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Protein

Cathelicidin-3

Gene

CATHL3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-3
Alternative name(s):
Bactenecin-7
Short name:
Bac7
PR-59
Gene namesi
Name:CATHL3
Synonyms:BAC7, BAC7.5
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 130101By similarityPRO_0000004712Add
BLAST
Peptidei131 – 19060Cathelicidin-3PRO_0000004713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Pyrrolidone carboxylic acidBy similarity
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi168 – 1703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JWEX-ray1.95C/D131-151[»]
4JWIX-ray1.90C/D165-173[»]
ProteinModelPortaliP50415.
SMRiP50415. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG006116.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQMASPSL GRCSLWLLLL GLLLPSASAQ ALSYREAVLR AVGQLNEKSS
60 70 80 90 100
EVNLYRLLEL DPPPKDAEDQ GARKPVSFRV KETVCPRMSQ QPPEQCDFKE
110 120 130 140 150
NGLVKQCVGT VSLDTSNDEF DLNCNELQSV RRLRPRRPRL PRPRPRPRPR
160 170 180 190
PRSLPLPRPQ PRRIPRPILL PWRPPRPIPR PQPQPIPRWL
Length:190
Mass (Da):21,829
Last modified:October 1, 1996 - v1
Checksum:iE4AAFB1600E98371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46852 mRNA. Translation: AAA85468.1.
PIRiS68230.
RefSeqiNP_001009301.1. NM_001009301.1.
UniGeneiOar.409.

Genome annotation databases

GeneIDi443311.
KEGGioas:443311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46852 mRNA. Translation: AAA85468.1.
PIRiS68230.
RefSeqiNP_001009301.1. NM_001009301.1.
UniGeneiOar.409.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JWEX-ray1.95C/D131-151[»]
4JWIX-ray1.90C/D165-173[»]
ProteinModelPortaliP50415.
SMRiP50415. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443311.
KEGGioas:443311.

Organism-specific databases

CTDi281037.

Phylogenomic databases

HOVERGENiHBG006116.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequences of three sheep myeloid cathelicidins."
    Bagella L., Scocchi M., Zanetti M.
    FEBS Lett. 376:225-228(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.

Entry informationi

Entry nameiCTHL3_SHEEP
AccessioniPrimary (citable) accession number: P50415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.