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P50411

- IPP2_RAT

UniProt

P50411 - IPP2_RAT

Protein

Protein phosphatase inhibitor 2

Gene

Ppp1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Inhibitor of protein-phosphatase 1.

    GO - Molecular functioni

    1. protein phosphatase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycogen metabolic process Source: UniProtKB-KW
    2. regulation of phosphoprotein phosphatase activity Source: InterPro
    3. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase inhibitor 2
    Short name:
    IPP-2
    Gene namesi
    Name:Ppp1r2
    Synonyms:Ipp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi621099. Ppp1r2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 205204Protein phosphatase inhibitor 2PRO_0000071484Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei44 – 441Phosphoserine; by ATMBy similarity
    Modified residuei73 – 731Phosphothreonine; by GSK3By similarity
    Modified residuei87 – 871PhosphoserineBy similarity
    Modified residuei121 – 1211PhosphoserineBy similarity
    Modified residuei122 – 1221PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP50411.
    PRIDEiP50411.

    PTM databases

    PhosphoSiteiP50411.

    Expressioni

    Tissue specificityi

    Central nervous system.

    Gene expression databases

    GenevestigatoriP50411.

    Interactioni

    Subunit structurei

    Heterodimer with PP1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002361.

    Structurei

    3D structure databases

    ProteinModelPortaliP50411.
    SMRiP50411. Positions 129-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 176Required for binding PPP1CCBy similarity
    Regioni43 – 5513Required for binding PPP1CCBy similarityAdd
    BLAST
    Regioni147 – 1504Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274671.
    GeneTreeiENSGT00390000004757.
    HOGENOMiHOG000017696.
    HOVERGENiHBG006170.
    InParanoidiP50411.
    KOiK16833.
    OMAiAAEESMN.
    OrthoDBiEOG776SR7.
    PhylomeDBiP50411.
    TreeFamiTF105536.

    Family and domain databases

    InterProiIPR007062. PPI-2.
    [Graphical view]
    PfamiPF04979. IPP-2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50411-1 [UniParc]FASTAAdd to Basket

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    MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM    50
    NILATYHPAD KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL 100
    AKKLAAAEGS EPKFRTREQE SSGEEDNDLS PEEREKKRQF EMKRKLHYNE 150
    GLNIKLARQL ISKDLHDDDE DEEMSETADA DSMNIEESNQ GSTAGDHLQH 200
    KSQSS 205
    Length:205
    Mass (Da):23,071
    Last modified:January 23, 2007 - v2
    Checksum:i5D58BC9435A2A5CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79213 mRNA. Translation: AAB35244.1.
    BC092194 mRNA. Translation: AAH92194.1.
    RefSeqiNP_620178.1. NM_138823.2.
    UniGeneiRn.4016.

    Genome annotation databases

    EnsembliENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
    GeneIDi192361.
    KEGGirno:192361.
    UCSCiRGD:621099. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79213 mRNA. Translation: AAB35244.1 .
    BC092194 mRNA. Translation: AAH92194.1 .
    RefSeqi NP_620178.1. NM_138823.2.
    UniGenei Rn.4016.

    3D structure databases

    ProteinModelPortali P50411.
    SMRi P50411. Positions 129-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002361.

    PTM databases

    PhosphoSitei P50411.

    Proteomic databases

    PaxDbi P50411.
    PRIDEi P50411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002361 ; ENSRNOP00000002361 ; ENSRNOG00000001733 .
    GeneIDi 192361.
    KEGGi rno:192361.
    UCSCi RGD:621099. rat.

    Organism-specific databases

    CTDi 5504.
    RGDi 621099. Ppp1r2.

    Phylogenomic databases

    eggNOGi NOG274671.
    GeneTreei ENSGT00390000004757.
    HOGENOMi HOG000017696.
    HOVERGENi HBG006170.
    InParanoidi P50411.
    KOi K16833.
    OMAi AAEESMN.
    OrthoDBi EOG776SR7.
    PhylomeDBi P50411.
    TreeFami TF105536.

    Miscellaneous databases

    NextBioi 623053.
    PROi P50411.

    Gene expression databases

    Genevestigatori P50411.

    Family and domain databases

    InterProi IPR007062. PPI-2.
    [Graphical view ]
    Pfami PF04979. IPP-2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system."
      Sakagami H., Kondo H.
      J. Chem. Neuroanat. 8:259-266(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiIPP2_RAT
    AccessioniPrimary (citable) accession number: P50411
    Secondary accession number(s): Q56A32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3