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Protein

Factor XIIa inhibitor

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.

Miscellaneous

Could be the ortholog of SERPING1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei434 – 435Reactive bond2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Fibrinolysis, Hemostasis

Protein family/group databases

MEROPSiI04.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor XIIa inhibitor
Short name:
XIIaINH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003252924 – 468Factor XIIa inhibitorAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 396By similarity
Disulfide bondi104 ↔ 179By similarity
Glycosylationi176N-linked (GlcNAc...) asparagineCurated1
Glycosylationi227N-linked (GlcNAc...) asparagineCurated1
Glycosylationi326N-linked (GlcNAc...) asparagineCurated1

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50448.
PeptideAtlasiP50448.
PRIDEiP50448.

Interactioni

Protein-protein interaction databases

IntActiP50448. 1 interactor.
MINTiMINT-1210803.
STRINGi9913.ENSBTAP00000021638.

Structurei

3D structure databases

ProteinModelPortaliP50448.
SMRiP50448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000231936.
HOVERGENiHBG104060.
KOiK04001.

Family and domain databases

InterProiView protein in InterPro
IPR015553. C1-inh.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF269. PTHR11461:SF269. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLTPLTL LLLLLLAGDR VTSDMIVGPG NLQEGESEGD SQKGGILDGE
60 70 80 90 100
SIQGNEDSPT LPITNLTVVP ATVTKPFSQP ATEPVQSTIQ PTAEPFCLAP
110 120 130 140 150
VTSCSDSEIR SAEAVLGEAL TDFSLRLYQD FSVLKKRETN FIFSPFSIAS
160 170 180 190 200
LLTQILLGAG GETRVSLEHL LSYPQNFSCV HHALRAFMSE GFTSFSQIFH
210 220 230 240 250
SSDLTIKDTF AEASQRLYGS SPRPLGNDST ASLELINDWV AKKTNLRIRR
260 270 280 290 300
LLDSLPEDTR LILLNAVALS AKWKIAFDKG RTSTKPFHLK SSAIKVPMMN
310 320 330 340 350
SKKYPVASFT DRTLNRPGGR LQLSHNLSFV ILVPQTVKHH LQDLEQALST
360 370 380 390 400
AVFKAVIKKL EMTKFHPTHL TMPRIKVQSS QDMLDYFDFI YDVNLCGLTE
410 420 430 440 450
DPDVQVSGIR HQATLELTES GVDATAASVV SVARNLLLFE VQQPFLFLLW
460
DQQHKFPVFM GRVYDPKG
Length:468
Mass (Da):51,723
Last modified:October 1, 1996 - v1
Checksum:iE5029063E199734D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78S → R AA sequence (PubMed:8457651).Curated1
Sequence conflicti84 – 85PV → TL AA sequence (PubMed:8457651).Curated2
Sequence conflicti87S → I AA sequence (PubMed:8457651).Curated1
Sequence conflicti92T → P AA sequence (PubMed:8457651).Curated1
Sequence conflicti97C → F AA sequence (PubMed:8457651).Curated1
Sequence conflicti134L → V AA sequence (PubMed:8457651).Curated1
Sequence conflicti171L → V AA sequence (PubMed:8457651).Curated1
Sequence conflicti207K → R AA sequence (PubMed:8457651).Curated1
Sequence conflicti332L → N AA sequence (PubMed:8457651).Curated1
Sequence conflicti336T → P AA sequence (PubMed:8457651).Curated1
Sequence conflicti409I → K AA sequence (PubMed:8457651).Curated1
Sequence conflicti462R → P AA sequence (PubMed:8457651).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30332 mRNA. Translation: AAA73928.1.
RefSeqiNP_777246.1. NM_174821.2.
UniGeneiBt.22969.

Genome annotation databases

GeneIDi281035.
KEGGibta:281035.

Similar proteinsi

Entry informationi

Entry nameiF12AI_BOVIN
AccessioniPrimary (citable) accession number: P50448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families