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Protein

5-hydroxytryptamine receptor 7

Gene

HTR7

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:HTR7
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82ExtracellularBy similarityAdd BLAST82
Transmembranei83 – 109Helical; Name=1By similarityAdd BLAST27
Topological domaini110 – 119CytoplasmicBy similarity10
Transmembranei120 – 145Helical; Name=2By similarityAdd BLAST26
Topological domaini146 – 157ExtracellularBy similarityAdd BLAST12
Transmembranei158 – 179Helical; Name=3By similarityAdd BLAST22
Topological domaini180 – 199CytoplasmicBy similarityAdd BLAST20
Transmembranei200 – 223Helical; Name=4By similarityAdd BLAST24
Topological domaini224 – 238ExtracellularBy similarityAdd BLAST15
Transmembranei239 – 261Helical; Name=5By similarityAdd BLAST23
Topological domaini262 – 329CytoplasmicBy similarityAdd BLAST68
Transmembranei330 – 353Helical; Name=6By similarityAdd BLAST24
Topological domaini354 – 365ExtracellularBy similarityAdd BLAST12
Transmembranei366 – 388Helical; Name=7By similarityAdd BLAST23
Topological domaini389 – 446CytoplasmicBy similarityAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689781 – 4465-hydroxytryptamine receptor 7Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi156 ↔ 232PROSITE-ProRule annotation
Lipidationi402S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006750.

Chemistry databases

BindingDBiP50407.

Structurei

3D structure databases

ProteinModelPortaliP50407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP50407.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGVNSSGRP DLYGHLHSIL LPGRGLPDWS PDGGADPGVS TWTPRLLSGV
60 70 80 90 100
PEVAASPSPS WDGTWDNVSG CGEQINYGRA EKVVIGSILT LITLLTIAGN
110 120 130 140 150
CLVVISVCFV KKLRQPSNYL IVSLALADLS VAVAVIPFVS VTDLIGGKWI
160 170 180 190 200
FGHFFCNVFI AMDVMCCTAS IMTLCVISID RYLGITRPLT YPVRQNGKCM
210 220 230 240 250
PKMILSVWLL SASITLPPLF GWAQNVNDDK VCLISQDFGY TIYSTAVAFY
260 270 280 290 300
IPMSVMLFMY YRIYKAARKS AAKHKFPGFP RVQPESIISL NGMVKLQKEV
310 320 330 340 350
EECANLSRLL KHERKNISIF KREQKAATTL GIIVGAFTVC WLPFFLLSTA
360 370 380 390 400
RPFICGTACS CIPLWVERTC LWLGYANSLI NPFIYAFFNR DLRTTYRSLL
410 420 430 440
QCQYRNINRK LSAAGMHEAL KLAERPERPE CVLQNSDYCR KKGHDS
Length:446
Mass (Da):49,614
Last modified:October 1, 1996 - v1
Checksum:iB63FA73712F3B088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41372 mRNA. Translation: AAA83015.1.
RefSeqiNP_001166435.1. NM_001172964.1.

Genome annotation databases

GeneIDi100135549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41372 mRNA. Translation: AAA83015.1.
RefSeqiNP_001166435.1. NM_001172964.1.

3D structure databases

ProteinModelPortaliP50407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006750.

Chemistry databases

BindingDBiP50407.
ChEMBLiCHEMBL5494.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135549.

Organism-specific databases

CTDi3363.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP50407.

Miscellaneous databases

PROiP50407.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT7R_CAVPO
AccessioniPrimary (citable) accession number: P50407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.