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Protein

Pulmonary surfactant-associated protein B

Gene

Sftpb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
Pulmonary surfactant-associated proteolipid SPL(Phe)
Gene namesi
Name:Sftpb
Synonyms:Sftp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109516. Sftpb.

Subcellular locationi

GO - Cellular componenti

  • alveolar lamellar body Source: GO_Central
  • cytoplasm Source: MGI
  • extracellular space Source: GO_Central
  • lysosome Source: InterPro
  • multivesicular body Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003165023 – 191Add BLAST169
ChainiPRO_0000031651192 – 270Pulmonary surfactant-associated protein BAdd BLAST79
PropeptideiPRO_0000031652271 – 377Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 142PROSITE-ProRule annotation
Disulfide bondi71 ↔ 136PROSITE-ProRule annotation
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi199 ↔ 268PROSITE-ProRule annotation
Disulfide bondi202 ↔ 262PROSITE-ProRule annotation
Disulfide bondi226 ↔ 237PROSITE-ProRule annotation
Disulfide bondi239InterchainPROSITE-ProRule annotation
Disulfide bondi295 ↔ 362PROSITE-ProRule annotation
Disulfide bondi298 ↔ 356PROSITE-ProRule annotation
Glycosylationi307N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi321 ↔ 331PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP50405.
PaxDbiP50405.
PRIDEiP50405.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056370.
CleanExiMM_SFTPB.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP50405. 1 interactor.
MINTiMINT-4109008.
STRINGi10090.ENSMUSP00000066805.

Structurei

3D structure databases

ProteinModelPortaliP50405.
SMRiP50405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 64Saposin A-typePROSITE-ProRule annotationAdd BLAST41
Domaini64 – 146Saposin B-type 1PROSITE-ProRule annotationAdd BLAST83
Domaini195 – 272Saposin B-type 2PROSITE-ProRule annotationAdd BLAST78
Domaini291 – 366Saposin B-type 3PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 saposin A-type domain.PROSITE-ProRule annotation
Contains 3 saposin B-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
InParanoidiP50405.
OMAiVWGHVGA.
OrthoDBiEOG091G0K86.
PhylomeDBiP50405.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSHLLQWL LLLPTLCCPG AAITSASSLE CAQGPQFWCQ SLEHAVQCRA
60 70 80 90 100
LGHCLQEVWG HAGANDLCQE CEDIVHLLTK MTKEDAFQEA IRKFLEQECD
110 120 130 140 150
ILPLKLLVPR CRQVLDVYLP LVIDYFQSQI NPKAICNHVG LCPRGQAKPE
160 170 180 190 200
QNPGMPDAVP NPLLDKLVLP VLPGALLARP GPHTQDFSEQ QLPIPLPFCW
210 220 230 240 250
LCRTLIKRVQ AVIPKGVLAV AVSQVCHVVP LVVGGICQCL AERYTVLLLD
260 270 280 290 300
ALLGRVVPQL VCGLVLRCST EDAMGPALPA VEPLIEEWPL QDTECHFCKS
310 320 330 340 350
VINQAWNTSE QAMPQAMHQA CLRFWLDRQK CEQFVEQHMP QLLALVPRSQ
360 370
DAHITCQALG VCEAPASPLQ CFQTPHL
Length:377
Mass (Da):41,728
Last modified:October 1, 1996 - v1
Checksum:iCB687A82BA3FC56C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78114 Genomic DNA. Translation: AAB34846.2.
RefSeqiNP_680088.1. NM_147779.2.
UniGeneiMm.46033.

Genome annotation databases

EnsembliENSMUST00000192630; ENSMUSP00000141551; ENSMUSG00000103879.
GeneIDi20388.
KEGGimmu:20388.
UCSCiuc057adr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78114 Genomic DNA. Translation: AAB34846.2.
RefSeqiNP_680088.1. NM_147779.2.
UniGeneiMm.46033.

3D structure databases

ProteinModelPortaliP50405.
SMRiP50405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50405. 1 interactor.
MINTiMINT-4109008.
STRINGi10090.ENSMUSP00000066805.

Proteomic databases

MaxQBiP50405.
PaxDbiP50405.
PRIDEiP50405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192630; ENSMUSP00000141551; ENSMUSG00000103879.
GeneIDi20388.
KEGGimmu:20388.
UCSCiuc057adr.1. mouse.

Organism-specific databases

CTDi6439.
MGIiMGI:109516. Sftpb.

Phylogenomic databases

eggNOGiKOG1340. Eukaryota.
ENOG410XSI5. LUCA.
HOGENOMiHOG000115745.
HOVERGENiHBG006905.
InParanoidiP50405.
OMAiVWGHVGA.
OrthoDBiEOG091G0K86.
PhylomeDBiP50405.

Miscellaneous databases

PROiP50405.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056370.
CleanExiMM_SFTPB.

Family and domain databases

Gene3Di1.10.225.10. 3 hits.
InterProiIPR003119. SAP_A.
IPR007856. SapB_1.
IPR008138. SapB_2.
IPR008373. Saposin.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF02199. SapA. 1 hit.
PF05184. SapB_1. 1 hit.
PF03489. SapB_2. 2 hits.
[Graphical view]
PRINTSiPR01797. SAPOSIN.
SMARTiSM00162. SAPA. 1 hit.
SM00741. SapB. 3 hits.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 3 hits.
PROSITEiPS51110. SAP_A. 1 hit.
PS50015. SAP_B. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSPB_MOUSE
AccessioniPrimary (citable) accession number: P50405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.