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Protein

Cathelicidin-3

Gene

CATHL3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-3
Alternative name(s):
Bactenecin-7
Short name:
Bac7
PR-59
Gene namesi
Name:CATHL3
Synonyms:BAC7, BAC7.5
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000471230 – 130By similarityAdd BLAST101
PeptideiPRO_0000004713131 – 190Cathelicidin-3Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP50415

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi168 – 170Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JWEX-ray1.95C/D131-151[»]
4JWIX-ray1.90C/D165-173[»]
ProteinModelPortaliP50415
SMRiP50415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG006116
KOiK13916

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
IPR018216 Cathelicidin_CS
PANTHERiPTHR10206 PTHR10206, 1 hit
PROSITEiView protein in PROSITE
PS00946 CATHELICIDINS_1, 1 hit
PS00947 CATHELICIDINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQMASPSL GRCSLWLLLL GLLLPSASAQ ALSYREAVLR AVGQLNEKSS
60 70 80 90 100
EVNLYRLLEL DPPPKDAEDQ GARKPVSFRV KETVCPRMSQ QPPEQCDFKE
110 120 130 140 150
NGLVKQCVGT VSLDTSNDEF DLNCNELQSV RRLRPRRPRL PRPRPRPRPR
160 170 180 190
PRSLPLPRPQ PRRIPRPILL PWRPPRPIPR PQPQPIPRWL
Length:190
Mass (Da):21,829
Last modified:October 1, 1996 - v1
Checksum:iE4AAFB1600E98371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46852 mRNA Translation: AAA85468.1
PIRiS68230
RefSeqiNP_001009301.1, NM_001009301.1
UniGeneiOar.409

Genome annotation databases

GeneIDi443311
KEGGioas:443311

Similar proteinsi

Entry informationi

Entry nameiCTHL3_SHEEP
AccessioniPrimary (citable) accession number: P50415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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