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P50406

- 5HT6R_HUMAN

UniProt

P50406 - 5HT6R_HUMAN

Protein

5-hydroxytryptamine receptor 6

Gene

HTR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

    GO - Molecular functioni

    1. histamine receptor activity Source: ProtInc
    2. protein binding Source: IntAct
    3. serotonin receptor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    3. learning Source: Ensembl
    4. long-term synaptic potentiation Source: Ensembl
    5. negative regulation of acetylcholine secretion, neurotransmission Source: Ensembl
    6. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
    7. negative regulation of glutamate secretion Source: Ensembl
    8. positive regulation of dopamine secretion Source: Ensembl
    9. positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
    10. response to drug Source: Ensembl
    11. response to estradiol Source: Ensembl
    12. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17064. Serotonin receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 6
    Short name:
    5-HT-6
    Short name:
    5-HT6
    Alternative name(s):
    Serotonin receptor 6
    Gene namesi
    Name:HTR6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:5301. HTR6.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4404405-hydroxytryptamine receptor 6PRO_0000068974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP50406.
    PRIDEiP50406.

    PTM databases

    PhosphoSiteiP50406.

    Expressioni

    Tissue specificityi

    Expressed in several human brain regions, most prominently in the caudate nucleus.

    Gene expression databases

    BgeeiP50406.
    CleanExiHS_HTR6.
    GenevestigatoriP50406.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FYNP062417EBI-1182222,EBI-515315

    Protein-protein interaction databases

    BioGridi109594. 1 interaction.
    IntActiP50406. 1 interaction.
    MINTiMINT-7214563.
    STRINGi9606.ENSP00000289753.

    Structurei

    3D structure databases

    ProteinModelPortaliP50406.
    SMRiP50406. Positions 29-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularBy similarityAdd
    BLAST
    Topological domaini58 – 647CytoplasmicBy similarity
    Topological domaini86 – 10015ExtracellularBy similarityAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicBy similarityAdd
    BLAST
    Topological domaini167 – 18418ExtracellularBy similarityAdd
    BLAST
    Topological domaini209 – 26557CytoplasmicBy similarityAdd
    BLAST
    Topological domaini291 – 2955ExtracellularBy similarity
    Topological domaini321 – 440120CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5723Helical; Name=1By similarityAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2By similarityAdd
    BLAST
    Transmembranei101 – 12222Helical; Name=3By similarityAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=4By similarityAdd
    BLAST
    Transmembranei185 – 20824Helical; Name=5By similarityAdd
    BLAST
    Transmembranei266 – 29025Helical; Name=6By similarityAdd
    BLAST
    Transmembranei296 – 32025Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299437.
    HOGENOMiHOG000241520.
    HOVERGENiHBG106962.
    InParanoidiP50406.
    KOiK04162.
    OMAiCLLWTAF.
    OrthoDBiEOG7XH6Q0.
    PhylomeDBiP50406.
    TreeFamiTF351753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL    50
    ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 100
    LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA 150
    WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP 200
    SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA 250
    DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG 300
    LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS 350
    PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL 400
    PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN 440
    Length:440
    Mass (Da):46,954
    Last modified:October 1, 1996 - v1
    Checksum:iC888F47650C1D2EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471V → M in CAA88929. (PubMed:7656980)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41147 mRNA. Translation: AAA92622.1.
    AY429105 mRNA. Translation: AAR07900.1.
    AL031727 Genomic DNA. Translation: CAI19020.1.
    CH471134 Genomic DNA. Translation: EAW94896.1.
    BC074995 mRNA. Translation: AAH74995.1.
    BC074996 mRNA. Translation: AAH74996.1.
    Z49119 mRNA. Translation: CAA88929.1.
    CCDSiCCDS197.1.
    PIRiJC5520.
    RefSeqiNP_000862.1. NM_000871.2.
    UniGeneiHs.22180.

    Genome annotation databases

    EnsembliENST00000289753; ENSP00000289753; ENSG00000158748.
    GeneIDi3362.
    KEGGihsa:3362.
    UCSCiuc001bcl.3. human.

    Polymorphism databases

    DMDMi1703010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41147 mRNA. Translation: AAA92622.1 .
    AY429105 mRNA. Translation: AAR07900.1 .
    AL031727 Genomic DNA. Translation: CAI19020.1 .
    CH471134 Genomic DNA. Translation: EAW94896.1 .
    BC074995 mRNA. Translation: AAH74995.1 .
    BC074996 mRNA. Translation: AAH74996.1 .
    Z49119 mRNA. Translation: CAA88929.1 .
    CCDSi CCDS197.1.
    PIRi JC5520.
    RefSeqi NP_000862.1. NM_000871.2.
    UniGenei Hs.22180.

    3D structure databases

    ProteinModelPortali P50406.
    SMRi P50406. Positions 29-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109594. 1 interaction.
    IntActi P50406. 1 interaction.
    MINTi MINT-7214563.
    STRINGi 9606.ENSP00000289753.

    Chemistry

    BindingDBi P50406.
    ChEMBLi CHEMBL3371.
    DrugBanki DB00889. Granisetron.
    DB00904. Ondansetron.
    DB06144. Sertindole.
    GuidetoPHARMACOLOGYi 11.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P50406.

    Polymorphism databases

    DMDMi 1703010.

    Proteomic databases

    PaxDbi P50406.
    PRIDEi P50406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289753 ; ENSP00000289753 ; ENSG00000158748 .
    GeneIDi 3362.
    KEGGi hsa:3362.
    UCSCi uc001bcl.3. human.

    Organism-specific databases

    CTDi 3362.
    GeneCardsi GC01P019991.
    HGNCi HGNC:5301. HTR6.
    MIMi 601109. gene.
    neXtProti NX_P50406.
    PharmGKBi PA29560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299437.
    HOGENOMi HOG000241520.
    HOVERGENi HBG106962.
    InParanoidi P50406.
    KOi K04162.
    OMAi CLLWTAF.
    OrthoDBi EOG7XH6Q0.
    PhylomeDBi P50406.
    TreeFami TF351753.

    Enzyme and pathway databases

    Reactomei REACT_17064. Serotonin receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii 5-HT6_receptor.
    GenomeRNAii 3362.
    NextBioi 13308.
    PROi P50406.
    SOURCEi Search...

    Gene expression databases

    Bgeei P50406.
    CleanExi HS_HTR6.
    Genevestigatori P50406.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor."
      Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., Sibley D.R., Roth B., Hamblin M.W.
      J. Neurochem. 66:47-56(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Corpus striatum.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    6. "Expression of serotonin receptor mRNAs in blood vessels."
      Ullmer C., Schmuck K., Kalkman H.O., Luebbert H.
      FEBS Lett. 370:215-221(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-280.
      Tissue: Corpus striatum.

    Entry informationi

    Entry namei5HT6R_HUMAN
    AccessioniPrimary (citable) accession number: P50406
    Secondary accession number(s): Q13640, Q5TGZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3