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P50446

- K2C6A_MOUSE

UniProt

P50446 - K2C6A_MOUSE

Protein

Keratin, type II cytoskeletal 6A

Gene

Krt6a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei403 – 4031Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intermediate filament organization Source: MGI
    2. keratinization Source: MGI
    3. morphogenesis of an epithelium Source: MGI
    4. Wnt signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 6A
    Alternative name(s):
    Cytokeratin-6A
    Short name:
    CK-6A
    Keratin-6-alpha
    Short name:
    mK6-alpha
    Keratin-6A
    Short name:
    K6A
    Gene namesi
    Name:Krt6a
    Synonyms:Ker2, Krt2-6, Krt2-6a, Krt6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1100845. Krt6a.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Keratin, type II cytoskeletal 6APRO_0000063736Add
    BLAST

    Proteomic databases

    MaxQBiP50446.
    PaxDbiP50446.
    PRIDEiP50446.

    PTM databases

    PhosphoSiteiP50446.

    Expressioni

    Tissue specificityi

    Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath.1 Publication

    Inductioni

    With the exception of specific body sites, keratin-6 expression is induced under conditions of epithelial hyperproliferation such as wound healing, certain skin diseases, cancer, and by treatment of the skin with the phorbol ester PMA.1 Publication

    Gene expression databases

    ArrayExpressiP50446.
    BgeeiP50446.
    CleanExiMM_KRT6A.
    GenevestigatoriP50446.

    Interactioni

    Subunit structurei

    Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201035. 3 interactions.
    IntActiP50446. 2 interactions.
    MINTiMINT-1859525.
    STRINGi10090.ENSMUSP00000023788.

    Structurei

    3D structure databases

    ProteinModelPortaliP50446.
    SMRiP50446. Positions 149-302, 318-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 151151HeadAdd
    BLAST
    Regioni152 – 461310RodAdd
    BLAST
    Regioni152 – 18736Coil 1AAdd
    BLAST
    Regioni188 – 20619Linker 1Add
    BLAST
    Regioni207 – 29892Coil 1BAdd
    BLAST
    Regioni299 – 32224Linker 12Add
    BLAST
    Regioni323 – 461139Coil 2Add
    BLAST
    Regioni462 – 55392TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG315845.
    GeneTreeiENSGT00610000085801.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiP50446.
    KOiK07605.
    OMAiMQDQVED.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiP50446.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTKTTIKSQ TSHRGYSASS ARVPGLNRSG FSSVSVCRSR GSGGSSAMCG    50
    GAGFGSRSLY GVGSSKRISI GGGSCGIGGG YGSRFGGSFG IGGGAGSGFG 100
    FGGGAGFGGG YGGAGFPVCP PGGIQEVTIN QSLLTPLNLQ IDPTIQRVRT 150
    EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ GTKTVRQNLE 200
    PMFEQYISNL RRQLDSIIGE RGRLDSELRN MQDTVEDYKS KYEDEINKRT 250
    AAENEFVTLK KDVDAAYMNK VELQAKADSL TDDINFLRAL YEAELSQMQT 300
    HISDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIAQRSRAE AESWYQTKYE 350
    ELQVTAGRHG DDLRNTKQEI AEINRMIQRL RSEIDHVKKQ CANLQAAIAD 400
    AEQRGEMALK DARGKLEGLE DALQKAKQDM ARLLKEYQEL MNVKLALDVE 450
    IATYRKLLEG EECRLNGEGV GPVNISVVQS TVSSGYGSAG GASSSLGLGG 500
    GSSYSYSSSH GLGGGFSAGS GRAIGGGLSS SGGLSSSTIK YTTTSSSKKS 550
    YRQ 553
    Length:553
    Mass (Da):59,335
    Last modified:January 23, 2007 - v3
    Checksum:iC4DF69569E738DAF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241P → L in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti121 – 1211P → L in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti173 – 1731L → M in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti180 – 1801L → M in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti191 – 1911G → D in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti199 – 1991L → M in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti224 – 2252LD → MN in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti233 – 2408DTVEDYKS → ELVEELRN in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti251 – 2511A → D in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti312 – 3121D → V in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti318 – 3181D → V in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti330 – 3323YED → FEV in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti344 – 3441W → L in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti432 – 4321R → M in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti438 – 4381Q → H in AAA39395. (PubMed:6207530)Curated
    Sequence conflicti498 – 4981L → M in AAA39395. (PubMed:6207530)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02108 mRNA. Translation: AAA39395.1.
    AB012033 Genomic DNA. Translation: BAA34178.1.
    BC080820 mRNA. Translation: AAH80820.1.
    CCDSiCCDS27860.1.
    PIRiI59009.
    RefSeqiNP_032502.3. NM_008476.3.
    UniGeneiMm.302399.

    Genome annotation databases

    EnsembliENSMUST00000023788; ENSMUSP00000023788; ENSMUSG00000058354.
    GeneIDi16687.
    KEGGimmu:16687.
    UCSCiuc007xtv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02108 mRNA. Translation: AAA39395.1 .
    AB012033 Genomic DNA. Translation: BAA34178.1 .
    BC080820 mRNA. Translation: AAH80820.1 .
    CCDSi CCDS27860.1.
    PIRi I59009.
    RefSeqi NP_032502.3. NM_008476.3.
    UniGenei Mm.302399.

    3D structure databases

    ProteinModelPortali P50446.
    SMRi P50446. Positions 149-302, 318-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201035. 3 interactions.
    IntActi P50446. 2 interactions.
    MINTi MINT-1859525.
    STRINGi 10090.ENSMUSP00000023788.

    PTM databases

    PhosphoSitei P50446.

    Proteomic databases

    MaxQBi P50446.
    PaxDbi P50446.
    PRIDEi P50446.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023788 ; ENSMUSP00000023788 ; ENSMUSG00000058354 .
    GeneIDi 16687.
    KEGGi mmu:16687.
    UCSCi uc007xtv.1. mouse.

    Organism-specific databases

    CTDi 3853.
    MGIi MGI:1100845. Krt6a.

    Phylogenomic databases

    eggNOGi NOG315845.
    GeneTreei ENSGT00610000085801.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi P50446.
    KOi K07605.
    OMAi MQDQVED.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi P50446.
    TreeFami TF317854.

    Miscellaneous databases

    ChiTaRSi KRT6A. mouse.
    NextBioi 290437.
    PROi P50446.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50446.
    Bgeei P50446.
    CleanExi MM_KRT6A.
    Genevestigatori P50446.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins."
      Steinert P.M., Parry D.A.D., Racoosin E.L., Idler W.W., Steven A.C., Trus B.L., Roop D.R.
      Proc. Natl. Acad. Sci. U.S.A. 81:5709-5713(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epidermis.
    2. "The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs."
      Takahashi K., Yan B., Yamanishi K., Imamura S., Coulombe P.A.
      Genomics 53:170-183(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: 129/Sv.
      Tissue: Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Jaw and Limb.
    4. "Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin."
      Finch J., Andrews K., Krieg P., Furstenberger G., Slaga T., Ootsuyama A., Tanooka H., Bowden G.T.
      Carcinogenesis 12:1519-1522(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 528-553.

    Entry informationi

    Entry nameiK2C6A_MOUSE
    AccessioniPrimary (citable) accession number: P50446
    Secondary accession number(s): Q9Z332
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3