P50411 (IPP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase inhibitor 2
Short name=IPP-2

Gene names

Name:	Ppp1r2
Synonyms:	Ipp2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibitor of protein-phosphatase 1.
Subunit structure	Heterodimer with PP1 By similarity.
Tissue specificity	Central nervous system.
Post-translational modification	Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex By similarity. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex By similarity.
Sequence similarities	Belongs to the protein phosphatase inhibitor 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen metabolism
Molecular function	Protein phosphatase inhibitor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of phosphoprotein phosphatase activity Inferred from electronic annotation. Source: InterPro regulation of signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	protein phosphatase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 205	204	Protein phosphatase inhibitor 2		PRO_0000071484
Regions
	Region	12 – 17	6	Required for binding PPP1CC By similarity
	Region	43 – 55	13	Required for binding PPP1CC By similarity
	Region	147 – 150	4	Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activity By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	44	1	Phosphoserine; by ATM By similarity
	Modified residue	73	1	Phosphothreonine; by GSK3 By similarity
	Modified residue	87	1	Phosphoserine By similarity
	Modified residue	121	1	Phosphoserine By similarity
	Modified residue	122	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50411 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 5D58BC9435A2A5CE	FASTA	205	23,071
	10 20 30 40 50 60 MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM NILATYHPAD 70 80 90 100 110 120 KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL AKKLAAAEGS EPKFRTREQE 130 140 150 160 170 180 SSGEEDNDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMSETADA 190 200 DSMNIEESNQ GSTAGDHLQH KSQSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system." Sakagami H., Kondo H. J. Chem. Neuroanat. 8:259-266(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S79213 mRNA. Translation: AAB35244.1. BC092194 mRNA. Translation: AAH92194.1.
IPI	IPI00400646.
RefSeq	NP_620178.1. NM_138823.2.
UniGene	Rn.4016.
3D structure databases
ProteinModelPortal	P50411.
SMR	P50411. Positions 129-168.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000002361.
PTM databases
PhosphoSite	P50411.
Proteomic databases
PaxDb	P50411.
PRIDE	P50411.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
GeneID	192361.
KEGG	rno:192361.
UCSC	RGD:621099. rat.
Organism-specific databases
CTD	5504.
RGD	621099. Ppp1r2.
Phylogenomic databases
eggNOG	NOG274671.
GeneTree	ENSGT00390000004757.
HOGENOM	HOG000017696.
HOVERGEN	HBG006170.
InParanoid	P50411.
KO	K16833.
OMA	KIDEPNT.
OrthoDB	EOG4PNXJC.
Gene expression databases
Genevestigator	P50411.
GermOnline	ENSRNOG00000001733. Rattus norvegicus.
Family and domain databases
InterPro	IPR007062. PPI-2. [Graphical view]
Pfam	PF04979. IPP-2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	623053.

Entry information

Entry name

IPP2_RAT

Accession

Primary (citable) accession number: P50411
Secondary accession number(s): Q56A32

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program