]
    ENST00000542677 ; ENSP00000438328 ; ENSG00000166401 . [P50452-3 ]
    GeneIDi 5271.
    KEGGi hsa:5271.
    UCSCi uc002ljt.3. human. [P50452-2 ]
    uc002lju.3. human. [P50452-1 ]

    Organism-specific databases

    CTDi 5271.
    GeneCardsi GC18P061637.
    HGNCi HGNC:8952. SERPINB8.
    HPAi CAB034300.
    MIMi 601697. gene.
    neXtProti NX_P50452.
    PharmGKBi PA35517.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P50452.
    KOi K13965.
    OMAi IRHHKTN.
    OrthoDBi EOG7327PB.
    PhylomeDBi P50452.
    TreeFami TF352619.

    Enzyme and pathway databases

    Reactomei REACT_641. Dissolution of Fibrin Clot.

    Miscellaneous databases

    GeneWikii SERPINB8.
    GenomeRNAii 5271.
    NextBioi 20364.
    PROi P50452.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50452.
    Bgeei P50452.
    CleanExi HS_SERPINB8.
    Genevestigatori P50452.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors."
      Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W.
      J. Biol. Chem. 270:29854-29861(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-359.
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-304.
      Tissue: Esophagus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPB8_HUMAN
    AccessioniPrimary (citable) accession number: P50452
    Secondary accession number(s): B4DTW2, Q7Z2V6, Q8N178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3