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Protein

Protein phosphatase inhibitor 2

Gene

Ppp1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:Ppp1r2
Synonyms:Ipp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621099. Ppp1r2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendritic spine Source: RGD
  • growth cone Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 205204Protein phosphatase inhibitor 2PRO_0000071484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei44 – 441Phosphoserine; by ATMBy similarity
Modified residuei73 – 731Phosphothreonine; by GSK3By similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei121 – 1211PhosphoserineBy similarity
Modified residuei122 – 1221PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50411.
PRIDEiP50411.

PTM databases

PhosphoSiteiP50411.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

GenevisibleiP50411. RN.

Interactioni

Subunit structurei

Heterodimer with PP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002361.

Structurei

3D structure databases

ProteinModelPortaliP50411.
SMRiP50411. Positions 129-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 176Required for binding PPP1CCBy similarity
Regioni43 – 5513Required for binding PPP1CCBy similarityAdd
BLAST
Regioni147 – 1504Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274671.
GeneTreeiENSGT00390000004757.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP50411.
KOiK16833.
OMAiEMKRKMH.
OrthoDBiEOG776SR7.
PhylomeDBiP50411.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL
110 120 130 140 150
AKKLAAAEGS EPKFRTREQE SSGEEDNDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMSETADA DSMNIEESNQ GSTAGDHLQH

KSQSS
Length:205
Mass (Da):23,071
Last modified:January 23, 2007 - v2
Checksum:i5D58BC9435A2A5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqiNP_620178.1. NM_138823.2.
UniGeneiRn.4016.

Genome annotation databases

EnsembliENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
GeneIDi192361.
KEGGirno:192361.
UCSCiRGD:621099. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqiNP_620178.1. NM_138823.2.
UniGeneiRn.4016.

3D structure databases

ProteinModelPortaliP50411.
SMRiP50411. Positions 129-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002361.

PTM databases

PhosphoSiteiP50411.

Proteomic databases

PaxDbiP50411.
PRIDEiP50411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
GeneIDi192361.
KEGGirno:192361.
UCSCiRGD:621099. rat.

Organism-specific databases

CTDi5504.
RGDi621099. Ppp1r2.

Phylogenomic databases

eggNOGiNOG274671.
GeneTreeiENSGT00390000004757.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP50411.
KOiK16833.
OMAiEMKRKMH.
OrthoDBiEOG776SR7.
PhylomeDBiP50411.
TreeFamiTF105536.

Miscellaneous databases

NextBioi623053.
PROiP50411.

Gene expression databases

GenevisibleiP50411. RN.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system."
    Sakagami H., Kondo H.
    J. Chem. Neuroanat. 8:259-266(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIPP2_RAT
AccessioniPrimary (citable) accession number: P50411
Secondary accession number(s): Q56A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.