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Protein

Pulmonary surfactant-associated protein D

Gene

Sftpd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-5683826. Surfactant metabolism.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Lung surfactant protein D
Gene namesi
Name:Sftpd
Synonyms:Sftp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109515. Sftpd.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • cytoplasm Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001746620 – 374Pulmonary surfactant-associated protein DAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34S-nitrosocysteineBy similarity1
Modified residuei39S-nitrosocysteineBy similarity1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi280 ↔ 372PROSITE-ProRule annotation
Disulfide bondi350 ↔ 364PROSITE-ProRule annotation

Post-translational modificationi

S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

MaxQBiP50404.
PaxDbiP50404.
PeptideAtlasiP50404.
PRIDEiP50404.

PTM databases

PhosphoSitePlusiP50404.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021795.
CleanExiMM_SFTPD.
GenevisibleiP50404. MM.

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Protein-protein interaction databases

BioGridi203194. 2 interactors.
DIPiDIP-46338N.
IntActiP50404. 2 interactors.
MINTiMINT-4134396.
STRINGi10090.ENSMUSP00000076383.

Structurei

3D structure databases

ProteinModelPortaliP50404.
SMRiP50404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 221Collagen-likeAdd BLAST177
Domaini259 – 374C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 253Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SFTPD family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP50404.
KOiK10068.
OMAiAENCVEI.
OrthoDBiEOG091G0MYV.
PhylomeDBiP50404.
TreeFamiTF330481.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFLSMLVL LVQPLGNLGA EMKSLSQRSV PNTCTLVMCS PTENGLPGRD
60 70 80 90 100
GRDGREGPRG EKGDPGLPGP MGLSGLQGPT GPVGPKGENG SAGEPGPKGE
110 120 130 140 150
RGLSGPPGLP GIPGPAGKEG PSGKQGNIGP QGKPGPKGEA GPKGEVGAPG
160 170 180 190 200
MQGSTGAKGS TGPKGERGAP GVQGAPGNAG AAGPAGPAGP QGAPGSRGPP
210 220 230 240 250
GLKGDRGVPG DRGIKGESGL PDSAALRQQM EALKGKLQRL EVAFSHYQKA
260 270 280 290 300
ALFPDGRSVG DKIFRTADSE KPFEDAQEMC KQAGGQLASP RSATENAAIQ
310 320 330 340 350
QLITAHNKAA FLSMTDVGTE GKFTYPTGEP LVYSNWAPGE PNNNGGAENC
360 370
VEIFTNGQWN DKACGEQRLV ICEF
Length:374
Mass (Da):37,688
Last modified:October 1, 1996 - v1
Checksum:iFE034261263F43E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40156 mRNA. Translation: AAA92021.1.
AF047742, AF047741 Genomic DNA. Translation: AAD31380.1.
AF192134 Genomic DNA. Translation: AAF15277.1.
BC003705 mRNA. Translation: AAH03705.1.
CCDSiCCDS26962.1.
RefSeqiNP_033186.1. NM_009160.2.
UniGeneiMm.1321.

Genome annotation databases

EnsembliENSMUST00000077136; ENSMUSP00000076383; ENSMUSG00000021795.
GeneIDi20390.
KEGGimmu:20390.
UCSCiuc007tcr.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-D

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40156 mRNA. Translation: AAA92021.1.
AF047742, AF047741 Genomic DNA. Translation: AAD31380.1.
AF192134 Genomic DNA. Translation: AAF15277.1.
BC003705 mRNA. Translation: AAH03705.1.
CCDSiCCDS26962.1.
RefSeqiNP_033186.1. NM_009160.2.
UniGeneiMm.1321.

3D structure databases

ProteinModelPortaliP50404.
SMRiP50404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203194. 2 interactors.
DIPiDIP-46338N.
IntActiP50404. 2 interactors.
MINTiMINT-4134396.
STRINGi10090.ENSMUSP00000076383.

PTM databases

PhosphoSitePlusiP50404.

Proteomic databases

MaxQBiP50404.
PaxDbiP50404.
PeptideAtlasiP50404.
PRIDEiP50404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077136; ENSMUSP00000076383; ENSMUSG00000021795.
GeneIDi20390.
KEGGimmu:20390.
UCSCiuc007tcr.2. mouse.

Organism-specific databases

CTDi6441.
MGIiMGI:109515. Sftpd.

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP50404.
KOiK10068.
OMAiAENCVEI.
OrthoDBiEOG091G0MYV.
PhylomeDBiP50404.
TreeFamiTF330481.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-5683826. Surfactant metabolism.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Miscellaneous databases

PROiP50404.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021795.
CleanExiMM_SFTPD.
GenevisibleiP50404. MM.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFTPD_MOUSE
AccessioniPrimary (citable) accession number: P50404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.