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P50405

- PSPB_MOUSE

UniProt

P50405 - PSPB_MOUSE

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Protein

Pulmonary surfactant-associated protein B

Gene

Sftpb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

GO - Biological processi

  1. respiratory gaseous exchange Source: UniProtKB-KW
  2. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Phe)
Gene namesi
Name:Sftpb
Synonyms:Sftp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:109516. Sftpb.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: UniProtKB-KW
  3. lysosome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 191169PRO_0000031650Add
BLAST
Chaini192 – 27079Pulmonary surfactant-associated protein BPRO_0000031651Add
BLAST
Propeptidei271 – 377107PRO_0000031652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 142PROSITE-ProRule annotation
Disulfide bondi71 ↔ 136PROSITE-ProRule annotation
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi199 ↔ 268PROSITE-ProRule annotation
Disulfide bondi202 ↔ 262PROSITE-ProRule annotation
Disulfide bondi226 ↔ 237PROSITE-ProRule annotation
Disulfide bondi239 – 239InterchainPROSITE-ProRule annotation
Disulfide bondi295 ↔ 362PROSITE-ProRule annotation
Disulfide bondi298 ↔ 356PROSITE-ProRule annotation
Glycosylationi307 – 3071N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi321 ↔ 331PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP50405.
PaxDbiP50405.
PRIDEiP50405.

Expressioni

Gene expression databases

BgeeiP50405.
CleanExiMM_SFTPB.
ExpressionAtlasiP50405. baseline and differential.
GenevestigatoriP50405.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

IntActiP50405. 1 interaction.
MINTiMINT-4109008.
STRINGi10090.ENSMUSP00000066805.

Structurei

3D structure databases

ProteinModelPortaliP50405.
SMRiP50405. Positions 68-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 6441Saposin A-typePROSITE-ProRule annotationAdd
BLAST
Domaini64 – 14683Saposin B-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 27278Saposin B-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini291 – 36676Saposin B-type 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 saposin A-type domain.PROSITE-ProRule annotation
Contains 3 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG286450.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
InParanoidiP50405.
PhylomeDBiP50405.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR008139. SaposinB.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50405-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKSHLLQWL LLLPTLCCPG AAITSASSLE CAQGPQFWCQ SLEHAVQCRA
60 70 80 90 100
LGHCLQEVWG HAGANDLCQE CEDIVHLLTK MTKEDAFQEA IRKFLEQECD
110 120 130 140 150
ILPLKLLVPR CRQVLDVYLP LVIDYFQSQI NPKAICNHVG LCPRGQAKPE
160 170 180 190 200
QNPGMPDAVP NPLLDKLVLP VLPGALLARP GPHTQDFSEQ QLPIPLPFCW
210 220 230 240 250
LCRTLIKRVQ AVIPKGVLAV AVSQVCHVVP LVVGGICQCL AERYTVLLLD
260 270 280 290 300
ALLGRVVPQL VCGLVLRCST EDAMGPALPA VEPLIEEWPL QDTECHFCKS
310 320 330 340 350
VINQAWNTSE QAMPQAMHQA CLRFWLDRQK CEQFVEQHMP QLLALVPRSQ
360 370
DAHITCQALG VCEAPASPLQ CFQTPHL
Length:377
Mass (Da):41,728
Last modified:October 1, 1996 - v1
Checksum:iCB687A82BA3FC56C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78114 Genomic DNA. Translation: AAB34846.2.
RefSeqiNP_680088.1. NM_147779.2.
UniGeneiMm.46033.

Genome annotation databases

GeneIDi20388.
UCSCiuc009cid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78114 Genomic DNA. Translation: AAB34846.2 .
RefSeqi NP_680088.1. NM_147779.2.
UniGenei Mm.46033.

3D structure databases

ProteinModelPortali P50405.
SMRi P50405. Positions 68-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50405. 1 interaction.
MINTi MINT-4109008.
STRINGi 10090.ENSMUSP00000066805.

Proteomic databases

MaxQBi P50405.
PaxDbi P50405.
PRIDEi P50405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20388.
UCSCi uc009cid.1. mouse.

Organism-specific databases

CTDi 6439.
MGIi MGI:109516. Sftpb.

Phylogenomic databases

eggNOGi NOG286450.
HOGENOMi HOG000115745.
HOVERGENi HBG006905.
InParanoidi P50405.
PhylomeDBi P50405.

Miscellaneous databases

NextBioi 298318.
PROi P50405.
SOURCEi Search...

Gene expression databases

Bgeei P50405.
CleanExi MM_SFTPB.
ExpressionAtlasi P50405. baseline and differential.
Genevestigatori P50405.

Family and domain databases

Gene3Di 1.10.225.10. 3 hits.
InterProi IPR003119. SapA.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view ]
PRINTSi PR01797. SAPOSIN.
SMARTi SM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 3 hits.
PROSITEi PS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and function of the mouse surfactant protein B gene."
    Bruno M.A., Bohinski R.J., Carter J.E., Foss K.A., Whitsett J.A.
    Am. J. Physiol. 268:L381-L389(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.

Entry informationi

Entry nameiPSPB_MOUSE
AccessioniPrimary (citable) accession number: P50405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3