Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P50405

- PSPB_MOUSE

UniProt

P50405 - PSPB_MOUSE

Protein

Pulmonary surfactant-associated protein B

Gene

Sftpb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

    GO - Biological processi

    1. respiratory gaseous exchange Source: UniProtKB-KW
    2. sphingolipid metabolic process Source: InterPro

    Keywords - Biological processi

    Gaseous exchange

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein B
    Short name:
    SP-B
    Alternative name(s):
    Pulmonary surfactant-associated proteolipid SPL(Phe)
    Gene namesi
    Name:Sftpb
    Synonyms:Sftp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109516. Sftpb.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. lysosome Source: InterPro

    Keywords - Cellular componenti

    Secreted, Surface film

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 191169PRO_0000031650Add
    BLAST
    Chaini192 – 27079Pulmonary surfactant-associated protein BPRO_0000031651Add
    BLAST
    Propeptidei271 – 377107PRO_0000031652Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 142PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 136PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
    Disulfide bondi199 ↔ 268PROSITE-ProRule annotation
    Disulfide bondi202 ↔ 262PROSITE-ProRule annotation
    Disulfide bondi226 ↔ 237PROSITE-ProRule annotation
    Disulfide bondi239 – 239InterchainPROSITE-ProRule annotation
    Disulfide bondi295 ↔ 362PROSITE-ProRule annotation
    Disulfide bondi298 ↔ 356PROSITE-ProRule annotation
    Glycosylationi307 – 3071N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi321 ↔ 331PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP50405.
    PaxDbiP50405.
    PRIDEiP50405.

    Expressioni

    Gene expression databases

    ArrayExpressiP50405.
    BgeeiP50405.
    CleanExiMM_SFTPB.
    GenevestigatoriP50405.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    IntActiP50405. 1 interaction.
    MINTiMINT-4109008.
    STRINGi10090.ENSMUSP00000066805.

    Structurei

    3D structure databases

    ProteinModelPortaliP50405.
    SMRiP50405. Positions 68-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 6441Saposin A-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini64 – 14683Saposin B-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 27278Saposin B-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 36676Saposin B-type 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 saposin A-type domain.PROSITE-ProRule annotation
    Contains 3 saposin B-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG286450.
    HOGENOMiHOG000115745.
    HOVERGENiHBG006905.
    InParanoidiP50405.
    PhylomeDBiP50405.

    Family and domain databases

    Gene3Di1.10.225.10. 3 hits.
    InterProiIPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view]
    PRINTSiPR01797. SAPOSIN.
    SMARTiSM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 3 hits.
    PROSITEiPS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50405-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKSHLLQWL LLLPTLCCPG AAITSASSLE CAQGPQFWCQ SLEHAVQCRA    50
    LGHCLQEVWG HAGANDLCQE CEDIVHLLTK MTKEDAFQEA IRKFLEQECD 100
    ILPLKLLVPR CRQVLDVYLP LVIDYFQSQI NPKAICNHVG LCPRGQAKPE 150
    QNPGMPDAVP NPLLDKLVLP VLPGALLARP GPHTQDFSEQ QLPIPLPFCW 200
    LCRTLIKRVQ AVIPKGVLAV AVSQVCHVVP LVVGGICQCL AERYTVLLLD 250
    ALLGRVVPQL VCGLVLRCST EDAMGPALPA VEPLIEEWPL QDTECHFCKS 300
    VINQAWNTSE QAMPQAMHQA CLRFWLDRQK CEQFVEQHMP QLLALVPRSQ 350
    DAHITCQALG VCEAPASPLQ CFQTPHL 377
    Length:377
    Mass (Da):41,728
    Last modified:October 1, 1996 - v1
    Checksum:iCB687A82BA3FC56C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78114 Genomic DNA. Translation: AAB34846.2.
    RefSeqiNP_680088.1. NM_147779.2.
    UniGeneiMm.46033.

    Genome annotation databases

    GeneIDi20388.
    UCSCiuc009cid.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78114 Genomic DNA. Translation: AAB34846.2 .
    RefSeqi NP_680088.1. NM_147779.2.
    UniGenei Mm.46033.

    3D structure databases

    ProteinModelPortali P50405.
    SMRi P50405. Positions 68-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P50405. 1 interaction.
    MINTi MINT-4109008.
    STRINGi 10090.ENSMUSP00000066805.

    Proteomic databases

    MaxQBi P50405.
    PaxDbi P50405.
    PRIDEi P50405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20388.
    UCSCi uc009cid.1. mouse.

    Organism-specific databases

    MGIi MGI:109516. Sftpb.

    Phylogenomic databases

    eggNOGi NOG286450.
    HOGENOMi HOG000115745.
    HOVERGENi HBG006905.
    InParanoidi P50405.
    PhylomeDBi P50405.

    Miscellaneous databases

    NextBioi 298318.
    PROi P50405.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50405.
    Bgeei P50405.
    CleanExi MM_SFTPB.
    Genevestigatori P50405.

    Family and domain databases

    Gene3Di 1.10.225.10. 3 hits.
    InterProi IPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01797. SAPOSIN.
    SMARTi SM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 3 hits.
    PROSITEi PS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and function of the mouse surfactant protein B gene."
      Bruno M.A., Bohinski R.J., Carter J.E., Foss K.A., Whitsett J.A.
      Am. J. Physiol. 268:L381-L389(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
      Tissue: Liver.

    Entry informationi

    Entry nameiPSPB_MOUSE
    AccessioniPrimary (citable) accession number: P50405
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3