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P50452

- SPB8_HUMAN

UniProt

P50452 - SPB8_HUMAN

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Protein
Serpin B8
Gene
SERPINB8, PI8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei339 – 3402Reactive bond By similarity

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: UniProtKB
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_641. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Alternative name(s):
Cytoplasmic antiproteinase 2
Short name:
CAP-2
Short name:
CAP2
Peptidase inhibitor 8
Short name:
PI-8
Gene namesi
Synonyms:PI8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:8952. SERPINB8.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serpin B8
PRO_0000094111Add
BLAST

Proteomic databases

MaxQBiP50452.
PaxDbiP50452.
PRIDEiP50452.

PTM databases

PhosphoSiteiP50452.

Expressioni

Gene expression databases

ArrayExpressiP50452.
BgeeiP50452.
CleanExiHS_SERPINB8.
GenevestigatoriP50452.

Organism-specific databases

HPAiCAB034300.

Interactioni

Protein-protein interaction databases

BioGridi111289. 6 interactions.
STRINGi9606.ENSP00000331368.

Structurei

3D structure databases

ProteinModelPortaliP50452.
SMRiP50452. Positions 1-374.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP50452.
KOiK13965.
OMAiIRHHKTN.
OrthoDBiEOG7327PB.
PhylomeDBiP50452.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P50452-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST    50
AAQMSQALCL YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF 100
LPDFKEYCQK FYQAELEELS FAEDTEECRK HINDWVAEKT EGKISEVLDA 150
GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE 200
AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV VEKALTYEKF 250
KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS 300
GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD 350
HPFLFFIRHH KTNCILFCGR FSSP 374
Length:374
Mass (Da):42,767
Last modified:November 4, 2008 - v2
Checksum:i7235A033519AC612
GO
Isoform 2 (identifier: P50452-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-374: VEKALTYEKF...ILFCGRFSSP → KE

Note: No experimental confirmation available.

Show »
Length:242
Mass (Da):27,673
Checksum:iB7CF7D13B3129681
GO
Isoform 3 (identifier: P50452-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Show »
Length:192
Mass (Da):22,134
Checksum:iEBDED15A48B73B5D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681R → Q.
Corresponds to variant rs1944270 [ dbSNP | Ensembl ].
VAR_047110
Natural varianti158 – 1581K → N.
Corresponds to variant rs1648493 [ dbSNP | Ensembl ].
VAR_047111
Natural varianti304 – 3041T → A.1 Publication
Corresponds to variant rs3169983 [ dbSNP | Ensembl ].
VAR_051947
Natural varianti359 – 3591H → R.1 Publication
Corresponds to variant rs3826616 [ dbSNP | Ensembl ].
VAR_051948

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 182182Missing in isoform 3.
VSP_055135Add
BLAST
Alternative sequencei241 – 374134VEKAL…RFSSP → KE in isoform 2.
VSP_043097Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L40377 mRNA. Translation: AAC41939.1.
AK300391 mRNA. Translation: BAG62124.1.
BX571754 mRNA. Translation: CAE11879.1.
AC009802 Genomic DNA. No translation available.
BC034528 mRNA. Translation: AAH34528.1.
CCDSiCCDS11991.1. [P50452-1]
CCDS42442.1. [P50452-2]
PIRiA59273.
RefSeqiNP_001027018.1. NM_001031848.1. [P50452-2]
NP_001263419.1. NM_001276490.1.
NP_002631.3. NM_002640.3. [P50452-1]
NP_942130.1. NM_198833.1. [P50452-1]
UniGeneiHs.368077.

Genome annotation databases

EnsembliENST00000353706; ENSP00000331368; ENSG00000166401. [P50452-1]
ENST00000397985; ENSP00000381072; ENSG00000166401. [P50452-1]
ENST00000397988; ENSP00000381075; ENSG00000166401. [P50452-2]
ENST00000542677; ENSP00000438328; ENSG00000166401.
GeneIDi5271.
KEGGihsa:5271.
UCSCiuc002ljt.3. human. [P50452-2]
uc002lju.3. human. [P50452-1]

Polymorphism databases

DMDMi212276474.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L40377 mRNA. Translation: AAC41939.1 .
AK300391 mRNA. Translation: BAG62124.1 .
BX571754 mRNA. Translation: CAE11879.1 .
AC009802 Genomic DNA. No translation available.
BC034528 mRNA. Translation: AAH34528.1 .
CCDSi CCDS11991.1. [P50452-1 ]
CCDS42442.1. [P50452-2 ]
PIRi A59273.
RefSeqi NP_001027018.1. NM_001031848.1. [P50452-2 ]
NP_001263419.1. NM_001276490.1.
NP_002631.3. NM_002640.3. [P50452-1 ]
NP_942130.1. NM_198833.1. [P50452-1 ]
UniGenei Hs.368077.

3D structure databases

ProteinModelPortali P50452.
SMRi P50452. Positions 1-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111289. 6 interactions.
STRINGi 9606.ENSP00000331368.

Protein family/group databases

MEROPSi I04.013.

PTM databases

PhosphoSitei P50452.

Polymorphism databases

DMDMi 212276474.

Proteomic databases

MaxQBi P50452.
PaxDbi P50452.
PRIDEi P50452.

Protocols and materials databases

DNASUi 5271.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000353706 ; ENSP00000331368 ; ENSG00000166401 . [P50452-1 ]
ENST00000397985 ; ENSP00000381072 ; ENSG00000166401 . [P50452-1 ]
ENST00000397988 ; ENSP00000381075 ; ENSG00000166401 . [P50452-2 ]
ENST00000542677 ; ENSP00000438328 ; ENSG00000166401 .
GeneIDi 5271.
KEGGi hsa:5271.
UCSCi uc002ljt.3. human. [P50452-2 ]
uc002lju.3. human. [P50452-1 ]

Organism-specific databases

CTDi 5271.
GeneCardsi GC18P061637.
HGNCi HGNC:8952. SERPINB8.
HPAi CAB034300.
MIMi 601697. gene.
neXtProti NX_P50452.
PharmGKBi PA35517.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P50452.
KOi K13965.
OMAi IRHHKTN.
OrthoDBi EOG7327PB.
PhylomeDBi P50452.
TreeFami TF352619.

Enzyme and pathway databases

Reactomei REACT_641. Dissolution of Fibrin Clot.

Miscellaneous databases

GeneWikii SERPINB8.
GenomeRNAii 5271.
NextBioi 20364.
PROi P50452.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50452.
Bgeei P50452.
CleanExi HS_SERPINB8.
Genevestigatori P50452.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors."
    Sprecher C.A., Morgenstern K.A., Mathewes S., Dahlen J.R., Schrader S.K., Foster D.C., Kisiel W.
    J. Biol. Chem. 270:29854-29861(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-359.
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-304.
    Tissue: Esophagus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPB8_HUMAN
AccessioniPrimary (citable) accession number: P50452
Secondary accession number(s): B4DTW2, Q7Z2V6, Q8N178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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