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P50406 (5HT6R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 6

Short name=5-HT-6
Short name=5-HT6
Alternative name(s):
Serotonin receptor 6
Gene names
Name:HTR6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in several human brain regions, most prominently in the caudate nucleus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement Ref.1. Source: ProtInc

brain development

Inferred from electronic annotation. Source: Ensembl

learning

Inferred from electronic annotation. Source: Ensembl

long-term synaptic potentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of acetylcholine secretion, neurotransmission

Inferred from electronic annotation. Source: Ensembl

negative regulation of gamma-aminobutyric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of dopamine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of gamma-aminobutyric acid secretion

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcilium

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionhistamine receptor activity

Traceable author statement Ref.1. Source: ProtInc

serotonin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FYNP062417EBI-1182222,EBI-515315

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4404405-hydroxytryptamine receptor 6
PRO_0000068974

Regions

Topological domain1 – 3434Extracellular By similarity
Transmembrane35 – 5723Helical; Name=1; By similarity
Topological domain58 – 647Cytoplasmic By similarity
Transmembrane65 – 8521Helical; Name=2; By similarity
Topological domain86 – 10015Extracellular By similarity
Transmembrane101 – 12222Helical; Name=3; By similarity
Topological domain123 – 14422Cytoplasmic By similarity
Transmembrane145 – 16622Helical; Name=4; By similarity
Topological domain167 – 18418Extracellular By similarity
Transmembrane185 – 20824Helical; Name=5; By similarity
Topological domain209 – 26557Cytoplasmic By similarity
Transmembrane266 – 29025Helical; Name=6; By similarity
Topological domain291 – 2955Extracellular By similarity
Transmembrane296 – 32025Helical; Name=7; By similarity
Topological domain321 – 440120Cytoplasmic By similarity

Amino acid modifications

Disulfide bond99 ↔ 180 By similarity

Experimental info

Sequence conflict2471V → M in CAA88929. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P50406 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C888F47650C1D2EF

FASTA44046,954
        10         20         30         40         50         60 
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT 

        70         80         90        100        110        120 
SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI 

       130        140        150        160        170        180 
SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC 

       190        200        210        220        230        240 
RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP 

       250        260        270        280        290        300 
RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG 

       310        320        330        340        350        360 
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP 

       370        380        390        400        410        420 
RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF 

       430        440 
FNIDPAEPEL RPHPLGIPTN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor."
Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., Sibley D.R., Roth B., Hamblin M.W.
J. Neurochem. 66:47-56(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corpus striatum.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[6]"Expression of serotonin receptor mRNAs in blood vessels."
Ullmer C., Schmuck K., Kalkman H.O., Luebbert H.
FEBS Lett. 370:215-221(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-280.
Tissue: Corpus striatum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41147 mRNA. Translation: AAA92622.1.
AY429105 mRNA. Translation: AAR07900.1.
AL031727 Genomic DNA. Translation: CAI19020.1.
CH471134 Genomic DNA. Translation: EAW94896.1.
BC074995 mRNA. Translation: AAH74995.1.
BC074996 mRNA. Translation: AAH74996.1.
Z49119 mRNA. Translation: CAA88929.1.
PIRJC5520.
RefSeqNP_000862.1. NM_000871.2.
UniGeneHs.22180.

3D structure databases

ProteinModelPortalP50406.
SMRP50406. Positions 29-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109594. 1 interaction.
IntActP50406. 1 interaction.
MINTMINT-7214563.
STRING9606.ENSP00000289753.

Chemistry

BindingDBP50406.
ChEMBLCHEMBL3371.
DrugBankDB00889. Granisetron.
DB00904. Ondansetron.
DB06144. Sertindole.
GuidetoPHARMACOLOGY11.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP50406.

Polymorphism databases

DMDM1703010.

Proteomic databases

PaxDbP50406.
PRIDEP50406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289753; ENSP00000289753; ENSG00000158748.
GeneID3362.
KEGGhsa:3362.
UCSCuc001bcl.3. human.

Organism-specific databases

CTD3362.
GeneCardsGC01P019991.
HGNCHGNC:5301. HTR6.
MIM601109. gene.
neXtProtNX_P50406.
PharmGKBPA29560.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299437.
HOGENOMHOG000241520.
HOVERGENHBG106962.
InParanoidP50406.
KOK04162.
OMACLLWTAF.
OrthoDBEOG7XH6Q0.
PhylomeDBP50406.
TreeFamTF351753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP50406.
CleanExHS_HTR6.
GenevestigatorP50406.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002232. 5HT6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF4. PTHR24247:SF4. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWiki5-HT6_receptor.
GenomeRNAi3362.
NextBio13308.
PROP50406.
SOURCESearch...

Entry information

Entry name5HT6R_HUMAN
AccessionPrimary (citable) accession number: P50406
Secondary accession number(s): Q13640, Q5TGZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries