Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Factor XIIa inhibitor

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei434 – 4352Reactive bond

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis

Protein family/group databases

MEROPSiI04.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor XIIa inhibitor
Short name:
XIIaINH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 468445Factor XIIa inhibitorPRO_0000032529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 396By similarity
Disulfide bondi104 ↔ 179By similarity
Glycosylationi176 – 1761N-linked (GlcNAc...)Curated
Glycosylationi227 – 2271N-linked (GlcNAc...)Curated
Glycosylationi326 – 3261N-linked (GlcNAc...)Curated

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50448.
PRIDEiP50448.

Interactioni

Protein-protein interaction databases

MINTiMINT-1210803.
STRINGi9913.ENSBTAP00000021638.

Structurei

3D structure databases

ProteinModelPortaliP50448.
SMRiP50448. Positions 100-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000231936.
HOVERGENiHBG104060.
KOiK04001.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLTPLTL LLLLLLAGDR VTSDMIVGPG NLQEGESEGD SQKGGILDGE
60 70 80 90 100
SIQGNEDSPT LPITNLTVVP ATVTKPFSQP ATEPVQSTIQ PTAEPFCLAP
110 120 130 140 150
VTSCSDSEIR SAEAVLGEAL TDFSLRLYQD FSVLKKRETN FIFSPFSIAS
160 170 180 190 200
LLTQILLGAG GETRVSLEHL LSYPQNFSCV HHALRAFMSE GFTSFSQIFH
210 220 230 240 250
SSDLTIKDTF AEASQRLYGS SPRPLGNDST ASLELINDWV AKKTNLRIRR
260 270 280 290 300
LLDSLPEDTR LILLNAVALS AKWKIAFDKG RTSTKPFHLK SSAIKVPMMN
310 320 330 340 350
SKKYPVASFT DRTLNRPGGR LQLSHNLSFV ILVPQTVKHH LQDLEQALST
360 370 380 390 400
AVFKAVIKKL EMTKFHPTHL TMPRIKVQSS QDMLDYFDFI YDVNLCGLTE
410 420 430 440 450
DPDVQVSGIR HQATLELTES GVDATAASVV SVARNLLLFE VQQPFLFLLW
460
DQQHKFPVFM GRVYDPKG
Length:468
Mass (Da):51,723
Last modified:October 1, 1996 - v1
Checksum:iE5029063E199734D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781S → R AA sequence (PubMed:8457651).Curated
Sequence conflicti84 – 852PV → TL AA sequence (PubMed:8457651).Curated
Sequence conflicti87 – 871S → I AA sequence (PubMed:8457651).Curated
Sequence conflicti92 – 921T → P AA sequence (PubMed:8457651).Curated
Sequence conflicti97 – 971C → F AA sequence (PubMed:8457651).Curated
Sequence conflicti134 – 1341L → V AA sequence (PubMed:8457651).Curated
Sequence conflicti171 – 1711L → V AA sequence (PubMed:8457651).Curated
Sequence conflicti207 – 2071K → R AA sequence (PubMed:8457651).Curated
Sequence conflicti332 – 3321L → N AA sequence (PubMed:8457651).Curated
Sequence conflicti336 – 3361T → P AA sequence (PubMed:8457651).Curated
Sequence conflicti409 – 4091I → K AA sequence (PubMed:8457651).Curated
Sequence conflicti462 – 4621R → P AA sequence (PubMed:8457651).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30332 mRNA. Translation: AAA73928.1.
RefSeqiNP_777246.1. NM_174821.2.
UniGeneiBt.22969.

Genome annotation databases

GeneIDi281035.
KEGGibta:281035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30332 mRNA. Translation: AAA73928.1.
RefSeqiNP_777246.1. NM_174821.2.
UniGeneiBt.22969.

3D structure databases

ProteinModelPortaliP50448.
SMRiP50448. Positions 100-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1210803.
STRINGi9913.ENSBTAP00000021638.

Protein family/group databases

MEROPSiI04.024.

Proteomic databases

PaxDbiP50448.
PRIDEiP50448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281035.
KEGGibta:281035.

Organism-specific databases

CTDi710.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000231936.
HOVERGENiHBG104060.
KOiK04001.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Edmeston J.E., Strumpfer A., Muldbjerg M., Halkier T., Macgillivray R.T.A.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Bovine factor XIIa inhibitor."
    Muldbjerg M., Markussen S., Magnusson S., Halkier T.
    Blood Coagul. Fibrinolysis 4:47-54(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Tissue: Liver.
  3. "Purification of a proteinase inhibitor from bovine serum with C1-inhibitor activity."
    van Nostrand W.E., Cunningham D.D.
    Biochim. Biophys. Acta 923:167-175(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-33.
    Tissue: Serum.

Entry informationi

Entry nameiF12AI_BOVIN
AccessioniPrimary (citable) accession number: P50448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Could be the ortholog of SERPING1.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.