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P50411 (IPP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase inhibitor 2

Short name=IPP-2
Gene names
Name:Ppp1r2
Synonyms:Ipp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibitor of protein-phosphatase 1.

Subunit structure

Heterodimer with PP1 By similarity.

Tissue specificity

Central nervous system.

Post-translational modification

Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex By similarity. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex By similarity.

Sequence similarities

Belongs to the protein phosphatase inhibitor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 205204Protein phosphatase inhibitor 2
PRO_0000071484

Regions

Region12 – 176Required for binding PPP1CC By similarity
Region43 – 5513Required for binding PPP1CC By similarity
Region147 – 1504Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activity By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue441Phosphoserine; by ATM By similarity
Modified residue731Phosphothreonine; by GSK3 By similarity
Modified residue871Phosphoserine By similarity
Modified residue1211Phosphoserine By similarity
Modified residue1221Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P50411 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 5D58BC9435A2A5CE

FASTA20523,071
        10         20         30         40         50         60 
MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM NILATYHPAD 

        70         80         90        100        110        120 
KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL AKKLAAAEGS EPKFRTREQE 

       130        140        150        160        170        180 
SSGEEDNDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMSETADA 

       190        200 
DSMNIEESNQ GSTAGDHLQH KSQSS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system."
Sakagami H., Kondo H.
J. Chem. Neuroanat. 8:259-266(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqNP_620178.1. NM_138823.2.
UniGeneRn.4016.

3D structure databases

ProteinModelPortalP50411.
SMRP50411. Positions 129-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000002361.

PTM databases

PhosphoSiteP50411.

Proteomic databases

PaxDbP50411.
PRIDEP50411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
GeneID192361.
KEGGrno:192361.
UCSCRGD:621099. rat.

Organism-specific databases

CTD5504.
RGD621099. Ppp1r2.

Phylogenomic databases

eggNOGNOG274671.
GeneTreeENSGT00390000004757.
HOGENOMHOG000017696.
HOVERGENHBG006170.
InParanoidP50411.
KOK16833.
OMAAAEESMN.
OrthoDBEOG776SR7.
PhylomeDBP50411.
TreeFamTF105536.

Gene expression databases

GenevestigatorP50411.

Family and domain databases

InterProIPR007062. PPI-2.
[Graphical view]
PfamPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623053.
PROP50411.

Entry information

Entry nameIPP2_RAT
AccessionPrimary (citable) accession number: P50411
Secondary accession number(s): Q56A32
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families