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Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Alternative name(s):
Alpha-S2B-casein
Gene namesi
Name:CSN1S2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2149. Ory c 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 182167Alpha-S2-caseinPRO_0000004456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024897.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP50419.
OMAiVMNPWDQ.
TreeFamiTF339561.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVALAKPKIE QSSSEETIAV SQEVSPNLEN ICSTACEEPI
60 70 80 90 100
KNINEVEYVE VPTEIKDQEF YQKVNLLQYL QALYQYPTVM DPWTRAETKA
110 120 130 140 150
IPFIRTMQYK QEKDATKHTS QKTELTEEEK AFLKYLDEMK QYYQKFVFPQ
160 170 180
YLKNAHHFQK TMNPWNHVKT IIYQSVPTLR YL
Length:182
Mass (Da):21,597
Last modified:October 1, 1996 - v1
Checksum:iF2432C2DA45550FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76909 mRNA. Translation: CAA54231.1.
PIRiS39776.
RefSeqiNP_001075870.1. NM_001082401.1.
UniGeneiOcu.2100.

Genome annotation databases

EnsembliENSOCUT00000025409; ENSOCUP00000024897; ENSOCUG00000023469.
GeneIDi100009288.
KEGGiocu:100009288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76909 mRNA. Translation: CAA54231.1.
PIRiS39776.
RefSeqiNP_001075870.1. NM_001082401.1.
UniGeneiOcu.2100.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024897.

Protein family/group databases

Allergomei2149. Ory c 8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000025409; ENSOCUP00000024897; ENSOCUG00000023469.
GeneIDi100009288.
KEGGiocu:100009288.

Organism-specific databases

CTDi100327035.

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP50419.
OMAiVMNPWDQ.
TreeFamiTF339561.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA2_RABIT
AccessioniPrimary (citable) accession number: P50419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.