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P50411

- IPP2_RAT

UniProt

P50411 - IPP2_RAT

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Protein

Protein phosphatase inhibitor 2

Gene

Ppp1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  1. protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. glycogen metabolic process Source: UniProtKB-KW
  2. regulation of phosphoprotein phosphatase activity Source: InterPro
  3. regulation of signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:Ppp1r2
Synonyms:Ipp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi621099. Ppp1r2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 205204Protein phosphatase inhibitor 2PRO_0000071484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei44 – 441Phosphoserine; by ATMBy similarity
Modified residuei73 – 731Phosphothreonine; by GSK3By similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei121 – 1211PhosphoserineBy similarity
Modified residuei122 – 1221PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex. Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50411.
PRIDEiP50411.

PTM databases

PhosphoSiteiP50411.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

GenevestigatoriP50411.

Interactioni

Subunit structurei

Heterodimer with PP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002361.

Structurei

3D structure databases

ProteinModelPortaliP50411.
SMRiP50411. Positions 129-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 176Required for binding PPP1CCBy similarity
Regioni43 – 5513Required for binding PPP1CCBy similarityAdd
BLAST
Regioni147 – 1504Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274671.
GeneTreeiENSGT00390000004757.
HOGENOMiHOG000017696.
HOVERGENiHBG006170.
InParanoidiP50411.
KOiK16833.
OMAiAAEESMN.
OrthoDBiEOG776SR7.
PhylomeDBiP50411.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50411-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSVVASAE QPRRTVEEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PDTPYHNMIG DDEDVCSDSE GNEVMTPEIL
110 120 130 140 150
AKKLAAAEGS EPKFRTREQE SSGEEDNDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMSETADA DSMNIEESNQ GSTAGDHLQH

KSQSS
Length:205
Mass (Da):23,071
Last modified:January 23, 2007 - v2
Checksum:i5D58BC9435A2A5CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79213 mRNA. Translation: AAB35244.1.
BC092194 mRNA. Translation: AAH92194.1.
RefSeqiNP_620178.1. NM_138823.2.
UniGeneiRn.4016.

Genome annotation databases

EnsembliENSRNOT00000002361; ENSRNOP00000002361; ENSRNOG00000001733.
GeneIDi192361.
KEGGirno:192361.
UCSCiRGD:621099. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79213 mRNA. Translation: AAB35244.1 .
BC092194 mRNA. Translation: AAH92194.1 .
RefSeqi NP_620178.1. NM_138823.2.
UniGenei Rn.4016.

3D structure databases

ProteinModelPortali P50411.
SMRi P50411. Positions 129-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002361.

PTM databases

PhosphoSitei P50411.

Proteomic databases

PaxDbi P50411.
PRIDEi P50411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002361 ; ENSRNOP00000002361 ; ENSRNOG00000001733 .
GeneIDi 192361.
KEGGi rno:192361.
UCSCi RGD:621099. rat.

Organism-specific databases

CTDi 5504.
RGDi 621099. Ppp1r2.

Phylogenomic databases

eggNOGi NOG274671.
GeneTreei ENSGT00390000004757.
HOGENOMi HOG000017696.
HOVERGENi HBG006170.
InParanoidi P50411.
KOi K16833.
OMAi AAEESMN.
OrthoDBi EOG776SR7.
PhylomeDBi P50411.
TreeFami TF105536.

Miscellaneous databases

NextBioi 623053.
PROi P50411.

Gene expression databases

Genevestigatori P50411.

Family and domain databases

InterProi IPR007062. PPI-2.
[Graphical view ]
Pfami PF04979. IPP-2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and its wide gene expression in the central nervous system."
    Sakagami H., Kondo H.
    J. Chem. Neuroanat. 8:259-266(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIPP2_RAT
AccessioniPrimary (citable) accession number: P50411
Secondary accession number(s): Q56A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3