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Protein

V-type proton ATPase subunit F

Gene

Atp6v1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in phagocytes.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit F
Short name:
V-ATPase subunit F
Alternative name(s):
V-ATPase 14 kDa subunit
Vacuolar proton pump subunit F
Gene namesi
Name:Atp6v1f
Synonyms:Atp6s14, Vatf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621552. Atp6v1f.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448011 – 119V-type proton ATPase subunit FAdd BLAST119

Proteomic databases

PaxDbiP50408.
PRIDEiP50408.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007392.
GenevisibleiP50408. RN.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

IntActiP50408. 1 interactor.
STRINGi10116.ENSRNOP00000009737.

Structurei

3D structure databases

ProteinModelPortaliP50408.
SMRiP50408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.Curated

Phylogenomic databases

eggNOGiKOG3432. Eukaryota.
COG1436. LUCA.
GeneTreeiENSGT00390000013208.
HOGENOMiHOG000056545.
HOVERGENiHBG004488.
InParanoidiP50408.
KOiK02151.
OMAiQNVAEMI.
OrthoDBiEOG091G0ZUA.
PhylomeDBiP50408.
TreeFamiTF300080.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiView protein in InterPro
IPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiView protein in Pfam
PF01990. ATP-synt_F. 1 hit.
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

Sequencei

Sequence statusi: Complete.

P50408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQRSIPAVLE IPSKEHPYDA
110
AKDSILRRAK GMFTAEDLR
Length:119
Mass (Da):13,370
Last modified:October 1, 1996 - v1
Checksum:i9FFA95BD2667AA2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43175 mRNA. Translation: AAB03684.1.
RefSeqiNP_446336.1. NM_053884.1.
UniGeneiRn.6167.

Genome annotation databases

EnsembliENSRNOT00000009737; ENSRNOP00000009737; ENSRNOG00000007392.
GeneIDi116664.
KEGGirno:116664.
UCSCiRGD:621552. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVATF_RAT
AccessioniPrimary (citable) accession number: P50408
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families