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Protein

Protein phosphatase inhibitor 2

Gene

Ppp1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein phosphatase inhibitor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:Ppp1r2
Synonyms:Ipp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621099. Ppp1r2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendritic spine Source: RGD
  • growth cone Source: RGD
  • protein phosphatase type 1 complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714842 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei44Phosphoserine; by ATMBy similarity1
Modified residuei73Phosphothreonine; by GSK3By similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei96PhosphothreonineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50411.
PRIDEiP50411.

PTM databases

iPTMnetiP50411.
PhosphoSitePlusiP50411.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

BgeeiENSRNOG00000001733.
GenevisibleiP50411. RN.

Interactioni

Subunit structurei

Heterodimer with PP1.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002361.

Structurei

3D structure databases

ProteinModelPortaliP50411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP50411.
KOiK16833.
OrthoDBiEOG091G12FK.
PhylomeDBiP50411.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL
110 120 130 140 150
AKKLAAAEGS EPKFRTREQE SSGEEDNDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMSETADA DSMNIEESNQ GSTAGDHLQH

KSQSS
Length:205
Mass (Da):23,071
Last modified:January 23, 2007 - v2
Checksum:i5D58BC9435A2A5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqiNP_620178.1. NM_138823.2.
UniGeneiRn.4016.

Genome annotation databases

GeneIDi192361.
KEGGirno:192361.
UCSCiRGD:621099. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqiNP_620178.1. NM_138823.2.
UniGeneiRn.4016.

3D structure databases

ProteinModelPortaliP50411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002361.

PTM databases

iPTMnetiP50411.
PhosphoSitePlusiP50411.

Proteomic databases

PaxDbiP50411.
PRIDEiP50411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192361.
KEGGirno:192361.
UCSCiRGD:621099. rat.

Organism-specific databases

CTDi5504.
RGDi621099. Ppp1r2.

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP50411.
KOiK16833.
OrthoDBiEOG091G12FK.
PhylomeDBiP50411.
TreeFamiTF105536.

Miscellaneous databases

PROiP50411.

Gene expression databases

BgeeiENSRNOG00000001733.
GenevisibleiP50411. RN.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPP2_RAT
AccessioniPrimary (citable) accession number: P50411
Secondary accession number(s): Q56A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.