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Protein

V-type proton ATPase subunit F

Gene

Atp6v1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:Atp6v1f
Synonyms:Atp6s14, Vatf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621552. Atp6v1f.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448011 – 119V-type proton ATPase subunit FAdd BLAST119

Proteomic databases

PaxDbiP50408.
PRIDEiP50408.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007392.
GenevisibleiP50408. RN.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

IntActiP50408. 1 interactor.
STRINGi10116.ENSRNOP00000009737.

Structurei

3D structure databases

ProteinModelPortaliP50408.
SMRiP50408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

eggNOGiKOG3432. Eukaryota.
COG1436. LUCA.
GeneTreeiENSGT00390000013208.
HOGENOMiHOG000056545.
HOVERGENiHBG004488.
InParanoidiP50408.
KOiK02151.
OMAiQNVAEMI.
OrthoDBiEOG091G0ZUA.
PhylomeDBiP50408.
TreeFamiTF300080.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

Sequencei

Sequence statusi: Complete.

P50408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQRSIPAVLE IPSKEHPYDA
110
AKDSILRRAK GMFTAEDLR
Length:119
Mass (Da):13,370
Last modified:October 1, 1996 - v1
Checksum:i9FFA95BD2667AA2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43175 mRNA. Translation: AAB03684.1.
RefSeqiNP_446336.1. NM_053884.1.
UniGeneiRn.6167.

Genome annotation databases

EnsembliENSRNOT00000009737; ENSRNOP00000009737; ENSRNOG00000007392.
GeneIDi116664.
KEGGirno:116664.
UCSCiRGD:621552. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43175 mRNA. Translation: AAB03684.1.
RefSeqiNP_446336.1. NM_053884.1.
UniGeneiRn.6167.

3D structure databases

ProteinModelPortaliP50408.
SMRiP50408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50408. 1 interactor.
STRINGi10116.ENSRNOP00000009737.

Proteomic databases

PaxDbiP50408.
PRIDEiP50408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009737; ENSRNOP00000009737; ENSRNOG00000007392.
GeneIDi116664.
KEGGirno:116664.
UCSCiRGD:621552. rat.

Organism-specific databases

CTDi9296.
RGDi621552. Atp6v1f.

Phylogenomic databases

eggNOGiKOG3432. Eukaryota.
COG1436. LUCA.
GeneTreeiENSGT00390000013208.
HOGENOMiHOG000056545.
HOVERGENiHBG004488.
InParanoidiP50408.
KOiK02151.
OMAiQNVAEMI.
OrthoDBiEOG091G0ZUA.
PhylomeDBiP50408.
TreeFamiTF300080.

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Miscellaneous databases

PROiP50408.

Gene expression databases

BgeeiENSRNOG00000007392.
GenevisibleiP50408. RN.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATF_RAT
AccessioniPrimary (citable) accession number: P50408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.