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Protein

Serpin B8

Gene

SERPINB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei339 – 3402Reactive bondBy similarity

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of endopeptidase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_641. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Alternative name(s):
Cytoplasmic antiproteinase 2
Short name:
CAP-2
Short name:
CAP2
Peptidase inhibitor 8
Short name:
PI-8
Gene namesi
Name:SERPINB8
Synonyms:PI8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:8952. SERPINB8.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35517.

Polymorphism and mutation databases

BioMutaiSERPINB8.
DMDMi212276474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serpin B8PRO_0000094111Add
BLAST

Proteomic databases

MaxQBiP50452.
PaxDbiP50452.
PRIDEiP50452.

PTM databases

PhosphoSiteiP50452.

Expressioni

Gene expression databases

BgeeiP50452.
CleanExiHS_SERPINB8.
ExpressionAtlasiP50452. baseline and differential.
GenevestigatoriP50452.

Organism-specific databases

HPAiCAB034300.

Interactioni

Protein-protein interaction databases

BioGridi111289. 15 interactions.
STRINGi9606.ENSP00000331368.

Structurei

3D structure databases

ProteinModelPortaliP50452.
SMRiP50452. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP50452.
KOiK13965.
OMAiSQALCLY.
OrthoDBiEOG7327PB.
PhylomeDBiP50452.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50452-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST
60 70 80 90 100
AAQMSQALCL YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF
110 120 130 140 150
LPDFKEYCQK FYQAELEELS FAEDTEECRK HINDWVAEKT EGKISEVLDA
160 170 180 190 200
GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE
210 220 230 240 250
AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV VEKALTYEKF
260 270 280 290 300
KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS
310 320 330 340 350
GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD
360 370
HPFLFFIRHH KTNCILFCGR FSSP
Length:374
Mass (Da):42,767
Last modified:November 4, 2008 - v2
Checksum:i7235A033519AC612
GO
Isoform 2 (identifier: P50452-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-374: VEKALTYEKF...ILFCGRFSSP → KE

Note: No experimental confirmation available.

Show »
Length:242
Mass (Da):27,673
Checksum:iB7CF7D13B3129681
GO
Isoform 3 (identifier: P50452-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Show »
Length:192
Mass (Da):22,134
Checksum:iEBDED15A48B73B5D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681R → Q.
Corresponds to variant rs1944270 [ dbSNP | Ensembl ].
VAR_047110
Natural varianti158 – 1581K → N.
Corresponds to variant rs1648493 [ dbSNP | Ensembl ].
VAR_047111
Natural varianti304 – 3041T → A.1 Publication
Corresponds to variant rs3169983 [ dbSNP | Ensembl ].
VAR_051947
Natural varianti359 – 3591H → R.1 Publication
Corresponds to variant rs3826616 [ dbSNP | Ensembl ].
VAR_051948

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 182182Missing in isoform 3. 1 PublicationVSP_055135Add
BLAST
Alternative sequencei241 – 374134VEKAL…RFSSP → KE in isoform 2. 1 PublicationVSP_043097Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40377 mRNA. Translation: AAC41939.1.
AK300391 mRNA. Translation: BAG62124.1.
BX571754 mRNA. Translation: CAE11879.1.
AC009802 Genomic DNA. No translation available.
BC034528 mRNA. Translation: AAH34528.1.
CCDSiCCDS11991.1. [P50452-1]
CCDS42442.1. [P50452-2]
CCDS62460.1. [P50452-3]
PIRiA59273.
RefSeqiNP_001027018.1. NM_001031848.1. [P50452-2]
NP_001263419.1. NM_001276490.1. [P50452-3]
NP_002631.3. NM_002640.3. [P50452-1]
NP_942130.1. NM_198833.1. [P50452-1]
UniGeneiHs.368077.

Genome annotation databases

EnsembliENST00000353706; ENSP00000331368; ENSG00000166401. [P50452-1]
ENST00000397985; ENSP00000381072; ENSG00000166401. [P50452-1]
ENST00000397988; ENSP00000381075; ENSG00000166401. [P50452-2]
ENST00000542677; ENSP00000438328; ENSG00000166401. [P50452-3]
GeneIDi5271.
KEGGihsa:5271.
UCSCiuc002ljt.3. human. [P50452-2]
uc002lju.3. human. [P50452-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40377 mRNA. Translation: AAC41939.1.
AK300391 mRNA. Translation: BAG62124.1.
BX571754 mRNA. Translation: CAE11879.1.
AC009802 Genomic DNA. No translation available.
BC034528 mRNA. Translation: AAH34528.1.
CCDSiCCDS11991.1. [P50452-1]
CCDS42442.1. [P50452-2]
CCDS62460.1. [P50452-3]
PIRiA59273.
RefSeqiNP_001027018.1. NM_001031848.1. [P50452-2]
NP_001263419.1. NM_001276490.1. [P50452-3]
NP_002631.3. NM_002640.3. [P50452-1]
NP_942130.1. NM_198833.1. [P50452-1]
UniGeneiHs.368077.

3D structure databases

ProteinModelPortaliP50452.
SMRiP50452. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111289. 15 interactions.
STRINGi9606.ENSP00000331368.

Protein family/group databases

MEROPSiI04.013.

PTM databases

PhosphoSiteiP50452.

Polymorphism and mutation databases

BioMutaiSERPINB8.
DMDMi212276474.

Proteomic databases

MaxQBiP50452.
PaxDbiP50452.
PRIDEiP50452.

Protocols and materials databases

DNASUi5271.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353706; ENSP00000331368; ENSG00000166401. [P50452-1]
ENST00000397985; ENSP00000381072; ENSG00000166401. [P50452-1]
ENST00000397988; ENSP00000381075; ENSG00000166401. [P50452-2]
ENST00000542677; ENSP00000438328; ENSG00000166401. [P50452-3]
GeneIDi5271.
KEGGihsa:5271.
UCSCiuc002ljt.3. human. [P50452-2]
uc002lju.3. human. [P50452-1]

Organism-specific databases

CTDi5271.
GeneCardsiGC18P061637.
HGNCiHGNC:8952. SERPINB8.
HPAiCAB034300.
MIMi601697. gene.
neXtProtiNX_P50452.
PharmGKBiPA35517.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP50452.
KOiK13965.
OMAiSQALCLY.
OrthoDBiEOG7327PB.
PhylomeDBiP50452.
TreeFamiTF352619.

Enzyme and pathway databases

ReactomeiREACT_641. Dissolution of Fibrin Clot.

Miscellaneous databases

GeneWikiiSERPINB8.
GenomeRNAii5271.
NextBioi20364.
PROiP50452.
SOURCEiSearch...

Gene expression databases

BgeeiP50452.
CleanExiHS_SERPINB8.
ExpressionAtlasiP50452. baseline and differential.
GenevestigatoriP50452.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors."
    Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W.
    J. Biol. Chem. 270:29854-29861(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-359.
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-304.
    Tissue: Esophagus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPB8_HUMAN
AccessioniPrimary (citable) accession number: P50452
Secondary accession number(s): B4DTW2, Q7Z2V6, Q8N178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: May 27, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.